Human chondroprogenitors in alginate-collagen hybrid scaffolds produce stable cartilage in vivo.

abstract：:Nerve conduits are promising alternatives for repairing nerve gaps; they provide a close microenvironment that supports nerve regeneration. In this sense, histological analysis of axonal growth is a determinant to achieve successful nerve regeneration. To evaluate this process, the most-used immunohistochemical marker...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Carriel V,Garzón I,Campos A,Cornelissen M,Alaminos M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:According to experimental studies, mesh implants may reduce in size up to 50.8% during their integration into soft tissues. This results in impaired mobility of the anterior abdominal wall and hernia recurrences, as well as affects patients' quality of life. Due to unsatisfactory radiographic contrast of pol...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shemyatovsky KA,Azimov RH,Alekhin AI,Kazantsev AA,Alekhin AA

更新日期：2020-05-01 00:00:00

abstract：:Massive bone defects are a challenge in orthopaedic research. Defective regeneration leads to bone atrophy, non-union of bone, and physical morbidity. Large animals are important models, however, production costs are high, nursing is complex, and evaluation methods are limited. A suitable laboratory animal model is re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Jiang H,Cheng P,Li D,Li J,Wang J,Gao Y,Zhang S,Cao T,Wang C,Yang L,Pei G

更新日期：2018-04-01 00:00:00

abstract：:'Off-the-shelf' tissue-engineered skin alternatives for epidermal and dermal skin layers are available; however, no such alternative for the subdermal fat layer exists. Without this well-vascularized layer, skin graft take is variable and grafts may have reduced mobility, contracture and contour defects. In this study...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Debels H,Gerrand YW,Poon CJ,Abberton KM,Morrison WA,Mitchell GM

更新日期：2017-04-01 00:00:00

abstract：:Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has been shown to ameliorate the injured central nervous system (CNS). Although these effects were initially attributed to the putative differentiation of MSCs towards the neural lineage, it is now known that most of them are mediated by the secretome. Up...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ribeiro CA,Salgado AJ,Fraga JS,Silva NA,Reis RL,Sousa N

更新日期：2011-08-01 00:00:00

abstract：:The creation of vascularized engineered tissues of clinically relevant size is a major challenge of tissue engineering. While it is known that endothelial and mural vascular cells are integral to the formation of stable blood vessels, the specific cell types and optimal conditions for engineered vascular networks are ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Trkov S,Eng G,Di Liddo R,Parnigotto PP,Vunjak-Novakovic G

更新日期：2010-03-01 00:00:00

abstract：:In orthopaedic medicine, connective tissues are often affected by traumatic or degenerative injuries, and surgical intervention is required. Rotator cuff tears are a common cause of shoulder pain and disability among adults. The development of graft materials for bridging the gap between tendon and bone after chronic ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gniesmer S,Brehm R,Hoffmann A,de Cassan D,Menzel H,Hoheisel AL,Glasmacher B,Willbold E,Reifenrath J,Wellmann M,Ludwig N,Tavassol F,Zimmerer R,Gellrich NC,Kampmann A

更新日期：2019-07-01 00:00:00

abstract：:Nonunion treatment has a high rate of success, although recalcitrant nonunion may determine the need for amputation. Therefore, new treatment options are continuously investigated in order to further reduce the risk of nonunion recurrence. This study aimed to (a) develop a new large animal model for bone atrophic nonu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dozza B,Salamanna F,Baleani M,Giavaresi G,Parrilli A,Zani L,Lucarelli E,Martini L,Fini M,Donati DM

更新日期：2018-09-01 00:00:00

abstract：:Bone marrow (BM) multipotent mesenchymal stromal cells (MSCs) present with multipotent differentiation potential and immunomodulatory properties. As an alternative to bone marrow, we have examined fetal membranes, amnion and chorion, of term human placenta as a potential source of multipotent MSCs. Here we show that a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Soncini M,Vertua E,Gibelli L,Zorzi F,Denegri M,Albertini A,Wengler GS,Parolini O

更新日期：2007-07-01 00:00:00

abstract：:Injections of bone marrow (BM) cell extract, known as 'BM soup', were previously reported to mitigate ionizing radiation (IR) injury to salivary glands (SGs). However, the optimal starting time and frequency to maintain BM soup therapeutic efficacy remains unknown. This study tested the optimal starting time and frequ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fang D,Shang S,Liu Y,Bakkar M,Sumita Y,Seuntjens J,Tran SD

更新日期：2018-02-01 00:00:00

abstract：:Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar-reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical trials have been condu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Spiekman M,van Dongen JA,Willemsen JC,Hoppe DL,van der Lei B,Harmsen MC

更新日期：2017-11-01 00:00:00

abstract：:The objective of this study was to test the hypothesis that platelet-rich plasma (PRP) pretreatment on a poly-lactic-co-glycolic acid (PLGA) mesh scaffold enhances the healing capacity of the meniscus with human chondrocyte-seeded scaffolds in vivo, even when the seeded number of cells was reduced from 10 million to o...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwak HS,Nam J,Lee JH,Kim HJ,Yoo JJ

更新日期：2017-02-01 00:00:00

abstract：:A highly efficient cardiac differentiation from human pluripotent stem cells (hPSCs) is achievable using existing methods, especially with the standard B27 induction system. However, bovine serum albumin (BSA), one of the essential ingredients in B27, may pose significant complications for clinical studies owing to it...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan Y,Han P,Gu Q,Chen G,Wang L,Ma R,Wu J,Feng C,Zhang Y,Wang L,Hu B,Li W,Hao J,Zhou Q

更新日期：2018-01-01 00:00:00

abstract：:The self-regeneration capacity of articular cartilage is limited, due to its avascular and aneural nature. Loaded explants and cell cultures demonstrated that chondrocyte metabolism can be regulated via physiologic loading. However, the explicit ranges of mechanical stimuli that correspond to favourable metabolic resp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tasci A,Ferguson SJ,Büchler P

更新日期：2011-03-01 00:00:00

abstract：:Keratin is an important protein used for wound healing and tissue recovery. In this study, keratin was first extracted from raw materials and chemically modified to obtain stable keratin (m-keratin). The raw and m-keratin were examined by Raman spectroscopy. The molecular weight of the m-keratin was analysed by SDS-PA...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yuan J,Geng J,Xing Z,Shim KJ,Han I,Kim JC,Kang IK,Shen J

更新日期：2015-09-01 00:00:00

abstract：:There is a need for new materials and architectures for tissue engineering and regenerative medicine. Based upon our recent results developing novel scaffold architecture, we hypothesized that this new architecture would foster vascularization, a particular need for tissue engineering. We report on the potential of su...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Keskar V,Gandhi M,Gemeinhart EJ,Gemeinhart RA

更新日期：2009-08-01 00:00:00

abstract：:Tissue engineering applications require an appropriate combination of a cell population, biochemical factors and scaffold materials. In this field, mesenchymal stem cells (MSCs) emerge as an attractive cell population, due to their ready availability and their potential to be differentiated into various mesodermal cel...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sart S,Errachid A,Schneider YJ,Agathos SN

更新日期：2013-07-01 00:00:00

abstract：:Nonvascularized fat grafting is a valuable technique for soft tissue reconstruction but poor survival of fat in the host environment remains a problem. A process known as cell-assisted transfer is used to enhance fat graft retention by adding stromal vascular fraction, an adipose-derived stem cell (ASC) rich content t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan SS,Zhan W,Poon CJ,Han X,Marre D,Boodhun S,Palmer JA,Mitchell GM,Morrison WA

更新日期：2018-02-01 00:00:00

abstract：:This study reports the manufacturing process of 3D interconnected macroporous tricalcium phosphate (TCP) scaffolds with controlled internal architecture by direct 3D printing (3DP), and high mechanical strength obtained by microwave sintering. TCP scaffolds with 27%, 35% and 41% designed macroporosity with pore sizes ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tarafder S,Balla VK,Davies NM,Bandyopadhyay A,Bose S

更新日期：2013-08-01 00:00:00

abstract：:Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ three-dimensional (3D) printing is an exciting and innovative biofabrication technology that enables the surgeon to deliver tissue-engineering techniques at the time and location of need. We ha...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Di Bella C,Duchi S,O'Connell CD,Blanchard R,Augustine C,Yue Z,Thompson F,Richards C,Beirne S,Onofrillo C,Bauquier SH,Ryan SD,Pivonka P,Wallace GG,Choong PF

更新日期：2018-03-01 00:00:00

abstract：:The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents that...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rodrigues DB,Oliveira JM,Santos TC,Reis RL

更新日期：2018-03-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) is used in 34-60% for osteoarthritic (OA) cartilage defects, although ACI is neither recommended nor designed for OA. Envisioning a hydrogel-based ACI for OA that uses chondrons instead of classically used chondrocytes, we hypothesized that human OA chondrons may outperform OA...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rothdiener M,Uynuk-Ool T,Südkamp N,Aurich M,Grodzinsky AJ,Kurz B,Rolauffs B

更新日期：2018-02-01 00:00:00

abstract：:Silk fibroin (SF) hydrogels can be obtained via self-assembly, but this process takes several days or weeks, being unfeasible to produce cell carrier hydrogels. In this work, a phospholipid, namely, 1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt (DMPG), was used to induce and accelerate the gelatio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Laomeephol C,Guedes M,Ferreira H,Reis RL,Kanokpanont S,Damrongsakkul S,Neves NM

更新日期：2020-01-01 00:00:00

abstract：:Spinal cord injury (SCI) is a neurological disorder that arises from a primary acute mechanical lesion, followed by a pathophysiological cascade of events that leads to further spinal cord tissue damage. Several preclinical and clinical studies have highlighted the ability of stem cell therapy to improve long-term fun...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mammana S,Gugliandolo A,Cavalli E,Diomede F,Iori R,Zappacosta R,Bramanti P,Conti P,Fontana A,Pizzicannella J,Mazzon E

更新日期：2019-07-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) are promising candidates for cell therapy and tissue engineering. We used mesenchymal stem cells from human bone marrow (hMSCs) as the seeding cells to investigate the potential of hepatocytic differentiation of hMSCs in porous polylactic glycolic acid (PLGA) scaffolds under p...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang J,Zong C,Shi D,Wang W,Shen D,Liu L,Tong X,Zheng Q,Gao C

更新日期：2012-01-01 00:00:00

abstract：:Cleft palate is one of the most common craniofacial defects in newborn babies. The characteristics of this genetic disease produce soft and hard tissue defects on the lip and maxilla, which cause not only aesthetic but also functional problems with speech, eating, and breathing. Bone grafts using autologous cancellous...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lee JM,Kim HY,Park JS,Lee DJ,Zhang S,Green DW,Okano T,Hong JH,Jung HS

更新日期：2019-02-01 00:00:00

abstract：:Poor angiogenesis within tissue-engineered grafts has been identified as a main challenge limiting the clinical introduction of bone tissue-engineering (BTE) approaches for the repair of large bone defects. Thick BTE grafts often exhibit poor cellular viability particularly at the core, leading to graft failure and la...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Liu Y,Chan JK,Teoh SH

更新日期：2015-02-01 00:00:00

abstract：:Obtaining an efficient, uniform and reproducible cell seeding of porous tubular scaffolds constitutes a major challenge for the successful development of tissue-engineered vascular grafts. In this study, a novel automated cell-seeding device utilizing direct cell deposition, patterning techniques and scaffold rotation...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mohebbi-Kalhori D,Rukhlova M,Ajji A,Bureau M,Moreno MJ

更新日期：2012-10-01 00:00:00

abstract：:Cranioplasty is necessary for patients that have undergone craniectomy following trauma, stroke or other causes of elevated intracranial pressure. This study assessed the effectiveness of treating cranial defects with allogeneic mesenchymal stromal cells (MSC) on a ceramic carrier and polymer scaffold, to produce viab...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Morrison DA,Kop AM,Nilasaroya A,Sturm M,Shaw K,Honeybul S

更新日期：2018-02-01 00:00:00

abstract：:The authors previously created HAp or CaCO(3) formed on or in agarose gels (HAp and CaCO(3) gels, respectively) as biocompatible and biodegradable bone graft materials. However, these gels have limitations for bone regeneration. Mesenchymal stromal cells (MSCs) have osteogenic potential and are considered useful for b...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mizuta N,Hattori K,Suzawa Y,Iwai S,Matsumoto T,Tadokoro M,Nakano T,Akashi M,Ohgushi H,Yura Y

更新日期：2013-01-01 00:00:00