Abstract：
:For the success of any biomaterial for tissue engineering, its mechanical properties and ability to support nutrient diffusion will be critical. Collagen scaffolds are ideal candidates, due to their ability to immerse cells in a biomimetic nanofibrous matrix. We have established O(2) diffusion coefficients through native, dense collagen scaffolds at two tissue-like densities, with and without photo-chemical crosslinking, by adapting an optical fibre-based system for real-time core O(2) monitoring deep within collagen constructs. Using a Fick's law model, we then derived O(2) diffusion coefficients; 4.5 × 10(-6) cm(2) /s for 11% density collagen scaffolds; 1.7 × 10(-6) cm(2) /s for 34% collagen scaffolds; 3.4 × 10(-6) cm(2) /s for photochemically crosslinked collagen scaffolds at 11%. Both O(2) diffusion coefficients of the 11% collagen fall within the range of native intestinal submucosa. The high diffusion coefficients of these collagen scaffolds, as well as their material properties, render them viable tissue-engineering matrices for tissue replacement.
journal_name
J Tissue Eng Regen Medjournal_title
Journal of tissue engineering and regenerative medicineauthors
Cheema U,Rong Z,Kirresh O,Macrobert AJ,Vadgama P,Brown RAdoi
10.1002/term.402subject
Has Abstractpub_date
2012-01-01 00:00:00pages
77-84issue
1eissn
1932-6254issn
1932-7005journal_volume
6pub_type
杂志文章abstract：:The development of scaffolds that combine the delivery of drugs with the physical support provided by electrospun fibres holds great potential in the field of nerve regeneration. Here it is proposed the incorporation of ibuprofen, a well-known non-steroidal anti-inflammatory drug, in electrospun fibres of the statisti...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.1792
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:According to experimental studies, mesh implants may reduce in size up to 50.8% during their integration into soft tissues. This results in impaired mobility of the anterior abdominal wall and hernia recurrences, as well as affects patients' quality of life. Due to unsatisfactory radiographic contrast of pol...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.3029
更新日期：2020-05-01 00:00:00
abstract：:The demineralized bone matrix (DBM) is the most widely used bone allograft, which is obtained by removing the mineral component of bone, leading to exposure of the proteins responsible for osteoinduction. For clinical use, DBM shall be formulated with a carrier that provides consistency and improves its osteoinduction...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.3012
更新日期：2020-03-01 00:00:00
abstract：:Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell-seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell-seeded and non-seeded fibrin-based biologi...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.1904
更新日期：2017-01-01 00:00:00
abstract：:There is a need for new materials and architectures for tissue engineering and regenerative medicine. Based upon our recent results developing novel scaffold architecture, we hypothesized that this new architecture would foster vascularization, a particular need for tissue engineering. We report on the potential of su...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.183
更新日期：2009-08-01 00:00:00
abstract：:Bone marrow mesenchymal stem cells (MSCs) are promising candidates for cell therapy and tissue engineering. We used mesenchymal stem cells from human bone marrow (hMSCs) as the seeding cells to investigate the potential of hepatocytic differentiation of hMSCs in porous polylactic glycolic acid (PLGA) scaffolds under p...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.393
更新日期：2012-01-01 00:00:00
abstract：:Despite the spontaneous regenerative capacity of the peripheral nervous system, large gap peripheral nerve injuries (PNIs) require bridging strategies. The limitations and suboptimal results obtained with autografts or hollow nerve conduits in the clinic urge the need for alternative treatments. Recently, we have desc...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.2249
更新日期：2017-12-01 00:00:00
abstract：:New injectable acrylic formulations have been prepared to be applied in restoration processes for intervertebral disks (IVDs). The solid phase of the formulations is composed of poly(methyl methacrylate) (PMMA), incorporating in some cases chondroitin sulphate (CS) as a regenerative bioactive molecule, whereas the liq...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.10
更新日期：2007-03-01 00:00:00
abstract：:In this communication, we introduce boron nitride nanotube (BNNT)-functionalised muscle cell/microfibre mesh constructs, obtained via tissue engineering, as a three-dimensional (3D) platform to study a wireless stimulation system for electrically responsive cells and tissues. Our stimulation strategy exploits the piez...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.1878
更新日期：2015-07-01 00:00:00
abstract：:Microstructure in terms of hierarchical assembly exists widely in mineralized biomaterials, fulfilling an important role in setting up their outstanding properties. The purpose of this study was to investigate the hierarchical assembly of enamel structure and functions, which are related to the unique characteristics ...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.21
更新日期：2007-05-01 00:00:00
abstract：:The self-regeneration capacity of articular cartilage is limited, due to its avascular and aneural nature. Loaded explants and cell cultures demonstrated that chondrocyte metabolism can be regulated via physiologic loading. However, the explicit ranges of mechanical stimuli that correspond to favourable metabolic resp...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.307
更新日期：2011-03-01 00:00:00
abstract：:Implanted porous precision templated scaffolds (PTS) with 40-µm spherical pores reduce inflammation and foreign body reaction (FBR) while increasing vascular density upon implantation. Larger or smaller pores, however, promote chronic inflammation and FBR. While macrophage (MØ) recruitment and polarization participate...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.3160
更新日期：2021-01-01 00:00:00
abstract：:Tissue engineering holds great promise to develop functional constructs resembling the structural organization of native tissues to improve or replace biological functions, with the ultimate goal of avoiding organ transplantation. In tissue engineering, cells are often seeded into artificial structures capable of supp...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章,评审
doi：10.1002/term.1978
更新日期：2016-09-01 00:00:00
abstract：:Lubricin, homologous to superficial zone protein (SZP), functions as a boundary lubricant in articular cartilage and plays an essential role in the maintenance of joint function and homeostasis. Wnt signalling plays a key role in joint development, including synovial joint formation, and several Wnt proteins are expre...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.1808
更新日期：2016-02-01 00:00:00
abstract：:Nerve conduits are promising alternatives for repairing nerve gaps; they provide a close microenvironment that supports nerve regeneration. In this sense, histological analysis of axonal growth is a determinant to achieve successful nerve regeneration. To evaluate this process, the most-used immunohistochemical marker...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.1949
更新日期：2017-02-01 00:00:00
abstract：:The gastroesophageal junction has been of clinical interest for some time due to its important role in preventing reflux of caustic stomach contents upward into the esophagus. Failure of this role has been identified as a key driver in gastroesophageal reflux disease, cancer of the lower esophagus, and aspiration-indu...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章,评审
doi：10.1002/term.3045
更新日期：2020-06-01 00:00:00
abstract：:Adipose tissue-derived microvascular fragments (ad-MVFs) are promising vascularization units for tissue engineering. In this study, we analysed the effects of normothermic (37°C) and subnormothermic (20°C) short-term cultivation on their viability and network forming capacity. Ad-MVFs from green fluorescent protein (G...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.2774
更新日期：2019-02-01 00:00:00
abstract：:There is a need for preclinical testing systems that predict the efficacy, safety and pharmacokinetics of cancer therapies better than existing in vitro and in vivo animal models. An approach to the development of predictive in vitro systems is to more closely recapitulate the cellular and spatial complexity of human ...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.2026
更新日期：2017-04-01 00:00:00
abstract：:In this study, a new foaming method, based on physical foaming combined with microwave-induced curing, is proposed in combination with a surface bioactivation to develop scaffold for bone tissue regeneration. In the first step of the process, a stable physical foaming was induced using a surfactant (Pluronic) as blowi...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.2241
更新日期：2017-01-01 00:00:00
abstract：:The treatment of lengthy peripheral nerve defect is challenging in the field of nerve regeneration. Our previous studies have shown that low-intensity pulsed ultrasound (LIPUS) could promote the proliferation, cell viability, and neural differentiation of induced pluripotent stem cells-derived neural crest stem cells ...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.2823
更新日期：2019-04-01 00:00:00
abstract：:Bone-like apatite is a carbonated hydroxyapatite with a small crystallite and low crystallinity. The formation of a layer consisting of bone-like apatite is an essential condition for bioactive materials to achieve direct bonding with living bone. A bone-like apatite layer can be formed on the surface of organic subst...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章,评审
doi：10.1002/term.3
更新日期：2007-01-01 00:00:00
abstract：:Treatment of terminal heart failure still poses a significant clinical problem. Cardiac tissue engineering could offer autologous solutions for the replacement of nonfunctional myocardial tissue. So far, soft matrix construction and missing large-scale prevascularization prevented the application of sizeable cardiac r...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.3129
更新日期：2020-12-01 00:00:00
abstract：:Developing and regenerating neurites respond to a variety of biophysical and biochemical cues in their micro-environment to reach target cells and establish appropriate synapses. Defining the hierarchal relationship of both types of cues to direct neurite growth carries broad significance for neural development, regen...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.2527
更新日期：2018-03-01 00:00:00
abstract：:Native articular cartilage is subjected to synovial fluid flow during normal joint function. Thus, it is believed that the morphogenesis of articular cartilage may be positively regulated by the application of similar stimulation in vitro. In the present study, the effect of fluid flow over the chondrogenic differenti...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.372
更新日期：2011-10-01 00:00:00
abstract：:Cranioplasty is necessary for patients that have undergone craniectomy following trauma, stroke or other causes of elevated intracranial pressure. This study assessed the effectiveness of treating cranial defects with allogeneic mesenchymal stromal cells (MSC) on a ceramic carrier and polymer scaffold, to produce viab...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type：
doi：10.1002/term.2459
更新日期：2018-02-01 00:00:00
abstract：:Electrospinning has recently gained widespread attention as a process capable of producing nanoscale fibres that mimic native extracellular matrix. In this study, we compared the osteogenic differentiation behaviour of human adipose stem cells (ASCs) on a 3D nanofibre matrix of type I rat tail collagen (RTC) and a 2D ...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.85
更新日期：2008-06-01 00:00:00
abstract：:Bone-patellar tendon-bone (BPTB) autografts are the gold standard for anterior cruciate ligament (ACL) reconstruction because the bony ends allow for superior healing and anchoring through bone-to-bone regeneration. However, the disadvantages of BPTB grafts include donor site morbidity and patellar rupture. In order t...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.1966
更新日期：2017-03-01 00:00:00
abstract：:Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human somatic cells has proved to be one of the most potentially useful discoveries in regenerative medicine. iPSCs are becoming an invaluable tool to study the pathology of different diseases and for drug screening. However, severa...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章,评审
doi：10.1002/term.2021
更新日期：2016-11-01 00:00:00
abstract：:Anti-inflammatory gene therapy can inhibit inflammation driven by TNFalpha in experimental models of rheumatoid arthritis. However, assessment of the therapeutic effect on cartilage and bone quality is either missing or unsatisfactory. A multimodal imaging approach, using confocal laser scanning microscopy (CLSM) and ...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.251
更新日期：2010-07-01 00:00:00
abstract：:Cartilage tissue engineering is making progress, but the competing available strategies still leave room for improvement and consensual overviews regarding the best combinations of scaffolds and cell sources are limited by the capacity to compare them directly. In addition, because most strategies involve autologous c...
journal_title：Journal of tissue engineering and regenerative medicine
pub_type： 杂志文章
doi：10.1002/term.2454
更新日期：2018-03-01 00:00:00
