Bone marrow-derived mesenchymal cells can rescue osteogenic capacity of devitalized autologous bone.

abstract：:Elastin, a major component of vascular matrices, critically determines vascular mechanics and maintains the quiescence of smooth muscle cells (SMCs). Attempts to regenerate elastin in elastin-compromised blood vessels using tissue-engineering approaches is limited by the unavailability of elastogenic cues to upregulat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kothapalli CR,Ramamurthi A

更新日期：2008-03-01 00:00:00

abstract：:Cartilage defects heal imperfectly and osteoarthritic changes develop frequently as a result. Although the existence of specific behaviours of chondrocytes derived from various depth-related zones in vitro has been known for over 20 years, only a relatively small body of in vitro studies has been performed with zonal ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Schuurman W,Klein TJ,Dhert WJ,van Weeren PR,Hutmacher DW,Malda J

更新日期：2015-06-01 00:00:00

abstract：:In the context of prevascularization strategies for tissue-engineering purposes, co-culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regeneration mechanisms and to identify factors that might positively influence...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dohle E,El Bagdadi K,Sader R,Choukroun J,James Kirkpatrick C,Ghanaati S

更新日期：2018-03-01 00:00:00

abstract：:In this communication, we introduce boron nitride nanotube (BNNT)-functionalised muscle cell/microfibre mesh constructs, obtained via tissue engineering, as a three-dimensional (3D) platform to study a wireless stimulation system for electrically responsive cells and tissues. Our stimulation strategy exploits the piez...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Danti S,Ciofani G,Pertici G,Moscato S,D'Alessandro D,Ciabatti E,Chiellini F,D'Acunto M,Mattoli V,Berrettini S

更新日期：2015-07-01 00:00:00

abstract：:New injectable acrylic formulations have been prepared to be applied in restoration processes for intervertebral disks (IVDs). The solid phase of the formulations is composed of poly(methyl methacrylate) (PMMA), incorporating in some cases chondroitin sulphate (CS) as a regenerative bioactive molecule, whereas the liq...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Larraz E,Elvira C,Fernández M,Parra J,Collía F,López-Bravo A,Román JS

更新日期：2007-03-01 00:00:00

abstract：:Healing of diabetic foot ulcers is a major challenge. Despite adhering to optimal standard of care (SOC), less than 30% of wounds heal after 20 weeks. Advanced cellular tissue-based products have shown better healing over SOC, albeit with great cost and modest improvement. We hypothesized no difference in healing effe...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tchanque-Fossuo CN,Dahle SE,Lev-Tov H,West KIM,Li CS,Rocke DM,Isseroff RR

更新日期：2019-08-01 00:00:00

abstract：:Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anticoagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fioretta ES,Dijkman PE,Emmert MY,Hoerstrup SP

更新日期：2018-01-01 00:00:00

abstract：:The ability to control facial skin physiology and appearance through the oral mucosa (transbuccally) is largely unexplored. Here, a hypothesis was tested that transbuccal delivery of fat tissue-supportive actives may trigger beneficial cosmetic responses at the level of the skin. First, the importance of the fat tissu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bojanowski K,Ma S,Applebaum R,Zhao H

更新日期：2020-08-01 00:00:00

abstract：:Current approaches for precision deposition of cells are not optimized for moist environments or for substrates with complex surface topographic features, for example, the surface of dermal matrices and other biomaterials. To overcome these challenges, an approach is presented that utilizes cell confinement in phase-s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Agarwal R,Liu G,Tam NW,Gratzer PF,Frampton JP

更新日期：2019-06-01 00:00:00

abstract：:Poly(glycerol sebacate) (PGS) is a biodegradable elastomer that has generated great interest as a scaffold material due to its desirable mechanical properties. However, the use of PGS in tissue engineering is limited by difficulties in casting micro- and nanofibrous structures, due to high temperatures and vacuum requ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sant S,Hwang CM,Lee SH,Khademhosseini A

更新日期：2011-04-01 00:00:00

abstract：:Clinical translation of engineered tissues into regenerative medicine applications, and the effort to reduce the use of animals for the screening of drugs and other compounds, result in an increasing demand for human tissues engineered in vitro for implantation, in vitro screening systems and basic research. Further d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rouwkema J,Gibbs S,Lutolf MP,Martin I,Vunjak-Novakovic G,Malda J

更新日期：2011-08-01 00:00:00

abstract：:Adipose-derived stromal cells (ASCs) are adult multipotent cells increasingly used for cell therapy due to their differentiation potential, their paracrine effect and their convenience. ASCs are currently selected from stromal vascular fractions (SVFs) of adipose tissue and expanded in 2D flasks following good manufac...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gadelorge M,Bourdens M,Espagnolle N,Bardiaux C,Murrell J,Savary L,Ribaud S,Chaput B,Sensebé L

更新日期：2018-01-01 00:00:00

abstract：:Anti-inflammatory gene therapy can inhibit inflammation driven by TNFalpha in experimental models of rheumatoid arthritis. However, assessment of the therapeutic effect on cartilage and bone quality is either missing or unsatisfactory. A multimodal imaging approach, using confocal laser scanning microscopy (CLSM) and ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Stok KS,Noël D,Apparailly F,Gould D,Chernajovsky Y,Jorgensen C,Müller R

更新日期：2010-07-01 00:00:00

abstract：:The effects of mesenchymal stem cells (MSCs) on the phenotype and function of natural killer T (NKT) cells is not understood. We used concanavalin A (Con A) and α-galactosylceramide (α-GalCer)-induced liver injury to evaluate the effects of MSCs on NKT-dependent hepatotoxicity. Mouse MSCs (mMSCs) significantly reduced...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gazdic M,Simovic Markovic B,Vucicevic L,Nikolic T,Djonov V,Arsenijevic N,Trajkovic V,Lukic ML,Volarevic V

更新日期：2018-02-01 00:00:00

abstract：:Glaucoma, a leading cause of blindness, is characterized by an increase in intraocular pressure, which is largely determined by resistance to aqueous humour outflow through the trabecular meshwork (TM). In glaucoma, the cellularity of the TM is decreased, and, as a result, stem cell therapies for the TM represent a po...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Snider EJ,Vannatta RT,Schildmeyer L,Stamer WD,Ethier CR

更新日期：2018-03-01 00:00:00

abstract：:Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions. However, a dearth of available donor organs for transplantation leads to the death of numerous patients waiting for a suitable organ donor. The potential of decellularized scaffolds, derived from native tissues or organs in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rana D,Zreiqat H,Benkirane-Jessel N,Ramakrishna S,Ramalingam M

更新日期：2017-04-01 00:00:00

abstract：:The objective of this preliminary study was to evaluate the applying of chitosan (CS)-based microparticles (MPs) in bone regeneration in vivo. The CS MPs were fabricated using our scale-up method, as previously described. Mesenchymal stem cells (MSC) were harvested from the femora and tibiae of Dark Agouti (DA) rats a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bhat A,Dreifke MB,Kandimalla Y,Gomez C,Ebraheim NA,Jayasuriya AC

更新日期：2010-10-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) are promising candidates for cell therapy and tissue engineering. We used mesenchymal stem cells from human bone marrow (hMSCs) as the seeding cells to investigate the potential of hepatocytic differentiation of hMSCs in porous polylactic glycolic acid (PLGA) scaffolds under p...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang J,Zong C,Shi D,Wang W,Shen D,Liu L,Tong X,Zheng Q,Gao C

更新日期：2012-01-01 00:00:00

abstract：:The composition and organization of the vocal fold extracellular matrix (ECM) provide the viscoelastic mechanical properties that are required to sustain high-frequency vibration during voice production. Although vocal injury and pathology are known to produce alterations in matrix physiology, the mechanisms responsib...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kutty JK,Webb K

更新日期：2010-01-01 00:00:00

abstract：:Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar-reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical trials have been condu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Spiekman M,van Dongen JA,Willemsen JC,Hoppe DL,van der Lei B,Harmsen MC

更新日期：2017-11-01 00:00:00

abstract：:Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human somatic cells has proved to be one of the most potentially useful discoveries in regenerative medicine. iPSCs are becoming an invaluable tool to study the pathology of different diseases and for drug screening. However, severa...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Revilla A,González C,Iriondo A,Fernández B,Prieto C,Marín C,Liste I

更新日期：2016-11-01 00:00:00

abstract：:Nonunion treatment has a high rate of success, although recalcitrant nonunion may determine the need for amputation. Therefore, new treatment options are continuously investigated in order to further reduce the risk of nonunion recurrence. This study aimed to (a) develop a new large animal model for bone atrophic nonu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dozza B,Salamanna F,Baleani M,Giavaresi G,Parrilli A,Zani L,Lucarelli E,Martini L,Fini M,Donati DM

更新日期：2018-09-01 00:00:00

abstract：:In order to examine the differentiation potential of the tenocytes expanded in our defined culture medium (reported previously) and the effect of sequential combination of the two culture conditions on human tenocytes, a two-dimensional and three-dimensional experimental approach was used. Human tenocytes were sequent...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu Y,Wang X,Zhang Y,Carr AJ,Zhu L,Xia Z,Sabokbar A

更新日期：2016-03-01 00:00:00

abstract：:Chronic proteolytic disruption of elastic fibres within the abdominal aortic wall results in wall vessel expansion to form rupture-prone abdominal aortic aneurysms (AAA). Arresting AAA growth is not possible as adult vascular smooth muscle cells (SMCs) poorly auto-regenerate and repair elastic fibres. Thus, there is a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Swaminathan G,Stoilov I,Broekelmann T,Mecham R,Ramamurthi A

更新日期：2018-01-01 00:00:00

abstract：:Carbonate apatite-coated calcium carbonate (CO3 Ap/CaCO3 ) was fabricated through a dissolution-precipitation reaction using CaCO3 granules as a precursor to accelerate bone replacement based on superior osteoconductivity of the CO3 Ap shell, along with Ca2+ release from the CaCO3 core and quicker resorption of the Ca...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fujioka-Kobayashi M,Tsuru K,Nagai H,Fujisawa K,Kudoh T,Ohe G,Ishikawa K,Miyamoto Y

更新日期：2018-10-01 00:00:00

abstract：:There has been increased interest in co-cultures of stem cells and chondrocytes for cartilage tissue engineering as there are the limitations associated with using either cell type alone. Drawbacks associated with the use of chondrocytes include the limited numbers of cells available for isolation from damaged or dise...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Critchley SE,Eswaramoorthy R,Kelly DJ

更新日期：2018-04-01 00:00:00

abstract：:Regenerative medicine aims to replace lost cells and to restore damaged tissues and organs by either tissue-engineering approaches or stimulation of endogenous processes. Due to their biological properties, stem cells promise to be an effective source for such strategies. Especially adult multipotent stem cells (ASCs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Reinke S,Dienelt A,Blankenstein A,Duda GN,Geissler S

更新日期：2016-01-01 00:00:00

abstract：:The effects of the stiffness of substrates on the cell behaviours of human bone marrow-derived mesenchymal stem cells (hBMSC) have been investigated, but the effects of the secondary structures of proteins in the substrates on the morphological transformation and differentiation of hBMSC have yet been elucidated. To i...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lo HY,Huang AL,Lee PC,Chung TW,Wang SS

更新日期：2018-04-01 00:00:00

abstract：:We recently showed the fortifying effect of poly-caprolactone (PCL) scaffold in liquid solder-mediated laser-assisted vascular repair (ssLAVR) of porcine carotid arteries, yielding a mean ± SD leaking point pressure of 488 ± 111 mmHg. Despite supraphysiological pressures, the frequency of adhesive failures was indicat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Pabittei DR,Heger M,Simonet M,van Tuijl S,van der Wal AC,Beek JF,Balm R,de Mol BA

更新日期：2012-11-01 00:00:00

abstract：:Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely efficient for economic viability given a relatively low value product and high (2 × 1012 ) cell dose. Therefore, the aim of these studies was to define the produc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bayley R,Ahmed F,Glen K,McCall M,Stacey A,Thomas R

更新日期：2018-01-01 00:00:00