Abstract:
BACKGROUND AND AIMS:Peptydil prolyl cis-trans isomerase (PIN-1), which specifically regulates the conformational changes following phosphorylation of several proteins, targets the inactive hyper-phosphorylated tau on the Thr231-Pro motif and directly restores its biological function. Interestingly, PIN-1 is oxidatively inhibited not only in Alzheimer's disease brain but also in the hippocampi of mild cognitive impairment (MCI) subjects. The PIN-1 gene is characterized by two single nucleotide polymorphisms (SNPs) in the promoter region which are associated with the risk of Alzheimer's disease. The aim of this study was to analyse the genotype and allele distributions of these PIN-1 SNPs in MCI subjects diagnosed respectively as amnestic MCI (a-MCI) and multiple impaired cognitive domains (mcd-MCI) on the basis of cognitive features. METHODS:-667 T/C and -842 C/G SNPs were genotyped by polymerase chain reaction (PCR) amplification and direct sequencing in 43 MCI subjects, with the intention of comparing -667 and -842 SNP frequencies with those previously described in 111 Alzheimer's disease patients (AD) and 73 healthy controls (HC). RESULTS:The allele frequencies of the -842 C/G SNP in a-MCI subjects are similar to those of AD subjects, while those of mcd-MCI are comparable to HC (G allele 83% in both a-MCI and AD; 95% and 94% in mcd-MCI and HC, respectively). A similar trend is also observed in -842 C/G genotypes. CONCLUSIONS:Since a-MCI is thought to be the preclinical form of AD, the similar genotype distribution of -842 SNP in AD and a-MCI, but not in mcd-MCI, suggests that it is potentially involved in the conversion of a-MCI to AD. In conclusion, these findings support the theory that polymorphisms of the PIN-1 gene can affect neurodegeneration and its clinical progression.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Arosio B,Segat L,Milanese M,Galimberti L,Calabresi C,Zanetti M,Trabattoni D,Annoni G,Crovella S,Vergani Cdoi
10.1007/BF03324722subject
Has Abstractpub_date
2007-10-01 00:00:00pages
406-9issue
5eissn
1594-0667issn
1720-8319pii
4182journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Accumulation of aggregated α-synuclein from the enteric nervous system is believed to be involved in the pathogenesis of Parkinson's disease (PD). The appendix contains abundant α-synuclein and lacks a blood-tissue barrier, suggesting that appendectomy might reduce α-synuclein aggregation, and therefore the ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40520-019-01354-9
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Changes in sensory- motor systems that occur with age result in a decrease in postural equilibrium, which has been linked with an increased risk of falling in the elderly. Stepping down backwards from a step perturbs dynamic postural equilibrium, thus offering an opportunity to analyze the biomechan...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324776
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND/AIM:Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug-drug interactions, prescribing cascades, and potentially inappropriate medication...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01239-x
更新日期:2020-04-01 00:00:00
abstract::Celiac disease is a genetic disorder, presenting with malabsorption-related problems because of mucosal damage after ingestion of gluten. The only known effective treatment is a gluten-free diet. Early diagnosis and treatment are essential in preventing complications due to malabsorption. Here we report the case of an...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324644
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The primary aim of the present study was to examine whether there is an association between blood pressure and the risk of subsequent cognitive decline in the oldest old. Various factors associated with blood pressure and cognitive function were considered. METHODS:The study comprised 599 individua...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03325209
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:The circadian rhythm of serum thyroid stimulating hormone (TSH) levels in patients with Alzheimer's disease was measured by means of a case-control study. METHODS:Serum samples from cases and controls were collected continuously for 2 days, and then once every 2 h (even number time-point during the first da...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0025-x
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Frailty is a geriatric syndrome that predicts increased morbidity and mortality. In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified. METHODS:Peripheral bl...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327392
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Aging, cancer and its treatment all contribute to increase the risk of deconditioning and sedentary behaviors. Mixed exercise is recognized to counteract the effects of aging and deconditioning as well as improving physical capacity during cancer treatment in adults. AIMS:To determine the impact of a mixed ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40520-018-1097-4
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Sagittal spinal alignment is an important determinant for proper spinal function. Alterations in spinal alignment may serve as leading factor for diminished body biomechanics. Although increased age is suggested to be associated with changes in lumbosacral alignment, in turn body posture, this is still a cur...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0274-3
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Hip and knee replacements have become increasingly common in the older population but the prevalence of these procedures and the potential impact on functioning towards the end of life have not been previously described. The aim of this study was to estimate the rates and distribution of hip and kne...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324481
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The relationships between blood pressure (BP) and cognition are complex and are still partly unclear. The impact of history of hypertension, present BP levels, and left ventricular hypertrophy (LVH) on cognition was investigated in a 10-year follow-up study of an aged population. METHODS:The popula...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324544
更新日期:2004-04-01 00:00:00
abstract::Falls in the elderly are very common and represent a serious cause of morbidity, severe disability and death. Impairments of the mechanisms of postural stability with age and the presence of acute and chronic diseases may favour the occurrence of falls in the elderly. Together with the adoption of non-pharmacological ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Low total lymphocyte count (TLC) has been found to be a poor prognostic factor in adults affected by heart diseases, malignancy, and renal failure. The aims of this study were to verify if a low TLC was associated with in-hospital mortality in older persons and to evaluate whether this association w...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324858
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Despite differences between the studies regarding methods for estimating low muscle mass, the European Working Group on Sarcopenia in Older People (EWGSOP) recommends use of two standard deviations (SDs) below the reference sex-specific means of healthy young adults. AIMS:The aim of this study was to determ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01448-4
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Attitude of healthcare providers toward older people is very important in the aging world. Neurologists contact older adults very frequently. We aimed to investigate the attitudes of neurologists toward older adults. MEASUREMENTS:We recorded participants age; sex; duration of clinical practice in neurology; ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-016-0606-6
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND AIMS:To evaluate the effect of interdisciplinary outpatient geriatrics on the use, cost, and quality of health services in a fee-for-service (FFS) environment of two networks of primary care clinics operated by a not-for-profit provider organization in Dallas County, Texas. METHODS:The Senior Health Net...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324884
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Adaptation to strength training in very old mobility-limited individuals is not fully characterized. Therefore, the aim of this study was to perform a thorough investigation of the adaptation to a lower body strength training regime in this population, with particular emphasis on the relationship between cha...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40520-019-01234-2
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The majority of older adults do not reach the physical activity guidelines. One possible explanation for this may be that older adults overestimate their physical activity levels, because they are unable to identify exercise intensity. METHODS:Forty-four older adults were recruited and randomly assigned int...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0746-3
更新日期:2018-01-01 00:00:00
abstract:AIMS:The objective of this study was to examine baseline frailty status (including cognitive deficits) and important clinical outcomes, to inform shared decision-making in older adults receiving transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS:We conducted a prospective, observational study of 82 TA...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01525-z
更新日期:2020-03-19 00:00:00
abstract::We present a 61-year-old man with marked peripheral blood eosinophilia, feature of hypereosinophilic syndrome, that later evolved into acute lymphocytic leukemia (ALL-L2). Initially the patient suffered from significant complications related to eosinophilic toxicity, including large urticarial hyperpigmented plaques, ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.3275/8337
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Acetylcholinesterase inhibitor (AChEis) therapy in Alzheimer Disease (AD) has been shown to provide cognitive benefits and to slow progression of the disease. AChEis have also been demonstrated to improve behavioral symptoms, although there seem to be subtle differences in the magnitude of response....
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324693
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Osteoporosis and fall fractures are increasing problems amongst the elderly. The aim of this study was to explore whether combined population-based and individual interventions directed at risk factors for osteoporosis and falls result in behavioral changes in an elderly population. METHODS:A quasi...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324654
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Given the impact of recurrent falls in older people, risk evaluation for falling is an important part of geriatric assessment. Available clinical tools usually do not include patients' self-perceived risk of falling. The objective of this study was to evaluate association with and predictive capacity of self-...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0130-x
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Diverticular disease of the colon also affects older people. Generally, older patients with diverticulitis may be regarded as too risky to undergo surgery. This retroprospective multicentric observational study aims to assess the safety and benefits of laparoscopic peritoneal lavage (LPL) in elderly patients...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,多中心研究
doi:10.1007/s40520-016-0644-0
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND AIMS:As life expectancy rises worldwide and the population grows older, psychopathology in older adults becomes a significant public health concern and intervention methods acquire renewed importance. The aim of the present study was to assess the efficacy of Life Review as an intervention strategy in wo...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/BF03324931
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND AIMS:This pilot study measured the effects of an original low-intensity training program, called "posture-balancing-mobility" (PBM), on muscular function. METHODS:Nine non-disabled, elderly (74.3 +/- 6 years) subjects were trained with the PBM technique for 11 weeks (2 sessions per week). Mean power and...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327350
更新日期:2002-12-01 00:00:00
abstract::Sarcopenic obesity (SO) refers to an obesity disease accompanied by low skeletal muscle quality, strength and/or function, which is more common in the elderly and seriously affects their quality of life and can lead to falls, unstable walking, balance disorders and fractures in the elderly. The increase in aging popul...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-019-01435-9
更新日期:2019-12-16 00:00:00
abstract::Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery t...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0838-0
更新日期:2018-07-01 00:00:00
abstract::Neoplastic diseases may be complicated by rheumatic diseases or may be occur with them. Dermatomyositis/polymyositis and polymyalgia rheumatica are described as paraneoplastic syndromes. We report a case with proximal muscular weakness as only symptom of colon cancer in the absence of other symptoms and laboratory abn...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0034-9
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND AND AIMS:The purpose of this study was to determine the relationship between whole body energy metabolism measured as oxygen consumption (VO2) and local muscle activity measured by positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG). METHODS:Ten community- dwelling older women (73-83 yrs) h...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03337747
更新日期:2011-06-01 00:00:00