Cranial reconstruction using allogeneic mesenchymal stromal cells: A phase 1 first-in-human trial.

abstract：:The purpose of this study was to develop freeze-dried chitosan formulations that can be solubilized in platelet-rich plasma (PRP) to form injectable implants for tissue repair. A systematic approach to adjust formulation parameters, including chitosan number average molar mass (Mn ), chitosan concentration and lyoprot...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chevrier A,Darras V,Picard G,Nelea M,Veilleux D,Lavertu M,Hoemann CD,Buschman MD

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study is to describe the treatment of an infected segmental bone defect in a cat using a novel, custom-designed titanium implant seeded with adipose-derived stem cells (AdMSCs) to facilitate osseous ingrowth and preserve limb function. Large bone defects occur secondary to trauma, infection, or neoplas...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fitzpatrick N,Black C,Choucroun M,Blunn G,Meswania J,Sanghani-Kerai A

更新日期：2020-10-01 00:00:00

abstract：:Implanted porous precision templated scaffolds (PTS) with 40-µm spherical pores reduce inflammation and foreign body reaction (FBR) while increasing vascular density upon implantation. Larger or smaller pores, however, promote chronic inflammation and FBR. While macrophage (MØ) recruitment and polarization participate...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hady TF,Hwang B,Pusic AD,Waworuntu RL,Mulligan M,Ratner B,Bryers JD

更新日期：2021-01-01 00:00:00

abstract：:Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have potential clinical utility in the treatment of a multitude of ailments and diseases, due to their relative ease of isolation from patients and their capacity to form many cell types. However, hBM-MSCs are sparse, and can only be isolated in very small qu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yuan Y,Kallos MS,Hunter C,Sen A

更新日期：2014-03-01 00:00:00

abstract：:Wound healing remains a major challenge in modern medicine. Bone marrow- (BM) and adipose tissue- (AT) derived mesenchymal stromal/stem cells (MSCs) are of great interest for tissue reconstruction due to their unique immunological properties and regenerative potential. The purpose of this study was to characterize BM ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hanson SE,Kleinbeck KR,Cantu D,Kim J,Bentz ML,Faucher LD,Kao WJ,Hematti P

更新日期：2016-02-01 00:00:00

abstract：:'Off-the-shelf' tissue-engineered skin alternatives for epidermal and dermal skin layers are available; however, no such alternative for the subdermal fat layer exists. Without this well-vascularized layer, skin graft take is variable and grafts may have reduced mobility, contracture and contour defects. In this study...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Debels H,Gerrand YW,Poon CJ,Abberton KM,Morrison WA,Mitchell GM

更新日期：2017-04-01 00:00:00

abstract：:Many studies have highlighted the role of silicon in human bone formation and maintenance. Silicon, in fact, is considered to nucleate the precipitation of hydroxyapatite and to reduce the bone resorption. For this reason, we have combined silk fibroin (SF) with silicon-releasing diatom particles (DPs), as potential m...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Le TDH,Liaudanskaya V,Bonani W,Migliaresi C,Motta A

更新日期：2018-01-01 00:00:00

abstract：:Bone-like apatite is a carbonated hydroxyapatite with a small crystallite and low crystallinity. The formation of a layer consisting of bone-like apatite is an essential condition for bioactive materials to achieve direct bonding with living bone. A bone-like apatite layer can be formed on the surface of organic subst...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ohtsuki C,Kamitakahara M,Miyazaki T

更新日期：2007-01-01 00:00:00

abstract：:Anti-inflammatory gene therapy can inhibit inflammation driven by TNFalpha in experimental models of rheumatoid arthritis. However, assessment of the therapeutic effect on cartilage and bone quality is either missing or unsatisfactory. A multimodal imaging approach, using confocal laser scanning microscopy (CLSM) and ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Stok KS,Noël D,Apparailly F,Gould D,Chernajovsky Y,Jorgensen C,Müller R

更新日期：2010-07-01 00:00:00

abstract：:Repairing the peripheral nerves following a segmental defect injury remains surgically challenging. Because of some disadvantages of nerve grafts, nerve regeneration, such as conduits combined with bone marrow-derived mesenchymal stem cells (BMSCs), may serve as an alternative. BMSCs expand under hypoxic conditions, d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang JP,Liao YT,Wu SH,Chiang ER,Hsu SH,Tseng TC,Hung SC

更新日期：2020-12-01 00:00:00

abstract：:Self-sustainability after implantation is one of the critical obstacles facing large engineered tissues. A preformed functional vascular network provides an effective solution for solving the mass transportation problem. With the support of mural cells, endothelial cells (ECs) can form microvessels within engineered t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Zhang L,Qian Z,Tahtinen M,Qi S,Zhao F

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a novel bioactive material (Biosilicate®) and low-level laser therapy (LLLT) on bone fracture consolidation in osteoporotic rats. Forty female Wistar rats were submitted to ovariectomy (OVX) to induce osteopenia. Eight weeks after surgery, the animals were random...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bossini PS,Rennó AC,Ribeiro DA,Fangel R,Peitl O,Zanotto ED,Parizotto NA

更新日期：2011-03-01 00:00:00

abstract：:Spatiotemporal changes in the extracellular matrix (ECM) were studied within abdominal aortic aneurysms (AAAs) generated in rats via elastase infusion. At 7, 14 and 21 days post-induction, AAA tissues were divided into proximal, mid- and distal regions, based on their location relative to the renal arteries and the re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Deb PP,Ramamurthi A

更新日期：2017-01-01 00:00:00

abstract：:This study investigates whether platelet-rich plasma (PRP) is an activator of tendon-derived stem cells (TDSCs) to promote regeneration of Achilles tendon post-rupture in rats. In the in vitro study, PRGF (activated PRP) significantly enhanced cell DNA synthesis, improved viability and promoted proliferation, while fa...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Xu K,Al-Ani MK,Sun Y,Xu W,Pan L,Song Y,Xu Z,Pan X,Yang L

更新日期：2017-04-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration has been described as an aberrant, cell-mediated, age- and genetics-dependent molecular degeneration process, which can be accelerated by nutritional, mechanical and toxic factors. Collective involvement of these factors can result in structural failures, which are often associat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mern DS,Beierfuß A,Thomé C,Hegewald AA

更新日期：2014-12-01 00:00:00

abstract：:In orthopaedic medicine, connective tissues are often affected by traumatic or degenerative injuries, and surgical intervention is required. Rotator cuff tears are a common cause of shoulder pain and disability among adults. The development of graft materials for bridging the gap between tendon and bone after chronic ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gniesmer S,Brehm R,Hoffmann A,de Cassan D,Menzel H,Hoheisel AL,Glasmacher B,Willbold E,Reifenrath J,Wellmann M,Ludwig N,Tavassol F,Zimmerer R,Gellrich NC,Kampmann A

更新日期：2019-07-01 00:00:00

abstract：:Clinical translation of engineered tissues into regenerative medicine applications, and the effort to reduce the use of animals for the screening of drugs and other compounds, result in an increasing demand for human tissues engineered in vitro for implantation, in vitro screening systems and basic research. Further d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rouwkema J,Gibbs S,Lutolf MP,Martin I,Vunjak-Novakovic G,Malda J

更新日期：2011-08-01 00:00:00

abstract：:Transplantation of bone marrow mesenchymal stem cells (BMSCs) has been considered to be a promising strategy for wound healing. However, poor viability of engrafted BMSCs and limited capabilities of differentiation into the desired cell types in wounds often hinder its application. Few studies report the induction of ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shou K,Huang Y,Qi B,Hu X,Ma Z,Lu A,Jian C,Zhang L,Yu A

更新日期：2018-02-01 00:00:00

abstract：:Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anticoagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fioretta ES,Dijkman PE,Emmert MY,Hoerstrup SP

更新日期：2018-01-01 00:00:00

abstract：:Nanopatterned (330 nm wide channels) type I collagen films were prepared by solvent casting on poly(dimethyl siloxane) (PDMS) templates. These films were rolled into tubular constructs and crosslinked. Tubular constructs were incubated under cell culture conditions for 28 days and examined by stereomicroscopy and scan...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Zorlutuna P,Hasirci N,Hasirci V

更新日期：2008-08-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) are promising candidates for cell therapy and tissue engineering. We used mesenchymal stem cells from human bone marrow (hMSCs) as the seeding cells to investigate the potential of hepatocytic differentiation of hMSCs in porous polylactic glycolic acid (PLGA) scaffolds under p...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang J,Zong C,Shi D,Wang W,Shen D,Liu L,Tong X,Zheng Q,Gao C

更新日期：2012-01-01 00:00:00

abstract：:For the success of any biomaterial for tissue engineering, its mechanical properties and ability to support nutrient diffusion will be critical. Collagen scaffolds are ideal candidates, due to their ability to immerse cells in a biomimetic nanofibrous matrix. We have established O(2) diffusion coefficients through nat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Cheema U,Rong Z,Kirresh O,Macrobert AJ,Vadgama P,Brown RA

更新日期：2012-01-01 00:00:00

abstract：:To create functional tissues having complex structures, bottom-up approaches to assembling small tissue modules into larger constructs have been emerging. Most of these approaches are based on chemical reactions or physical interactions at the interface between tissue modules. Here we report a biological assembly appr...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Riesberg JJ,Shen W

更新日期：2015-09-01 00:00:00

abstract：:Biodegradable porous scaffolds have been investigated as an alternative approach to current metal, ceramic, and polymer bone graft substitutes for lost or damaged bone tissues. Although there have been many studies investigating the effects of scaffold architecture on bone formation, many of these scaffolds were fabri...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Saito E,Liao EE,Hu WW,Krebsbach PH,Hollister SJ

更新日期：2013-02-01 00:00:00

abstract：:Our recent clinical studies have demonstrated that autologous implantation of human cultured periosteal (hCP) sheets in combination with porous hydroxylapatite (HAp) particles at the site of periodontal bone defects strikingly facilitates tissue regeneration. To better understand how the hCP sheet functions at the imp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kawase T,Okuda K,Kogami H,Nakayama H,Nagata M,Nakata K,Yoshie H

更新日期：2009-03-01 00:00:00

abstract：:Obtaining an efficient, uniform and reproducible cell seeding of porous tubular scaffolds constitutes a major challenge for the successful development of tissue-engineered vascular grafts. In this study, a novel automated cell-seeding device utilizing direct cell deposition, patterning techniques and scaffold rotation...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mohebbi-Kalhori D,Rukhlova M,Ajji A,Bureau M,Moreno MJ

更新日期：2012-10-01 00:00:00

abstract：:Nerve guides are currently being fabricated by blending a variety of biomaterials with different proteins. Adding proteins, which can support nerve repair and regeneration, optimizes the biological properties of a nerve guide. In our study we have blended glial cell line-derived nerve growth factor (GDNF) and laminin ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Patel M,Mao L,Wu B,Vandevord PJ

更新日期：2007-09-01 00:00:00

abstract：:The effects of mesenchymal stem cells (MSCs) on the phenotype and function of natural killer T (NKT) cells is not understood. We used concanavalin A (Con A) and α-galactosylceramide (α-GalCer)-induced liver injury to evaluate the effects of MSCs on NKT-dependent hepatotoxicity. Mouse MSCs (mMSCs) significantly reduced...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gazdic M,Simovic Markovic B,Vucicevic L,Nikolic T,Djonov V,Arsenijevic N,Trajkovic V,Lukic ML,Volarevic V

更新日期：2018-02-01 00:00:00

abstract：:The osteo-regenerative properties of allograft have recently been enhanced by addition of autogenous human bone marrow stromal cells (HBMSCs). Limitations in the use of allograft have prompted the investigation of tantalum trabecular metal (TTM) as a potential alternative. TTM is already in widespread orthopaedic use,...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Smith JO,Sengers BG,Aarvold A,Tayton ER,Dunlop DG,Oreffo RO

更新日期：2014-04-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) is used in 34-60% for osteoarthritic (OA) cartilage defects, although ACI is neither recommended nor designed for OA. Envisioning a hydrogel-based ACI for OA that uses chondrons instead of classically used chondrocytes, we hypothesized that human OA chondrons may outperform OA...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rothdiener M,Uynuk-Ool T,Südkamp N,Aurich M,Grodzinsky AJ,Kurz B,Rolauffs B

更新日期：2018-02-01 00:00:00