Abstract:
:With only a single class of antiviral drugs existing for treatment of influenza (neuraminidase inhibitors), the search for novel effective compounds is urgently needed. We evaluated a low molecular mass compound, enisamium iodide (FAV00A), against influenza virus infections in primary differentiated normal human bronchial epithelial (NHBE) cells, and in ferrets. FAV00A (500 µg/ml) markedly inhibited influenza virus replication and reduced viral M-gene expression in NHBE cells. Treatment of ferrets with FAV00A (200 mg/kg once daily for 7 days) initiated 24 h after inoculation with 105 TCID50 of influenza A/Wisconsin/67/2005 (H3N2) virus resulted in a significant decrease in virus titers in the upper respiratory tract. Our data show that FAV00A exhibits an antiviral effect against influenza virus in NHBE cells and provides some benefits in a ferret model. Thus, further Keywords: antiviral agents; enisamium iodide; influenza virus; MDCK cells; NHBE cells; ferrets.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Cocking D,Cinatl J,Boltz DA,Peng X,Johnson W,Muzzio M,Syarkevych O,Kostyuk G,Goy A,Mueller L,Margitich VIdoi
10.4149/av_2018_211subject
Has Abstractpub_date
2018-01-01 00:00:00pages
191-195issue
2eissn
0001-723Xissn
1336-2305journal_volume
62pub_type
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