Platelet-rich fibrin-based matrices to improve angiogenesis in an in vitro co-culture model for bone tissue engineering.

abstract：:Bone marrow stromal cells (BMSC) transplantation enhances functional recovery after cerebral infarct, but the optimal delivery route is undetermined. This study was aimed to assess whether a novel cell-sheet technology non-invasively serves therapeutic benefits to ischemic stroke. First, the monolayered cell sheet was...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ito M,Shichinohe H,Houkin K,Kuroda S

更新日期：2017-02-01 00:00:00

abstract：:To create functional tissues having complex structures, bottom-up approaches to assembling small tissue modules into larger constructs have been emerging. Most of these approaches are based on chemical reactions or physical interactions at the interface between tissue modules. Here we report a biological assembly appr...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Riesberg JJ,Shen W

更新日期：2015-09-01 00:00:00

abstract：:Tissue engineering holds great promise to develop functional constructs resembling the structural organization of native tissues to improve or replace biological functions, with the ultimate goal of avoiding organ transplantation. In tissue engineering, cells are often seeded into artificial structures capable of supp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Khorshidi S,Solouk A,Mirzadeh H,Mazinani S,Lagaron JM,Sharifi S,Ramakrishna S

更新日期：2016-09-01 00:00:00

abstract：:Regenerative medicine aims to replace lost cells and to restore damaged tissues and organs by either tissue-engineering approaches or stimulation of endogenous processes. Due to their biological properties, stem cells promise to be an effective source for such strategies. Especially adult multipotent stem cells (ASCs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Reinke S,Dienelt A,Blankenstein A,Duda GN,Geissler S

更新日期：2016-01-01 00:00:00

abstract：:The successful integration of in vitro-generated tissues is dependent on adequate vascularization in vivo. Human outgrowth endothelial cells (OECs) isolated from the mononuclear cell fraction of peripheral blood represent a potent population of circulating endothelial progenitors that could provide a cell source for r...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ghanaati S,Fuchs S,Webber MJ,Orth C,Barbeck M,Gomes ME,Reis RL,Kirkpatrick CJ

更新日期：2011-06-01 00:00:00

abstract：:Nonvascularized fat grafting is a valuable technique for soft tissue reconstruction but poor survival of fat in the host environment remains a problem. A process known as cell-assisted transfer is used to enhance fat graft retention by adding stromal vascular fraction, an adipose-derived stem cell (ASC) rich content t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan SS,Zhan W,Poon CJ,Han X,Marre D,Boodhun S,Palmer JA,Mitchell GM,Morrison WA

更新日期：2018-02-01 00:00:00

abstract：:Adipose tissue-derived microvascular fragments (ad-MVFs) are promising vascularization units for tissue engineering. In this study, we analysed the effects of normothermic (37°C) and subnormothermic (20°C) short-term cultivation on their viability and network forming capacity. Ad-MVFs from green fluorescent protein (G...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Laschke MW,Heß A,Scheuer C,Karschnia P,Menger MD

更新日期：2019-02-01 00:00:00

abstract：:Tendon healing still represents a challenge for clinicians because it is slow and incomplete. The most injured is the Achilles tendon, and surgery is the therapeutic strategy often adopted because it provides a quicker functional recovery. Peritendinous adhesions are the main complication of surgery with hyperplasia a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Veronesi F,Giavaresi G,Bellini D,Casagranda V,Pressato D,Fini M

更新日期：2020-08-01 00:00:00

abstract：:Cartilage defects heal imperfectly and osteoarthritic changes develop frequently as a result. Although the existence of specific behaviours of chondrocytes derived from various depth-related zones in vitro has been known for over 20 years, only a relatively small body of in vitro studies has been performed with zonal ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Schuurman W,Klein TJ,Dhert WJ,van Weeren PR,Hutmacher DW,Malda J

更新日期：2015-06-01 00:00:00

abstract：:Cell-matrix interactions in a three-dimensional (3D) extracellular matrix (ECM) are of fundamental importance in living tissue, and their in vitro reconstruction in bioartificial structures represents a core target of contemporary tissue engineering concepts. For a detailed analysis of cell-matrix interaction under hi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Akhyari P,Ziegler H,Gwanmesia P,Barth M,Schilp S,Huelsmann J,Hoffmann S,Bosch J,Kögler G,Lichtenberg A

更新日期：2014-09-01 00:00:00

abstract：:The full-thickness skin wound is a common skin complication affecting millions of people worldwide. Delayed treatment of this condition causes the loss of skin function and integrity that could lead to the development of chronic wounds or even death. This study was aimed to develop a rapid wound treatment modality usi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mh Busra F,Rajab NF,Tabata Y,Saim AB,B H Idrus R,Chowdhury SR

更新日期：2019-05-01 00:00:00

abstract：:For preventing the scar contracture of host tissue and adjusting the tensile strength of covering cell sheets, a controlled collagen crosslinking step process in the preparation of skin-fibroblast sheets for repairing wound was investigated by using β-aminopropionitrile (BAPN), a collagen crosslinking inhibitor, in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kanzaki M,Yamato M,Takagi R,Kikkawa T,Isaka T,Okano T,Onuki T

更新日期：2013-05-01 00:00:00

abstract：:Poly(ether imide) (PEI), which can be chemically functionalized with biologically active ligands, has emerged as a potential biomaterial for medical implants. Electrospun PEI scaffolds have shown advantageous properties, such as enhanced endothelial cell adherence, proliferation and low platelet adhesion in in vitro e...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haase T,Krost A,Sauter T,Kratz K,Peter J,Kamann S,Jung F,Lendlein A,Zohlnhöfer D,Rüder C

更新日期：2017-04-01 00:00:00

abstract：:Massive bone defects are a challenge in orthopaedic research. Defective regeneration leads to bone atrophy, non-union of bone, and physical morbidity. Large animals are important models, however, production costs are high, nursing is complex, and evaluation methods are limited. A suitable laboratory animal model is re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Jiang H,Cheng P,Li D,Li J,Wang J,Gao Y,Zhang S,Cao T,Wang C,Yang L,Pei G

更新日期：2018-04-01 00:00:00

abstract：:Surface-modified titanium (Ti) samples with hydroxyapatite (HAp) and heparin (Hep)-bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared, and their efficacies on the enhancements of bone formation and osseointegration in vitro and in vivo were examined as compared to Ti/HAp and Ti/Hep/BMP-2. Th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang DH,Lee DW,Kwon YD,Kim HJ,Chun HJ,Jang JW,Khang G

更新日期：2015-09-01 00:00:00

abstract：:The creation of vascularized engineered tissues of clinically relevant size is a major challenge of tissue engineering. While it is known that endothelial and mural vascular cells are integral to the formation of stable blood vessels, the specific cell types and optimal conditions for engineered vascular networks are ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Trkov S,Eng G,Di Liddo R,Parnigotto PP,Vunjak-Novakovic G

更新日期：2010-03-01 00:00:00

abstract：:The purpose of this study was to develop freeze-dried chitosan formulations that can be solubilized in platelet-rich plasma (PRP) to form injectable implants for tissue repair. A systematic approach to adjust formulation parameters, including chitosan number average molar mass (Mn ), chitosan concentration and lyoprot...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chevrier A,Darras V,Picard G,Nelea M,Veilleux D,Lavertu M,Hoemann CD,Buschman MD

更新日期：2018-01-01 00:00:00

abstract：:Recellularization of ex vivo-derived scaffolds remains a significant hurdle primarily due to the scaffolds subcellular pore size that restricts initial cell seeding to the scaffolds periphery and inhibits migration over time. With the aim to improve cell migration, repopulation, and graft mechanics, the effects of a f...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Van de Walle AB,Moore MC,McFetridge PS

更新日期：2020-03-01 00:00:00

abstract：:Chronic proteolytic disruption of elastic fibres within the abdominal aortic wall results in wall vessel expansion to form rupture-prone abdominal aortic aneurysms (AAA). Arresting AAA growth is not possible as adult vascular smooth muscle cells (SMCs) poorly auto-regenerate and repair elastic fibres. Thus, there is a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Swaminathan G,Stoilov I,Broekelmann T,Mecham R,Ramamurthi A

更新日期：2018-01-01 00:00:00

abstract：:In orthopaedic medicine, connective tissues are often affected by traumatic or degenerative injuries, and surgical intervention is required. Rotator cuff tears are a common cause of shoulder pain and disability among adults. The development of graft materials for bridging the gap between tendon and bone after chronic ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gniesmer S,Brehm R,Hoffmann A,de Cassan D,Menzel H,Hoheisel AL,Glasmacher B,Willbold E,Reifenrath J,Wellmann M,Ludwig N,Tavassol F,Zimmerer R,Gellrich NC,Kampmann A

更新日期：2019-07-01 00:00:00

abstract：:Carbonate apatite-coated calcium carbonate (CO3 Ap/CaCO3 ) was fabricated through a dissolution-precipitation reaction using CaCO3 granules as a precursor to accelerate bone replacement based on superior osteoconductivity of the CO3 Ap shell, along with Ca2+ release from the CaCO3 core and quicker resorption of the Ca...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fujioka-Kobayashi M,Tsuru K,Nagai H,Fujisawa K,Kudoh T,Ohe G,Ishikawa K,Miyamoto Y

更新日期：2018-10-01 00:00:00

abstract：:Healing of diabetic foot ulcers is a major challenge. Despite adhering to optimal standard of care (SOC), less than 30% of wounds heal after 20 weeks. Advanced cellular tissue-based products have shown better healing over SOC, albeit with great cost and modest improvement. We hypothesized no difference in healing effe...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tchanque-Fossuo CN,Dahle SE,Lev-Tov H,West KIM,Li CS,Rocke DM,Isseroff RR

更新日期：2019-08-01 00:00:00

abstract：:The mechanism for stem cell-mediated improvement following acute myocardial infarction has been actively debated. We support hypotheses that the stem cell effect is primarily paracrine factor-linked. We used a heparin-presenting injectable nanofibre network to bind and deliver paracrine factors derived from hypoxic co...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Webber MJ,Han X,Murthy SN,Rajangam K,Stupp SI,Lomasney JW

更新日期：2010-12-01 00:00:00

abstract：:Injections of bone marrow (BM) cell extract, known as 'BM soup', were previously reported to mitigate ionizing radiation (IR) injury to salivary glands (SGs). However, the optimal starting time and frequency to maintain BM soup therapeutic efficacy remains unknown. This study tested the optimal starting time and frequ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fang D,Shang S,Liu Y,Bakkar M,Sumita Y,Seuntjens J,Tran SD

更新日期：2018-02-01 00:00:00

abstract：:Osteochondral defects of the ankle are common lesions affecting the talar cartilage and subchondral bone. Current treatments include cell-based therapies but are frequently associated with donor-site morbidity. Our objective is to characterize the posterior process of the talus (SP) and the os trigonum (OT) tissues an...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Correia SI,Silva-Correia J,Pereira H,Canadas RF,da Silva Morais A,Frias AM,Sousa RA,van Dijk CN,Espregueira-Mendes J,Reis RL,Oliveira JM

更新日期：2017-07-01 00:00:00

abstract：:The aim of this study was to optimize culture conditions for human mesenchymal stem cells (hMSCs) in β-tricalcium phosphate ceramics with large interconnected channels. Fully interconnected macrochannels comprising pore diameters of 750 µm and 1400 µm were inserted into microporous β-tricalcium phosphate (β-TCP) scaff...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bernhardt A,Lode A,Peters F,Gelinsky M

更新日期：2011-06-01 00:00:00

abstract：:Implanted porous precision templated scaffolds (PTS) with 40-µm spherical pores reduce inflammation and foreign body reaction (FBR) while increasing vascular density upon implantation. Larger or smaller pores, however, promote chronic inflammation and FBR. While macrophage (MØ) recruitment and polarization participate...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hady TF,Hwang B,Pusic AD,Waworuntu RL,Mulligan M,Ratner B,Bryers JD

更新日期：2021-01-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) are promising candidates for cell therapy and tissue engineering. We used mesenchymal stem cells from human bone marrow (hMSCs) as the seeding cells to investigate the potential of hepatocytic differentiation of hMSCs in porous polylactic glycolic acid (PLGA) scaffolds under p...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang J,Zong C,Shi D,Wang W,Shen D,Liu L,Tong X,Zheng Q,Gao C

更新日期：2012-01-01 00:00:00

abstract：:Rapid advances in the isolation of multipotent progenitor cells, routinely called mesenchymal stromal/stem cells (MSCs), from various human tissues and organs have provided impetus to the field of cell therapy and regenerative medicine. The most widely studied sources of MSCs include bone marrow, adipose, muscle, peri...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Brown C,McKee C,Bakshi S,Walker K,Hakman E,Halassy S,Svinarich D,Dodds R,Govind CK,Chaudhry GR

更新日期：2019-09-01 00:00:00

abstract：:In this study, a simple three-dimensional (3D) suspension culture method for the expansion and cardiac differentiation of human induced pluripotent stem cells (hiPSCs) is reported. The culture methods were easily adapted from two-dimensional (2D) to 3D culture without any additional manipulations. When hiPSCs were dir...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haraguchi Y,Matsuura K,Shimizu T,Yamato M,Okano T

更新日期：2015-12-01 00:00:00