Nanopatterned collagen tubes for vascular tissue engineering.

Abstract:

:Nanopatterned (330 nm wide channels) type I collagen films were prepared by solvent casting on poly(dimethyl siloxane) (PDMS) templates. These films were rolled into tubular constructs and crosslinked. Tubular constructs were incubated under cell culture conditions for 28 days and examined by stereomicroscopy and scanning electron microscopy (SEM) for the integrity of the structure. The nanopatterned films were also seeded with human vascular smooth muscle cells (VSMCs) and examined after immunostaining with fluorescence microscopy and SEM to assess the cell phenotype and alignment on the nanopatterns on the films.

journal_name

J Tissue Eng Regen Med

authors

Zorlutuna P,Hasirci N,Hasirci V

doi

10.1002/term.99

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

373-7

issue

6

eissn

1932-6254

issn

1932-7005

journal_volume

2

pub_type

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