Cartilage regeneration using zonal chondrocyte subpopulations: a promising approach or an overcomplicated strategy?

abstract：:This work reports the effects of phosphoserine addition on the biodegradability of calcium phosphate cements. The characteristics of a phosphoserine-modified calcium phosphate cement without collagen in a large animal model are presented here for the first time. Critical size bone defects in the proximal tibia of 10 s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Offer L,Veigel B,Pavlidis T,Heiss C,Gelinsky M,Reinstorf A,Wenisch S,Lips KS,Schnettler R

更新日期：2011-01-01 00:00:00

abstract：:Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell-seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell-seeded and non-seeded fibrin-based biologi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tao ZW,Favreau JT,Guyette JP,Hansen KJ,Lessard J,Burford E,Pins GD,Gaudette GR

更新日期：2017-01-01 00:00:00

abstract：:Despite the spontaneous regenerative capacity of the peripheral nervous system, large gap peripheral nerve injuries (PNIs) require bridging strategies. The limitations and suboptimal results obtained with autografts or hollow nerve conduits in the clinic urge the need for alternative treatments. Recently, we have desc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sanen K,Martens W,Georgiou M,Ameloot M,Lambrichts I,Phillips J

更新日期：2017-12-01 00:00:00

abstract：:To create functional tissues having complex structures, bottom-up approaches to assembling small tissue modules into larger constructs have been emerging. Most of these approaches are based on chemical reactions or physical interactions at the interface between tissue modules. Here we report a biological assembly appr...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Riesberg JJ,Shen W

更新日期：2015-09-01 00:00:00

abstract：:The objective was to improve proliferation and chondrogenic potential of adipose stem cells (ASCs) by expansion on extracellular matrix (ECM) deposited by either ASCs or synovium-derived stem cells (SDSCs). ASCs isolated from porcine infrapatellar fat pad were separately expanded on conventional plastic flasks, ASC-de...

journal_title：Journal of tissue engineering and regenerative medicine

authors： He F,Pei M

更新日期：2013-01-01 00:00:00

abstract：:Several recent studies have demonstrated that stem cell differentiation can be generated by derivatives of retinoic acid. In this study we chose retinoic acid (RA) for inducing neural differentiation of rat muscle-derived stem cells (rMDSCs). rMDSCs were pre-induced with 10 ng/ml basic fibroblast growth factor (bFGF) ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kim ES,Kim GH,Kang ML,Kang YM,Kang KN,Hwang KC,Min BH,Kim JH,Kim MS

更新日期：2011-05-01 00:00:00

abstract：:Prudent choices of cell sources and biomaterials, as well as meticulous cultivation of the tissue microenvironment, are essential to improving outcomes of tissue engineering treatments. With the goal of providing a high-quality alternative for bone and cartilage tissue engineering, we investigated the capability of bo...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Baracho Trindade Hill A,Speri Alves AA,da Silva Nunes Barreto R,Fernandes Bressan F,Miglino MA,Mansano Garcia J

更新日期：2020-11-01 00:00:00

abstract：:Current approaches for precision deposition of cells are not optimized for moist environments or for substrates with complex surface topographic features, for example, the surface of dermal matrices and other biomaterials. To overcome these challenges, an approach is presented that utilizes cell confinement in phase-s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Agarwal R,Liu G,Tam NW,Gratzer PF,Frampton JP

更新日期：2019-06-01 00:00:00

abstract：:Spatiotemporal changes in the extracellular matrix (ECM) were studied within abdominal aortic aneurysms (AAAs) generated in rats via elastase infusion. At 7, 14 and 21 days post-induction, AAA tissues were divided into proximal, mid- and distal regions, based on their location relative to the renal arteries and the re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Deb PP,Ramamurthi A

更新日期：2017-01-01 00:00:00

abstract：:The mechanism for stem cell-mediated improvement following acute myocardial infarction has been actively debated. We support hypotheses that the stem cell effect is primarily paracrine factor-linked. We used a heparin-presenting injectable nanofibre network to bind and deliver paracrine factors derived from hypoxic co...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Webber MJ,Han X,Murthy SN,Rajangam K,Stupp SI,Lomasney JW

更新日期：2010-12-01 00:00:00

abstract：:Peripheral human nerves fail to regenerate across long tube implants (>2 cm), and tissue-engineered nerve grafts represent a promising treatment alternative. The present study aims to investigate the testosterone propionate (TP) repair effect of acellular nerve allograft (ANA) seeded with allogeneic bone marrow mesenc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chen C,Tian Y,Wang J,Zhang X,Nan L,Dai P,Gao Y,Zheng S,Liu W,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:Allogenic bone graft has been considered the gold standard in connection with bone graft material in revision joint arthroplasty. However, the lack of osteogenic potential and the risk of disease transmission are clinical challenges. The use of osteoinductive materials, such as demineralized bone matrix (DBM), alone o...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Babiker H,Ding M,Overgaard S

更新日期：2016-03-01 00:00:00

abstract：:Elastin, a major component of vascular matrices, critically determines vascular mechanics and maintains the quiescence of smooth muscle cells (SMCs). Attempts to regenerate elastin in elastin-compromised blood vessels using tissue-engineering approaches is limited by the unavailability of elastogenic cues to upregulat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kothapalli CR,Ramamurthi A

更新日期：2008-03-01 00:00:00

abstract：:The composition and organization of the vocal fold extracellular matrix (ECM) provide the viscoelastic mechanical properties that are required to sustain high-frequency vibration during voice production. Although vocal injury and pathology are known to produce alterations in matrix physiology, the mechanisms responsib...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kutty JK,Webb K

更新日期：2010-01-01 00:00:00

abstract：:Biomaterials capable of controlling the release of multiple growth factors (GFs) could potentially promote the integration of co-transplanted neural progenitor cells (NPCs) and stimulate the plasticity and regenerability of the lesioned spinal cord. As a first step towards the employment of such a vehicle for cell the...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Cizkova D,Slovinska L,Grulova I,Salzet M,Cikos S,Kryukov O,Cohen S

更新日期：2015-08-01 00:00:00

abstract：:Cleft palate is one of the most common craniofacial defects in newborn babies. The characteristics of this genetic disease produce soft and hard tissue defects on the lip and maxilla, which cause not only aesthetic but also functional problems with speech, eating, and breathing. Bone grafts using autologous cancellous...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lee JM,Kim HY,Park JS,Lee DJ,Zhang S,Green DW,Okano T,Hong JH,Jung HS

更新日期：2019-02-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) transplantation enhances functional recovery after cerebral infarct, but the optimal delivery route is undetermined. This study was aimed to assess whether a novel cell-sheet technology non-invasively serves therapeutic benefits to ischemic stroke. First, the monolayered cell sheet was...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ito M,Shichinohe H,Houkin K,Kuroda S

更新日期：2017-02-01 00:00:00

abstract：:The idea of rescuing the body self-repair capability lost during evolution is progressively gaining ground in regenerative medicine. In particular, growth factors and bioactive molecules derived from activated platelets emerged as promising therapeutic agents acting as trigger for repair of tissue lesions and restorat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Nguyen VT,Cancedda R,Descalzi F

更新日期：2018-03-01 00:00:00

abstract：:Tissue engineering of skeletal muscle is an encouraging possibility for the treatment of muscle loss through the creation of functional muscle tissue in vitro from human stem cells. Currently, the preferred stem cells are primary, non-immunogenic satellite cells ( = myoblasts). The objective of this study was to deter...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Stern-Straeter J,Bonaterra GA,Kassner SS,Zügel S,Hörmann K,Kinscherf R,Goessler UR

更新日期：2011-08-01 00:00:00

abstract：:In this study, clinoptilolite (CLN) was employed as a reinforcement in a polymer-based composite scaffold in bone tissue engineering and evaluated in vivo for the first time. Highly porous, mechanically stable, and osteogenic CLN/PCL-PEG-PCL (CLN/PCEC) scaffolds were fabricated with modified particulate leaching/compr...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Pazarçeviren AE,Dikmen T,Altunbaş K,Yaprakçı V,Erdemli Ö,Keskin D,Tezcaner A

更新日期：2020-01-01 00:00:00

abstract：:There is a need for preclinical testing systems that predict the efficacy, safety and pharmacokinetics of cancer therapies better than existing in vitro and in vivo animal models. An approach to the development of predictive in vitro systems is to more closely recapitulate the cellular and spatial complexity of human ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Marshall LE,Goliwas KF,Miller LM,Penman AD,Frost AR,Berry JL

更新日期：2017-04-01 00:00:00

abstract：:In the context of prevascularization strategies for tissue-engineering purposes, co-culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regeneration mechanisms and to identify factors that might positively influence...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dohle E,El Bagdadi K,Sader R,Choukroun J,James Kirkpatrick C,Ghanaati S

更新日期：2018-03-01 00:00:00

abstract：:This study reports the manufacturing process of 3D interconnected macroporous tricalcium phosphate (TCP) scaffolds with controlled internal architecture by direct 3D printing (3DP), and high mechanical strength obtained by microwave sintering. TCP scaffolds with 27%, 35% and 41% designed macroporosity with pore sizes ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tarafder S,Balla VK,Davies NM,Bandyopadhyay A,Bose S

更新日期：2013-08-01 00:00:00

abstract：:The creation of vascularized engineered tissues of clinically relevant size is a major challenge of tissue engineering. While it is known that endothelial and mural vascular cells are integral to the formation of stable blood vessels, the specific cell types and optimal conditions for engineered vascular networks are ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Trkov S,Eng G,Di Liddo R,Parnigotto PP,Vunjak-Novakovic G

更新日期：2010-03-01 00:00:00

abstract：:Nonvascularized fat grafting is a valuable technique for soft tissue reconstruction but poor survival of fat in the host environment remains a problem. A process known as cell-assisted transfer is used to enhance fat graft retention by adding stromal vascular fraction, an adipose-derived stem cell (ASC) rich content t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan SS,Zhan W,Poon CJ,Han X,Marre D,Boodhun S,Palmer JA,Mitchell GM,Morrison WA

更新日期：2018-02-01 00:00:00

abstract：:Recellularization of ex vivo-derived scaffolds remains a significant hurdle primarily due to the scaffolds subcellular pore size that restricts initial cell seeding to the scaffolds periphery and inhibits migration over time. With the aim to improve cell migration, repopulation, and graft mechanics, the effects of a f...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Van de Walle AB,Moore MC,McFetridge PS

更新日期：2020-03-01 00:00:00

abstract：:This study aims to investigate the superiorities of fast degrading elastomeric poly(glycerol sebacate) (PGS)/polycaprolactone (PCL) grafts over autologous vein grafts in the reconstruction of carotid artery, thus providing more suitable vascular grafts for carotid artery replacement. We fabricated small arterial graft...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang X,Gao Z,Liu H,Wu W

更新日期：2019-07-01 00:00:00

abstract：:Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar-reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical trials have been condu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Spiekman M,van Dongen JA,Willemsen JC,Hoppe DL,van der Lei B,Harmsen MC

更新日期：2017-11-01 00:00:00

abstract：:Adipose-derived stromal cells (ASCs) are adult multipotent cells increasingly used for cell therapy due to their differentiation potential, their paracrine effect and their convenience. ASCs are currently selected from stromal vascular fractions (SVFs) of adipose tissue and expanded in 2D flasks following good manufac...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gadelorge M,Bourdens M,Espagnolle N,Bardiaux C,Murrell J,Savary L,Ribaud S,Chaput B,Sensebé L

更新日期：2018-01-01 00:00:00

abstract：:Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human somatic cells has proved to be one of the most potentially useful discoveries in regenerative medicine. iPSCs are becoming an invaluable tool to study the pathology of different diseases and for drug screening. However, severa...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Revilla A,González C,Iriondo A,Fernández B,Prieto C,Marín C,Liste I

更新日期：2016-11-01 00:00:00