Self-curing acrylic formulations with applications in intervertebral disk restoration: drug release and biological behaviour.

abstract：:Bone marrow (BM) multipotent mesenchymal stromal cells (MSCs) present with multipotent differentiation potential and immunomodulatory properties. As an alternative to bone marrow, we have examined fetal membranes, amnion and chorion, of term human placenta as a potential source of multipotent MSCs. Here we show that a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Soncini M,Vertua E,Gibelli L,Zorzi F,Denegri M,Albertini A,Wengler GS,Parolini O

更新日期：2007-07-01 00:00:00

abstract：:Poly(glycerol sebacate) (PGS) is a biodegradable elastomer that has generated great interest as a scaffold material due to its desirable mechanical properties. However, the use of PGS in tissue engineering is limited by difficulties in casting micro- and nanofibrous structures, due to high temperatures and vacuum requ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sant S,Hwang CM,Lee SH,Khademhosseini A

更新日期：2011-04-01 00:00:00

abstract：:Nonvascularized fat grafting is a valuable technique for soft tissue reconstruction but poor survival of fat in the host environment remains a problem. A process known as cell-assisted transfer is used to enhance fat graft retention by adding stromal vascular fraction, an adipose-derived stem cell (ASC) rich content t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan SS,Zhan W,Poon CJ,Han X,Marre D,Boodhun S,Palmer JA,Mitchell GM,Morrison WA

更新日期：2018-02-01 00:00:00

abstract：:This study aims to investigate the superiorities of fast degrading elastomeric poly(glycerol sebacate) (PGS)/polycaprolactone (PCL) grafts over autologous vein grafts in the reconstruction of carotid artery, thus providing more suitable vascular grafts for carotid artery replacement. We fabricated small arterial graft...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang X,Gao Z,Liu H,Wu W

更新日期：2019-07-01 00:00:00

abstract：:The osteo-regenerative properties of allograft have recently been enhanced by addition of autogenous human bone marrow stromal cells (HBMSCs). Limitations in the use of allograft have prompted the investigation of tantalum trabecular metal (TTM) as a potential alternative. TTM is already in widespread orthopaedic use,...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Smith JO,Sengers BG,Aarvold A,Tayton ER,Dunlop DG,Oreffo RO

更新日期：2014-04-01 00:00:00

abstract：:Massive bone defects are a challenge in orthopaedic research. Defective regeneration leads to bone atrophy, non-union of bone, and physical morbidity. Large animals are important models, however, production costs are high, nursing is complex, and evaluation methods are limited. A suitable laboratory animal model is re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Jiang H,Cheng P,Li D,Li J,Wang J,Gao Y,Zhang S,Cao T,Wang C,Yang L,Pei G

更新日期：2018-04-01 00:00:00

abstract：:Despite the high prevalence of skin conditions in the horse, there is a dearth of literature on the culture and biology of equine skin cells, and this is partially attributable to the lack of suitable in vitro skin models. The objective of this study was to develop a three-dimensional (3D) culture system that would su...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sharma R,Barakzai SZ,Taylor SE,Donadeu FX

更新日期：2016-08-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are typically obtained for research or therapeutic applications by isolating and subculturing adherent cells from bone marrow on tissue-culture substrates using growth media. The purity and properties of the resulting populations can be affected greatly by the conditions under whic...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Jung S,Sen A,Rosenberg L,Behie LA

更新日期：2012-05-01 00:00:00

abstract：:Adipose stem cells (ASCs) represent a cell population with great potential for tissue engineering applications. Several articles have been published showing the proliferation and differentiation potential, the markers and the wide range of potential applications of these cells. In the majority of these studies the ASC...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rada T,Reis RL,Gomes ME

更新日期：2009-02-01 00:00:00

abstract：:Skin and oral mucosa substitutes are a therapeutic option for closing hard-to-heal skin and oral wounds. Our aim was to develop bi-layered skin and gingiva substitutes, from 3 mm diameter biopsies, cultured under identical conditions, which are compliant with current European regulations for advanced therapy medicinal...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Boink MA,Roffel S,Breetveld M,Thon M,Haasjes MSP,Waaijman T,Scheper RJ,Blok CS,Gibbs S

更新日期：2018-02-01 00:00:00

abstract：:Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anticoagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fioretta ES,Dijkman PE,Emmert MY,Hoerstrup SP

更新日期：2018-01-01 00:00:00

abstract：:Repairing the peripheral nerves following a segmental defect injury remains surgically challenging. Because of some disadvantages of nerve grafts, nerve regeneration, such as conduits combined with bone marrow-derived mesenchymal stem cells (BMSCs), may serve as an alternative. BMSCs expand under hypoxic conditions, d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang JP,Liao YT,Wu SH,Chiang ER,Hsu SH,Tseng TC,Hung SC

更新日期：2020-12-01 00:00:00

abstract：:A highly efficient cardiac differentiation from human pluripotent stem cells (hPSCs) is achievable using existing methods, especially with the standard B27 induction system. However, bovine serum albumin (BSA), one of the essential ingredients in B27, may pose significant complications for clinical studies owing to it...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan Y,Han P,Gu Q,Chen G,Wang L,Ma R,Wu J,Feng C,Zhang Y,Wang L,Hu B,Li W,Hao J,Zhou Q

更新日期：2018-01-01 00:00:00

abstract：:Current approaches for precision deposition of cells are not optimized for moist environments or for substrates with complex surface topographic features, for example, the surface of dermal matrices and other biomaterials. To overcome these challenges, an approach is presented that utilizes cell confinement in phase-s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Agarwal R,Liu G,Tam NW,Gratzer PF,Frampton JP

更新日期：2019-06-01 00:00:00

abstract：:In recent years, transforming growth factor-β3 (TGFβ3) has interested more and more researchers with its competence in engineered histogenesis. In the present study we employed recombinant adenoviral vectors to deliver the constitutively active TGFβ3 gene to human dermal fibroblasts, which could maintain the continuou...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yao Y,Zhang F,Zhou R,Li M,Wang DA

更新日期：2010-10-01 00:00:00

abstract：:To spatially control therapeutic gene delivery for potential tissue engineering applications, a biotin-avidin interaction strategy was applied to immobilize viral vectors on biomaterial scaffolds. Both adenoviral vectors and gelatin sponges were biotinylated and avidin was applied to link them in a virus-biotin-avidin...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hu WW,Wang Z,Krebsbach PH

更新日期：2016-02-01 00:00:00

abstract：:Cartilage defects heal imperfectly and osteoarthritic changes develop frequently as a result. Although the existence of specific behaviours of chondrocytes derived from various depth-related zones in vitro has been known for over 20 years, only a relatively small body of in vitro studies has been performed with zonal ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Schuurman W,Klein TJ,Dhert WJ,van Weeren PR,Hutmacher DW,Malda J

更新日期：2015-06-01 00:00:00

abstract：:Nucleus pulposus (NP) regeneration by the application of injectable cell-embedded hydrogels is an appealing approach for tissue engineering. We investigated a thermo-reversible hydrogel (TR-HG), based on a modified polysaccharide with a thermo-reversible polyamide [poly(N-isopropylacrylamide), pNIPAM], which is made t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Malonzo C,Chan SC,Kabiri A,Eglin D,Grad S,Bonél HM,Benneker LM,Gantenbein-Ritter B

更新日期：2015-12-01 00:00:00

abstract：:In order to examine the differentiation potential of the tenocytes expanded in our defined culture medium (reported previously) and the effect of sequential combination of the two culture conditions on human tenocytes, a two-dimensional and three-dimensional experimental approach was used. Human tenocytes were sequent...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu Y,Wang X,Zhang Y,Carr AJ,Zhu L,Xia Z,Sabokbar A

更新日期：2016-03-01 00:00:00

abstract：:The goal of this study was to evaluate human epiphyseal chondroprogenitor cells (ECPs) as a potential new cell source for cartilage regeneration. ECPs were compared to human bone marrow stromal cells (MSCs) and human adult articular chondrocytes (ACs) for their chondrogenic potential and phenotypic stability in vitro ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Studer D,Cavalli E,Formica FA,Kuhn GA,Salzmann G,Mumme M,Steinwachs MR,Laurent-Applegate LA,Maniura-Weber K,Zenobi-Wong M

更新日期：2017-11-01 00:00:00

abstract：:Restoration of the external ear and nose in human patients, in either congenital deformity or acquired defects, is a challenge in reconstructive surgery. Optimization of the currently available materials is necessary for rhinoplasty and microtia correction to avoid intraoperative manoeuvring and early rejection. The a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bhattacharya R,Das P,Joardar SN,Biswas BK,Batabyal S,Das PK,Nandi SK

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study is to describe the treatment of an infected segmental bone defect in a cat using a novel, custom-designed titanium implant seeded with adipose-derived stem cells (AdMSCs) to facilitate osseous ingrowth and preserve limb function. Large bone defects occur secondary to trauma, infection, or neoplas...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fitzpatrick N,Black C,Choucroun M,Blunn G,Meswania J,Sanghani-Kerai A

更新日期：2020-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been suggested as a potential cell source for tendon/ligament tissue engineering. Extrinsic cues, such as the chemical and physical properties of scaffolds, as well as external forces, play an important role in fibroblastic differentiation of these cells. In this study, we employed a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu Y,Lei J,Koob TJ,Temenoff JS

更新日期：2016-12-01 00:00:00

abstract：:Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell-seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell-seeded and non-seeded fibrin-based biologi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tao ZW,Favreau JT,Guyette JP,Hansen KJ,Lessard J,Burford E,Pins GD,Gaudette GR

更新日期：2017-01-01 00:00:00

abstract：:Elastin, a major component of vascular matrices, critically determines vascular mechanics and maintains the quiescence of smooth muscle cells (SMCs). Attempts to regenerate elastin in elastin-compromised blood vessels using tissue-engineering approaches is limited by the unavailability of elastogenic cues to upregulat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kothapalli CR,Ramamurthi A

更新日期：2008-03-01 00:00:00

abstract：:Healing of diabetic foot ulcers is a major challenge. Despite adhering to optimal standard of care (SOC), less than 30% of wounds heal after 20 weeks. Advanced cellular tissue-based products have shown better healing over SOC, albeit with great cost and modest improvement. We hypothesized no difference in healing effe...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tchanque-Fossuo CN,Dahle SE,Lev-Tov H,West KIM,Li CS,Rocke DM,Isseroff RR

更新日期：2019-08-01 00:00:00

abstract：:Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have potential clinical utility in the treatment of a multitude of ailments and diseases, due to their relative ease of isolation from patients and their capacity to form many cell types. However, hBM-MSCs are sparse, and can only be isolated in very small qu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yuan Y,Kallos MS,Hunter C,Sen A

更新日期：2014-03-01 00:00:00

abstract：:Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely efficient for economic viability given a relatively low value product and high (2 × 1012 ) cell dose. Therefore, the aim of these studies was to define the produc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bayley R,Ahmed F,Glen K,McCall M,Stacey A,Thomas R

更新日期：2018-01-01 00:00:00

abstract：:The objective of this study was to evaluate whether growth factors (FGF-2, FGF-4 and FGF-6) used alone or in combination with TGFβ2 are able to increase the proliferation and induce the differentiation of human bone marrow mesenchymal stem cells (hMSCs) to chondrocytes, with a view to using them in cartilage tissue en...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bosetti M,Boccafoschi F,Leigheb M,Bianchi AE,Cannas M

更新日期：2012-03-01 00:00:00

abstract：:In this study, clinoptilolite (CLN) was employed as a reinforcement in a polymer-based composite scaffold in bone tissue engineering and evaluated in vivo for the first time. Highly porous, mechanically stable, and osteogenic CLN/PCL-PEG-PCL (CLN/PCEC) scaffolds were fabricated with modified particulate leaching/compr...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Pazarçeviren AE,Dikmen T,Altunbaş K,Yaprakçı V,Erdemli Ö,Keskin D,Tezcaner A

更新日期：2020-01-01 00:00:00