Latent infection and measles meningoencephalitis in Syrian hamsters.

Abstract:

:A strain designated 42-Edmonston was isolated from the brain of a Syrian hamster 30 days after inoculation during the neonatal period with the reference "wild" measles virus strain Edmonston which produced a latent infection accompanied by production of measles antibody and insignificant pathomorphological changes. Intracerebral inoculation with the 42-Edmonston strain of newborn, one day-and 5-7-day-old Syrian hamsters resulted in the development of acute measles encephalitis with typical clinical symptoms and pathomorphological changes. It is suggested that selection and adaptation of a neurotropic measles virus variant probably had occurred in the course of virus persistence in the Syrian hamster brain.

journal_name

Acta Virol

journal_title

Acta virologica

authors

Eliseeva IYa,Ravkina LI,Karmysheva VYa

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

222-7

issue

3

eissn

0001-723X

issn

1336-2305

journal_volume

21

pub_type

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