Injection site tumours and preceding pathological changes in rats treated subcutaneously with surfactants and carcinogens.

abstract：:The nature of the invasive growth pattern and microvessel density (MVD) have been suggested to be predictors of prognosis in primary colorectal cancer (CRC) and colorectal liver metastases. The purpose of the present study was to determine whether these two histological features were interrelated and to assess their r...

journal_title：British journal of cancer

authors： Rajaganeshan R,Prasad R,Guillou PJ,Chalmers CR,Scott N,Sarkar R,Poston G,Jayne DG

更新日期：2007-04-10 00:00:00

abstract：:Karyotyping and marker analysis of G- and C-banded metaphases from a metastatic bronchial carcinoma revealed a dominant stemline with five markers and four sidelines with additional markers. One to three minute bodies were noted in the majority of cells and these were classified as markers. On the basis of this analys...

journal_title：British journal of cancer

authors： Pickthall VJ

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wid...

journal_title：British journal of cancer

authors： Saunders EJ,Dadaev T,Leongamornlert DA,Al Olama AA,Benlloch S,Giles GG,Wiklund F,Gronberg H,Haiman CA,Schleutker J,Nordestgaard BG,Travis RC,Neal D,Pasayan N,Khaw KT,Stanford JL,Blot WJ,Thibodeau SN,Maier C,Kibel AS

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:CXC chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) have important roles in promoting tumour growth and metastasis. Therefore, targeting CXCR4 could be a promising strategy for treatment of human cancer. METHODS:To achieve this goal, we developed a h...

journal_title：British journal of cancer

authors： Yang Q,Zhang F,Ding Y,Huang J,Chen S,Wu Q,Wang Z,Wang Z,Chen C

更新日期：2014-03-04 00:00:00

abstract：BACKGROUND:Prognosis of localised gastrointestinal stromal tumour (GIST) is heterogeneous, notably for patients with AFIP intermediate or high risk of relapse, who are candidates to adjuvant imatinib. We hypothesised that gene expression profiles might improve the prognostication and help to refine the indications for ...

journal_title：British journal of cancer

authors： Bertucci F,Finetti P,Ostrowski J,Kim WK,Kim H,Pantaleo MA,Astolfi A,Polkowski M,Birnbaum D

更新日期：2012-10-09 00:00:00

abstract：:We investigated whether cholecystectomy is associated with subsequent cancer and, if so, whether the association is likely to be causal, by undertaking a retrospective cohort study using linked medical statistics, comprising a cholecystectomy group (n=39 254) and a reference cohort admitted for a range of other medica...

journal_title：British journal of cancer

authors： Goldacre MJ,Abisgold JD,Seagroatt V,Yeates D

更新日期：2005-04-11 00:00:00

abstract：:Records of approximately 310,000 patients admitted to the 10 hospitals in Botswana between 1960 and 1972 have been studied and details of 1445 patients with malignant tumours abstracted. For the 894 tumours for which there was some supporting evidence--at best histological proof and minimally a clinical description of...

journal_title：British journal of cancer

authors： Macrae SM,Cook BV

更新日期：1975-07-01 00:00:00

abstract：:To understand genetic events which play a role in the development and/or progression of human endometrial cancer, we studied allelotypes on all autosomal chromosomes, as well as chromosome X, with 42 microsatellite markers and 56 endometrial cancers. The most frequent loss of heterozygosity (LOH) was observed on the l...

journal_title：British journal of cancer

authors： Nagase S,Sato S,Tezuka F,Wada Y,Yajima A,Horii A

更新日期：1996-12-01 00:00:00

abstract：:Darbepoetin alfa (Aranesp), Amgen) is a novel erythropoiesis-stimulating protein with a serum half-life longer than recombinant human erythropoietin (Epo), used in the treatment of cancer-associated anaemia. Anaemia is known to adversely affect prognosis and response to treatment in cancer patients. Solid tumours cont...

journal_title：British journal of cancer

authors： Shannon AM,Bouchier-Hayes DJ,Condron CM,Toomey D

更新日期：2005-07-25 00:00:00

abstract：:Swedish population-based incidence and mortality rates for cancer of the uterine cervix, both in situ and invasive, during the period 1958 to 1981 were determined by means of a dynamic model. This new approach describes without any preconceptions the development of the disease as a sequential process over the stages c...

journal_title：British journal of cancer

authors： Gustafsson L,Adami HO

更新日期：1989-07-01 00:00:00

abstract：:To evaluate the efficacy and safety of capecitabine and cisplatin in patients with recurrent gastric cancer after fluoropyrimidine-based adjuvant therapy. Patients with histologically confirmed and measurable advanced gastric cancer that had relapsed after fluoropyrimidine-based adjuvant chemotherapy received oral cap...

journal_title：British journal of cancer

authors： Kang HJ,Chang HM,Kim TW,Ryu MH,Sohn HJ,Yook JH,Oh ST,Kim BS,Lee JS,Kang YK

更新日期：2005-01-31 00:00:00

abstract：:The effect of acute carbon monoxide (CO) breathing on blood oxygenation and tumour hypoxia was related to the radiation response of the C3H/Tif mammary carcinoma. Blood gas analysis showed that CO breathing caused a time- and dose-dependent formation of carboxyhaemoglobin (HbCO), a significant left shift of the oxygen...

journal_title：British journal of cancer

authors： Grau C,Khalil AA,Nordsmark M,Horsman MR,Overgaard J

更新日期：1994-01-01 00:00:00

abstract：:The Type 1 family of growth factor receptors includes epidermal growth factor receptor (EGFR), c-erbB-2, c-erbB-3 and c-erbB-4. Overexpression of the first two members is associated with poorer prognosis in patients with breast carcinoma. In this study we examined the expression of c-erbB-4 protein using the monoclona...

journal_title：British journal of cancer

authors： Kew TY,Bell JA,Pinder SE,Denley H,Srinivasan R,Gullick WJ,Nicholson RI,Blamey RW,Ellis IO

更新日期：2000-03-01 00:00:00

abstract：:This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 mic...

journal_title：British journal of cancer

authors： Manning LS,Radin NS

更新日期：1999-11-01 00:00:00

abstract：:Bryostatin 1 is a novel macrocyclic lactone activator of protein kinase C (PKC) which has clinical potential as an anti-cancer agent. The mechanism of action of this agent is unknown, but protein kinase C has been implicated. In order to investigate this possibility, we have developed P388 sublines resistant to bryost...

journal_title：British journal of cancer

authors： Prendiville J,McGown AT,Gescher A,Dickson AJ,Courage C,Pettit GR,Crowther D,Fox BW

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women ...

journal_title：British journal of cancer

authors： Lavelle K,Downing A,Thomas J,Lawrence G,Forman D,Oliver SE

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer. METHODS:A tissue microarray of 1420 primary colorectal cancers and 57 normal mucosa samples was immunostained for CD133, CD...

journal_title：British journal of cancer

authors： Lugli A,Iezzi G,Hostettler I,Muraro MG,Mele V,Tornillo L,Carafa V,Spagnoli G,Terracciano L,Zlobec I

更新日期：2010-07-27 00:00:00

abstract：:The aim of this study was to examine the effects of oral and transdermal oestrogen replacement therapy on the risk of colorectal cancer. Data from a nested case-control study, designed to investigate the effect of hormone replacement therapy (HRT) on colorectal cancer were analysed. New cases of colorectal cancer, dia...

journal_title：British journal of cancer

authors： Csizmadi I,Collet JP,Benedetti A,Boivin JF,Hanley JA

更新日期：2004-01-12 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in...

journal_title：British journal of cancer

authors： Surakhy M,Wallace M,Bond E,Grochola LF,Perez H,Di Giovannantonio M,Zhang P,Malkin D,Carter H,Parise IZS,Zambetti G,Komechen H,Paraizo MM,Pagadala MS,Pinto EM,Lalli E,Figueiredo BC,Bond GL

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describ...

journal_title：British journal of cancer

authors： Belin L,Tan A,De Rycke Y,Dechartres A

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumour cells containing mutant p53 in this subset of ES patients. METHODS:PRIMA-1...

journal_title：British journal of cancer

authors： Aryee DN,Niedan S,Ban J,Schwentner R,Muehlbacher K,Kauer M,Kofler R,Kovar H

更新日期：2013-11-12 00:00:00

abstract：:Measurement of DNA polymerase in leukaemic guinea-pig plasms reveals the presence of low levels of sedimentable and non-sedimentable enzymic activities. Since the sedimentable DNA polymerase is ribonuclease sensitive, uses poly(C).oligo(dG) as template, and bands in a sucrose density gradient at 1-17 g/ml it is though...

journal_title：British journal of cancer

authors： Hallinan FM,Maclean N

更新日期：1976-04-01 00:00:00

abstract：:We have shown that doxorubicin entrapped in cardiolipin liposomes retain antitumour efficacy in mice but had diminished cardiac uptake and cardiotoxicity. Such liposomes are preferentially taken up by spleen. In a previous study we showed that a single dose of liposomal doxorubicin is not more toxic than free doxorubi...

journal_title：British journal of cancer

authors： Rahman A,Joher A,Neefe JR

更新日期：1986-09-01 00:00:00

abstract：:Because the focus of nasopharyngeal carcinoma (NPC) is very close to intracranial organs, it often makes incursions into cranial cavity. Identification of intracranial invasion-associated indicators will provide potential therapeutic targets for NPC patients with intracranial invasion. In this regard, Human Xpro HC-pl...

journal_title：British journal of cancer

authors： Liu SJ,Sun YM,Tian DF,He YC,Zeng L,He Y,Ling CQ,Sun SH

更新日期：2008-01-29 00:00:00

abstract：:The prevalence (lifetime occurrence) rate of cancers of the reproductive system (uterus, ovary, cervix and vagina) and breast cancer was determined for 5,398 living alumnae, 2,622 of whom were former college athletes and 2,776 non-athletes, from data on medical and reproductive history, athletic training and diet. The...

journal_title：British journal of cancer

authors： Frisch RE,Wyshak G,Albright NL,Albright TE,Schiff I,Jones KP,Witschi J,Shiang E,Koff E,Marguglio M

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial cancer. METHODS:Pre-therapeutic s...

journal_title：British journal of cancer

authors： Seebacher V,Hofstetter G,Polterauer S,Reinthaller A,Grimm C,Schwameis R,Taucher S,Wagener A,Marth C,Concin N

更新日期：2013-07-09 00:00:00

abstract：BACKGROUND:We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). METHODS:Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating ...

journal_title：British journal of cancer

authors： Chovanec M,Cierna Z,Miskovska V,Machalekova K,Kalavska K,Rejlekova K,Svetlovska D,Macak D,Spanik S,Kajo K,Babal P,De Giorgi U,Mego M,Mardiak J

更新日期：2018-03-20 00:00:00

abstract：:Patients affected by squamous cell carcinoma of the head and neck (HNSCC) show frequent occurrence of multiple cancers and widespread precancerous lesions in the mucosa of the upper respiratory tract, a phenomenon known as field cancerization. In this study, we investigated the role of genetic instability in the devel...

journal_title：British journal of cancer

authors： Piccinin S,Gasparotto D,Vukosavljevic T,Barzan L,Sulfaro S,Maestro R,Boiocchi M

更新日期：1998-11-01 00:00:00

abstract：:The incidence of colorectal carcinoma is rising at an alarming pace in Asian urban societies such as Hong Kong. Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. We compared the reported age incidence of colorectal carcinoma in...

journal_title：British journal of cancer

authors： Yuen ST,Chung LP,Leung SY,Luk IS,Chan SY,Ho JC,Ho JW,Wyllie AH

更新日期：1997-01-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naive T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose. The effects of rad...

journal_title：British journal of cancer

authors： Merrick A,Errington F,Milward K,O'Donnell D,Harrington K,Bateman A,Pandha H,Vile R,Morrison E,Selby P,Melcher A

更新日期：2005-04-25 00:00:00