Abstract：
:Herpes simplex virus 1 (HSV-1) is one of the most prevalent human pathogens in both industrialized and developing countries. This study was performed to analyze the antiviral activity of purified flavonoid from Polygonum perfoliatum L. against HSV-1 infection in vitro and in vivo. Flavonoid showed no inhibitory effect, when treated before virus infection, but it strongly inhibited viral replication and cell-to-cell spread which was vital for the virus's propagation. The therapeutic effect of the flavonoid in treating HSV-1 induced encephalitis was also investigated in mice. A dose-dependent increase of survival rate and mean survival time (MST) were observed in the flavonoid-treated mice. These results suggested that the flavonoid may be a viable therapeutic option for recurrent HSV-1 infection.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Zhang QG,Wei F,Liu Q,Chen LJ,Liu YY,Luo F,Xiong HR,Yang ZQdoi
10.4149/av_2014_04_368subject
Has Abstractpub_date
2014-01-01 00:00:00pages
368-73issue
4eissn
0001-723Xissn
1336-2305journal_volume
58pub_type
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