Low-amplitude high frequency vibration down-regulates myostatin and atrogin-1 expression, two components of the atrophy pathway in muscle cells.

abstract：:Damage of non-vascularised tissues such as cartilage and cornea can result in healing processes accompanied by a non-physiological angiogenesis. Peptidic aptamers have recently been reported to block the vascular endothelial growth factor (VEGF). However, the therapeutic applications of these aptamers are limited due ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Perugini V,Guildford AL,Silva-Correia J,Oliveira JM,Meikle ST,Reis RL,Santin M

更新日期：2018-02-01 00:00:00

abstract：:A feasibility study was undertaken to examine the potential of biodegradable HEMA-lactate-dextran (HEMA-LLA-D)-based cryogels as scaffolds for cartilage tissue engineering. This was a preliminary in vitro study giving essential information on the biocompatibility of cryogels with cartilage cells. HEMA-lactate (HEMA-LL...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bölgen N,Yang Y,Korkusuz P,Güzel E,El Haj AJ,Pişkin E

更新日期：2011-11-01 00:00:00

abstract：:The purpose of this study was to develop freeze-dried chitosan formulations that can be solubilized in platelet-rich plasma (PRP) to form injectable implants for tissue repair. A systematic approach to adjust formulation parameters, including chitosan number average molar mass (Mn ), chitosan concentration and lyoprot...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chevrier A,Darras V,Picard G,Nelea M,Veilleux D,Lavertu M,Hoemann CD,Buschman MD

更新日期：2018-01-01 00:00:00

abstract：:Spinal cord injury (SCI) is a neurological disorder that arises from a primary acute mechanical lesion, followed by a pathophysiological cascade of events that leads to further spinal cord tissue damage. Several preclinical and clinical studies have highlighted the ability of stem cell therapy to improve long-term fun...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mammana S,Gugliandolo A,Cavalli E,Diomede F,Iori R,Zappacosta R,Bramanti P,Conti P,Fontana A,Pizzicannella J,Mazzon E

更新日期：2019-07-01 00:00:00

abstract：:There is a need for new materials and architectures for tissue engineering and regenerative medicine. Based upon our recent results developing novel scaffold architecture, we hypothesized that this new architecture would foster vascularization, a particular need for tissue engineering. We report on the potential of su...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Keskar V,Gandhi M,Gemeinhart EJ,Gemeinhart RA

更新日期：2009-08-01 00:00:00

abstract：:Nonunion treatment has a high rate of success, although recalcitrant nonunion may determine the need for amputation. Therefore, new treatment options are continuously investigated in order to further reduce the risk of nonunion recurrence. This study aimed to (a) develop a new large animal model for bone atrophic nonu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dozza B,Salamanna F,Baleani M,Giavaresi G,Parrilli A,Zani L,Lucarelli E,Martini L,Fini M,Donati DM

更新日期：2018-09-01 00:00:00

abstract：:Human bone marrow-derived mesenchymal stem cells (MSCs) have limited growth potential in vitro and cease to divide due to replicative senescence, which from a tissue-engineering perspective has practical implications, such as defining the correct starting points for differentiation and transplantation. Time spent in c...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bertolo A,Mehr M,Janner-Jametti T,Graumann U,Aebli N,Baur M,Ferguson SJ,Stoyanov JV

更新日期：2016-02-01 00:00:00

abstract：:The creation of vascularized engineered tissues of clinically relevant size is a major challenge of tissue engineering. While it is known that endothelial and mural vascular cells are integral to the formation of stable blood vessels, the specific cell types and optimal conditions for engineered vascular networks are ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Trkov S,Eng G,Di Liddo R,Parnigotto PP,Vunjak-Novakovic G

更新日期：2010-03-01 00:00:00

abstract：:Low immunogenicity and high repopulation capacity are crucial determinants for the functional and structural performance of acellular cardiovascular implants. The present study evaluates a detergent-free, non-proteolytic, actin-disassembling regimen (BIO) for decellularization of heart valve and vessel grafts, particu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Assmann A,Struß M,Schiffer F,Heidelberg F,Munakata H,Timchenko EV,Timchenko PE,Kaufmann T,Huynh K,Sugimura Y,Leidl Q,Pinto A,Stoldt VR,Lichtenberg A,Akhyari P

更新日期：2017-12-01 00:00:00

abstract：:For the success of any biomaterial for tissue engineering, its mechanical properties and ability to support nutrient diffusion will be critical. Collagen scaffolds are ideal candidates, due to their ability to immerse cells in a biomimetic nanofibrous matrix. We have established O(2) diffusion coefficients through nat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Cheema U,Rong Z,Kirresh O,Macrobert AJ,Vadgama P,Brown RA

更新日期：2012-01-01 00:00:00

abstract：:Adipose stem cells (ASCs) represent a cell population with great potential for tissue engineering applications. Several articles have been published showing the proliferation and differentiation potential, the markers and the wide range of potential applications of these cells. In the majority of these studies the ASC...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rada T,Reis RL,Gomes ME

更新日期：2009-02-01 00:00:00

abstract：:In this study, a simple three-dimensional (3D) suspension culture method for the expansion and cardiac differentiation of human induced pluripotent stem cells (hiPSCs) is reported. The culture methods were easily adapted from two-dimensional (2D) to 3D culture without any additional manipulations. When hiPSCs were dir...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haraguchi Y,Matsuura K,Shimizu T,Yamato M,Okano T

更新日期：2015-12-01 00:00:00

abstract：:Several techniques have been introduced to improve the pulp revascularization outcomes. The use of the tissue graft can create more practical tissue regeneration, provide vascular supply, and enhance tissue healing. The aim of the present study was to investigate the histologic and molecular outcomes of pulp revascula...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Khazaei S,Khademi A,Torabinejad M,Nasr Esfahani MH,Khazaei M,Razavi SM

更新日期：2020-09-01 00:00:00

abstract：:Restoration of the external ear and nose in human patients, in either congenital deformity or acquired defects, is a challenge in reconstructive surgery. Optimization of the currently available materials is necessary for rhinoplasty and microtia correction to avoid intraoperative manoeuvring and early rejection. The a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bhattacharya R,Das P,Joardar SN,Biswas BK,Batabyal S,Das PK,Nandi SK

更新日期：2019-01-01 00:00:00

abstract：:This work reports the effects of phosphoserine addition on the biodegradability of calcium phosphate cements. The characteristics of a phosphoserine-modified calcium phosphate cement without collagen in a large animal model are presented here for the first time. Critical size bone defects in the proximal tibia of 10 s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Offer L,Veigel B,Pavlidis T,Heiss C,Gelinsky M,Reinstorf A,Wenisch S,Lips KS,Schnettler R

更新日期：2011-01-01 00:00:00

abstract：:Regenerative medicine aims to replace lost cells and to restore damaged tissues and organs by either tissue-engineering approaches or stimulation of endogenous processes. Due to their biological properties, stem cells promise to be an effective source for such strategies. Especially adult multipotent stem cells (ASCs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Reinke S,Dienelt A,Blankenstein A,Duda GN,Geissler S

更新日期：2016-01-01 00:00:00

abstract：:Bone marrow (BM) multipotent mesenchymal stromal cells (MSCs) present with multipotent differentiation potential and immunomodulatory properties. As an alternative to bone marrow, we have examined fetal membranes, amnion and chorion, of term human placenta as a potential source of multipotent MSCs. Here we show that a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Soncini M,Vertua E,Gibelli L,Zorzi F,Denegri M,Albertini A,Wengler GS,Parolini O

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:According to experimental studies, mesh implants may reduce in size up to 50.8% during their integration into soft tissues. This results in impaired mobility of the anterior abdominal wall and hernia recurrences, as well as affects patients' quality of life. Due to unsatisfactory radiographic contrast of pol...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shemyatovsky KA,Azimov RH,Alekhin AI,Kazantsev AA,Alekhin AA

更新日期：2020-05-01 00:00:00

abstract：:Rapid vascular remodelling of damaged dermal tissue is required to heal burn wounds. Thymosin β4 (Tβ4) is a growth factor that has been shown to promote angiogenesis and dermal wound repair. However, the underlying mechanisms based on Tβ4 function have not yet been fully investigated. In the present study, we investig...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kim S,Kwon J

更新日期：2017-04-01 00:00:00

abstract：:The ability to control facial skin physiology and appearance through the oral mucosa (transbuccally) is largely unexplored. Here, a hypothesis was tested that transbuccal delivery of fat tissue-supportive actives may trigger beneficial cosmetic responses at the level of the skin. First, the importance of the fat tissu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bojanowski K,Ma S,Applebaum R,Zhao H

更新日期：2020-08-01 00:00:00

abstract：:Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ three-dimensional (3D) printing is an exciting and innovative biofabrication technology that enables the surgeon to deliver tissue-engineering techniques at the time and location of need. We ha...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Di Bella C,Duchi S,O'Connell CD,Blanchard R,Augustine C,Yue Z,Thompson F,Richards C,Beirne S,Onofrillo C,Bauquier SH,Ryan SD,Pivonka P,Wallace GG,Choong PF

更新日期：2018-03-01 00:00:00

abstract：:Poly(ether imide) (PEI), which can be chemically functionalized with biologically active ligands, has emerged as a potential biomaterial for medical implants. Electrospun PEI scaffolds have shown advantageous properties, such as enhanced endothelial cell adherence, proliferation and low platelet adhesion in in vitro e...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haase T,Krost A,Sauter T,Kratz K,Peter J,Kamann S,Jung F,Lendlein A,Zohlnhöfer D,Rüder C

更新日期：2017-04-01 00:00:00

abstract：:Bone-patellar tendon-bone (BPTB) autografts are the gold standard for anterior cruciate ligament (ACL) reconstruction because the bony ends allow for superior healing and anchoring through bone-to-bone regeneration. However, the disadvantages of BPTB grafts include donor site morbidity and patellar rupture. In order t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chung EJ,Sugimoto MJ,Koh JL,Ameer GA

更新日期：2017-03-01 00:00:00

abstract：:Prudent choices of cell sources and biomaterials, as well as meticulous cultivation of the tissue microenvironment, are essential to improving outcomes of tissue engineering treatments. With the goal of providing a high-quality alternative for bone and cartilage tissue engineering, we investigated the capability of bo...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Baracho Trindade Hill A,Speri Alves AA,da Silva Nunes Barreto R,Fernandes Bressan F,Miglino MA,Mansano Garcia J

更新日期：2020-11-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) is used in 34-60% for osteoarthritic (OA) cartilage defects, although ACI is neither recommended nor designed for OA. Envisioning a hydrogel-based ACI for OA that uses chondrons instead of classically used chondrocytes, we hypothesized that human OA chondrons may outperform OA...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rothdiener M,Uynuk-Ool T,Südkamp N,Aurich M,Grodzinsky AJ,Kurz B,Rolauffs B

更新日期：2018-02-01 00:00:00

abstract：:Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwon DY,Park JH,Jang SH,Park JY,Jang JW,Min BH,Kim WD,Lee HB,Lee J,Kim MS

更新日期：2018-02-01 00:00:00

abstract：:In order to examine the differentiation potential of the tenocytes expanded in our defined culture medium (reported previously) and the effect of sequential combination of the two culture conditions on human tenocytes, a two-dimensional and three-dimensional experimental approach was used. Human tenocytes were sequent...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu Y,Wang X,Zhang Y,Carr AJ,Zhu L,Xia Z,Sabokbar A

更新日期：2016-03-01 00:00:00

abstract：:Previous researches have emphasized on suitability of decellularized tissues for regenerative applications. The decellularization of cartilage tissue has always been a challenge as the final product must be balanced in both immunogenic residue and mechanical properties. This study was designed to compare and optimize ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ghassemi T,Saghatoleslami N,Mahdavi-Shahri N,Matin MM,Gheshlaghi R,Moradi A

更新日期：2019-10-01 00:00:00

abstract：:The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents that...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rodrigues DB,Oliveira JM,Santos TC,Reis RL

更新日期：2018-03-01 00:00:00

abstract：:The objective of this study was to test the hypothesis that platelet-rich plasma (PRP) pretreatment on a poly-lactic-co-glycolic acid (PLGA) mesh scaffold enhances the healing capacity of the meniscus with human chondrocyte-seeded scaffolds in vivo, even when the seeded number of cells was reduced from 10 million to o...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwak HS,Nam J,Lee JH,Kim HJ,Yoo JJ

更新日期：2017-02-01 00:00:00