Chondrogenic induction of human mesenchymal stem cells using combined growth factors for cartilage tissue engineering.

abstract：:Recellularization of ex vivo-derived scaffolds remains a significant hurdle primarily due to the scaffolds subcellular pore size that restricts initial cell seeding to the scaffolds periphery and inhibits migration over time. With the aim to improve cell migration, repopulation, and graft mechanics, the effects of a f...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Van de Walle AB,Moore MC,McFetridge PS

更新日期：2020-03-01 00:00:00

abstract：:The regeneration and establishment of osseointegration within oral peri-implant bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous and/or biomaterial-based bone grafting. The objective of this systematic review was to answer the focused questio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shanbhag S,Pandis N,Mustafa K,Nyengaard JR,Stavropoulos A

更新日期：2018-01-01 00:00:00

abstract：:Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has been shown to ameliorate the injured central nervous system (CNS). Although these effects were initially attributed to the putative differentiation of MSCs towards the neural lineage, it is now known that most of them are mediated by the secretome. Up...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ribeiro CA,Salgado AJ,Fraga JS,Silva NA,Reis RL,Sousa N

更新日期：2011-08-01 00:00:00

abstract：:The gastroesophageal junction has been of clinical interest for some time due to its important role in preventing reflux of caustic stomach contents upward into the esophagus. Failure of this role has been identified as a key driver in gastroesophageal reflux disease, cancer of the lower esophagus, and aspiration-indu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Vogt CD,Panoskaltsis-Mortari A

更新日期：2020-06-01 00:00:00

abstract：:A feasibility study was undertaken to examine the potential of biodegradable HEMA-lactate-dextran (HEMA-LLA-D)-based cryogels as scaffolds for cartilage tissue engineering. This was a preliminary in vitro study giving essential information on the biocompatibility of cryogels with cartilage cells. HEMA-lactate (HEMA-LL...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bölgen N,Yang Y,Korkusuz P,Güzel E,El Haj AJ,Pişkin E

更新日期：2011-11-01 00:00:00

abstract：:Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions. However, a dearth of available donor organs for transplantation leads to the death of numerous patients waiting for a suitable organ donor. The potential of decellularized scaffolds, derived from native tissues or organs in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rana D,Zreiqat H,Benkirane-Jessel N,Ramakrishna S,Ramalingam M

更新日期：2017-04-01 00:00:00

abstract：:Rapid vascular remodelling of damaged dermal tissue is required to heal burn wounds. Thymosin β4 (Tβ4) is a growth factor that has been shown to promote angiogenesis and dermal wound repair. However, the underlying mechanisms based on Tβ4 function have not yet been fully investigated. In the present study, we investig...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kim S,Kwon J

更新日期：2017-04-01 00:00:00

abstract：:Poor angiogenesis within tissue-engineered grafts has been identified as a main challenge limiting the clinical introduction of bone tissue-engineering (BTE) approaches for the repair of large bone defects. Thick BTE grafts often exhibit poor cellular viability particularly at the core, leading to graft failure and la...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Liu Y,Chan JK,Teoh SH

更新日期：2015-02-01 00:00:00

abstract：:In the context of prevascularization strategies for tissue-engineering purposes, co-culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regeneration mechanisms and to identify factors that might positively influence...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dohle E,El Bagdadi K,Sader R,Choukroun J,James Kirkpatrick C,Ghanaati S

更新日期：2018-03-01 00:00:00

abstract：:Cleft palate is one of the most common craniofacial defects in newborn babies. The characteristics of this genetic disease produce soft and hard tissue defects on the lip and maxilla, which cause not only aesthetic but also functional problems with speech, eating, and breathing. Bone grafts using autologous cancellous...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lee JM,Kim HY,Park JS,Lee DJ,Zhang S,Green DW,Okano T,Hong JH,Jung HS

更新日期：2019-02-01 00:00:00

abstract：:Osteochondral defects of the ankle are common lesions affecting the talar cartilage and subchondral bone. Current treatments include cell-based therapies but are frequently associated with donor-site morbidity. Our objective is to characterize the posterior process of the talus (SP) and the os trigonum (OT) tissues an...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Correia SI,Silva-Correia J,Pereira H,Canadas RF,da Silva Morais A,Frias AM,Sousa RA,van Dijk CN,Espregueira-Mendes J,Reis RL,Oliveira JM

更新日期：2017-07-01 00:00:00

abstract：:Our knowledge of the immunomodulatory role of mesenchymal stem cells (MSCs) in both the innate and adaptive immune systems has dramatically expanded, providing great promise for treating various autoimmune diseases. However, the contribution of MSCs to Th17-dominant immune disease, such as psoriasis and its underlying...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kim JY,Park M,Kim YH,Ryu KH,Lee KH,Cho KA,Woo SY

更新日期：2018-02-01 00:00:00

abstract：:Macroporous calcium phosphate cement (CPC) with stem cell seeding is promising for bone regeneration. The objective of this study was to investigate the effects of co-delivering autologous bone marrow mesenchymal stem cells (BMSCs) and autologous platelet-rich plasma (PRP) in CPC scaffold for bone regeneration in mini...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu G,Shi Z,Xu HHK,Yang B,Weir MD,Li G,Song Y,Wang J,Hu K,Wang P,Zhao L

更新日期：2018-02-01 00:00:00

abstract：:Biomaterials capable of controlling the release of multiple growth factors (GFs) could potentially promote the integration of co-transplanted neural progenitor cells (NPCs) and stimulate the plasticity and regenerability of the lesioned spinal cord. As a first step towards the employment of such a vehicle for cell the...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Cizkova D,Slovinska L,Grulova I,Salzet M,Cikos S,Kryukov O,Cohen S

更新日期：2015-08-01 00:00:00

abstract：:Surface-modified titanium (Ti) samples with hydroxyapatite (HAp) and heparin (Hep)-bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared, and their efficacies on the enhancements of bone formation and osseointegration in vitro and in vivo were examined as compared to Ti/HAp and Ti/Hep/BMP-2. Th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang DH,Lee DW,Kwon YD,Kim HJ,Chun HJ,Jang JW,Khang G

更新日期：2015-09-01 00:00:00

abstract：:In this study, a simple three-dimensional (3D) suspension culture method for the expansion and cardiac differentiation of human induced pluripotent stem cells (hiPSCs) is reported. The culture methods were easily adapted from two-dimensional (2D) to 3D culture without any additional manipulations. When hiPSCs were dir...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haraguchi Y,Matsuura K,Shimizu T,Yamato M,Okano T

更新日期：2015-12-01 00:00:00

abstract：:The authors previously created HAp or CaCO(3) formed on or in agarose gels (HAp and CaCO(3) gels, respectively) as biocompatible and biodegradable bone graft materials. However, these gels have limitations for bone regeneration. Mesenchymal stromal cells (MSCs) have osteogenic potential and are considered useful for b...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mizuta N,Hattori K,Suzawa Y,Iwai S,Matsumoto T,Tadokoro M,Nakano T,Akashi M,Ohgushi H,Yura Y

更新日期：2013-01-01 00:00:00

abstract：:The goal of this study was to evaluate human epiphyseal chondroprogenitor cells (ECPs) as a potential new cell source for cartilage regeneration. ECPs were compared to human bone marrow stromal cells (MSCs) and human adult articular chondrocytes (ACs) for their chondrogenic potential and phenotypic stability in vitro ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Studer D,Cavalli E,Formica FA,Kuhn GA,Salzmann G,Mumme M,Steinwachs MR,Laurent-Applegate LA,Maniura-Weber K,Zenobi-Wong M

更新日期：2017-11-01 00:00:00

abstract：:Postoperative mucosal regeneration of the middle ear cavity and the mastoid cavity is of great importance after middle ear surgery. However, the epithelialization of the mucosa in the middle ear is retarded because chronic inflammation without epithelialization aggravates gas exchange and clinical function. These envi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hama T,Yamamoto K,Yaguchi Y,Murakami D,Sasaki H,Yamato M,Okano T,Kojima H

更新日期：2017-04-01 00:00:00

abstract：:Tissue engineering holds great promise to develop functional constructs resembling the structural organization of native tissues to improve or replace biological functions, with the ultimate goal of avoiding organ transplantation. In tissue engineering, cells are often seeded into artificial structures capable of supp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Khorshidi S,Solouk A,Mirzadeh H,Mazinani S,Lagaron JM,Sharifi S,Ramakrishna S

更新日期：2016-09-01 00:00:00

abstract：:Several techniques have been introduced to improve the pulp revascularization outcomes. The use of the tissue graft can create more practical tissue regeneration, provide vascular supply, and enhance tissue healing. The aim of the present study was to investigate the histologic and molecular outcomes of pulp revascula...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Khazaei S,Khademi A,Torabinejad M,Nasr Esfahani MH,Khazaei M,Razavi SM

更新日期：2020-09-01 00:00:00

abstract：:Tissue engineered tracheae have been successfully implanted to treat a small number of patients on compassionate grounds. The treatment has not become mainstream due to the time taken to produce the scaffold and the resultant financial costs. We have developed a method for decellularization (DC) based on vacuum techno...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lange P,Greco K,Partington L,Carvalho C,Oliani S,Birchall MA,Sibbons PD,Lowdell MW,Ansari T

更新日期：2017-03-01 00:00:00

abstract：:Regenerative medicine aims to replace lost cells and to restore damaged tissues and organs by either tissue-engineering approaches or stimulation of endogenous processes. Due to their biological properties, stem cells promise to be an effective source for such strategies. Especially adult multipotent stem cells (ASCs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Reinke S,Dienelt A,Blankenstein A,Duda GN,Geissler S

更新日期：2016-01-01 00:00:00

abstract：:Bone extracellular matrix (ECM) is composed of mineralized collagen fibrils which support biological apatite nucleation that participates in bone outstanding properties. Understanding and mimicking bone morphological and physiological parameters at a biological scale is a major challenge in tissue engineering scaffold...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rodrigues MT,Martins A,Dias IR,Viegas CA,Neves NM,Gomes ME,Reis RL

更新日期：2012-11-01 00:00:00

abstract：:Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ three-dimensional (3D) printing is an exciting and innovative biofabrication technology that enables the surgeon to deliver tissue-engineering techniques at the time and location of need. We ha...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Di Bella C,Duchi S,O'Connell CD,Blanchard R,Augustine C,Yue Z,Thompson F,Richards C,Beirne S,Onofrillo C,Bauquier SH,Ryan SD,Pivonka P,Wallace GG,Choong PF

更新日期：2018-03-01 00:00:00

abstract：:Nanopatterned (330 nm wide channels) type I collagen films were prepared by solvent casting on poly(dimethyl siloxane) (PDMS) templates. These films were rolled into tubular constructs and crosslinked. Tubular constructs were incubated under cell culture conditions for 28 days and examined by stereomicroscopy and scan...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Zorlutuna P,Hasirci N,Hasirci V

更新日期：2008-08-01 00:00:00

abstract：:Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar-reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical trials have been condu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Spiekman M,van Dongen JA,Willemsen JC,Hoppe DL,van der Lei B,Harmsen MC

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a novel bioactive material (Biosilicate®) and low-level laser therapy (LLLT) on bone fracture consolidation in osteoporotic rats. Forty female Wistar rats were submitted to ovariectomy (OVX) to induce osteopenia. Eight weeks after surgery, the animals were random...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bossini PS,Rennó AC,Ribeiro DA,Fangel R,Peitl O,Zanotto ED,Parizotto NA

更新日期：2011-03-01 00:00:00

abstract：:Bone-patellar tendon-bone (BPTB) autografts are the gold standard for anterior cruciate ligament (ACL) reconstruction because the bony ends allow for superior healing and anchoring through bone-to-bone regeneration. However, the disadvantages of BPTB grafts include donor site morbidity and patellar rupture. In order t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chung EJ,Sugimoto MJ,Koh JL,Ameer GA

更新日期：2017-03-01 00:00:00

abstract：:Poly(ether imide) (PEI), which can be chemically functionalized with biologically active ligands, has emerged as a potential biomaterial for medical implants. Electrospun PEI scaffolds have shown advantageous properties, such as enhanced endothelial cell adherence, proliferation and low platelet adhesion in in vitro e...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haase T,Krost A,Sauter T,Kratz K,Peter J,Kamann S,Jung F,Lendlein A,Zohlnhöfer D,Rüder C

更新日期：2017-04-01 00:00:00