Inhibition of herpesvirus DNA synthesis by 9-beta-D-arabinofuranosyladenine in cellular and cell-free systems.

abstract：:Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (-)Huperzine A resulted in the racemic mixture of (+/-)Huperzine A. We have therefore compared the in vitro and in vivo effects of (+/-)Huperzine A with those of (-)Huperzine A in ...

journal_title：Annals of the New York Academy of Sciences

authors： Hanin I,Tang XC,Kindel GL,Kozikowski AP

更新日期：1993-09-24 00:00:00

abstract：:The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGP...

journal_title：Annals of the New York Academy of Sciences

authors： Liebscher I,Ackley B,Araç D,Ariestanti DM,Aust G,Bae BI,Bista BR,Bridges JP,Duman JG,Engel FB,Giera S,Goffinet AM,Hall RA,Hamann J,Hartmann N,Lin HH,Liu M,Luo R,Mogha A,Monk KR,Peeters MC,Prömel S,Ressl S,Sc

更新日期：2014-12-01 00:00:00

abstract：:Statistical learning is a set of cognitive mechanisms allowing for extracting regularities from the environment and segmenting continuous sensory input into discrete units. The current study used functional magnetic resonance imaging (fMRI) (N = 25) in conjunction with an artificial language learning paradigm to provi...

journal_title：Annals of the New York Academy of Sciences

authors： Ordin M,Polyanskaya L,Soto D

更新日期：2020-05-01 00:00:00

abstract：:In the past few years it has been shown that, like many other non-neuroendocrine cells, adipocytes possess a mechanism for triggered exocytosis. Endocytosis and exocytosis affect the plasma membrane surface area, which can be directly monitored with electrophysiological patch-clamp techniques by measuring membrane cap...

journal_title：Annals of the New York Academy of Sciences

authors： Chowdhury HH,Grilc S,Zorec R

更新日期：2005-06-01 00:00:00

abstract：:Primary hyperparathyroidism (PHPT) results from excessive secretion of parathyroid hormone (PTH), and catabolic and anabolic effects of PTH on bone may lead to overall deleterious effects on skeleton. The aim of this study was to analyze the changes in lumbar spine bone mineral density (BMD) in patients with PHPT who ...

journal_title：Annals of the New York Academy of Sciences

authors： Lumachi F,Camozzi V,Ermani M,Nardi A,Luisetto G

更新日期：2007-11-01 00:00:00

abstract：:Fructosamine-3-kinase (FN3K) and the more recently discovered fructosamine-3-kinase-related protein (FN3KRP) appear to protect proteins from nonenzymatic glycation. To gain a better understanding of these enzymes we performed a series of investigations including (1) in silico comparisons of their promoters; (2) real-t...

journal_title：Annals of the New York Academy of Sciences

authors： Conner JR,Beisswenger PJ,Szwergold BS

更新日期：2005-06-01 00:00:00

abstract：:With the demographic aging of populations worldwide, diseases associated with aging are becoming more prevalent and costly to individuals, families, and healthcare systems. Among aging-related impairments, a decline in cognitive function is of particular concern, as it erodes memory and processing abilities and eventu...

journal_title：Annals of the New York Academy of Sciences

authors： Tucker KL

更新日期：2016-03-01 00:00:00

abstract：:A brief overview of the different techniques used to estimate the probable maximum precipitation (PMP) is presented. As a particular case, the 1-day PMP over Catalonia has been calculated and mapped with a high spatial resolution. For this purpose, the annual maximum daily rainfall series from 145 pluviometric station...

journal_title：Annals of the New York Academy of Sciences

authors： Casas MC,Rodríguez R,Nieto R,Redaño A

更新日期：2008-12-01 00:00:00

abstract：:The plasma levels and the glycosylation of acute-phase proteins (APP) are subject to marked changes during acute and chronic inflammation. The pathophysiological variations in different glycoforms of APP in serum most likely result from changes in the glycosylation process during their biosynthesis in the parenchymal ...

journal_title：Annals of the New York Academy of Sciences

authors： Van Dijk W,Mackiewicz A

更新日期：1995-07-21 00:00:00

abstract：:A four- to fivefold overexpression of the gene for the Alzheimer beta/A4 amyloid precursor protein (APP) in individuals with Down's Syndrome (DS) appears to be responsible for the fifty year earlier onset of Alzheimer's disease (AD) pathology in DS compared to the normal population. It is therefore likely that a dereg...

journal_title：Annals of the New York Academy of Sciences

authors： Beyreuther K,Pollwein P,Multhaup G,Mönning U,König G,Dyrks T,Schubert W,Masters CL

更新日期：1993-09-24 00:00:00

abstract：:Inflammation plays a key role in excessive bone loss in conditions such as rheumatoid arthritis and periodontitis. An important paradigm in immunology is that inflammatory factors activate feedback inhibition mechanisms to restrain inflammation and limit associated tissue damage. We hypothesized that inflammatory fact...

journal_title：Annals of the New York Academy of Sciences

authors： Ivashkiv LB,Zhao B,Park-Min KH,Takami M

更新日期：2011-11-01 00:00:00

abstract：:1 alpha,25-Dihydroxyvitamin D3, the active form of vitamin D3, induced maturation of circulating monocytes to form macrophage-epithelioid cells and multinucleated giant cells in vitro. Calcitriol not only promoted the differentiation of monocytes, as shown by the marked morphological changes and enhanced secretion of ...

journal_title：Annals of the New York Academy of Sciences

authors： Ohta M,Okabe T,Ozawa K,Urabe A,Takaku F

更新日期：1986-01-01 00:00:00

abstract：:There are multiple connections from the entorhinal cortex (EC) to the hippocampus that carry the information from the EC to the hippocampus. Layer II cells of the medial EC innervating the dentate gyrus (DG)-molecular layer possess K(+)-outward currents and inward rectifier currents that are potentially modulated by c...

journal_title：Annals of the New York Academy of Sciences

authors： Heinemann U,Schmitz D,Eder C,Gloveli T

更新日期：2000-06-01 00:00:00

abstract：:Our studies have indicated that normal human placental cytosol contains a complex mixture of nucleoside kinase enzymes, some of which conform to previously characterized activities. Deoxyadenosine is phosphorylated by deoxycytidine kinase, adenosine kinase, and two as yet uncharacterized activities. Deoxyguanosine pho...

journal_title：Annals of the New York Academy of Sciences

authors： Hurley MC,Fox IH

更新日期：1985-01-01 00:00:00

abstract：:There are two types of escapes in conservative dynamical systems with two degrees of freedom: escapes to infinity and escapes to certain singular points at a finite distance. In both cases the areas on a surface of section are not preserved. We consider the basins of escape to infinity in simple Hamiltonian systems. T...

journal_title：Annals of the New York Academy of Sciences

authors： Contopoulos G,Harsoula M

更新日期：2005-06-01 00:00:00

abstract：:The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP)-3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data ...

journal_title：Annals of the New York Academy of Sciences

authors： Priego T,Ibañez De Cáceres I,Martín AI,Villanúa MA,López-Calderón A

更新日期：2002-11-01 00:00:00

abstract：:In recent years, different subphenotypes of obesity have been described, including metabolically healthy obesity (MHO), in which a proportion of obese individuals, despite excess body fat, remain free of metabolic abnormalities and increased cardiometabolic risk. In the absence of a universally accepted set of criteri...

journal_title：Annals of the New York Academy of Sciences

authors： Phillips CM

更新日期：2017-03-01 00:00:00

abstract：:The gastrointestinal tract (GIT) appears to be the main site of entry for the pathological isoform of prions (PrP(sc)). To understand how the PrP(sc) internalization process occurs, it is important to characterize the cell types that express normal prion protein (PrP(c)) along the GIT. To do so, we studied the distrib...

journal_title：Annals of the New York Academy of Sciences

authors： Marcos Z,Bodegas ME,Sesma MP,Guembe L

更新日期：2005-04-01 00:00:00

abstract：:The surprising discovery in 1990 that estrogen modulates hippocampal structural plasticity launched a whole new field of scientific inquiry. Over the past two decades, estrogen-induced spinogenesis has been described in several brain areas involved in cognition in a number of species, in both sexes and on multiple tim...

journal_title：Annals of the New York Academy of Sciences

authors： Dumitriu D,Rapp PR,McEwen BS,Morrison JH

更新日期：2010-08-01 00:00:00

abstract：:The dentate gyrus of the rat forms in three developmental phases, each of which is characterized by neuronal birth, migration and death. Recent evidence indicates that adrenal steroids regulate neuronal birth, death, and possibly migration throughout the life of the animal. However, the observation that very few neuro...

journal_title：Annals of the New York Academy of Sciences

authors： Gould E

更新日期：1994-11-14 00:00:00

abstract：:As part of an ongoing randomized clinical trial for childhood-abuse-related PTSD, this study examined the association between PTSD and unresolved attachment as measured by the Adult Attachment Interview in a sample of 52 female childhood-abuse survivors. Results revealed that 55% of the sample was classified as preocc...

journal_title：Annals of the New York Academy of Sciences

authors： Stovall-McClough KC,Cloitre M

更新日期：2003-12-01 00:00:00

abstract：:The present study was aimed at finding neural correlates of aesthetic versus descriptive listening of the same musical cadences. Results showed that aesthetic listening generated greater right frontocentral negativities than did descriptive listening, indicating distinct cortical mechanisms for aesthetic versus descri...

journal_title：Annals of the New York Academy of Sciences

authors： Brattico E,Jacobsen T,De Baene W,Nakai N,Tervaniemi M

更新日期：2003-11-01 00:00:00

abstract：:Understanding the predictive relationships between climate variability and coccidioidomycosis is of great importance for the development of an effective public health decision-support system. Preliminary regression-based climate modeling studies have shown that about 80% of the variance in seasonal coccidioidomycosis ...

journal_title：Annals of the New York Academy of Sciences

authors： Comrie AC,Glueck MF

更新日期：2007-09-01 00:00:00

abstract：:Needle free jet injection guns have been used extensively in both veterinary and human health to deliver both vaccine and drugs, but in recent years, concerns have mounted for their potential to transmit blood borne disease agents among consecutive vaccinates. A Ped-O-Jet type jet injection device was used to deliver ...

journal_title：Annals of the New York Academy of Sciences

authors： Sweat JM,Abdy M,Weniger BG,Harrington R,Coyle B,Abuknesha RA,Gibbs EP

更新日期：2000-01-01 00:00:00

abstract：:Every year thousands of young teenagers are afflicted with different types of cancer and receive gonadotoxic chemotherapy and radiotherapy regimens, causing depletion of germ cells in the gonads and premature gonadal failure. In this review, we discuss and outline the current strategies and the future directions of fe...

journal_title：Annals of the New York Academy of Sciences

authors： Oktem O,Oktay K

更新日期：2008-01-01 00:00:00

abstract：:Converging lines of evidence indicate that withdrawal from prolonged exposure to stimulants and alcohol results in synaptic deficits of both dopamine (DA) and serotonin (5-HT). According to the dual deficit model proposed by the authors, DA dysfunction during cocaine or alcohol withdrawal underlies anhedonia and psych...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman RB,Partilla JS,Dersch CM,Carroll FI,Rice KC,Baumann MH

更新日期：2000-09-01 00:00:00

abstract：:In order to analyze neuronal computations in the first olfactory processing center, the olfactory bulb, we measured odor-evoked activity patterns across large numbers of neurons within the intact olfactory bulb of zebrafish using optical and electrophysiological methods. We found that the olfactory bulb performs multi...

journal_title：Annals of the New York Academy of Sciences

authors： Friedrich RW,Yaksi E,Judkewitz B,Wiechert MT

更新日期：2009-07-01 00:00:00

abstract：:SPAG-1, a sporozoite surface antigen of T. annulata, has previously been shown to elicit partial protection when used, as an hepatitis B core antigen fusion, to immunize cattle. The objective of this study was to try and improve the protective capacity of this antigen by enlisting different vaccine strategies. Cattle ...

journal_title：Annals of the New York Academy of Sciences

authors： Boulter NR,Brown CG,Kirvar E,Glass E,Campbell J,Morzaria S,Nene V,Musoke A,D'Oliveira C,Gubbels MJ,Jongejan F,Hall FR

更新日期：1998-06-29 00:00:00

abstract：:Liquid membrane reactors are well known for metal extraction. This technology may also be applied to the immobilization of enzymes in enzyme emulsions. The use of liquid membrane reactors for enzymatic bioconversions has several advantages in comparison to solid membrane reactors and conventional immobilization techni...

journal_title：Annals of the New York Academy of Sciences

authors： Scheper T,Makryaleas K,Nowottny C,Likidis Z,Tsikas D,Schügerl K

更新日期：1987-01-01 00:00:00

abstract：:Between 4 and 13% of people with schizophrenia commit suicide and between 25 and 50% make a suicide attempt, a reflection of the devastating toll this syndrome takes on the quality of life, that is, the subjective and objective sense of well-being. Many risk factors for suicide in schizophrenia have been identified, t...

journal_title：Annals of the New York Academy of Sciences

authors： Meltzer HY

更新日期：2001-04-01 00:00:00