Abstract：
:In order to determine the definitive importance of T- and B-lymphocytes in immunity to Rickettsia conorii, mice genetically deficient in T-cells, B-cells, or both T- and B-cells were infected experimentally. T-lymphocytes rather than humoral antibodies were crucial to rickettsial clearance and a reduced mortality rate. Mice incapable of an antibody response to polysaccharide capsular antigens effectively controlled rickettsial infection with no mortality. In contrast, nude mice produced antibody to thymus-independent antigens early in the course of infection, yet experienced severe rickettsial infection resulting in deaths. The observed hepatic lesions are similar to those of boutonneuse fever. This model offers the opportunity to investigate rickettsial immune mechanisms and hepatic injury.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Montenegro NR,Walker DH,Hegarty BCsubject
Has Abstractpub_date
1984-11-01 00:00:00pages
508-14issue
6eissn
0001-723Xissn
1336-2305journal_volume
28pub_type
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