Antiviral effect of a derivative of isonicotinic acid enisamium iodide (FAV00A) against influenza virus.

Abstract:

:With only a single class of antiviral drugs existing for treatment of influenza (neuraminidase inhibitors), the search for novel effective compounds is urgently needed. We evaluated a low molecular mass compound, enisamium iodide (FAV00A), against influenza virus infections in primary differentiated normal human bronchial epithelial (NHBE) cells, and in ferrets. FAV00A (500 µg/ml) markedly inhibited influenza virus replication and reduced viral M-gene expression in NHBE cells. Treatment of ferrets with FAV00A (200 mg/kg once daily for 7 days) initiated 24 h after inoculation with 105 TCID50 of influenza A/Wisconsin/67/2005 (H3N2) virus resulted in a significant decrease in virus titers in the upper respiratory tract. Our data show that FAV00A exhibits an antiviral effect against influenza virus in NHBE cells and provides some benefits in a ferret model. Thus, further Keywords: antiviral agents; enisamium iodide; influenza virus; MDCK cells; NHBE cells; ferrets.

journal_name

Acta Virol

journal_title

Acta virologica

authors

Cocking D,Cinatl J,Boltz DA,Peng X,Johnson W,Muzzio M,Syarkevych O,Kostyuk G,Goy A,Mueller L,Margitich VI

doi

10.4149/av_2018_211

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

191-195

issue

2

eissn

0001-723X

issn

1336-2305

journal_volume

62

pub_type

杂志文章
  • Replication of Langat virus in immunocompetent cells of mice subjected to immobilization stress.

    abstract::Immobilization stress (hypokinesis) in Balb/c mice may aggravate asymptomatic infection with Langat virus (strain TP-21) as evidenced by 4-fold increased lethality in comparison with control animals. The virus levels in the spleen and brain of stressed and infected mice and the in vitro yield of the virus in immunocom...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Ozherelkov SV,Khozinsky VV,Semenov BF

    更新日期:1990-05-01 00:00:00

  • Two genetically similar H9N2 influenza viruses isolated from different species show similar virulence in minks but different virulence in mice.

    abstract::The H9N2 influenza virus has been frequently endemic in poultry, infected mammals and humans and has threatened public health. It is therefore imperative to understand the molecular mechanism enabling this virus to jump from avian to mammalian species. In this study, two H9N2 influenza viruses were isolated from the s...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:10.4149/av_2020_109

    authors: Ren W,Zhang CH,Li G,Liu G,Shan H,Li J

    更新日期:2020-01-01 00:00:00

  • Increased incidence of mumps in the Czech Republic in the years 2011 and 2012.

    abstract::A nation-wide vaccination against mumps that had been launched in the Czech Republic in 1987 eliminated great outbreaks (up to 100,000 cases per year) of this disease in 1955-1988, but did not prevent small outbreaks (a few thousand cases per year) in 1995-1996, 2005-2007, and 2010-2012. The extent of these small outb...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Lexová P,Limberková R,Cástková J,Kynčl J

    更新日期:2013-01-01 00:00:00

  • Porcine mitogen-induced interferon.

    abstract::Induction of porcine interferon (PoIFN) with different lectins (phytohaemagglutinin, Lens culinaris lectin, Arachis hypogea lectin) in various concentrations (500, 50 and 5 micrograms/ml) was studied. Kinetics of PoIFN appearance was analyzed by antiviral and antiproliferative tests in human transformed and nontransfo...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Filipic B,Golob A,Struna T,Likar M

    更新日期:1994-04-01 00:00:00

  • Hepatitis C virus infection of mouse hepatoma cell expressing human CD81 or LDLR.

    abstract::Hepatitis C virus (HCV) infection represents a serious public health problem worldwide. Development of new therapeutics against HCV has been hampered by the lack of a small-animal model. Until now, it has been unclear which host factors influence the HCV infection. It was known that human CD81 (hCD81) or low-density l...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:10.4149/av_2009_03_185

    authors: Lv LP,Jia SZ,Wang QL,Zhang YY,Zhou H,Xu JB

    更新日期:2009-01-01 00:00:00

  • Modulation in response to temperature of Mayaro virus proteosynthesis in Aedes Albopictus cells.

    abstract::Incubation of Aedes albopictus cells infected with Mayaro virus at 37 degrees C causes inhibition of virus replication. During the first hour post infection (p.i.) incubation at 37 degrees C inhibited cellular and virus proteosynthesis. A preferential translation of heat shock proteins 82 kD and 70 kD was observed. Af...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Carvalho Mda G,Mezêncio Jda S,Rebello M,Freitas MS

    更新日期:1989-05-01 00:00:00

  • A peptide vaccine based on a B-cell epitope on the VP1 protein of enterovirus 70 induces a strong antibody response.

    abstract::Enterovirus 70 (EV70) is the causative agent of acute hemorrhagic conjunctivitis (AHC), for which no effective vaccine is available. This study revealed a high reactivity of the N-terminal region of EV70 VP1 (VP1-1) with an anti-EV70 mouse serum. The analysis of overlapping synthetic peptides of VP1-1 identified a B-c...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:10.4149/av_2012_04_337

    authors: Park KB,Lim BK,Ye MB,Chung SY,Nam JH

    更新日期:2012-01-01 00:00:00

  • High Th1-type cytokine serum levels in patients with infectious mononucleosis.

    abstract::Most adults are asymptomatically infected with Epstein-Barr virus (EBV). Primary EBV infection is commonly associated with acute infectious mononucleosis (IM). T cell immune activation plays an important role in EBV-associated diseases. IM shows a mainly Th1-type profile, so Th1-type cytokines such as interleukin-2 (I...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Corsi MM,Ruscica M,Passoni D,Scarmozzino MG,Gulletta E

    更新日期:2004-01-01 00:00:00

  • Identification of a novel member of the family Betaflexiviridae from the hallucinogenic plant Salvia divinorum.

    abstract::Betaflexiviridae is a family of plant-infecting RNA viruses with 11 recognized genera, of which genomes have diverse organization with three to six open reading frames (ORFs). A genome sequence of a novel Betaflexiviridae species, named Salvia divinorum RNA virus 1 (SdRV1), was identified in Salvia divinorum, herbal m...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:10.4149/av_2019_401

    authors: Goh CJ,Hahn Y

    更新日期:2019-01-01 00:00:00

  • Rickettsiae as organisms.

    abstract::Although most pathogenic rickettsiae are obligate intracellular parasites, it is clear that they are bacteria. As such, form and function in rickettsiae are closely similar to form and function found in their free-living counterparts. This review of rickettsiae as bacteria portrays the broad similarities of rickettsia...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Ormsbee RA

    更新日期:1985-09-01 00:00:00

  • Identification of a novel human sand family protein in human fibroblasts induced by herpes simplex virus 1 binding.

    abstract::Studies on interaction between Herpes simplex virus 1 (HSV-1) and human fibroblasts KMB-17 have demonstrated that HSV-1 binding to the cell surface could induce a specific gene response. In this study, the HSV-1 stimulation-related gene 1 (HSRG1), a new so far unknown gene function of cellular response induced by a sp...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Dong S,Dong C,Liu L,Che Y,Sun M,Hu F,Li J,Li Q

    更新日期:2003-01-01 00:00:00

  • Protection of rabbits against lapinized rinderpest virus with purified envelope glycoproteins of peste-des-petits-ruminants and rinderpest viruses.

    abstract::Haemagglutinin (HA) and fusion (F) proteins of peste-des-petits-ruminants virus (PPRV) and rinderpest virus (RPV) were purified by immunoaffinity chromatography. The purified proteins were characterized by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS-PAGE). Rabbit hyperimmune sera ...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Devireddy LR,Raghavan R,Ramachandran S,Subbarao SM

    更新日期:1998-11-01 00:00:00

  • S100P, a peculiar member of S100 family of calcium-binding proteins implicated in cancer.

    abstract::S100P belongs to several members of the S100 family of calcium-binding proteins, associated with malignant phenotype. Altered levels of S100P expression have been described at different stages and types of cancer. Transcriptional regulation involves different pathways activated by glucocorticoids, growth factors and b...

    journal_title:Acta virologica

    pub_type: 杂志文章,评审

    doi:10.4149/av_2013_02_238

    authors: Tóthová V,Gibadulinová A

    更新日期:2013-01-01 00:00:00

  • Behaviour of ts mutants of pseudorabies virus in the range between permissive and nonpermissive temperature.

    abstract::The growth properties of pseudorabies virus (PRV) strain V BUK, wild type and its four ts mutants, were examined using highly accurate temperature measurements in the incubator and on the cell sheet. The transition from permissive to nonpermissive temperature occurred within an interval of 1 degree C. The midpoint of ...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Hegenscheid B,Stäber H,Waschke K,Rosenthal HA

    更新日期:1982-01-01 00:00:00

  • Correlation between reproductive and interfering activities of epidemic and thermosensitive influenza virus strains.

    abstract::Differences in interfering activities were demonstrated between low-passage epidemic and thermosensitive cold-adapted strains of influenza viruses A and B in experiments on chick embryos inoculated on the chorioallantoic membranes and on white mice. At a high multiplicity of infection the thermosensitive variants show...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Aleksandrova GI,Dekhtyareva NI,Medvedeva TE,Shneider MA

    更新日期:1982-05-01 00:00:00

  • Effect of cellular inhibitors on the infection of various susceptible cells with vesicular stomatitis virus.

    abstract::The effect of some cellular function inhibitors on adsorption and successive events of penetration of vesicular stomatitis virus to phylogenetically unrelated permissive cells was investigated. Treatment of HeLa, CER, EPC and Aedes albopictus cells with colcemide and cytochalasin D which affect cytoskeleton organizati...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Superti F,Seganti L,Orsi N

    更新日期:1988-11-01 00:00:00

  • Use of Tomato leaf curl virus (TYLCV) truncated Rep gene sequence to engineer TYLCV resistance in tomato plants.

    abstract::Tomato yellow leaf curl disease causes severe losses in tomato production throughout Mediterranean countries including Tunisia. In order to generate engineered resistance to this disease, an intron-hairpin RNA construct harboring a Tomato yellow leaf curl Sardinia virus (TYLCSV) truncated replication-associated protei...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:10.4149/av_2009_02_99

    authors: Ben Tamarzizt H,Gharsallah Chouchane S,Lengliz R,Maxwell DP,Marrakchi M,Fakhfakh H,Gorsane F

    更新日期:2009-01-01 00:00:00

  • Ultrastructural localization by immunoperoxidase techniques of influenza virus antigens in abortive infection of L cells.

    abstract::An abortive infection was induced in L cells by influenza virus A/Hong Kong/68 (H3N2). With the use of antibody and peroxidase-labelled protein A, the localization of virus protein synthesis but not the maturation of virus particles was demonstrated at the ultrastructural level. Five days after inoculation (p.i.), the...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Ciampor F,Sidorenko EV,Taikova NV,Bystrická M

    更新日期:1981-11-01 00:00:00

  • Replication of poxvirus DNA in chick embryo fibroblasts.

    abstract::Replication of vaccinia virus DNA in chick embryo fibroblasts at a high multiplicity of infection started after 4-6 hr, reached a maximum at the 12th hr and was completed 18 hr after inoculation (p.i.). An analysis of newly synthesised DNAs in the period of the highest rate of synthesis revealed the formation of short...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Chelyapov NV,Chernos VI

    更新日期:1981-01-01 00:00:00

  • Reactions of immune sera against the nucleocapsid, envelope and whole herpes simplex virus type 1.

    abstract::Antibodies against (a) naked particles, (b) virus envelope, and (c) whole herpes simplex virus (HSV) type 1 were investigated. Immune rabbit serum against naked particles (and formalized naked particles) contained virus neutralizing (VN) antibody in a low titre as compared to the titre of complement-fixing (CF) antibo...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Lesso J,Hána L,Matis J

    更新日期:1976-02-01 00:00:00

  • Role of genes 4 and 6 for the expression of some biological properties of influenza virus A/PR/8/34.

    abstract::Genetic composition and biological properties of influenza virus recombinants A/PR/8/34 (H1N1) and A/Greifswald/6/74 (H3N2) were analysed. The haemagglutinin (HA) gene of the strain A/PR/8/34 was shown an important part of the gene complex determining the virulence for mice, the yield of HA and the plaque forming capa...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Döhner L,Herrmann B,Mentel R,Krenz S

    更新日期:1983-11-01 00:00:00

  • A rickettsia-like organism showing positive immunofluorescence with antisera to Coxiella burnetii in Haemaphysalis inermis ticks.

    abstract::A rickettsia-like organism (RLO) was detected in the oocytes of Haemaphysalis inermis ticks. The RLOs were about 5 microns long bent rods with a definite inner structure. They were Gram-negative and could be visualized by Giemsa but not by Gimenez staining. Attempts to cultivate the RLO in chick embryo yolk sacs, vari...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Kovácová E,Rehácek J,Ciampor F

    更新日期:1981-09-01 00:00:00

  • Neopterin and soluble CD14 levels as indicators of immune activation in cases with low anti-HCV reactivity and true HCV infection.

    abstract::Neopterin and soluble CD14 (sCD14) are detected at high levels in hepatitis C virus (HCV) infections. We aimed to evaluate the role of these plasma immune activation biomarkers, for the indirect assessment of immune activation status of patients with low anti-HCV reactivity and a HCV infection. Low anti-HCV reactivity...

    journal_title:Acta virologica

    pub_type: 杂志文章,多中心研究

    doi:10.4149/av_2017_304

    authors: Habip Z,Sohrabi P,Saribas S,Caliskan R,Demirci M,Karakullukcu A,Atalik K,Yuksel P,Uysal O,Kosan E,Bahar Tokman H,Kocazeybek B

    更新日期:2017-01-01 00:00:00

  • Ribonuclease-resistant RNA of Kemerovo virus.

    abstract::RNA of partially purified Kemerovo virus sedimented in a relatively broad region in sucrose density gradient with a peak at 14 S. Approximately 65% of this RNA was resistant to the action of ribonuclease which indicates the double-stranded nature of Kemerovo virus RNA. ...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Rosenbergová M,Slávik I

    更新日期:1975-01-01 00:00:00

  • Evaluation of anti-influenza efficiency of polyclonal IgG antibodies specific to the ectodomain of M2 protein of influenza A virus by passive immunization of mice.

    abstract::We attempted to quantify the protective potential of polyclonal IgG antibodies specific to the ectodomain of M2 protein (eM2) of influenza A virus (IAV) against lethal influenza infection of mice. For this purpose, eM2 conjugated with keyhole limpet hemocyanin (KLH) or KLH alone were administered with Freund's adjuvan...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:10.4149/av_2011_03_261

    authors: Király J,Varečková E,Mucha V,Kostolanský F

    更新日期:2011-01-01 00:00:00

  • The antisense 5' end of the V2 gene confers enhanced resistance against the monopartite begomovirus cotton leaf curl Kokhran virus-Burewala strain.

    abstract::Whitefly-transmitted viruses of the genus Begomovirus (the family Geminiviridae) have become a limiting factor for agricultural productivity in many warmer parts of the world. The economies of Pakistan and India have, since the early 1990s, suffered losses due to cotton leaf curl disease (CLCuD). The disease is caused...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:10.4149/av_2019_101

    authors: Ali I,Khurshid M,Iqbal Z,Shafiq M,Amin I,Mansoor S,Briddon RW

    更新日期:2019-01-01 00:00:00

  • Genetic characterization of vaccine and field strains of serotype A foot-and-mouth disease virus from India.

    abstract::Extreme antigenic and genetic heterogeneity of serotype A foot-and-mouth disease virus (FMDV) population has resulted in change of vaccine strains in India twice in the last decade. In such a situation, complete characterization of the vaccine strains is imperative. With regard to the frequent outbreaks of this diseas...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:10.4149/av_2011_04_349

    authors: Mohapatra JK,Pawar SS,Tosh C,Subramaniam S,Palsamy R,Sanyal A,Hemadri D,Pattnaik B

    更新日期:2011-01-01 00:00:00

  • Effect of maternal varicella-zoster virus infection on the outcome of pregnancy and the analysis of transplacental virus transmission.

    abstract::In result of 20 pregnancies complicated by varicella 11 healthy and 6 defective offspring were born, 2 pregnancies were aborted by the physician and one pregnancy terminated by stillbirth of 3 siblings. Laboratory investigation of 16 pregnancies has shown that transplacental transfer of varicella-zoster (VZ) virus did...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Trlifajová J,Benda R,Benes C

    更新日期:1986-05-01 00:00:00

  • Selection for plaque variants of two California group arboviruses (Jamestown canyon and La Crosse) by passage in natural vertebrate hosts.

    abstract::The plaque size and distribution of prototype La Crosse (LAC) and Jamestown Canyon (JC) viruses were investigated in Vero cell cultures. The effect of serial passage of the viruses in their natural vertebrate hosts - the chipmunk and grey squirrel for LAC and the white-tailed deer for JC virus - was studied. Prototype...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Issel CJ,Pantuwatana S,Yuill TM,Hanson RP

    更新日期:1975-07-01 00:00:00

  • Attenuated influenza B virus recombinants obtained by crossing of B/England/2608/76 virus with a cold-adapted B/Leningrad/14/17/55 strain.

    abstract::Crossing of an attenuated influenza B virus strain (B/Leningrad/14/17/55) passaged at a low temperature with a virulent influenza B virus strain (B/England/2608/76) yielded recombinants similar in the antigenic specificity of their haemagglutinin (HA) and neuraminidase (NA) to B/England/2608/76 strain, but possessing ...

    journal_title:Acta virologica

    pub_type: 杂志文章

    doi:

    authors: Medvedeva TE,Gordon MA,Ghendon YZ,Klimov AI,Alexandrova GI

    更新日期:1983-07-01 00:00:00