Mesenchymal stem cells from a hypoxic culture improve nerve regeneration.

abstract：:Macroporous calcium phosphate cement (CPC) with stem cell seeding is promising for bone regeneration. The objective of this study was to investigate the effects of co-delivering autologous bone marrow mesenchymal stem cells (BMSCs) and autologous platelet-rich plasma (PRP) in CPC scaffold for bone regeneration in mini...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu G,Shi Z,Xu HHK,Yang B,Weir MD,Li G,Song Y,Wang J,Hu K,Wang P,Zhao L

更新日期：2018-02-01 00:00:00

abstract：:The development of a functional microvasculature is critical to the long-term survival of implanted tissue-engineered constructs. Dynamic culture conditions have been shown to significantly modulate phenotypic characteristics and stimulate proliferation of cells within hydrogel-based tissue engineered blood vessels. A...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gassman AA,Kuprys T,Ucuzian AA,Brey E,Matsumura A,Pang Y,Larson J,Greisler HP

更新日期：2011-05-01 00:00:00

abstract：:Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions. However, a dearth of available donor organs for transplantation leads to the death of numerous patients waiting for a suitable organ donor. The potential of decellularized scaffolds, derived from native tissues or organs in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rana D,Zreiqat H,Benkirane-Jessel N,Ramakrishna S,Ramalingam M

更新日期：2017-04-01 00:00:00

abstract：:Healing of diabetic foot ulcers is a major challenge. Despite adhering to optimal standard of care (SOC), less than 30% of wounds heal after 20 weeks. Advanced cellular tissue-based products have shown better healing over SOC, albeit with great cost and modest improvement. We hypothesized no difference in healing effe...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tchanque-Fossuo CN,Dahle SE,Lev-Tov H,West KIM,Li CS,Rocke DM,Isseroff RR

更新日期：2019-08-01 00:00:00

abstract：:To spatially control therapeutic gene delivery for potential tissue engineering applications, a biotin-avidin interaction strategy was applied to immobilize viral vectors on biomaterial scaffolds. Both adenoviral vectors and gelatin sponges were biotinylated and avidin was applied to link them in a virus-biotin-avidin...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hu WW,Wang Z,Krebsbach PH

更新日期：2016-02-01 00:00:00

abstract：:The creation of vascularized engineered tissues of clinically relevant size is a major challenge of tissue engineering. While it is known that endothelial and mural vascular cells are integral to the formation of stable blood vessels, the specific cell types and optimal conditions for engineered vascular networks are ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Trkov S,Eng G,Di Liddo R,Parnigotto PP,Vunjak-Novakovic G

更新日期：2010-03-01 00:00:00

abstract：:Postoperative mucosal regeneration of the middle ear cavity and the mastoid cavity is of great importance after middle ear surgery. However, the epithelialization of the mucosa in the middle ear is retarded because chronic inflammation without epithelialization aggravates gas exchange and clinical function. These envi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hama T,Yamamoto K,Yaguchi Y,Murakami D,Sasaki H,Yamato M,Okano T,Kojima H

更新日期：2017-04-01 00:00:00

abstract：:Biomaterials and, especially, scaffolds may function as temporary extracellular matrix (ECM), mimicking in vivo environmental structures and facilitating cell growth and tissue regeneration. ECM is composed mostly of glycosaminoglycans (GAGs) and proteins, the ratio of GAGs, hyaluronic acid (HA):sulphated GAGs (sGAGs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Herrero-Mendez A,Palomares T,Castro B,Herrero J,Alonso-Varona A

更新日期：2016-12-01 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) has been proposed to exert beneficial effects on peripheral nerve regeneration after a peripheral nerve injury, but the functional recovery in the denervated limb is still limited. In this study, we used low-level laser therapy (LLLT) as an adjunct therapy for MSC trans...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang CC,Wang J,Chen SC,Hsieh YL

更新日期：2016-02-01 00:00:00

abstract：:Cardiac stem cells (CSCs) represent a logical cell type to exploit as a regenerative treatment option for tissue damage accrued as a result of a myocardial infarction. However, the isolation and expansion of CSCs prior to cell transplantation is time consuming, costly and invasive, and the reliability of cell expansio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： O'Neill HS,O'Sullivan J,Porteous N,Ruiz-Hernandez E,Kelly HM,O'Brien FJ,Duffy GP

更新日期：2018-01-01 00:00:00

abstract：:Clinical translation of engineered tissues into regenerative medicine applications, and the effort to reduce the use of animals for the screening of drugs and other compounds, result in an increasing demand for human tissues engineered in vitro for implantation, in vitro screening systems and basic research. Further d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rouwkema J,Gibbs S,Lutolf MP,Martin I,Vunjak-Novakovic G,Malda J

更新日期：2011-08-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a novel bioactive material (Biosilicate®) and low-level laser therapy (LLLT) on bone fracture consolidation in osteoporotic rats. Forty female Wistar rats were submitted to ovariectomy (OVX) to induce osteopenia. Eight weeks after surgery, the animals were random...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bossini PS,Rennó AC,Ribeiro DA,Fangel R,Peitl O,Zanotto ED,Parizotto NA

更新日期：2011-03-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) is used in 34-60% for osteoarthritic (OA) cartilage defects, although ACI is neither recommended nor designed for OA. Envisioning a hydrogel-based ACI for OA that uses chondrons instead of classically used chondrocytes, we hypothesized that human OA chondrons may outperform OA...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rothdiener M,Uynuk-Ool T,Südkamp N,Aurich M,Grodzinsky AJ,Kurz B,Rolauffs B

更新日期：2018-02-01 00:00:00

abstract：:Keratin is an important protein used for wound healing and tissue recovery. In this study, keratin was first extracted from raw materials and chemically modified to obtain stable keratin (m-keratin). The raw and m-keratin were examined by Raman spectroscopy. The molecular weight of the m-keratin was analysed by SDS-PA...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yuan J,Geng J,Xing Z,Shim KJ,Han I,Kim JC,Kang IK,Shen J

更新日期：2015-09-01 00:00:00

abstract：:Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwon DY,Park JH,Jang SH,Park JY,Jang JW,Min BH,Kim WD,Lee HB,Lee J,Kim MS

更新日期：2018-02-01 00:00:00

abstract：:Nonvascularized fat grafting is a valuable technique for soft tissue reconstruction but poor survival of fat in the host environment remains a problem. A process known as cell-assisted transfer is used to enhance fat graft retention by adding stromal vascular fraction, an adipose-derived stem cell (ASC) rich content t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan SS,Zhan W,Poon CJ,Han X,Marre D,Boodhun S,Palmer JA,Mitchell GM,Morrison WA

更新日期：2018-02-01 00:00:00

abstract：:In this communication, we introduce boron nitride nanotube (BNNT)-functionalised muscle cell/microfibre mesh constructs, obtained via tissue engineering, as a three-dimensional (3D) platform to study a wireless stimulation system for electrically responsive cells and tissues. Our stimulation strategy exploits the piez...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Danti S,Ciofani G,Pertici G,Moscato S,D'Alessandro D,Ciabatti E,Chiellini F,D'Acunto M,Mattoli V,Berrettini S

更新日期：2015-07-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) transplantation enhances functional recovery after cerebral infarct, but the optimal delivery route is undetermined. This study was aimed to assess whether a novel cell-sheet technology non-invasively serves therapeutic benefits to ischemic stroke. First, the monolayered cell sheet was...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ito M,Shichinohe H,Houkin K,Kuroda S

更新日期：2017-02-01 00:00:00

abstract：:The availability of autologous articular chondrocytes remains a limiting issue in matrix assisted autologous chondrocyte transplantation. Non-articular heterotopic chondrocytes could be an alternative autologous cell source. The aims of this study were to establish heterotopic chondrocyte cocultures to analyze cell-ce...

journal_title：Journal of tissue engineering and regenerative medicine

authors： El Sayed K,Marzahn U,John T,Hoyer M,Zreiqat H,Witthuhn A,Kohl B,Haisch A,Schulze-Tanzil G

更新日期：2013-01-01 00:00:00

abstract：:For preventing the scar contracture of host tissue and adjusting the tensile strength of covering cell sheets, a controlled collagen crosslinking step process in the preparation of skin-fibroblast sheets for repairing wound was investigated by using β-aminopropionitrile (BAPN), a collagen crosslinking inhibitor, in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kanzaki M,Yamato M,Takagi R,Kikkawa T,Isaka T,Okano T,Onuki T

更新日期：2013-05-01 00:00:00

abstract：:Nucleus pulposus (NP) regeneration by the application of injectable cell-embedded hydrogels is an appealing approach for tissue engineering. We investigated a thermo-reversible hydrogel (TR-HG), based on a modified polysaccharide with a thermo-reversible polyamide [poly(N-isopropylacrylamide), pNIPAM], which is made t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Malonzo C,Chan SC,Kabiri A,Eglin D,Grad S,Bonél HM,Benneker LM,Gantenbein-Ritter B

更新日期：2015-12-01 00:00:00

abstract：:Wound healing remains a major challenge in modern medicine. Bone marrow- (BM) and adipose tissue- (AT) derived mesenchymal stromal/stem cells (MSCs) are of great interest for tissue reconstruction due to their unique immunological properties and regenerative potential. The purpose of this study was to characterize BM ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hanson SE,Kleinbeck KR,Cantu D,Kim J,Bentz ML,Faucher LD,Kao WJ,Hematti P

更新日期：2016-02-01 00:00:00

abstract：:Nerve conduits are promising alternatives for repairing nerve gaps; they provide a close microenvironment that supports nerve regeneration. In this sense, histological analysis of axonal growth is a determinant to achieve successful nerve regeneration. To evaluate this process, the most-used immunohistochemical marker...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Carriel V,Garzón I,Campos A,Cornelissen M,Alaminos M

更新日期：2017-02-01 00:00:00

abstract：:A highly efficient cardiac differentiation from human pluripotent stem cells (hPSCs) is achievable using existing methods, especially with the standard B27 induction system. However, bovine serum albumin (BSA), one of the essential ingredients in B27, may pose significant complications for clinical studies owing to it...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan Y,Han P,Gu Q,Chen G,Wang L,Ma R,Wu J,Feng C,Zhang Y,Wang L,Hu B,Li W,Hao J,Zhou Q

更新日期：2018-01-01 00:00:00

abstract：:Surface-modified titanium (Ti) samples with hydroxyapatite (HAp) and heparin (Hep)-bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared, and their efficacies on the enhancements of bone formation and osseointegration in vitro and in vivo were examined as compared to Ti/HAp and Ti/Hep/BMP-2. Th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang DH,Lee DW,Kwon YD,Kim HJ,Chun HJ,Jang JW,Khang G

更新日期：2015-09-01 00:00:00

abstract：:Prevascularization is essential to ensure the viability, functionality, and successful integration of tissue-engineered three-dimensional (3D) constructs with surrounding host tissues after transplantation. Human mesenchymal stem cell (hMSC) sheet can be prevascularized by coculturing with endothelial cells (ECs), and...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Jia W,Sharma D,He W,Xing Q,Zhao F

更新日期：2021-01-11 00:00:00

abstract：:In order to examine the differentiation potential of the tenocytes expanded in our defined culture medium (reported previously) and the effect of sequential combination of the two culture conditions on human tenocytes, a two-dimensional and three-dimensional experimental approach was used. Human tenocytes were sequent...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu Y,Wang X,Zhang Y,Carr AJ,Zhu L,Xia Z,Sabokbar A

更新日期：2016-03-01 00:00:00

abstract：:The demineralized bone matrix (DBM) is the most widely used bone allograft, which is obtained by removing the mineral component of bone, leading to exposure of the proteins responsible for osteoinduction. For clinical use, DBM shall be formulated with a carrier that provides consistency and improves its osteoinduction...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ramis JM,Blasco-Ferrer M,Calvo J,Villa O,Cladera MM,Corbillo C,Gayà A,Monjo M

更新日期：2020-03-01 00:00:00

abstract：:Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell-seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell-seeded and non-seeded fibrin-based biologi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tao ZW,Favreau JT,Guyette JP,Hansen KJ,Lessard J,Burford E,Pins GD,Gaudette GR

更新日期：2017-01-01 00:00:00

abstract：:The combination of scaffolds and mesenchymal stromal cells (MSCs) is a promising approach in bone tissue engineering (BTE). Knowledge on the survival, outgrowth and bone-forming capacity of MSCs in vivo is limited. Bioluminescence imaging (BLI), histomorphometry and immunohistochemistry were combined to study the fate...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Prins HJ,Fernandes H,Rozemuller H,van Blitterswijk C,de Boer J,Martens AC

更新日期：2016-03-01 00:00:00