Tissue engineering of the gastroesophageal junction.

abstract：:Nanopatterned (330 nm wide channels) type I collagen films were prepared by solvent casting on poly(dimethyl siloxane) (PDMS) templates. These films were rolled into tubular constructs and crosslinked. Tubular constructs were incubated under cell culture conditions for 28 days and examined by stereomicroscopy and scan...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Zorlutuna P,Hasirci N,Hasirci V

更新日期：2008-08-01 00:00:00

abstract：:Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely efficient for economic viability given a relatively low value product and high (2 × 1012 ) cell dose. Therefore, the aim of these studies was to define the produc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bayley R,Ahmed F,Glen K,McCall M,Stacey A,Thomas R

更新日期：2018-01-01 00:00:00

abstract：:Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has been shown to ameliorate the injured central nervous system (CNS). Although these effects were initially attributed to the putative differentiation of MSCs towards the neural lineage, it is now known that most of them are mediated by the secretome. Up...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ribeiro CA,Salgado AJ,Fraga JS,Silva NA,Reis RL,Sousa N

更新日期：2011-08-01 00:00:00

abstract：:New injectable acrylic formulations have been prepared to be applied in restoration processes for intervertebral disks (IVDs). The solid phase of the formulations is composed of poly(methyl methacrylate) (PMMA), incorporating in some cases chondroitin sulphate (CS) as a regenerative bioactive molecule, whereas the liq...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Larraz E,Elvira C,Fernández M,Parra J,Collía F,López-Bravo A,Román JS

更新日期：2007-03-01 00:00:00

abstract：:Limitations of current treatments for intervertebral disc (IVD) degeneration have promoted interest in the development of tissue-engineering approaches. Injectable hydrogels loaded with cells can be used as a substitute material for the inner IVD part, the nucleus pulposus (NP), and provide an opportunity for minimall...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tsaryk R,Silva-Correia J,Oliveira JM,Unger RE,Landes C,Brochhausen C,Ghanaati S,Reis RL,Kirkpatrick CJ

更新日期：2017-03-01 00:00:00

abstract：:In the context of prevascularization strategies for tissue-engineering purposes, co-culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regeneration mechanisms and to identify factors that might positively influence...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dohle E,El Bagdadi K,Sader R,Choukroun J,James Kirkpatrick C,Ghanaati S

更新日期：2018-03-01 00:00:00

abstract：:Tissue-engineering strategies may be employed in the development of in vitro breast tissue models for use in testing regimens of drug therapies and vaccines. The physical and chemical interactions that occur among cells and extracellular matrix components can also be elucidated with these models to gain an understandi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Parzel CA,Pepper ME,Burg T,Groff RE,Burg KJ

更新日期：2009-06-01 00:00:00

abstract：:Developing and regenerating neurites respond to a variety of biophysical and biochemical cues in their micro-environment to reach target cells and establish appropriate synapses. Defining the hierarchal relationship of both types of cues to direct neurite growth carries broad significance for neural development, regen...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tuft BW,Xu L,Leigh B,Lee D,Guymon CA,Hansen MR

更新日期：2018-03-01 00:00:00

abstract：:Implanted porous precision templated scaffolds (PTS) with 40-µm spherical pores reduce inflammation and foreign body reaction (FBR) while increasing vascular density upon implantation. Larger or smaller pores, however, promote chronic inflammation and FBR. While macrophage (MØ) recruitment and polarization participate...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hady TF,Hwang B,Pusic AD,Waworuntu RL,Mulligan M,Ratner B,Bryers JD

更新日期：2021-01-01 00:00:00

abstract：:In clinical cases, many orthopaedists have been troubled with bone fragility, such as fractures after devitalization therapy for bone tumour, pathological fractures and metastatic tumours. The aim of this study was to determine whether loss of osteogenic capacity of devitalized autologous bones can be rescued using cu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tohma Y,Ohgushi H,Morishita T,Dohi Y,Tadokoro M,Tanaka Y,Takakura Y

更新日期：2008-01-01 00:00:00

abstract：:The effects of the stiffness of substrates on the cell behaviours of human bone marrow-derived mesenchymal stem cells (hBMSC) have been investigated, but the effects of the secondary structures of proteins in the substrates on the morphological transformation and differentiation of hBMSC have yet been elucidated. To i...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lo HY,Huang AL,Lee PC,Chung TW,Wang SS

更新日期：2018-04-01 00:00:00

abstract：:There has been increased interest in co-cultures of stem cells and chondrocytes for cartilage tissue engineering as there are the limitations associated with using either cell type alone. Drawbacks associated with the use of chondrocytes include the limited numbers of cells available for isolation from damaged or dise...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Critchley SE,Eswaramoorthy R,Kelly DJ

更新日期：2018-04-01 00:00:00

abstract：:Repairing the peripheral nerves following a segmental defect injury remains surgically challenging. Because of some disadvantages of nerve grafts, nerve regeneration, such as conduits combined with bone marrow-derived mesenchymal stem cells (BMSCs), may serve as an alternative. BMSCs expand under hypoxic conditions, d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang JP,Liao YT,Wu SH,Chiang ER,Hsu SH,Tseng TC,Hung SC

更新日期：2020-12-01 00:00:00

abstract：:Injections of bone marrow (BM) cell extract, known as 'BM soup', were previously reported to mitigate ionizing radiation (IR) injury to salivary glands (SGs). However, the optimal starting time and frequency to maintain BM soup therapeutic efficacy remains unknown. This study tested the optimal starting time and frequ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fang D,Shang S,Liu Y,Bakkar M,Sumita Y,Seuntjens J,Tran SD

更新日期：2018-02-01 00:00:00

abstract：:Many studies have highlighted the role of silicon in human bone formation and maintenance. Silicon, in fact, is considered to nucleate the precipitation of hydroxyapatite and to reduce the bone resorption. For this reason, we have combined silk fibroin (SF) with silicon-releasing diatom particles (DPs), as potential m...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Le TDH,Liaudanskaya V,Bonani W,Migliaresi C,Motta A

更新日期：2018-01-01 00:00:00

abstract：:The goal of this study was to evaluate human epiphyseal chondroprogenitor cells (ECPs) as a potential new cell source for cartilage regeneration. ECPs were compared to human bone marrow stromal cells (MSCs) and human adult articular chondrocytes (ACs) for their chondrogenic potential and phenotypic stability in vitro ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Studer D,Cavalli E,Formica FA,Kuhn GA,Salzmann G,Mumme M,Steinwachs MR,Laurent-Applegate LA,Maniura-Weber K,Zenobi-Wong M

更新日期：2017-11-01 00:00:00

abstract：:Adipose tissue-derived microvascular fragments (ad-MVFs) are promising vascularization units for tissue engineering. In this study, we analysed the effects of normothermic (37°C) and subnormothermic (20°C) short-term cultivation on their viability and network forming capacity. Ad-MVFs from green fluorescent protein (G...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Laschke MW,Heß A,Scheuer C,Karschnia P,Menger MD

更新日期：2019-02-01 00:00:00

abstract：:The aim of this work was to study the in vitro biocompatibility of glass-ceramic scaffolds based on 45S5 Bioglass, using a human osteosarcoma cell line (HOS-TE85). The highly porous scaffolds were produced by the foam replication technique. Two different types of scaffolds with different porosities were analysed. They...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bretcanu O,Misra S,Roy I,Renghini C,Fiori F,Boccaccini AR,Salih V

更新日期：2009-02-01 00:00:00

abstract：:Osteochondral defects of the ankle are common lesions affecting the talar cartilage and subchondral bone. Current treatments include cell-based therapies but are frequently associated with donor-site morbidity. Our objective is to characterize the posterior process of the talus (SP) and the os trigonum (OT) tissues an...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Correia SI,Silva-Correia J,Pereira H,Canadas RF,da Silva Morais A,Frias AM,Sousa RA,van Dijk CN,Espregueira-Mendes J,Reis RL,Oliveira JM

更新日期：2017-07-01 00:00:00

abstract：:Carbonate apatite-coated calcium carbonate (CO3 Ap/CaCO3 ) was fabricated through a dissolution-precipitation reaction using CaCO3 granules as a precursor to accelerate bone replacement based on superior osteoconductivity of the CO3 Ap shell, along with Ca2+ release from the CaCO3 core and quicker resorption of the Ca...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Fujioka-Kobayashi M,Tsuru K,Nagai H,Fujisawa K,Kudoh T,Ohe G,Ishikawa K,Miyamoto Y

更新日期：2018-10-01 00:00:00

abstract：:The regeneration and establishment of osseointegration within oral peri-implant bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous and/or biomaterial-based bone grafting. The objective of this systematic review was to answer the focused questio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shanbhag S,Pandis N,Mustafa K,Nyengaard JR,Stavropoulos A

更新日期：2018-01-01 00:00:00

abstract：:Tissue engineering holds great promise to develop functional constructs resembling the structural organization of native tissues to improve or replace biological functions, with the ultimate goal of avoiding organ transplantation. In tissue engineering, cells are often seeded into artificial structures capable of supp...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Khorshidi S,Solouk A,Mirzadeh H,Mazinani S,Lagaron JM,Sharifi S,Ramakrishna S

更新日期：2016-09-01 00:00:00

abstract：:The idea of rescuing the body self-repair capability lost during evolution is progressively gaining ground in regenerative medicine. In particular, growth factors and bioactive molecules derived from activated platelets emerged as promising therapeutic agents acting as trigger for repair of tissue lesions and restorat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Nguyen VT,Cancedda R,Descalzi F

更新日期：2018-03-01 00:00:00

abstract：:Native articular cartilage is subjected to synovial fluid flow during normal joint function. Thus, it is believed that the morphogenesis of articular cartilage may be positively regulated by the application of similar stimulation in vitro. In the present study, the effect of fluid flow over the chondrogenic differenti...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Alves da Silva ML,Martins A,Costa-Pinto AR,Correlo VM,Sol P,Bhattacharya M,Faria S,Reis RL,Neves NM

更新日期：2011-10-01 00:00:00

abstract：:Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human somatic cells has proved to be one of the most potentially useful discoveries in regenerative medicine. iPSCs are becoming an invaluable tool to study the pathology of different diseases and for drug screening. However, severa...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Revilla A,González C,Iriondo A,Fernández B,Prieto C,Marín C,Liste I

更新日期：2016-11-01 00:00:00

abstract：:Spatiotemporal changes in the extracellular matrix (ECM) were studied within abdominal aortic aneurysms (AAAs) generated in rats via elastase infusion. At 7, 14 and 21 days post-induction, AAA tissues were divided into proximal, mid- and distal regions, based on their location relative to the renal arteries and the re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Deb PP,Ramamurthi A

更新日期：2017-01-01 00:00:00

abstract：:This study reports the manufacturing process of 3D interconnected macroporous tricalcium phosphate (TCP) scaffolds with controlled internal architecture by direct 3D printing (3DP), and high mechanical strength obtained by microwave sintering. TCP scaffolds with 27%, 35% and 41% designed macroporosity with pore sizes ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tarafder S,Balla VK,Davies NM,Bandyopadhyay A,Bose S

更新日期：2013-08-01 00:00:00

abstract：:Clinical translation of engineered tissues into regenerative medicine applications, and the effort to reduce the use of animals for the screening of drugs and other compounds, result in an increasing demand for human tissues engineered in vitro for implantation, in vitro screening systems and basic research. Further d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rouwkema J,Gibbs S,Lutolf MP,Martin I,Vunjak-Novakovic G,Malda J

更新日期：2011-08-01 00:00:00

abstract：:Healing of diabetic foot ulcers is a major challenge. Despite adhering to optimal standard of care (SOC), less than 30% of wounds heal after 20 weeks. Advanced cellular tissue-based products have shown better healing over SOC, albeit with great cost and modest improvement. We hypothesized no difference in healing effe...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tchanque-Fossuo CN,Dahle SE,Lev-Tov H,West KIM,Li CS,Rocke DM,Isseroff RR

更新日期：2019-08-01 00:00:00

abstract：:'Off-the-shelf' tissue-engineered skin alternatives for epidermal and dermal skin layers are available; however, no such alternative for the subdermal fat layer exists. Without this well-vascularized layer, skin graft take is variable and grafts may have reduced mobility, contracture and contour defects. In this study...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Debels H,Gerrand YW,Poon CJ,Abberton KM,Morrison WA,Mitchell GM

更新日期：2017-04-01 00:00:00