NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells.

abstract：:The fate of a neuron in the developing brain to multiply, differentiate, or die in an apoptotic manner depends on the expression of genes that are involved in regulating the cell cycle. Recent studies determined the involvement of several genes, including cyclin A and B2, in dopamine-induced apoptosis in cultured chic...

journal_title：Annals of the New York Academy of Sciences

authors： Porat S,Simantov R

更新日期：1999-01-01 00:00:00

abstract：:Pulmonary sarcoidosis is a disease characterized by increased numbers of T lymphocytes within the alveolar structures and the consequent spontaneous release of a variety of mediators relevant to the pathogenesis of this disorder. This phenomenon is associated with a different expansion of the T cell subpopulations pre...

journal_title：Annals of the New York Academy of Sciences

authors： Rossi GA,Sacco O,Cosulich E,Balbi B,Risso A,Ravazzoni C

更新日期：1986-01-01 00:00:00

abstract：:Washington State's law for sexually violent predators was enacted in 1990; since then, 14 other states have passed similar laws authorizing civil commitment for dangerous sexual offenders following their prison terms. Although the law has survived constitutional challenges at both the state and in the U.S. Supreme Cou...

journal_title：Annals of the New York Academy of Sciences

authors： Lieb R

更新日期：2003-06-01 00:00:00

abstract：:This study investigates the complete genome sequences of the Nine Mile, K, and G isolates to improve our understanding of the unique virulence properties of C. burnetii and to provide important insight into the genome architecture and genetic diversity of this pathogen. ...

journal_title：Annals of the New York Academy of Sciences

authors： Beare PA,Porcella SF,Seshadri R,Samuel JE,Heinzen RA

更新日期：2005-12-01 00:00:00

abstract：:Clumps of corona cells were separated from oocytes at the moment of fertilization control and were subsequently processed and cut into 1-mu sections to study their general morphologic patterns. This study revealed an extensive phagocytosis of spermatozoa by corona cells. Clumps of mural granulosa cells of comparable s...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnenborg R,Gordts S,Ongkowidjojo R,Brosens I

更新日期：1985-01-01 00:00:00

abstract：:Since the publication of Heinz Kohut's last book in 1984, "self psychology" has become much more diverse in its perspectives and even fragmented in its applications. Perhaps due in large part to Kohut's own inconsistencies and lack of clarity on certain major points of theory and technique, self psychology currently l...

journal_title：Annals of the New York Academy of Sciences

authors： Gehrie MJ

更新日期：2009-04-01 00:00:00

abstract：:Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was ad...

journal_title：Annals of the New York Academy of Sciences

authors： Soffritti M,Belpoggi F,Lambertin L,Lauriola M,Padovani M,Maltoni C

更新日期：2002-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion...

journal_title：Annals of the New York Academy of Sciences

authors： Seki T,Nakatani M,Taki C,Shinohara Y,Ozawa M,Nishimura S,Ito H,Shioda S

更新日期：2006-07-01 00:00:00

abstract：:BALB/c mice infected with Rowson-Parr virus, a lymphatic leukemia virus isolated from the Friend complex, undergo a rapid depression of antibody response. Spleen cells from these mice in culture show a similar deficit in the response to stimulation with sheep red cells and inhibit the reactivity of normal splenocytes....

journal_title：Annals of the New York Academy of Sciences

authors： Bendinelli M,Toniolo A

更新日期：1976-01-01 00:00:00

abstract：:The DNase activity and circulating DNA (cirDNA) concentration in blood plasma of healthy donors, patients with chronic prostatitis, and patients with prostate tumors were analyzed. The concentration of the cirDNA from plasma was determined by PicoGreen fluorescent assay. DNase activity in blood was measured using the ...

journal_title：Annals of the New York Academy of Sciences

authors： Cherepanova AV,Tamkovich SN,Bryzgunova OE,Vlassov VV,Laktionov PP

更新日期：2008-08-01 00:00:00

abstract：:In hereditary HTG rats, basal systolic blood pressure using tail-cuff sphygmomanometry was significantly higher (122.1 +/- 2.1 mm Hg; n = 16) than that in NTG animals (107.1 +/- 1.52; n = 16). A low salt diet did not influence blood pressure in NTG rats during the consecutive 4 weekly periods. However, in the second w...

journal_title：Annals of the New York Academy of Sciences

authors： Lichardus B,Seböková E,Jezová D,Mitková A,Zemánková A,Földes O,Vrána A,Klimes I

更新日期：1993-06-14 00:00:00

abstract：:The overarching role of coenzyme Q(10) in gene regulation, bioenergy formation, cellular redox poise regulation, and hydrogen peroxide formation is presented. Coenzyme Q(10) has a central role acting as a prooxidant in the generation of H(2)O(2). Contrary to the dogma that superoxide and H(2)O(2) formation are highly ...

journal_title：Annals of the New York Academy of Sciences

authors： Linnane AW,Eastwood H

更新日期：2006-05-01 00:00:00

abstract：:In Wegener's granulomatosis (WG), antiproteinase 3 (PR3) autoantibodies (PR3-ANCA) are crucial in the development of generalized vasculitis. Wegener's pathognomonic lesion, a granulomatous inflammation of the upper and lower respiratory tract, contains abundant lymphocytes and macrophages. Lymphocyte clusters in germi...

journal_title：Annals of the New York Academy of Sciences

authors： Voswinkel J,Müller A,Lamprecht P

更新日期：2005-06-01 00:00:00

abstract：:Phagocytes play a major role in several diseases. In particular mononuclear phagocyte-derived foam cells have a prominent role in the development of the atherosclerotic lesions. Macrophages are present in all stages of atherogenesis; they internalize lipoproteins and accumulate cholesterol. Moreover, lipid-filled macr...

journal_title：Annals of the New York Academy of Sciences

authors： Paoletti R,Bellosta S,Bernini F

更新日期：1997-12-15 00:00:00

abstract：:The understanding and control of embryo implantation represents the major challenge for assisted reproductive technologies. Along with developments in basic research and efforts to optimize embryo quality, the improvement of noninvasive and reliable methods to assess uterine receptivity constitutes an important step t...

journal_title：Annals of the New York Academy of Sciences

authors： Fanchin R

更新日期：2001-09-01 00:00:00

abstract：:Many autoimmune diseases are chronic conditions that progress over the course of years, and are characterized by the presence of autoantibodies that precede the overt disease by months or years. As examples, the presence of two islet cell antibodies (ICA) are associated with a 50% risk of developing diabetes mellitus ...

journal_title：Annals of the New York Academy of Sciences

authors： Harel M,Shoenfeld Y

更新日期：2006-06-01 00:00:00

abstract：:Little is known about the role of the basolateral amygdala (BLA) in regulating hypothalamic-pituitary-adrenal (HPA) activity, particularly chronic stress-induced HPA activity. In the current studies, we examined the effects of manipulations of the BLA on HPA responses to the eighth restraint, to novel restraint after ...

journal_title：Annals of the New York Academy of Sciences

authors： Bhatnagar S,Vining C,Denski K

更新日期：2004-12-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are the largest known family of cell surface receptors, and they control many important physiological events, including sensory perception, chemotaxis, neurotransmission, and energy homeostasis. However, GPCR signaling can be difficult to study in vivo because of the multitude of GP...

journal_title：Annals of the New York Academy of Sciences

authors： Srinivasan S,Vaisse C,Conklin BR

更新日期：2003-06-01 00:00:00

abstract：:Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

journal_title：Annals of the New York Academy of Sciences

authors： Moffat SD

更新日期：2005-12-01 00:00:00

abstract：:It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of agin...

journal_title：Annals of the New York Academy of Sciences

authors： Hodes RJ,Sierra F,Austad SN,Epel E,Neigh GN,Erlandson KM,Schafer MJ,LeBrasseur NK,Wiley C,Campisi J,Sehl ME,Scalia R,Eguchi S,Kasinath BS,Halter JB,Cohen HJ,Demark-Wahnefried W,Ahles TA,Barzilai N,Hurria A,Hunt PW

更新日期：2016-12-01 00:00:00

abstract：:To minimize technical problems relating to excessive size (600-800 mu in diameter) of standard alginate microcapsules (CSM) for pancreatic islet graft immunoisolation, we have developed two novel minimal volume, chemically identical, capsule prototypes (MVC): 1) coherent microcapsules (CM), and 2) medium-size microcap...

journal_title：Annals of the New York Academy of Sciences

authors： Calafiore R,Basta G,Luca G,Boselli C,Bufalari A,Bufalari A,Cassarani MP,Giustozzi GM,Brunetti P

更新日期：1999-06-18 00:00:00

abstract：:Conservation translocation of species varies from restoring historic populations to managing the relocation of imperiled species to new locations. We review the literature in three areas--translocation, managed relocation, and conservation decision making--to inform conservation translocation under changing climates. ...

journal_title：Annals of the New York Academy of Sciences

authors： Schwartz MW,Martin TG

更新日期：2013-05-01 00:00:00

abstract：:In summary, immediate hypersensitivity reactions to luminal antigens occur in the intestine and result in pathophysiology including increased permeability and ion secretion. The mechanism involves activation of mast cells with neural amplification (FIG. 5). Released mediators/neurotransmitters may act independently or...

journal_title：Annals of the New York Academy of Sciences

authors： Perdue MH,Kosecka U,Crowe S

更新日期：1992-01-01 00:00:00

abstract：:Natural systems cannot be closed to the environment. At the same time there is a necessity for closure in order to build the system. It is this quint-essential tension between openness and closure that drives systems to unfold into further stages or levels of growth and development. In other words, the emergence of or...

journal_title：Annals of the New York Academy of Sciences

authors： Alvarez De Lorenzana JM

更新日期：2000-01-01 00:00:00

abstract：:Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan...

journal_title：Annals of the New York Academy of Sciences

authors： Cervi J,Marotta F,Bater C,Masulair K,Minelli E,Harada M,Marandola P

更新日期：2006-05-01 00:00:00

abstract：:In this study, we analyzed the effect of Bcl-2 overexpression, an important anti-apoptotic protein, by using two hypothalamic cell lines, GT1-7puro or GT1-7bcl-2. 3-Nitropropionic acid (3-NP) mediated a dose-dependent decrease in cell viability in GT1-7puro cells, as determined by following the MTT (3-(4,5-dimethylthi...

journal_title：Annals of the New York Academy of Sciences

authors： Brito O,Almeida S,Oliveira CR,Rego AC

更新日期：2003-12-01 00:00:00

abstract：:The LGR7/RXFP1 and LGR8/RXFP2 receptors are unique receptors among the G-protein-coupled receptors (GPCRs) in having a low-density lipoprotein class A (LDL-A) module. Their complex gene organization, among the intron-richest of the GPCRs, suggests that alternative splicing is a common occurrence. We have therefore inv...

journal_title：Annals of the New York Academy of Sciences

authors： Kern A,Bryant-Greenwood GD

更新日期：2009-04-01 00:00:00

abstract：:The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has bee...

journal_title：Annals of the New York Academy of Sciences

authors： Holodick NE,Rothstein TL

更新日期：2015-12-01 00:00:00

abstract：:The role of the potent proinflammatory cytokine IL-1 in disease could clinically be investigated with the development of the IL-1 blocking agent anakinra (Kineret), a recombinant IL-1 receptor antagonist. It was first tested in patients with sepsis without much benefit but was later FDA approved for the treatment of p...

journal_title：Annals of the New York Academy of Sciences

authors： Goldbach-Mansky R

更新日期：2009-12-01 00:00:00

abstract：:Every year thousands of young teenagers are afflicted with different types of cancer and receive gonadotoxic chemotherapy and radiotherapy regimens, causing depletion of germ cells in the gonads and premature gonadal failure. In this review, we discuss and outline the current strategies and the future directions of fe...

journal_title：Annals of the New York Academy of Sciences

authors： Oktem O,Oktay K

更新日期：2008-01-01 00:00:00