当前位置： SCI文献检索 > Journal of Tissue Engineering and Regenerative Medicine期刊下所有文献 > Development of decellularized scaffolds for stem cell-driven tissue engineering.

Development of decellularized scaffolds for stem cell-driven tissue engineering.

Abstract：

:Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions. However, a dearth of available donor organs for transplantation leads to the death of numerous patients waiting for a suitable organ donor. The potential of decellularized scaffolds, derived from native tissues or organs in the form of scaffolds has been evolved as a promising approach in tissue-regenerative medicine for translating functional organ replacements. In recent years, donor organs, such as heart, liver, lung and kidneys, have been reported to provide acellular extracellular matrix (ECM)-based scaffolds through the process called 'decellularization' and proved to show the potential of recellularization with selected cell populations, particularly with stem cells. In fact, decellularized stem cell matrix (DSCM) has also emerged as a potent biological scaffold for controlling stem cell fate and function during tissue organization. Despite the proven potential of decellularized scaffolds in tissue engineering, the molecular mechanism responsible for stem cell interactions with decellularized scaffolds is still unclear. Stem cells interact with, and respond to, various signals/cues emanating from their ECM. The ability to harness the regenerative potential of stem cells via decellularized ECM-based scaffolds has promising implications for tissue-regenerative medicine. Keeping these points in view, this article reviews the current status of decellularized scaffolds for stem cells, with particular focus on: (a) concept and various methods of decellularization; (b) interaction of stem cells with decellularized scaffolds; (c) current recellularization strategies, with associated challenges; and (iv) applications of the decellularized scaffolds in stem cell-driven tissue engineering and regenerative medicine. Copyright © 2015 John Wiley & Sons, Ltd.

journal_name

J Tissue Eng Regen Med

journal_title

Journal of tissue engineering and regenerative medicine

authors

Rana D,Zreiqat H,Benkirane-Jessel N,Ramakrishna S,Ramalingam M

doi

10.1002/term.2061

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

942-965

issue

4

eissn

1932-6254

issn

1932-7005

journal_volume

11

pub_type

杂志文章,评审

相关文献

Journal of Tissue Engineering and Regenerative Medicine文献大全
  • A novel approach to human cranial tissue regeneration and frontal sinus obliteration with an autogenous platelet-rich/fibrin-rich composite matrix: 10 patients with a 6-10 year follow-up.

    abstract：:Advanced frontal sinus disease non-responsive to conservative therapy has been treated with fat obliteration for decades. More recently, a wide variety of autogenous, allogenic or synthetic materials have also been used. In this study we present a treatment based on totally autogenous procedures and materials that was...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.534

    authors： Mendonça-Caridad J,Lopez PJ,Fayos FV,Miery G

    更新日期：2013-06-01 00:00:00

  • An in vitro expansion score for tissue-engineering applications with human bone marrow-derived mesenchymal stem cells.

    abstract：:Human bone marrow-derived mesenchymal stem cells (MSCs) have limited growth potential in vitro and cease to divide due to replicative senescence, which from a tissue-engineering perspective has practical implications, such as defining the correct starting points for differentiation and transplantation. Time spent in c...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.1734

    authors： Bertolo A,Mehr M,Janner-Jametti T,Graumann U,Aebli N,Baur M,Ferguson SJ,Stoyanov JV

    更新日期：2016-02-01 00:00:00

  • Characterization of human myoblast differentiation for tissue-engineering purposes by quantitative gene expression analysis.

    abstract：:Tissue engineering of skeletal muscle is an encouraging possibility for the treatment of muscle loss through the creation of functional muscle tissue in vitro from human stem cells. Currently, the preferred stem cells are primary, non-immunogenic satellite cells ( = myoblasts). The objective of this study was to deter...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.417

    authors： Stern-Straeter J,Bonaterra GA,Kassner SS,Zügel S,Hörmann K,Kinscherf R,Goessler UR

    更新日期：2011-08-01 00:00:00

  • Kartogenin with PRP promotes the formation of fibrocartilage zone in the tendon-bone interface.

    abstract：:Treatment of tendon-bone junction injuries is a challenge because tendon-bone interface often heals poorly and the fibrocartilage zone, which reduces stress concentration, at the interface is not formed. In this study, we used a compound called kartogenin (KGN) with platelet-rich plasma (PRP) to induce the formation o...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2258

    authors： Zhou Y,Zhang J,Yang J,Narava M,Zhao G,Yuan T,Wu H,Zheng N,Hogan MV,Wang JH

    更新日期：2017-12-01 00:00:00

  • Production of pancreatic progenitor cells from human induced pluripotent stem cells using a three-dimensional suspension bioreactor system.

    abstract：:Islet replacement is a promising strategy for the treatment of patients with type 1 diabetes and patients who have undergone total pancreatectomy. Recent progress in cellular reprogramming technology may allow the transplantation of a patient's own pancreatic cells. Although many studies have reported the differentiat...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2228

    authors： Mihara Y,Matsuura K,Sakamoto Y,Okano T,Kokudo N,Shimizu T

    更新日期：2017-11-01 00:00:00

  • In vitro and in vivo enhancement of osteogenic capacity in a synthetic BMP-2 derived peptide-coated mineralized collagen composite.

    abstract：:Enhancement of osteogenic capacity was achieved in a mineralized collagen composite, nano-hydroxyapatite/collagen (nHAC), by loading with synthetic peptides derived from BMP-2 residues 32-48 (P17-BMP-2). Rabbit marrow stromal cells (MSCs) were used in vitro to study cell biocompatibility, attachment and differentiatio...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.1705

    authors： Zhang X,Guo WG,Cui H,Liu HY,Zhang Y,Müller WE,Cui FZ

    更新日期：2016-02-01 00:00:00

  • Continuous supply of TGFβ3 via adenoviral vector promotes type I collagen and viability of fibroblasts in alginate hydrogel.

    abstract：:In recent years, transforming growth factor-β3 (TGFβ3) has interested more and more researchers with its competence in engineered histogenesis. In the present study we employed recombinant adenoviral vectors to deliver the constitutively active TGFβ3 gene to human dermal fibroblasts, which could maintain the continuou...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.263

    authors： Yao Y,Zhang F,Zhou R,Li M,Wang DA

    更新日期：2010-10-01 00:00:00

  • Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases.

    abstract：:The mechanism for stem cell-mediated improvement following acute myocardial infarction has been actively debated. We support hypotheses that the stem cell effect is primarily paracrine factor-linked. We used a heparin-presenting injectable nanofibre network to bind and deliver paracrine factors derived from hypoxic co...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.273

    authors： Webber MJ,Han X,Murthy SN,Rajangam K,Stupp SI,Lomasney JW

    更新日期：2010-12-01 00:00:00

  • Sequential adaptation of perfusion and transport conditions significantly improves vascular construct recellularization and biomechanics.

    abstract：:Recellularization of ex vivo-derived scaffolds remains a significant hurdle primarily due to the scaffolds subcellular pore size that restricts initial cell seeding to the scaffolds periphery and inhibits migration over time. With the aim to improve cell migration, repopulation, and graft mechanics, the effects of a f...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.3015

    authors： Van de Walle AB,Moore MC,McFetridge PS

    更新日期：2020-03-01 00:00:00

  • Isolation and characterization of mesenchymal cells from human fetal membranes.

    abstract：:Bone marrow (BM) multipotent mesenchymal stromal cells (MSCs) present with multipotent differentiation potential and immunomodulatory properties. As an alternative to bone marrow, we have examined fetal membranes, amnion and chorion, of term human placenta as a potential source of multipotent MSCs. Here we show that a...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.40

    authors： Soncini M,Vertua E,Gibelli L,Zorzi F,Denegri M,Albertini A,Wengler GS,Parolini O

    更新日期：2007-07-01 00:00:00

  • 3D ingrowth of bovine articular chondrocytes in biodegradable cryogel scaffolds for cartilage tissue engineering.

    abstract：:A feasibility study was undertaken to examine the potential of biodegradable HEMA-lactate-dextran (HEMA-LLA-D)-based cryogels as scaffolds for cartilage tissue engineering. This was a preliminary in vitro study giving essential information on the biocompatibility of cryogels with cartilage cells. HEMA-lactate (HEMA-LL...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.375

    authors： Bölgen N,Yang Y,Korkusuz P,Güzel E,El Haj AJ,Pişkin E

    更新日期：2011-11-01 00:00:00

  • Label-free relative quantification of secreted proteins as a non-invasive method for the quality control of chondrogenesis in bioengineered substitutes for cartilage repair.

    abstract：:Cartilage tissue engineering is making progress, but the competing available strategies still leave room for improvement and consensual overviews regarding the best combinations of scaffolds and cell sources are limited by the capacity to compare them directly. In addition, because most strategies involve autologous c...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2454

    authors： Henrionnet C,Gillet P,Mainard D,Vincourt JB,Pinzano A

    更新日期：2018-03-01 00:00:00

  • Prevascularization of natural nanofibrous extracellular matrix for engineering completely biological three-dimensional prevascularized tissues for diverse applications.

    abstract：:Self-sustainability after implantation is one of the critical obstacles facing large engineered tissues. A preformed functional vascular network provides an effective solution for solving the mass transportation problem. With the support of mural cells, endothelial cells (ECs) can form microvessels within engineered t...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2512

    authors： Zhang L,Qian Z,Tahtinen M,Qi S,Zhao F

    更新日期：2018-03-01 00:00:00

  • Quantitative imaging of cartilage and bone for functional assessment of gene therapy approaches in experimental arthritis.

    abstract：:Anti-inflammatory gene therapy can inhibit inflammation driven by TNFalpha in experimental models of rheumatoid arthritis. However, assessment of the therapeutic effect on cartilage and bone quality is either missing or unsatisfactory. A multimodal imaging approach, using confocal laser scanning microscopy (CLSM) and ...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.251

    authors： Stok KS,Noël D,Apparailly F,Gould D,Chernajovsky Y,Jorgensen C,Müller R

    更新日期：2010-07-01 00:00:00

  • Meniscal repair in vivo using human chondrocyte-seeded PLGA mesh scaffold pretreated with platelet-rich plasma.

    abstract：:The objective of this study was to test the hypothesis that platelet-rich plasma (PRP) pretreatment on a poly-lactic-co-glycolic acid (PLGA) mesh scaffold enhances the healing capacity of the meniscus with human chondrocyte-seeded scaffolds in vivo, even when the seeded number of cells was reduced from 10 million to o...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.1938

    authors： Kwak HS,Nam J,Lee JH,Kim HJ,Yoo JJ

    更新日期：2017-02-01 00:00:00

  • Phenotype-based selection of bone marrow mesenchymal stem cell-derived smooth muscle cells for elastic matrix regenerative repair in abdominal aortic aneurysms.

    abstract：:Chronic proteolytic disruption of elastic fibres within the abdominal aortic wall results in wall vessel expansion to form rupture-prone abdominal aortic aneurysms (AAA). Arresting AAA growth is not possible as adult vascular smooth muscle cells (SMCs) poorly auto-regenerate and repair elastic fibres. Thus, there is a...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2349

    authors： Swaminathan G,Stoilov I,Broekelmann T,Mecham R,Ramamurthi A

    更新日期：2018-01-01 00:00:00

  • Review of vascularised bone tissue-engineering strategies with a focus on co-culture systems.

    abstract：:Poor angiogenesis within tissue-engineered grafts has been identified as a main challenge limiting the clinical introduction of bone tissue-engineering (BTE) approaches for the repair of large bone defects. Thick BTE grafts often exhibit poor cellular viability particularly at the core, leading to graft failure and la...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章,评审

    doi：10.1002/term.1617

    authors： Liu Y,Chan JK,Teoh SH

    更新日期：2015-02-01 00:00:00

  • Fabrication and evaluation of carbonate apatite-coated calcium carbonate bone substitutes for bone tissue engineering.

    abstract：:Carbonate apatite-coated calcium carbonate (CO3 Ap/CaCO3 ) was fabricated through a dissolution-precipitation reaction using CaCO3 granules as a precursor to accelerate bone replacement based on superior osteoconductivity of the CO3 Ap shell, along with Ca2+ release from the CaCO3 core and quicker resorption of the Ca...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2742

    authors： Fujioka-Kobayashi M,Tsuru K,Nagai H,Fujisawa K,Kudoh T,Ohe G,Ishikawa K,Miyamoto Y

    更新日期：2018-10-01 00:00:00

  • Novel method for the isolation of adipose stem cells (ASCs).

    abstract：:Adipose stem cells (ASCs) represent a cell population with great potential for tissue engineering applications. Several articles have been published showing the proliferation and differentiation potential, the markers and the wide range of potential applications of these cells. In the majority of these studies the ASC...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.141

    authors： Rada T,Reis RL,Gomes ME

    更新日期：2009-02-01 00:00:00

  • Phosphoserine-modified calcium phosphate cements: bioresorption and substitution.

    abstract：:This work reports the effects of phosphoserine addition on the biodegradability of calcium phosphate cements. The characteristics of a phosphoserine-modified calcium phosphate cement without collagen in a large animal model are presented here for the first time. Critical size bone defects in the proximal tibia of 10 s...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.283

    authors： Offer L,Veigel B,Pavlidis T,Heiss C,Gelinsky M,Reinstorf A,Wenisch S,Lips KS,Schnettler R

    更新日期：2011-01-01 00:00:00

  • Uniform 40-µm-pore diameter precision templated scaffolds promote a pro-healing host response by extracellular vesicle immune communication.

    abstract：:Implanted porous precision templated scaffolds (PTS) with 40-µm spherical pores reduce inflammation and foreign body reaction (FBR) while increasing vascular density upon implantation. Larger or smaller pores, however, promote chronic inflammation and FBR. While macrophage (MØ) recruitment and polarization participate...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.3160

    authors： Hady TF,Hwang B,Pusic AD,Waworuntu RL,Mulligan M,Ratner B,Bryers JD

    更新日期：2021-01-01 00:00:00

  • A comparison study of different decellularization treatments on bovine articular cartilage.

    abstract：:Previous researches have emphasized on suitability of decellularized tissues for regenerative applications. The decellularization of cartilage tissue has always been a challenge as the final product must be balanced in both immunogenic residue and mechanical properties. This study was designed to compare and optimize ...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2936

    authors： Ghassemi T,Saghatoleslami N,Mahdavi-Shahri N,Matin MM,Gheshlaghi R,Moradi A

    更新日期：2019-10-01 00:00:00

  • A biodegradable tri-component graft for anterior cruciate ligament reconstruction.

    abstract：:Bone-patellar tendon-bone (BPTB) autografts are the gold standard for anterior cruciate ligament (ACL) reconstruction because the bony ends allow for superior healing and anchoring through bone-to-bone regeneration. However, the disadvantages of BPTB grafts include donor site morbidity and patellar rupture. In order t...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.1966

    authors： Chung EJ,Sugimoto MJ,Koh JL,Ameer GA

    更新日期：2017-03-01 00:00:00

  • Mesenchymal stem cells: Cell therapy and regeneration potential.

    abstract：:Rapid advances in the isolation of multipotent progenitor cells, routinely called mesenchymal stromal/stem cells (MSCs), from various human tissues and organs have provided impetus to the field of cell therapy and regenerative medicine. The most widely studied sources of MSCs include bone marrow, adipose, muscle, peri...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章,评审

    doi：10.1002/term.2914

    authors： Brown C,McKee C,Bakshi S,Walker K,Hakman E,Halassy S,Svinarich D,Dodds R,Govind CK,Chaudhry GR

    更新日期：2019-09-01 00:00:00

  • Development of a bioreactor system for pre-endothelialized cardiac patch generation with enhanced viscoelastic properties by combined collagen I compression and stromal cell culture.

    abstract：:Treatment of terminal heart failure still poses a significant clinical problem. Cardiac tissue engineering could offer autologous solutions for the replacement of nonfunctional myocardial tissue. So far, soft matrix construction and missing large-scale prevascularization prevented the application of sizeable cardiac r...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.3129

    authors： Krziminski C,Kammann S,Hansmann J,Edenhofer F,Dandekar G,Walles H,Leistner M

    更新日期：2020-12-01 00:00:00

  • In vivo analysis of vascularization and biocompatibility of electrospun polycaprolactone fibre mats in the rat femur chamber.

    abstract：:In orthopaedic medicine, connective tissues are often affected by traumatic or degenerative injuries, and surgical intervention is required. Rotator cuff tears are a common cause of shoulder pain and disability among adults. The development of graft materials for bridging the gap between tendon and bone after chronic ...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2868

    authors： Gniesmer S,Brehm R,Hoffmann A,de Cassan D,Menzel H,Hoheisel AL,Glasmacher B,Willbold E,Reifenrath J,Wellmann M,Ludwig N,Tavassol F,Zimmerer R,Gellrich NC,Kampmann A

    更新日期：2019-07-01 00:00:00

  • A biological approach to assembling tissue modules through endothelial capillary network formation.

    abstract：:To create functional tissues having complex structures, bottom-up approaches to assembling small tissue modules into larger constructs have been emerging. Most of these approaches are based on chemical reactions or physical interactions at the interface between tissue modules. Here we report a biological assembly appr...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2008

    authors： Riesberg JJ,Shen W

    更新日期：2015-09-01 00:00:00

  • Spatial distribution and survival of human and goat mesenchymal stromal cells on hydroxyapatite and β-tricalcium phosphate.

    abstract：:The combination of scaffolds and mesenchymal stromal cells (MSCs) is a promising approach in bone tissue engineering (BTE). Knowledge on the survival, outgrowth and bone-forming capacity of MSCs in vivo is limited. Bioluminescence imaging (BLI), histomorphometry and immunohistochemistry were combined to study the fate...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.1681

    authors： Prins HJ,Fernandes H,Rozemuller H,van Blitterswijk C,de Boer J,Martens AC

    更新日期：2016-03-01 00:00:00

  • Biodegrading highly porous elastomeric graft regenerates muscular and innervated carotid artery-Comparative study with vein graft.

    abstract：:This study aims to investigate the superiorities of fast degrading elastomeric poly(glycerol sebacate) (PGS)/polycaprolactone (PCL) grafts over autologous vein grafts in the reconstruction of carotid artery, thus providing more suitable vascular grafts for carotid artery replacement. We fabricated small arterial graft...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.2856

    authors： Yang X,Gao Z,Liu H,Wu W

    更新日期：2019-07-01 00:00:00

  • Differential expression of GAP-43 and neurofilament during peripheral nerve regeneration through bio-artificial conduits.

    abstract：:Nerve conduits are promising alternatives for repairing nerve gaps; they provide a close microenvironment that supports nerve regeneration. In this sense, histological analysis of axonal growth is a determinant to achieve successful nerve regeneration. To evaluate this process, the most-used immunohistochemical marker...

    journal_title：Journal of tissue engineering and regenerative medicine

    pub_type： 杂志文章

    doi：10.1002/term.1949

    authors： Carriel V,Garzón I,Campos A,Cornelissen M,Alaminos M

    更新日期：2017-02-01 00:00:00