Controlled collagen crosslinking process in tissue-engineered fibroblast sheets for preventing scar contracture on the surface of lungs.

abstract：:Cell-matrix interactions in a three-dimensional (3D) extracellular matrix (ECM) are of fundamental importance in living tissue, and their in vitro reconstruction in bioartificial structures represents a core target of contemporary tissue engineering concepts. For a detailed analysis of cell-matrix interaction under hi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Akhyari P,Ziegler H,Gwanmesia P,Barth M,Schilp S,Huelsmann J,Hoffmann S,Bosch J,Kögler G,Lichtenberg A

更新日期：2014-09-01 00:00:00

abstract：:Silk fibroin (SF) hydrogels can be obtained via self-assembly, but this process takes several days or weeks, being unfeasible to produce cell carrier hydrogels. In this work, a phospholipid, namely, 1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt (DMPG), was used to induce and accelerate the gelatio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Laomeephol C,Guedes M,Ferreira H,Reis RL,Kanokpanont S,Damrongsakkul S,Neves NM

更新日期：2020-01-01 00:00:00

abstract：:New injectable acrylic formulations have been prepared to be applied in restoration processes for intervertebral disks (IVDs). The solid phase of the formulations is composed of poly(methyl methacrylate) (PMMA), incorporating in some cases chondroitin sulphate (CS) as a regenerative bioactive molecule, whereas the liq...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Larraz E,Elvira C,Fernández M,Parra J,Collía F,López-Bravo A,Román JS

更新日期：2007-03-01 00:00:00

abstract：:Bone extracellular matrix (ECM) is composed of mineralized collagen fibrils which support biological apatite nucleation that participates in bone outstanding properties. Understanding and mimicking bone morphological and physiological parameters at a biological scale is a major challenge in tissue engineering scaffold...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rodrigues MT,Martins A,Dias IR,Viegas CA,Neves NM,Gomes ME,Reis RL

更新日期：2012-11-01 00:00:00

abstract：:Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwon DY,Park JH,Jang SH,Park JY,Jang JW,Min BH,Kim WD,Lee HB,Lee J,Kim MS

更新日期：2018-02-01 00:00:00

abstract：:Microstructure in terms of hierarchical assembly exists widely in mineralized biomaterials, fulfilling an important role in setting up their outstanding properties. The purpose of this study was to investigate the hierarchical assembly of enamel structure and functions, which are related to the unique characteristics ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Cui FZ,Ge J

更新日期：2007-05-01 00:00:00

abstract：:Bone-like apatite is a carbonated hydroxyapatite with a small crystallite and low crystallinity. The formation of a layer consisting of bone-like apatite is an essential condition for bioactive materials to achieve direct bonding with living bone. A bone-like apatite layer can be formed on the surface of organic subst...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ohtsuki C,Kamitakahara M,Miyazaki T

更新日期：2007-01-01 00:00:00

abstract：:Rapid advances in the isolation of multipotent progenitor cells, routinely called mesenchymal stromal/stem cells (MSCs), from various human tissues and organs have provided impetus to the field of cell therapy and regenerative medicine. The most widely studied sources of MSCs include bone marrow, adipose, muscle, peri...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Brown C,McKee C,Bakshi S,Walker K,Hakman E,Halassy S,Svinarich D,Dodds R,Govind CK,Chaudhry GR

更新日期：2019-09-01 00:00:00

abstract：:Native articular cartilage is subjected to synovial fluid flow during normal joint function. Thus, it is believed that the morphogenesis of articular cartilage may be positively regulated by the application of similar stimulation in vitro. In the present study, the effect of fluid flow over the chondrogenic differenti...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Alves da Silva ML,Martins A,Costa-Pinto AR,Correlo VM,Sol P,Bhattacharya M,Faria S,Reis RL,Neves NM

更新日期：2011-10-01 00:00:00

abstract：:Bone marrow (BM) multipotent mesenchymal stromal cells (MSCs) present with multipotent differentiation potential and immunomodulatory properties. As an alternative to bone marrow, we have examined fetal membranes, amnion and chorion, of term human placenta as a potential source of multipotent MSCs. Here we show that a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Soncini M,Vertua E,Gibelli L,Zorzi F,Denegri M,Albertini A,Wengler GS,Parolini O

更新日期：2007-07-01 00:00:00

abstract：:To spatially control therapeutic gene delivery for potential tissue engineering applications, a biotin-avidin interaction strategy was applied to immobilize viral vectors on biomaterial scaffolds. Both adenoviral vectors and gelatin sponges were biotinylated and avidin was applied to link them in a virus-biotin-avidin...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hu WW,Wang Z,Krebsbach PH

更新日期：2016-02-01 00:00:00

abstract：:This study aims to investigate the superiorities of fast degrading elastomeric poly(glycerol sebacate) (PGS)/polycaprolactone (PCL) grafts over autologous vein grafts in the reconstruction of carotid artery, thus providing more suitable vascular grafts for carotid artery replacement. We fabricated small arterial graft...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang X,Gao Z,Liu H,Wu W

更新日期：2019-07-01 00:00:00

abstract：:Many types of cells respond to applied direct current electric fields (dcEFs) by directional cell migration, a phenomenon called galvanotaxis or electrotaxis. In this study, electrotaxis was used to control cell migration. We designed a new electrotaxis incubator and chamber system to facilitate long-term (> 12 h) obs...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kim MS,Lee MH,Kwon BJ,Seo HJ,Koo MA,You KE,Kim D,Park JC

更新日期：2017-03-01 00:00:00

abstract：:Aerosol-based cell therapy has emerged as a novel and promising therapeutic strategy for treating lung diseases. The goal of this study was to determine the safety and efficacy of aerosol-based airway epithelial cell (AEC) delivery in the setting of acute lung injury induced by tracheal brushing in rabbit. Twenty-four...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kardia E,Ch'ng ES,Yahaya BH

更新日期：2018-02-01 00:00:00

abstract：:Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ three-dimensional (3D) printing is an exciting and innovative biofabrication technology that enables the surgeon to deliver tissue-engineering techniques at the time and location of need. We ha...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Di Bella C,Duchi S,O'Connell CD,Blanchard R,Augustine C,Yue Z,Thompson F,Richards C,Beirne S,Onofrillo C,Bauquier SH,Ryan SD,Pivonka P,Wallace GG,Choong PF

更新日期：2018-03-01 00:00:00

abstract：:Carbonate apatite-coated calcium carbonate (CO3 Ap/CaCO3 ) was fabricated through a dissolution-precipitation reaction using CaCO3 granules as a precursor to accelerate bone replacement based on superior osteoconductivity of the CO3 Ap shell, along with Ca2+ release from the CaCO3 core and quicker resorption of the Ca...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fujioka-Kobayashi M,Tsuru K,Nagai H,Fujisawa K,Kudoh T,Ohe G,Ishikawa K,Miyamoto Y

更新日期：2018-10-01 00:00:00

abstract：:Surface-modified titanium (Ti) samples with hydroxyapatite (HAp) and heparin (Hep)-bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared, and their efficacies on the enhancements of bone formation and osseointegration in vitro and in vivo were examined as compared to Ti/HAp and Ti/Hep/BMP-2. Th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang DH,Lee DW,Kwon YD,Kim HJ,Chun HJ,Jang JW,Khang G

更新日期：2015-09-01 00:00:00

abstract：:Biomaterials and, especially, scaffolds may function as temporary extracellular matrix (ECM), mimicking in vivo environmental structures and facilitating cell growth and tissue regeneration. ECM is composed mostly of glycosaminoglycans (GAGs) and proteins, the ratio of GAGs, hyaluronic acid (HA):sulphated GAGs (sGAGs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Herrero-Mendez A,Palomares T,Castro B,Herrero J,Alonso-Varona A

更新日期：2016-12-01 00:00:00

abstract：:Peripheral human nerves fail to regenerate across long tube implants (>2 cm), and tissue-engineered nerve grafts represent a promising treatment alternative. The present study aims to investigate the testosterone propionate (TP) repair effect of acellular nerve allograft (ANA) seeded with allogeneic bone marrow mesenc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chen C,Tian Y,Wang J,Zhang X,Nan L,Dai P,Gao Y,Zheng S,Liu W,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:In the context of prevascularization strategies for tissue-engineering purposes, co-culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regeneration mechanisms and to identify factors that might positively influence...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dohle E,El Bagdadi K,Sader R,Choukroun J,James Kirkpatrick C,Ghanaati S

更新日期：2018-03-01 00:00:00

abstract：:The development of scaffolds that combine the delivery of drugs with the physical support provided by electrospun fibres holds great potential in the field of nerve regeneration. Here it is proposed the incorporation of ibuprofen, a well-known non-steroidal anti-inflammatory drug, in electrospun fibres of the statisti...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Pires LR,Guarino V,Oliveira MJ,Ribeiro CC,Barbosa MA,Ambrosio L,Pêgo AP

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:According to experimental studies, mesh implants may reduce in size up to 50.8% during their integration into soft tissues. This results in impaired mobility of the anterior abdominal wall and hernia recurrences, as well as affects patients' quality of life. Due to unsatisfactory radiographic contrast of pol...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shemyatovsky KA,Azimov RH,Alekhin AI,Kazantsev AA,Alekhin AA

更新日期：2020-05-01 00:00:00

abstract：:Bone-patellar tendon-bone (BPTB) autografts are the gold standard for anterior cruciate ligament (ACL) reconstruction because the bony ends allow for superior healing and anchoring through bone-to-bone regeneration. However, the disadvantages of BPTB grafts include donor site morbidity and patellar rupture. In order t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chung EJ,Sugimoto MJ,Koh JL,Ameer GA

更新日期：2017-03-01 00:00:00

abstract：:The aim of this study was to optimize culture conditions for human mesenchymal stem cells (hMSCs) in β-tricalcium phosphate ceramics with large interconnected channels. Fully interconnected macrochannels comprising pore diameters of 750 µm and 1400 µm were inserted into microporous β-tricalcium phosphate (β-TCP) scaff...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bernhardt A,Lode A,Peters F,Gelinsky M

更新日期：2011-06-01 00:00:00

abstract：:Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anticoagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fioretta ES,Dijkman PE,Emmert MY,Hoerstrup SP

更新日期：2018-01-01 00:00:00

abstract：:To create functional tissues having complex structures, bottom-up approaches to assembling small tissue modules into larger constructs have been emerging. Most of these approaches are based on chemical reactions or physical interactions at the interface between tissue modules. Here we report a biological assembly appr...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Riesberg JJ,Shen W

更新日期：2015-09-01 00:00:00

abstract：:Research in regenerative medicine is developing at a significantly quick pace. Cell-based bone and cartilage replacement is an evolving therapy aiming at the treatment of patients who suffer from limb amputation, damaged tissues and various bone and cartilage-related disorders. Stem cells are undifferentiated cells wi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： El Tamer MK,Reis RL

更新日期：2009-07-01 00:00:00

abstract：:In clinical cases, many orthopaedists have been troubled with bone fragility, such as fractures after devitalization therapy for bone tumour, pathological fractures and metastatic tumours. The aim of this study was to determine whether loss of osteogenic capacity of devitalized autologous bones can be rescued using cu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tohma Y,Ohgushi H,Morishita T,Dohi Y,Tadokoro M,Tanaka Y,Takakura Y

更新日期：2008-01-01 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) has been proposed to exert beneficial effects on peripheral nerve regeneration after a peripheral nerve injury, but the functional recovery in the denervated limb is still limited. In this study, we used low-level laser therapy (LLLT) as an adjunct therapy for MSC trans...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang CC,Wang J,Chen SC,Hsieh YL

更新日期：2016-02-01 00:00:00

abstract：:The gastroesophageal junction has been of clinical interest for some time due to its important role in preventing reflux of caustic stomach contents upward into the esophagus. Failure of this role has been identified as a key driver in gastroesophageal reflux disease, cancer of the lower esophagus, and aspiration-indu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Vogt CD,Panoskaltsis-Mortari A

更新日期：2020-06-01 00:00:00