Surface modification of titanium with hydroxyapatite-heparin-BMP-2 enhances the efficacy of bone formation and osseointegration in vitro and in vivo.

abstract：BACKGROUND:According to experimental studies, mesh implants may reduce in size up to 50.8% during their integration into soft tissues. This results in impaired mobility of the anterior abdominal wall and hernia recurrences, as well as affects patients' quality of life. Due to unsatisfactory radiographic contrast of pol...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shemyatovsky KA,Azimov RH,Alekhin AI,Kazantsev AA,Alekhin AA

更新日期：2020-05-01 00:00:00

abstract：:Nucleus pulposus (NP) regeneration by the application of injectable cell-embedded hydrogels is an appealing approach for tissue engineering. We investigated a thermo-reversible hydrogel (TR-HG), based on a modified polysaccharide with a thermo-reversible polyamide [poly(N-isopropylacrylamide), pNIPAM], which is made t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Malonzo C,Chan SC,Kabiri A,Eglin D,Grad S,Bonél HM,Benneker LM,Gantenbein-Ritter B

更新日期：2015-12-01 00:00:00

abstract：:Tissue-engineering strategies may be employed in the development of in vitro breast tissue models for use in testing regimens of drug therapies and vaccines. The physical and chemical interactions that occur among cells and extracellular matrix components can also be elucidated with these models to gain an understandi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Parzel CA,Pepper ME,Burg T,Groff RE,Burg KJ

更新日期：2009-06-01 00:00:00

abstract：:Spatiotemporal changes in the extracellular matrix (ECM) were studied within abdominal aortic aneurysms (AAAs) generated in rats via elastase infusion. At 7, 14 and 21 days post-induction, AAA tissues were divided into proximal, mid- and distal regions, based on their location relative to the renal arteries and the re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Deb PP,Ramamurthi A

更新日期：2017-01-01 00:00:00

abstract：:Our recent clinical studies have demonstrated that autologous implantation of human cultured periosteal (hCP) sheets in combination with porous hydroxylapatite (HAp) particles at the site of periodontal bone defects strikingly facilitates tissue regeneration. To better understand how the hCP sheet functions at the imp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kawase T,Okuda K,Kogami H,Nakayama H,Nagata M,Nakata K,Yoshie H

更新日期：2009-03-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) are promising candidates for cell therapy and tissue engineering. We used mesenchymal stem cells from human bone marrow (hMSCs) as the seeding cells to investigate the potential of hepatocytic differentiation of hMSCs in porous polylactic glycolic acid (PLGA) scaffolds under p...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang J,Zong C,Shi D,Wang W,Shen D,Liu L,Tong X,Zheng Q,Gao C

更新日期：2012-01-01 00:00:00

abstract：:Osteochondral defects of the ankle are common lesions affecting the talar cartilage and subchondral bone. Current treatments include cell-based therapies but are frequently associated with donor-site morbidity. Our objective is to characterize the posterior process of the talus (SP) and the os trigonum (OT) tissues an...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Correia SI,Silva-Correia J,Pereira H,Canadas RF,da Silva Morais A,Frias AM,Sousa RA,van Dijk CN,Espregueira-Mendes J,Reis RL,Oliveira JM

更新日期：2017-07-01 00:00:00

abstract：:Research in regenerative medicine is developing at a significantly quick pace. Cell-based bone and cartilage replacement is an evolving therapy aiming at the treatment of patients who suffer from limb amputation, damaged tissues and various bone and cartilage-related disorders. Stem cells are undifferentiated cells wi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： El Tamer MK,Reis RL

更新日期：2009-07-01 00:00:00

abstract：:Advanced frontal sinus disease non-responsive to conservative therapy has been treated with fat obliteration for decades. More recently, a wide variety of autogenous, allogenic or synthetic materials have also been used. In this study we present a treatment based on totally autogenous procedures and materials that was...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mendonça-Caridad J,Lopez PJ,Fayos FV,Miery G

更新日期：2013-06-01 00:00:00

abstract：:There is a need for new materials and architectures for tissue engineering and regenerative medicine. Based upon our recent results developing novel scaffold architecture, we hypothesized that this new architecture would foster vascularization, a particular need for tissue engineering. We report on the potential of su...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Keskar V,Gandhi M,Gemeinhart EJ,Gemeinhart RA

更新日期：2009-08-01 00:00:00

abstract：:Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anticoagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fioretta ES,Dijkman PE,Emmert MY,Hoerstrup SP

更新日期：2018-01-01 00:00:00

abstract：:Elastin, a major component of vascular matrices, critically determines vascular mechanics and maintains the quiescence of smooth muscle cells (SMCs). Attempts to regenerate elastin in elastin-compromised blood vessels using tissue-engineering approaches is limited by the unavailability of elastogenic cues to upregulat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kothapalli CR,Ramamurthi A

更新日期：2008-03-01 00:00:00

abstract：:Implanted porous precision templated scaffolds (PTS) with 40-µm spherical pores reduce inflammation and foreign body reaction (FBR) while increasing vascular density upon implantation. Larger or smaller pores, however, promote chronic inflammation and FBR. While macrophage (MØ) recruitment and polarization participate...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hady TF,Hwang B,Pusic AD,Waworuntu RL,Mulligan M,Ratner B,Bryers JD

更新日期：2021-01-01 00:00:00

abstract：:The objective of this study was to test the hypothesis that platelet-rich plasma (PRP) pretreatment on a poly-lactic-co-glycolic acid (PLGA) mesh scaffold enhances the healing capacity of the meniscus with human chondrocyte-seeded scaffolds in vivo, even when the seeded number of cells was reduced from 10 million to o...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwak HS,Nam J,Lee JH,Kim HJ,Yoo JJ

更新日期：2017-02-01 00:00:00

abstract：:The aim of this work was to study the in vitro biocompatibility of glass-ceramic scaffolds based on 45S5 Bioglass, using a human osteosarcoma cell line (HOS-TE85). The highly porous scaffolds were produced by the foam replication technique. Two different types of scaffolds with different porosities were analysed. They...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bretcanu O,Misra S,Roy I,Renghini C,Fiori F,Boccaccini AR,Salih V

更新日期：2009-02-01 00:00:00

abstract：:Aerosol-based cell therapy has emerged as a novel and promising therapeutic strategy for treating lung diseases. The goal of this study was to determine the safety and efficacy of aerosol-based airway epithelial cell (AEC) delivery in the setting of acute lung injury induced by tracheal brushing in rabbit. Twenty-four...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kardia E,Ch'ng ES,Yahaya BH

更新日期：2018-02-01 00:00:00

abstract：:Many studies have highlighted the role of silicon in human bone formation and maintenance. Silicon, in fact, is considered to nucleate the precipitation of hydroxyapatite and to reduce the bone resorption. For this reason, we have combined silk fibroin (SF) with silicon-releasing diatom particles (DPs), as potential m...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Le TDH,Liaudanskaya V,Bonani W,Migliaresi C,Motta A

更新日期：2018-01-01 00:00:00

abstract：:Microstructure in terms of hierarchical assembly exists widely in mineralized biomaterials, fulfilling an important role in setting up their outstanding properties. The purpose of this study was to investigate the hierarchical assembly of enamel structure and functions, which are related to the unique characteristics ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Cui FZ,Ge J

更新日期：2007-05-01 00:00:00

abstract：:Dermal papilla cells (DPCs) interact with epithelial stem cells and induce hair folliculogenesis. Cell-based therapies using expanded DPCs for hair regeneration have been unsuccessful in humans. Two major challenges remain: first, expanded DPCs obtained from adult hair follicles have functional limitations; second, a ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Aoi N,Inoue K,Kato H,Suga H,Higashino T,Eto H,Doi K,Araki J,Iida T,Katsuta T,Yoshimura K

更新日期：2012-02-01 00:00:00

abstract：:This study investigates whether platelet-rich plasma (PRP) is an activator of tendon-derived stem cells (TDSCs) to promote regeneration of Achilles tendon post-rupture in rats. In the in vitro study, PRGF (activated PRP) significantly enhanced cell DNA synthesis, improved viability and promoted proliferation, while fa...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Xu K,Al-Ani MK,Sun Y,Xu W,Pan L,Song Y,Xu Z,Pan X,Yang L

更新日期：2017-04-01 00:00:00

abstract：:Poly(ether imide) (PEI), which can be chemically functionalized with biologically active ligands, has emerged as a potential biomaterial for medical implants. Electrospun PEI scaffolds have shown advantageous properties, such as enhanced endothelial cell adherence, proliferation and low platelet adhesion in in vitro e...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haase T,Krost A,Sauter T,Kratz K,Peter J,Kamann S,Jung F,Lendlein A,Zohlnhöfer D,Rüder C

更新日期：2017-04-01 00:00:00

abstract：:The idea of rescuing the body self-repair capability lost during evolution is progressively gaining ground in regenerative medicine. In particular, growth factors and bioactive molecules derived from activated platelets emerged as promising therapeutic agents acting as trigger for repair of tissue lesions and restorat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Nguyen VT,Cancedda R,Descalzi F

更新日期：2018-03-01 00:00:00

abstract：:For preventing the scar contracture of host tissue and adjusting the tensile strength of covering cell sheets, a controlled collagen crosslinking step process in the preparation of skin-fibroblast sheets for repairing wound was investigated by using β-aminopropionitrile (BAPN), a collagen crosslinking inhibitor, in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kanzaki M,Yamato M,Takagi R,Kikkawa T,Isaka T,Okano T,Onuki T

更新日期：2013-05-01 00:00:00

abstract：:Rapid vascular remodelling of damaged dermal tissue is required to heal burn wounds. Thymosin β4 (Tβ4) is a growth factor that has been shown to promote angiogenesis and dermal wound repair. However, the underlying mechanisms based on Tβ4 function have not yet been fully investigated. In the present study, we investig...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kim S,Kwon J

更新日期：2017-04-01 00:00:00

abstract：:Peripheral human nerves fail to regenerate across long tube implants (>2 cm), and tissue-engineered nerve grafts represent a promising treatment alternative. The present study aims to investigate the testosterone propionate (TP) repair effect of acellular nerve allograft (ANA) seeded with allogeneic bone marrow mesenc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chen C,Tian Y,Wang J,Zhang X,Nan L,Dai P,Gao Y,Zheng S,Liu W,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:The gastroesophageal junction has been of clinical interest for some time due to its important role in preventing reflux of caustic stomach contents upward into the esophagus. Failure of this role has been identified as a key driver in gastroesophageal reflux disease, cancer of the lower esophagus, and aspiration-indu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Vogt CD,Panoskaltsis-Mortari A

更新日期：2020-06-01 00:00:00

abstract：:A highly efficient cardiac differentiation from human pluripotent stem cells (hPSCs) is achievable using existing methods, especially with the standard B27 induction system. However, bovine serum albumin (BSA), one of the essential ingredients in B27, may pose significant complications for clinical studies owing to it...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan Y,Han P,Gu Q,Chen G,Wang L,Ma R,Wu J,Feng C,Zhang Y,Wang L,Hu B,Li W,Hao J,Zhou Q

更新日期：2018-01-01 00:00:00

abstract：:Previous researches have emphasized on suitability of decellularized tissues for regenerative applications. The decellularization of cartilage tissue has always been a challenge as the final product must be balanced in both immunogenic residue and mechanical properties. This study was designed to compare and optimize ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ghassemi T,Saghatoleslami N,Mahdavi-Shahri N,Matin MM,Gheshlaghi R,Moradi A

更新日期：2019-10-01 00:00:00

abstract：:The objective was to improve proliferation and chondrogenic potential of adipose stem cells (ASCs) by expansion on extracellular matrix (ECM) deposited by either ASCs or synovium-derived stem cells (SDSCs). ASCs isolated from porcine infrapatellar fat pad were separately expanded on conventional plastic flasks, ASC-de...

journal_title：Journal of tissue engineering and regenerative medicine

authors： He F,Pei M

更新日期：2013-01-01 00:00:00

abstract：:Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwon DY,Park JH,Jang SH,Park JY,Jang JW,Min BH,Kim WD,Lee HB,Lee J,Kim MS

更新日期：2018-02-01 00:00:00