Rapid vascularization of starch-poly(caprolactone) in vivo by outgrowth endothelial cells in co-culture with primary osteoblasts.

abstract：:Human mesenchymal stem cells (hMSCs) are typically obtained for research or therapeutic applications by isolating and subculturing adherent cells from bone marrow on tissue-culture substrates using growth media. The purity and properties of the resulting populations can be affected greatly by the conditions under whic...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Jung S,Sen A,Rosenberg L,Behie LA

更新日期：2012-05-01 00:00:00

abstract：:Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely efficient for economic viability given a relatively low value product and high (2 × 1012 ) cell dose. Therefore, the aim of these studies was to define the produc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bayley R,Ahmed F,Glen K,McCall M,Stacey A,Thomas R

更新日期：2018-01-01 00:00:00

abstract：:The effects of mesenchymal stem cells (MSCs) on the phenotype and function of natural killer T (NKT) cells is not understood. We used concanavalin A (Con A) and α-galactosylceramide (α-GalCer)-induced liver injury to evaluate the effects of MSCs on NKT-dependent hepatotoxicity. Mouse MSCs (mMSCs) significantly reduced...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gazdic M,Simovic Markovic B,Vucicevic L,Nikolic T,Djonov V,Arsenijevic N,Trajkovic V,Lukic ML,Volarevic V

更新日期：2018-02-01 00:00:00

abstract：:The combination of scaffolds and mesenchymal stromal cells (MSCs) is a promising approach in bone tissue engineering (BTE). Knowledge on the survival, outgrowth and bone-forming capacity of MSCs in vivo is limited. Bioluminescence imaging (BLI), histomorphometry and immunohistochemistry were combined to study the fate...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Prins HJ,Fernandes H,Rozemuller H,van Blitterswijk C,de Boer J,Martens AC

更新日期：2016-03-01 00:00:00

abstract：:Current approaches for precision deposition of cells are not optimized for moist environments or for substrates with complex surface topographic features, for example, the surface of dermal matrices and other biomaterials. To overcome these challenges, an approach is presented that utilizes cell confinement in phase-s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Agarwal R,Liu G,Tam NW,Gratzer PF,Frampton JP

更新日期：2019-06-01 00:00:00

abstract：:Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions. However, a dearth of available donor organs for transplantation leads to the death of numerous patients waiting for a suitable organ donor. The potential of decellularized scaffolds, derived from native tissues or organs in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rana D,Zreiqat H,Benkirane-Jessel N,Ramakrishna S,Ramalingam M

更新日期：2017-04-01 00:00:00

abstract：:The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents that...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rodrigues DB,Oliveira JM,Santos TC,Reis RL

更新日期：2018-03-01 00:00:00

abstract：:Poly(glycerol sebacate) (PGS) is a biodegradable elastomer that has generated great interest as a scaffold material due to its desirable mechanical properties. However, the use of PGS in tissue engineering is limited by difficulties in casting micro- and nanofibrous structures, due to high temperatures and vacuum requ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sant S,Hwang CM,Lee SH,Khademhosseini A

更新日期：2011-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been suggested as a potential cell source for tendon/ligament tissue engineering. Extrinsic cues, such as the chemical and physical properties of scaffolds, as well as external forces, play an important role in fibroblastic differentiation of these cells. In this study, we employed a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu Y,Lei J,Koob TJ,Temenoff JS

更新日期：2016-12-01 00:00:00

abstract：:Adipose tissue-derived microvascular fragments (ad-MVFs) are promising vascularization units for tissue engineering. In this study, we analysed the effects of normothermic (37°C) and subnormothermic (20°C) short-term cultivation on their viability and network forming capacity. Ad-MVFs from green fluorescent protein (G...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Laschke MW,Heß A,Scheuer C,Karschnia P,Menger MD

更新日期：2019-02-01 00:00:00

abstract：:For preventing the scar contracture of host tissue and adjusting the tensile strength of covering cell sheets, a controlled collagen crosslinking step process in the preparation of skin-fibroblast sheets for repairing wound was investigated by using β-aminopropionitrile (BAPN), a collagen crosslinking inhibitor, in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kanzaki M,Yamato M,Takagi R,Kikkawa T,Isaka T,Okano T,Onuki T

更新日期：2013-05-01 00:00:00

abstract：:Recellularization of ex vivo-derived scaffolds remains a significant hurdle primarily due to the scaffolds subcellular pore size that restricts initial cell seeding to the scaffolds periphery and inhibits migration over time. With the aim to improve cell migration, repopulation, and graft mechanics, the effects of a f...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Van de Walle AB,Moore MC,McFetridge PS

更新日期：2020-03-01 00:00:00

abstract：:Advanced frontal sinus disease non-responsive to conservative therapy has been treated with fat obliteration for decades. More recently, a wide variety of autogenous, allogenic or synthetic materials have also been used. In this study we present a treatment based on totally autogenous procedures and materials that was...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mendonça-Caridad J,Lopez PJ,Fayos FV,Miery G

更新日期：2013-06-01 00:00:00

abstract：:The self-regeneration capacity of articular cartilage is limited, due to its avascular and aneural nature. Loaded explants and cell cultures demonstrated that chondrocyte metabolism can be regulated via physiologic loading. However, the explicit ranges of mechanical stimuli that correspond to favourable metabolic resp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tasci A,Ferguson SJ,Büchler P

更新日期：2011-03-01 00:00:00

abstract：:Transplantation of bone marrow mesenchymal stem cells (BMSCs) has been considered to be a promising strategy for wound healing. However, poor viability of engrafted BMSCs and limited capabilities of differentiation into the desired cell types in wounds often hinder its application. Few studies report the induction of ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shou K,Huang Y,Qi B,Hu X,Ma Z,Lu A,Jian C,Zhang L,Yu A

更新日期：2018-02-01 00:00:00

abstract：:Cardiac stem cells (CSCs) represent a logical cell type to exploit as a regenerative treatment option for tissue damage accrued as a result of a myocardial infarction. However, the isolation and expansion of CSCs prior to cell transplantation is time consuming, costly and invasive, and the reliability of cell expansio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： O'Neill HS,O'Sullivan J,Porteous N,Ruiz-Hernandez E,Kelly HM,O'Brien FJ,Duffy GP

更新日期：2018-01-01 00:00:00

abstract：:Despite the spontaneous regenerative capacity of the peripheral nervous system, large gap peripheral nerve injuries (PNIs) require bridging strategies. The limitations and suboptimal results obtained with autografts or hollow nerve conduits in the clinic urge the need for alternative treatments. Recently, we have desc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sanen K,Martens W,Georgiou M,Ameloot M,Lambrichts I,Phillips J

更新日期：2017-12-01 00:00:00

abstract：:Restoration of the external ear and nose in human patients, in either congenital deformity or acquired defects, is a challenge in reconstructive surgery. Optimization of the currently available materials is necessary for rhinoplasty and microtia correction to avoid intraoperative manoeuvring and early rejection. The a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bhattacharya R,Das P,Joardar SN,Biswas BK,Batabyal S,Das PK,Nandi SK

更新日期：2019-01-01 00:00:00

abstract：:Peripheral human nerves fail to regenerate across long tube implants (>2 cm), and tissue-engineered nerve grafts represent a promising treatment alternative. The present study aims to investigate the testosterone propionate (TP) repair effect of acellular nerve allograft (ANA) seeded with allogeneic bone marrow mesenc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chen C,Tian Y,Wang J,Zhang X,Nan L,Dai P,Gao Y,Zheng S,Liu W,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:Glaucoma, a leading cause of blindness, is characterized by an increase in intraocular pressure, which is largely determined by resistance to aqueous humour outflow through the trabecular meshwork (TM). In glaucoma, the cellularity of the TM is decreased, and, as a result, stem cell therapies for the TM represent a po...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Snider EJ,Vannatta RT,Schildmeyer L,Stamer WD,Ethier CR

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study is to describe the treatment of an infected segmental bone defect in a cat using a novel, custom-designed titanium implant seeded with adipose-derived stem cells (AdMSCs) to facilitate osseous ingrowth and preserve limb function. Large bone defects occur secondary to trauma, infection, or neoplas...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fitzpatrick N,Black C,Choucroun M,Blunn G,Meswania J,Sanghani-Kerai A

更新日期：2020-10-01 00:00:00

abstract：:Tendon healing still represents a challenge for clinicians because it is slow and incomplete. The most injured is the Achilles tendon, and surgery is the therapeutic strategy often adopted because it provides a quicker functional recovery. Peritendinous adhesions are the main complication of surgery with hyperplasia a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Veronesi F,Giavaresi G,Bellini D,Casagranda V,Pressato D,Fini M

更新日期：2020-08-01 00:00:00

abstract：:Whole body vibration (WBV) is a very widespread mechanical stimulus used in physical therapy, rehabilitation and fitness centres. It has been demonstrated that vibration induces improvements in muscular strength and performance and increases bone density. We investigated the effects of low-amplitude, high frequency vi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ceccarelli G,Benedetti L,Galli D,Prè D,Silvani G,Crosetto N,Magenes G,Cusella De Angelis MG

更新日期：2014-05-01 00:00:00

abstract：:Chronic proteolytic disruption of elastic fibres within the abdominal aortic wall results in wall vessel expansion to form rupture-prone abdominal aortic aneurysms (AAA). Arresting AAA growth is not possible as adult vascular smooth muscle cells (SMCs) poorly auto-regenerate and repair elastic fibres. Thus, there is a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Swaminathan G,Stoilov I,Broekelmann T,Mecham R,Ramamurthi A

更新日期：2018-01-01 00:00:00

abstract：:The development of a functional microvasculature is critical to the long-term survival of implanted tissue-engineered constructs. Dynamic culture conditions have been shown to significantly modulate phenotypic characteristics and stimulate proliferation of cells within hydrogel-based tissue engineered blood vessels. A...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gassman AA,Kuprys T,Ucuzian AA,Brey E,Matsumura A,Pang Y,Larson J,Greisler HP

更新日期：2011-05-01 00:00:00

abstract：:A phytomolecule, icaritin, has been identified and shown to be osteopromotive for the prevention of osteoporosis and osteonecrosis. This study aimed to produce a bioactive poly (l-lactide-co-glycolide)-tricalcium phosphate (PLGA-TCP)-based porous scaffold incorporating the osteopromotive phytomolecule icaritin, using ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Xie XH,Wang XL,Zhang G,He YX,Leng Y,Tang TT,Pan X,Qin L

更新日期：2015-08-01 00:00:00

abstract：:The demineralized bone matrix (DBM) is the most widely used bone allograft, which is obtained by removing the mineral component of bone, leading to exposure of the proteins responsible for osteoinduction. For clinical use, DBM shall be formulated with a carrier that provides consistency and improves its osteoinduction...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ramis JM,Blasco-Ferrer M,Calvo J,Villa O,Cladera MM,Corbillo C,Gayà A,Monjo M

更新日期：2020-03-01 00:00:00

abstract：:Cartilage tissue engineering is making progress, but the competing available strategies still leave room for improvement and consensual overviews regarding the best combinations of scaffolds and cell sources are limited by the capacity to compare them directly. In addition, because most strategies involve autologous c...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Henrionnet C,Gillet P,Mainard D,Vincourt JB,Pinzano A

更新日期：2018-03-01 00:00:00

abstract：:Electrospinning has recently gained widespread attention as a process capable of producing nanoscale fibres that mimic native extracellular matrix. In this study, we compared the osteogenic differentiation behaviour of human adipose stem cells (ASCs) on a 3D nanofibre matrix of type I rat tail collagen (RTC) and a 2D ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sefcik LS,Neal RA,Kaszuba SN,Parker AM,Katz AJ,Ogle RC,Botchwey EA

更新日期：2008-06-01 00:00:00

abstract：:The authors previously created HAp or CaCO(3) formed on or in agarose gels (HAp and CaCO(3) gels, respectively) as biocompatible and biodegradable bone graft materials. However, these gels have limitations for bone regeneration. Mesenchymal stromal cells (MSCs) have osteogenic potential and are considered useful for b...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mizuta N,Hattori K,Suzawa Y,Iwai S,Matsumoto T,Tadokoro M,Nakano T,Akashi M,Ohgushi H,Yura Y

更新日期：2013-01-01 00:00:00