Human gingival mesenchymal stem cells pretreated with vesicular moringin nanostructures as a new therapeutic approach in a mouse model of spinal cord injury.

abstract：:The present study aimed to investigate the effect of structure (design and porosity) on the matrix stiffness and osteogenic activity of stem cells cultured on poly(ester-urethane) (PEU) scaffolds. Different three-dimensional (3D) forms of scaffold were prepared from lysine-based PEU using traditional salt-leaching and...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kiziltay A,Marcos-Fernandez A,San Roman J,Sousa RA,Reis RL,Hasirci V,Hasirci N

更新日期：2015-08-01 00:00:00

abstract：:Nucleus pulposus (NP) regeneration by the application of injectable cell-embedded hydrogels is an appealing approach for tissue engineering. We investigated a thermo-reversible hydrogel (TR-HG), based on a modified polysaccharide with a thermo-reversible polyamide [poly(N-isopropylacrylamide), pNIPAM], which is made t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Malonzo C,Chan SC,Kabiri A,Eglin D,Grad S,Bonél HM,Benneker LM,Gantenbein-Ritter B

更新日期：2015-12-01 00:00:00

abstract：:Many studies have highlighted the role of silicon in human bone formation and maintenance. Silicon, in fact, is considered to nucleate the precipitation of hydroxyapatite and to reduce the bone resorption. For this reason, we have combined silk fibroin (SF) with silicon-releasing diatom particles (DPs), as potential m...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Le TDH,Liaudanskaya V,Bonani W,Migliaresi C,Motta A

更新日期：2018-01-01 00:00:00

abstract：:Repairing the peripheral nerves following a segmental defect injury remains surgically challenging. Because of some disadvantages of nerve grafts, nerve regeneration, such as conduits combined with bone marrow-derived mesenchymal stem cells (BMSCs), may serve as an alternative. BMSCs expand under hypoxic conditions, d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Wang JP,Liao YT,Wu SH,Chiang ER,Hsu SH,Tseng TC,Hung SC

更新日期：2020-12-01 00:00:00

abstract：:The authors previously created HAp or CaCO(3) formed on or in agarose gels (HAp and CaCO(3) gels, respectively) as biocompatible and biodegradable bone graft materials. However, these gels have limitations for bone regeneration. Mesenchymal stromal cells (MSCs) have osteogenic potential and are considered useful for b...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Mizuta N,Hattori K,Suzawa Y,Iwai S,Matsumoto T,Tadokoro M,Nakano T,Akashi M,Ohgushi H,Yura Y

更新日期：2013-01-01 00:00:00

abstract：:Whole body vibration (WBV) is a very widespread mechanical stimulus used in physical therapy, rehabilitation and fitness centres. It has been demonstrated that vibration induces improvements in muscular strength and performance and increases bone density. We investigated the effects of low-amplitude, high frequency vi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ceccarelli G,Benedetti L,Galli D,Prè D,Silvani G,Crosetto N,Magenes G,Cusella De Angelis MG

更新日期：2014-05-01 00:00:00

abstract：:The development of a functional microvasculature is critical to the long-term survival of implanted tissue-engineered constructs. Dynamic culture conditions have been shown to significantly modulate phenotypic characteristics and stimulate proliferation of cells within hydrogel-based tissue engineered blood vessels. A...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gassman AA,Kuprys T,Ucuzian AA,Brey E,Matsumura A,Pang Y,Larson J,Greisler HP

更新日期：2011-05-01 00:00:00

abstract：:To create functional tissues having complex structures, bottom-up approaches to assembling small tissue modules into larger constructs have been emerging. Most of these approaches are based on chemical reactions or physical interactions at the interface between tissue modules. Here we report a biological assembly appr...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Riesberg JJ,Shen W

更新日期：2015-09-01 00:00:00

abstract：:Nanopatterned (330 nm wide channels) type I collagen films were prepared by solvent casting on poly(dimethyl siloxane) (PDMS) templates. These films were rolled into tubular constructs and crosslinked. Tubular constructs were incubated under cell culture conditions for 28 days and examined by stereomicroscopy and scan...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Zorlutuna P,Hasirci N,Hasirci V

更新日期：2008-08-01 00:00:00

abstract：:Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human somatic cells has proved to be one of the most potentially useful discoveries in regenerative medicine. iPSCs are becoming an invaluable tool to study the pathology of different diseases and for drug screening. However, severa...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Revilla A,González C,Iriondo A,Fernández B,Prieto C,Marín C,Liste I

更新日期：2016-11-01 00:00:00

abstract：:Nerve guides are currently being fabricated by blending a variety of biomaterials with different proteins. Adding proteins, which can support nerve repair and regeneration, optimizes the biological properties of a nerve guide. In our study we have blended glial cell line-derived nerve growth factor (GDNF) and laminin ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Patel M,Mao L,Wu B,Vandevord PJ

更新日期：2007-09-01 00:00:00

abstract：:Allogenic bone graft has been considered the gold standard in connection with bone graft material in revision joint arthroplasty. However, the lack of osteogenic potential and the risk of disease transmission are clinical challenges. The use of osteoinductive materials, such as demineralized bone matrix (DBM), alone o...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Babiker H,Ding M,Overgaard S

更新日期：2016-03-01 00:00:00

abstract：:The mechanism for stem cell-mediated improvement following acute myocardial infarction has been actively debated. We support hypotheses that the stem cell effect is primarily paracrine factor-linked. We used a heparin-presenting injectable nanofibre network to bind and deliver paracrine factors derived from hypoxic co...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Webber MJ,Han X,Murthy SN,Rajangam K,Stupp SI,Lomasney JW

更新日期：2010-12-01 00:00:00

abstract：:Damage of non-vascularised tissues such as cartilage and cornea can result in healing processes accompanied by a non-physiological angiogenesis. Peptidic aptamers have recently been reported to block the vascular endothelial growth factor (VEGF). However, the therapeutic applications of these aptamers are limited due ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Perugini V,Guildford AL,Silva-Correia J,Oliveira JM,Meikle ST,Reis RL,Santin M

更新日期：2018-02-01 00:00:00

abstract：:The objective was to improve proliferation and chondrogenic potential of adipose stem cells (ASCs) by expansion on extracellular matrix (ECM) deposited by either ASCs or synovium-derived stem cells (SDSCs). ASCs isolated from porcine infrapatellar fat pad were separately expanded on conventional plastic flasks, ASC-de...

journal_title：Journal of tissue engineering and regenerative medicine

authors： He F,Pei M

更新日期：2013-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been suggested as a potential cell source for tendon/ligament tissue engineering. Extrinsic cues, such as the chemical and physical properties of scaffolds, as well as external forces, play an important role in fibroblastic differentiation of these cells. In this study, we employed a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu Y,Lei J,Koob TJ,Temenoff JS

更新日期：2016-12-01 00:00:00

abstract：:Enhancement of osteogenic capacity was achieved in a mineralized collagen composite, nano-hydroxyapatite/collagen (nHAC), by loading with synthetic peptides derived from BMP-2 residues 32-48 (P17-BMP-2). Rabbit marrow stromal cells (MSCs) were used in vitro to study cell biocompatibility, attachment and differentiatio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Zhang X,Guo WG,Cui H,Liu HY,Zhang Y,Müller WE,Cui FZ

更新日期：2016-02-01 00:00:00

abstract：:The idea of rescuing the body self-repair capability lost during evolution is progressively gaining ground in regenerative medicine. In particular, growth factors and bioactive molecules derived from activated platelets emerged as promising therapeutic agents acting as trigger for repair of tissue lesions and restorat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Nguyen VT,Cancedda R,Descalzi F

更新日期：2018-03-01 00:00:00

abstract：:The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents that...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rodrigues DB,Oliveira JM,Santos TC,Reis RL

更新日期：2018-03-01 00:00:00

abstract：:Despite the high prevalence of skin conditions in the horse, there is a dearth of literature on the culture and biology of equine skin cells, and this is partially attributable to the lack of suitable in vitro skin models. The objective of this study was to develop a three-dimensional (3D) culture system that would su...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sharma R,Barakzai SZ,Taylor SE,Donadeu FX

更新日期：2016-08-01 00:00:00

abstract：:Poly(ether imide) (PEI), which can be chemically functionalized with biologically active ligands, has emerged as a potential biomaterial for medical implants. Electrospun PEI scaffolds have shown advantageous properties, such as enhanced endothelial cell adherence, proliferation and low platelet adhesion in in vitro e...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haase T,Krost A,Sauter T,Kratz K,Peter J,Kamann S,Jung F,Lendlein A,Zohlnhöfer D,Rüder C

更新日期：2017-04-01 00:00:00

abstract：:In this study human bone marrow stromal cells (hBMSCs) were cultured on three-dimensional porous scaffolds of biomimetically mineralized collagen type I developed for bone engineering. Three different cell numbers were used for seeding of the nanocomposites, and the impact of the seeding density on proliferation and o...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lode A,Bernhardt A,Gelinsky M

更新日期：2008-10-01 00:00:00

abstract：:A highly efficient cardiac differentiation from human pluripotent stem cells (hPSCs) is achievable using existing methods, especially with the standard B27 induction system. However, bovine serum albumin (BSA), one of the essential ingredients in B27, may pose significant complications for clinical studies owing to it...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan Y,Han P,Gu Q,Chen G,Wang L,Ma R,Wu J,Feng C,Zhang Y,Wang L,Hu B,Li W,Hao J,Zhou Q

更新日期：2018-01-01 00:00:00

abstract：:This work reports the effects of phosphoserine addition on the biodegradability of calcium phosphate cements. The characteristics of a phosphoserine-modified calcium phosphate cement without collagen in a large animal model are presented here for the first time. Critical size bone defects in the proximal tibia of 10 s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Offer L,Veigel B,Pavlidis T,Heiss C,Gelinsky M,Reinstorf A,Wenisch S,Lips KS,Schnettler R

更新日期：2011-01-01 00:00:00

abstract：:Postoperative mucosal regeneration of the middle ear cavity and the mastoid cavity is of great importance after middle ear surgery. However, the epithelialization of the mucosa in the middle ear is retarded because chronic inflammation without epithelialization aggravates gas exchange and clinical function. These envi...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hama T,Yamamoto K,Yaguchi Y,Murakami D,Sasaki H,Yamato M,Okano T,Kojima H

更新日期：2017-04-01 00:00:00

abstract：:Skin and oral mucosa substitutes are a therapeutic option for closing hard-to-heal skin and oral wounds. Our aim was to develop bi-layered skin and gingiva substitutes, from 3 mm diameter biopsies, cultured under identical conditions, which are compliant with current European regulations for advanced therapy medicinal...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Boink MA,Roffel S,Breetveld M,Thon M,Haasjes MSP,Waaijman T,Scheper RJ,Blok CS,Gibbs S

更新日期：2018-02-01 00:00:00

abstract：:Spatiotemporal changes in the extracellular matrix (ECM) were studied within abdominal aortic aneurysms (AAAs) generated in rats via elastase infusion. At 7, 14 and 21 days post-induction, AAA tissues were divided into proximal, mid- and distal regions, based on their location relative to the renal arteries and the re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Deb PP,Ramamurthi A

更新日期：2017-01-01 00:00:00

abstract：:Biomaterials and, especially, scaffolds may function as temporary extracellular matrix (ECM), mimicking in vivo environmental structures and facilitating cell growth and tissue regeneration. ECM is composed mostly of glycosaminoglycans (GAGs) and proteins, the ratio of GAGs, hyaluronic acid (HA):sulphated GAGs (sGAGs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Herrero-Mendez A,Palomares T,Castro B,Herrero J,Alonso-Varona A

更新日期：2016-12-01 00:00:00

abstract：:Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has been shown to ameliorate the injured central nervous system (CNS). Although these effects were initially attributed to the putative differentiation of MSCs towards the neural lineage, it is now known that most of them are mediated by the secretome. Up...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ribeiro CA,Salgado AJ,Fraga JS,Silva NA,Reis RL,Sousa N

更新日期：2011-08-01 00:00:00

abstract：:Aerosol-based cell therapy has emerged as a novel and promising therapeutic strategy for treating lung diseases. The goal of this study was to determine the safety and efficacy of aerosol-based airway epithelial cell (AEC) delivery in the setting of acute lung injury induced by tracheal brushing in rabbit. Twenty-four...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kardia E,Ch'ng ES,Yahaya BH

更新日期：2018-02-01 00:00:00