A novel approach to human cranial tissue regeneration and frontal sinus obliteration with an autogenous platelet-rich/fibrin-rich composite matrix: 10 patients with a 6-10 year follow-up.

abstract：:Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human somatic cells has proved to be one of the most potentially useful discoveries in regenerative medicine. iPSCs are becoming an invaluable tool to study the pathology of different diseases and for drug screening. However, severa...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Revilla A,González C,Iriondo A,Fernández B,Prieto C,Marín C,Liste I

更新日期：2016-11-01 00:00:00

abstract：:Limitations of current treatments for intervertebral disc (IVD) degeneration have promoted interest in the development of tissue-engineering approaches. Injectable hydrogels loaded with cells can be used as a substitute material for the inner IVD part, the nucleus pulposus (NP), and provide an opportunity for minimall...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tsaryk R,Silva-Correia J,Oliveira JM,Unger RE,Landes C,Brochhausen C,Ghanaati S,Reis RL,Kirkpatrick CJ

更新日期：2017-03-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) transplantation enhances functional recovery after cerebral infarct, but the optimal delivery route is undetermined. This study was aimed to assess whether a novel cell-sheet technology non-invasively serves therapeutic benefits to ischemic stroke. First, the monolayered cell sheet was...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ito M,Shichinohe H,Houkin K,Kuroda S

更新日期：2017-02-01 00:00:00

abstract：:In clinical cases, many orthopaedists have been troubled with bone fragility, such as fractures after devitalization therapy for bone tumour, pathological fractures and metastatic tumours. The aim of this study was to determine whether loss of osteogenic capacity of devitalized autologous bones can be rescued using cu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tohma Y,Ohgushi H,Morishita T,Dohi Y,Tadokoro M,Tanaka Y,Takakura Y

更新日期：2008-01-01 00:00:00

abstract：:Allogenic bone graft has been considered the gold standard in connection with bone graft material in revision joint arthroplasty. However, the lack of osteogenic potential and the risk of disease transmission are clinical challenges. The use of osteoinductive materials, such as demineralized bone matrix (DBM), alone o...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Babiker H,Ding M,Overgaard S

更新日期：2016-03-01 00:00:00

abstract：:Injections of bone marrow (BM) cell extract, known as 'BM soup', were previously reported to mitigate ionizing radiation (IR) injury to salivary glands (SGs). However, the optimal starting time and frequency to maintain BM soup therapeutic efficacy remains unknown. This study tested the optimal starting time and frequ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fang D,Shang S,Liu Y,Bakkar M,Sumita Y,Seuntjens J,Tran SD

更新日期：2018-02-01 00:00:00

abstract：:A feasibility study was undertaken to examine the potential of biodegradable HEMA-lactate-dextran (HEMA-LLA-D)-based cryogels as scaffolds for cartilage tissue engineering. This was a preliminary in vitro study giving essential information on the biocompatibility of cryogels with cartilage cells. HEMA-lactate (HEMA-LL...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bölgen N,Yang Y,Korkusuz P,Güzel E,El Haj AJ,Pişkin E

更新日期：2011-11-01 00:00:00

abstract：:Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anticoagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fioretta ES,Dijkman PE,Emmert MY,Hoerstrup SP

更新日期：2018-01-01 00:00:00

abstract：:A highly efficient cardiac differentiation from human pluripotent stem cells (hPSCs) is achievable using existing methods, especially with the standard B27 induction system. However, bovine serum albumin (BSA), one of the essential ingredients in B27, may pose significant complications for clinical studies owing to it...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan Y,Han P,Gu Q,Chen G,Wang L,Ma R,Wu J,Feng C,Zhang Y,Wang L,Hu B,Li W,Hao J,Zhou Q

更新日期：2018-01-01 00:00:00

abstract：:Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwon DY,Park JH,Jang SH,Park JY,Jang JW,Min BH,Kim WD,Lee HB,Lee J,Kim MS

更新日期：2018-02-01 00:00:00

abstract：:Cardiac stem cells (CSCs) represent a logical cell type to exploit as a regenerative treatment option for tissue damage accrued as a result of a myocardial infarction. However, the isolation and expansion of CSCs prior to cell transplantation is time consuming, costly and invasive, and the reliability of cell expansio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： O'Neill HS,O'Sullivan J,Porteous N,Ruiz-Hernandez E,Kelly HM,O'Brien FJ,Duffy GP

更新日期：2018-01-01 00:00:00

abstract：:The self-regeneration capacity of articular cartilage is limited, due to its avascular and aneural nature. Loaded explants and cell cultures demonstrated that chondrocyte metabolism can be regulated via physiologic loading. However, the explicit ranges of mechanical stimuli that correspond to favourable metabolic resp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tasci A,Ferguson SJ,Büchler P

更新日期：2011-03-01 00:00:00

abstract：:The development of a functional microvasculature is critical to the long-term survival of implanted tissue-engineered constructs. Dynamic culture conditions have been shown to significantly modulate phenotypic characteristics and stimulate proliferation of cells within hydrogel-based tissue engineered blood vessels. A...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gassman AA,Kuprys T,Ucuzian AA,Brey E,Matsumura A,Pang Y,Larson J,Greisler HP

更新日期：2011-05-01 00:00:00

abstract：:Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has been shown to ameliorate the injured central nervous system (CNS). Although these effects were initially attributed to the putative differentiation of MSCs towards the neural lineage, it is now known that most of them are mediated by the secretome. Up...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ribeiro CA,Salgado AJ,Fraga JS,Silva NA,Reis RL,Sousa N

更新日期：2011-08-01 00:00:00

abstract：:The objective of this study was to evaluate whether growth factors (FGF-2, FGF-4 and FGF-6) used alone or in combination with TGFβ2 are able to increase the proliferation and induce the differentiation of human bone marrow mesenchymal stem cells (hMSCs) to chondrocytes, with a view to using them in cartilage tissue en...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bosetti M,Boccafoschi F,Leigheb M,Bianchi AE,Cannas M

更新日期：2012-03-01 00:00:00

abstract：:The regeneration and establishment of osseointegration within oral peri-implant bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous and/or biomaterial-based bone grafting. The objective of this systematic review was to answer the focused questio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shanbhag S,Pandis N,Mustafa K,Nyengaard JR,Stavropoulos A

更新日期：2018-01-01 00:00:00

abstract：:The ability to control facial skin physiology and appearance through the oral mucosa (transbuccally) is largely unexplored. Here, a hypothesis was tested that transbuccal delivery of fat tissue-supportive actives may trigger beneficial cosmetic responses at the level of the skin. First, the importance of the fat tissu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bojanowski K,Ma S,Applebaum R,Zhao H

更新日期：2020-08-01 00:00:00

abstract：:Adipose-derived stromal cells (ASCs) are adult multipotent cells increasingly used for cell therapy due to their differentiation potential, their paracrine effect and their convenience. ASCs are currently selected from stromal vascular fractions (SVFs) of adipose tissue and expanded in 2D flasks following good manufac...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gadelorge M,Bourdens M,Espagnolle N,Bardiaux C,Murrell J,Savary L,Ribaud S,Chaput B,Sensebé L

更新日期：2018-01-01 00:00:00

abstract：:In the context of prevascularization strategies for tissue-engineering purposes, co-culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regeneration mechanisms and to identify factors that might positively influence...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dohle E,El Bagdadi K,Sader R,Choukroun J,James Kirkpatrick C,Ghanaati S

更新日期：2018-03-01 00:00:00

abstract：:Bone extracellular matrix (ECM) is composed of mineralized collagen fibrils which support biological apatite nucleation that participates in bone outstanding properties. Understanding and mimicking bone morphological and physiological parameters at a biological scale is a major challenge in tissue engineering scaffold...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rodrigues MT,Martins A,Dias IR,Viegas CA,Neves NM,Gomes ME,Reis RL

更新日期：2012-11-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a novel bioactive material (Biosilicate®) and low-level laser therapy (LLLT) on bone fracture consolidation in osteoporotic rats. Forty female Wistar rats were submitted to ovariectomy (OVX) to induce osteopenia. Eight weeks after surgery, the animals were random...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bossini PS,Rennó AC,Ribeiro DA,Fangel R,Peitl O,Zanotto ED,Parizotto NA

更新日期：2011-03-01 00:00:00

abstract：:The composition and organization of the vocal fold extracellular matrix (ECM) provide the viscoelastic mechanical properties that are required to sustain high-frequency vibration during voice production. Although vocal injury and pathology are known to produce alterations in matrix physiology, the mechanisms responsib...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kutty JK,Webb K

更新日期：2010-01-01 00:00:00

abstract：:Despite the spontaneous regenerative capacity of the peripheral nervous system, large gap peripheral nerve injuries (PNIs) require bridging strategies. The limitations and suboptimal results obtained with autografts or hollow nerve conduits in the clinic urge the need for alternative treatments. Recently, we have desc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sanen K,Martens W,Georgiou M,Ameloot M,Lambrichts I,Phillips J

更新日期：2017-12-01 00:00:00

abstract：:To spatially control therapeutic gene delivery for potential tissue engineering applications, a biotin-avidin interaction strategy was applied to immobilize viral vectors on biomaterial scaffolds. Both adenoviral vectors and gelatin sponges were biotinylated and avidin was applied to link them in a virus-biotin-avidin...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hu WW,Wang Z,Krebsbach PH

更新日期：2016-02-01 00:00:00

abstract：:Poly(glycerol sebacate) (PGS) is a biodegradable elastomer that has generated great interest as a scaffold material due to its desirable mechanical properties. However, the use of PGS in tissue engineering is limited by difficulties in casting micro- and nanofibrous structures, due to high temperatures and vacuum requ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sant S,Hwang CM,Lee SH,Khademhosseini A

更新日期：2011-04-01 00:00:00

abstract：:Skin and oral mucosa substitutes are a therapeutic option for closing hard-to-heal skin and oral wounds. Our aim was to develop bi-layered skin and gingiva substitutes, from 3 mm diameter biopsies, cultured under identical conditions, which are compliant with current European regulations for advanced therapy medicinal...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Boink MA,Roffel S,Breetveld M,Thon M,Haasjes MSP,Waaijman T,Scheper RJ,Blok CS,Gibbs S

更新日期：2018-02-01 00:00:00

abstract：:Bone-like apatite is a carbonated hydroxyapatite with a small crystallite and low crystallinity. The formation of a layer consisting of bone-like apatite is an essential condition for bioactive materials to achieve direct bonding with living bone. A bone-like apatite layer can be formed on the surface of organic subst...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ohtsuki C,Kamitakahara M,Miyazaki T

更新日期：2007-01-01 00:00:00

abstract：:Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have potential clinical utility in the treatment of a multitude of ailments and diseases, due to their relative ease of isolation from patients and their capacity to form many cell types. However, hBM-MSCs are sparse, and can only be isolated in very small qu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yuan Y,Kallos MS,Hunter C,Sen A

更新日期：2014-03-01 00:00:00

abstract：:Many studies have highlighted the role of silicon in human bone formation and maintenance. Silicon, in fact, is considered to nucleate the precipitation of hydroxyapatite and to reduce the bone resorption. For this reason, we have combined silk fibroin (SF) with silicon-releasing diatom particles (DPs), as potential m...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Le TDH,Liaudanskaya V,Bonani W,Migliaresi C,Motta A

更新日期：2018-01-01 00:00:00

abstract：:The availability of autologous articular chondrocytes remains a limiting issue in matrix assisted autologous chondrocyte transplantation. Non-articular heterotopic chondrocytes could be an alternative autologous cell source. The aims of this study were to establish heterotopic chondrocyte cocultures to analyze cell-ce...

journal_title：Journal of tissue engineering and regenerative medicine

authors： El Sayed K,Marzahn U,John T,Hoyer M,Zreiqat H,Witthuhn A,Kohl B,Haisch A,Schulze-Tanzil G

更新日期：2013-01-01 00:00:00