Abstract:
BACKGROUND:Despite differences between the studies regarding methods for estimating low muscle mass, the European Working Group on Sarcopenia in Older People (EWGSOP) recommends use of two standard deviations (SDs) below the reference sex-specific means of healthy young adults. AIMS:The aim of this study was to determine the cutoff points of skeletal muscle mass index (SMI) and handgrip strength (HS) in Turkish population and to compare the power of different cutoff points to predict comprehensive geriatric assessment (CGA) parameters. METHODS:Two hundred and eight young healthy volunteers (104 women, 104 men) were included in the study to define SMI, HS cutoff values. 1150 older adults (784 women, 366 men) underwent CGA, including physical performance, activities of daily living (ADL), HS and frailty. Body composition was obtained from every participant by bioimpedance analysis (BIA). CGA parameters of sarcopenic patients according to EWGSOP and new Turkish cutoff points were compared. RESULTS:SMI cutoff points were defined 5.70 kg/m2 for women, 8.33 kg/m2 for men. HS thresholds were calculated as 14 kg for women, 28 kg for men using measurements of healthy young adult reference. Considering the new threshold values, the prevalence of sarcopenia was 10% (7% women, 17% men). When new sarcopenia criteria were applied and covariates were adjusted, sarcopenia was found to be more closely related to ADL impairment, balance, frailty in men, and balance, slow walking speed, ADL impairment, frailty in women (p < 0.05). DISCUSSION:Muscle mass and strength may vary between populations because of ethnicity and other related discrepancies. The evaluation of sarcopenia according to the present guidelines may cause overdiagnosis in some populations. CONCLUSION:Cutoff points specific to populations should be determined.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Ates Bulut E,Soysal P,Dokuzlar O,Kocyigit SE,Aydin AE,Yavuz I,Isik ATdoi
10.1007/s40520-019-01448-4subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1749-1755issue
9eissn
1594-0667issn
1720-8319pii
10.1007/s40520-019-01448-4journal_volume
32pub_type
杂志文章abstract:BACKGROUND:Alzheimer's disease (AD) and type 2 diabetes, two diseases that contribute considerable morbidity and mortality in middle-age and elderly people, coexist and progress in parallel, leading to the presumption that one may cause the other. However, a causative link has not yet been established. METHODS:This st...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0181-z
更新日期:2014-02-01 00:00:00
abstract::Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery t...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0838-0
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Although several investigations have tested physical activity a few months or one year after hip fracture, only a few have assessed physical activity shortly after hip fracture. The aim of this study was to evaluate how physical function two weeks after hip fracture operation predicts 12-month morta...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327405
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Whether or not there has been a "compression of morbidity" in older ages has been vividly debated during the last decades. Previous studies have found indications of both improved and deteriorated health among elderly persons. Few studies have analyzed how changes in health indicators are influenced...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324463
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:A lack of understanding of the causes of attrition in longitudinal studies of older adults may lead to higher attrition rates and bias longitudinal study results. In longitudinal epidemiological studies of Alzheimer's disease and related dementias, high rates of attrition may cause a systematic underestimatio...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-1087-6
更新日期:2019-09-01 00:00:00
abstract::We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cyto...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0383-7
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND AIM:Several measurements were taken for frailty classification in geriatric population. "Frailty index" is based on "deficits in health," but it is still not available in Italian version. Thus, the aim of the present work was to validate a version of "frailty index" for the Italian geriatric community. ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0793-9
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Although nutritional status plays an important part in the physical performance and disability of older people, this relationship has been little studied in developing countries. AIMS:A study on the effects of nutritional status on the physical performance and functional status of elderly people living in r...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-016-0591-9
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03351076
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Choroidal endothelial dysfunction plays key role in wet-type age-related macular degeneration (AMD). Peripheral vascular endothelial function is not known in wet AMD. OBJECTIVE:We aimed to analyze peripheral vascular endothelial function in cases with wet-type age-related macular degeneration by measuring f...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0377-5
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Endogenous brain-derived neurotrophic factor (BDNF) is thought to be protective against the neurodegeneration seen in Parkinson's disease (PD), and is thought to increase during exercise. This has been proposed as a possible mechanism by which exercise improves outcomes for people with PD. We conducted a p...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01353-w
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:There is a high burden of antipsychotic use in residential aged care facilities (RACFs) and there is concern regarding potential inappropriate prescribing of antipsychotics in response to mild behavioural symptoms. Antipsychotic use has been associated with a higher risk of mortality in community-dwelling ol...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01518-y
更新日期:2020-03-11 00:00:00
abstract:BACKGROUND:Most studies on atrial fibrillation (AF) epidemiology, treatment, and outcomes have included mainly Caucasians patients. The world literature on AF in other ethnicities is very limited particularly in the elderly. AIMS:The aim of this study was to compare the clinical characteristics, treatment and outcome ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.3275/8757
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence and related factors of cognitive impairment in community-dwelling older residents in Beijing, China. METHODS:This is a cross-sectional study. A total of 2017 older individuals aged ≥ 60 years from Beijing Longitudinal Study of Aging were included in this study. Information on d...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-0943-8
更新日期:2019-01-01 00:00:00
abstract::Epidemiological studies of suicide in the elderly indicate that, in the last few decades, there has been a relevant increase in suicide rates in old age in a number of Asian and Latin nations, with an almost parallel decrease in Anglo-Saxon counties. Mental disorders, particularly depression, physical illness, persona...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/BF03324486
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Polypharmacy has been associated with worse cognitive performance, but its impact on mild cognitive impairment (MCI) progression to dementia has not been explored. AIMS:The aims of the study were to investigate the association between multidrug regimens and MCI progression, and the possible mediation of dru...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01420-2
更新日期:2019-11-22 00:00:00
abstract:BACKGROUND AND AIMS:Atrial fibrillation (AF) is the most frequent arrhythmia in elderly patients. Aims of this study were to evaluate the predictors of arterial stiffness after external cardioversion (ECV) of AF and to establish whether a link exists between vascular properties and left atrial diameter (LAD). METHODS:...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0173-z
更新日期:2014-06-01 00:00:00
abstract:INTRODUCTION:Syphilis is a systemic human disease which is caused by infection with the spirochete Treponema pallidum. It is spread worldwide, and there has recently been an increase in its incidence. Neurosyphilis (NS) can have a variety of presentations; meningovascular NS is a specific affection of the Treponema whi...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-1052-4
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND AIMS:The aim of this study was to investigate superoxide dismutase (SOD) activity together with malondialdehyde (MDA) levels in a group of Chinese patients with age-related macular degeneration (AMD). METHODS:Serum SOD activity and MDA levels were analysed in 56 AMD patients with subtypes (early dry, ge...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324965
更新日期:2011-08-01 00:00:00
abstract::MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-020-01516-0
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND AND AIMS:To evaluate the effect of interdisciplinary outpatient geriatrics on the use, cost, and quality of health services in a fee-for-service (FFS) environment of two networks of primary care clinics operated by a not-for-profit provider organization in Dallas County, Texas. METHODS:The Senior Health Net...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324884
更新日期:2008-12-01 00:00:00
abstract::The aim of the study was to look firstly at the changes that occurred in depressive symptomatology over a 5-year period among originally 75-year-old residents in three Nordic localities: Glostrup in Denmark, Göteborg in Sweden and Jyväskylä in Finland, and secondly, at some selected variables if they predicted depress...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:The circadian rhythm of serum thyroid stimulating hormone (TSH) levels in patients with Alzheimer's disease was measured by means of a case-control study. METHODS:Serum samples from cases and controls were collected continuously for 2 days, and then once every 2 h (even number time-point during the first da...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0025-x
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND AND AIMS:The process applied to identify fall risks in frail elderly persons remains a matter of debate. We intended to develop a fall screening instrument for clinically defined subgroups of long-term care residents, to be administered by nursing staff. METHODS:Fall risk indicators were selected by multipl...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324595
更新日期:2005-06-01 00:00:00
abstract:AIMS:The aim of this pilot study was to examine the effect of a home-made oral supplement on body weight and energy intake of old people residing in a nursing home. METHODS:Sixty-six old (65+ years) nursing home residents were included and divided into three classes according to their Mini Nutritional Assessment (MNA)...
journal_title:Aging clinical and experimental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF03324439
更新日期:2002-06-01 00:00:00
abstract:AIM:To evaluate the role of balance and gait disorders, comorbidities and laboratory abnormalities in the occurrence of falls in an institutionalized elderly population. METHODS:We made a non-interventional, prospective, observational study in elderly institutionalized people. Comorbidities and information on treatmen...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0304-1
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Low total lymphocyte count (TLC) has been found to be a poor prognostic factor in adults affected by heart diseases, malignancy, and renal failure. The aims of this study were to verify if a low TLC was associated with in-hospital mortality in older persons and to evaluate whether this association w...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324858
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer's disease (AD), respectively. METHODS:We describe the clinical and positron emission tomography (PET) findings for two individuals, one with ea...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0049-2
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Squamous cell carcinoma (SCC) of the oral tongue is one of the most frequent head and neck cancers. The over-70-year age group is the fastest growing segment of the population. Age, however, is not considered a prognostic factor in oral tongue SCC. This study investigated the clinical and histopatho...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324964
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Although many older persons choose to postpone retirement, the health consequences of this decision are still debated. This study aimed at determining the impact of continued employment on life-style, well-being, health and survival in a cohort of community-dwelling 70-year-olds. METHODS:A longitud...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327419
更新日期:2005-12-01 00:00:00