Enhancing human nucleus pulposus cells for biological treatment approaches of degenerative intervertebral disc diseases: a systematic review.

Abstract:

:Intervertebral disc (IVD) degeneration has been described as an aberrant, cell-mediated, age- and genetics-dependent molecular degeneration process, which can be accelerated by nutritional, mechanical and toxic factors. Collective involvement of these factors can result in structural failures, which are often associated with pain. Current treatment approaches are restricted to symptomatic therapies, not addressing options of restoring structural or biological deterioration of the IVD as the underlying problem. Therapeutic potentials of IVD cell transplantation, biomaterials, inhibiting or activating bioactive factors, including gene-therapeutic approaches, have been shown in vitro or in small animal models. Since human degenerative IVD cells display distinctive features with regard to cell biology and regenerative potential, we attempted a systematic review, investigating the in vitro response of human nucleus pulposus cells to different stimuli. Therefore, we conducted an electronic database search on Medline through July 2011 to identify, compare and discuss publications concerning the effects of cell-cell stimulation, bioactive factors, biomaterials and combinations thereof in terms of cell isolation, proliferation, differentiation and matrix protein synthesis. This survey and discussion might serve as a source for designing future biological treatment strategies for the human IVD.

journal_name

J Tissue Eng Regen Med

authors

Mern DS,Beierfuß A,Thomé C,Hegewald AA

doi

10.1002/term.1583

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

925-36

issue

12

eissn

1932-6254

issn

1932-7005

journal_volume

8

pub_type

杂志文章,评审
  • Review of vascularised bone tissue-engineering strategies with a focus on co-culture systems.

    abstract::Poor angiogenesis within tissue-engineered grafts has been identified as a main challenge limiting the clinical introduction of bone tissue-engineering (BTE) approaches for the repair of large bone defects. Thick BTE grafts often exhibit poor cellular viability particularly at the core, leading to graft failure and la...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章,评审

    doi:10.1002/term.1617

    authors: Liu Y,Chan JK,Teoh SH

    更新日期:2015-02-01 00:00:00

  • Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions.

    abstract::A highly efficient cardiac differentiation from human pluripotent stem cells (hPSCs) is achievable using existing methods, especially with the standard B27 induction system. However, bovine serum albumin (BSA), one of the essential ingredients in B27, may pose significant complications for clinical studies owing to it...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2381

    authors: Tan Y,Han P,Gu Q,Chen G,Wang L,Ma R,Wu J,Feng C,Zhang Y,Wang L,Hu B,Li W,Hao J,Zhou Q

    更新日期:2018-01-01 00:00:00

  • Autologous human nasal epithelial cell sheet using temperature-responsive culture insert for transplantation after middle ear surgery.

    abstract::Postoperative mucosal regeneration of the middle ear cavity and the mastoid cavity is of great importance after middle ear surgery. However, the epithelialization of the mucosa in the middle ear is retarded because chronic inflammation without epithelialization aggravates gas exchange and clinical function. These envi...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2012

    authors: Hama T,Yamamoto K,Yaguchi Y,Murakami D,Sasaki H,Yamato M,Okano T,Kojima H

    更新日期:2017-04-01 00:00:00

  • Characterizing differences between MSCs and TM cells: Toward autologous stem cell therapies for the glaucomatous trabecular meshwork.

    abstract::Glaucoma, a leading cause of blindness, is characterized by an increase in intraocular pressure, which is largely determined by resistance to aqueous humour outflow through the trabecular meshwork (TM). In glaucoma, the cellularity of the TM is decreased, and, as a result, stem cell therapies for the TM represent a po...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2488

    authors: Snider EJ,Vannatta RT,Schildmeyer L,Stamer WD,Ethier CR

    更新日期:2018-03-01 00:00:00

  • Nanopatterned collagen tubes for vascular tissue engineering.

    abstract::Nanopatterned (330 nm wide channels) type I collagen films were prepared by solvent casting on poly(dimethyl siloxane) (PDMS) templates. These films were rolled into tubular constructs and crosslinked. Tubular constructs were incubated under cell culture conditions for 28 days and examined by stereomicroscopy and scan...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.99

    authors: Zorlutuna P,Hasirci N,Hasirci V

    更新日期:2008-08-01 00:00:00

  • In vitro biocompatibility of 45S5 Bioglass-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate).

    abstract::The aim of this work was to study the in vitro biocompatibility of glass-ceramic scaffolds based on 45S5 Bioglass, using a human osteosarcoma cell line (HOS-TE85). The highly porous scaffolds were produced by the foam replication technique. Two different types of scaffolds with different porosities were analysed. They...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.150

    authors: Bretcanu O,Misra S,Roy I,Renghini C,Fiori F,Boccaccini AR,Salih V

    更新日期:2009-02-01 00:00:00

  • Mesenchymal stem cells from a hypoxic culture improve nerve regeneration.

    abstract::Repairing the peripheral nerves following a segmental defect injury remains surgically challenging. Because of some disadvantages of nerve grafts, nerve regeneration, such as conduits combined with bone marrow-derived mesenchymal stem cells (BMSCs), may serve as an alternative. BMSCs expand under hypoxic conditions, d...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.3136

    authors: Wang JP,Liao YT,Wu SH,Chiang ER,Hsu SH,Tseng TC,Hung SC

    更新日期:2020-12-01 00:00:00

  • Phosphoserine-modified calcium phosphate cements: bioresorption and substitution.

    abstract::This work reports the effects of phosphoserine addition on the biodegradability of calcium phosphate cements. The characteristics of a phosphoserine-modified calcium phosphate cement without collagen in a large animal model are presented here for the first time. Critical size bone defects in the proximal tibia of 10 s...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.283

    authors: Offer L,Veigel B,Pavlidis T,Heiss C,Gelinsky M,Reinstorf A,Wenisch S,Lips KS,Schnettler R

    更新日期:2011-01-01 00:00:00

  • Bone regeneration in minipigs via calcium phosphate cement scaffold delivering autologous bone marrow mesenchymal stem cells and platelet-rich plasma.

    abstract::Macroporous calcium phosphate cement (CPC) with stem cell seeding is promising for bone regeneration. The objective of this study was to investigate the effects of co-delivering autologous bone marrow mesenchymal stem cells (BMSCs) and autologous platelet-rich plasma (PRP) in CPC scaffold for bone regeneration in mini...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2416

    authors: Qiu G,Shi Z,Xu HHK,Yang B,Weir MD,Li G,Song Y,Wang J,Hu K,Wang P,Zhao L

    更新日期:2018-02-01 00:00:00

  • Delivering stem cells to the healthy heart on biological sutures: effects on regional mechanical function.

    abstract::Current cardiac cell therapies cannot effectively target and retain cells in a specific area of the heart. Cell-seeded biological sutures were previously developed to overcome this limitation, demonstrating targeted delivery with > 60% cell retention. In this study, both cell-seeded and non-seeded fibrin-based biologi...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.1904

    authors: Tao ZW,Favreau JT,Guyette JP,Hansen KJ,Lessard J,Burford E,Pins GD,Gaudette GR

    更新日期:2017-01-01 00:00:00

  • Benefits of concurrent delivery of hyaluronan and IGF-1 cues to regeneration of crosslinked elastin matrices by adult rat vascular cells.

    abstract::Elastin, a major component of vascular matrices, critically determines vascular mechanics and maintains the quiescence of smooth muscle cells (SMCs). Attempts to regenerate elastin in elastin-compromised blood vessels using tissue-engineering approaches is limited by the unavailability of elastogenic cues to upregulat...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.70

    authors: Kothapalli CR,Ramamurthi A

    更新日期:2008-03-01 00:00:00

  • Virus immobilization on biomaterial scaffolds through biotin-avidin interaction for improving bone regeneration.

    abstract::To spatially control therapeutic gene delivery for potential tissue engineering applications, a biotin-avidin interaction strategy was applied to immobilize viral vectors on biomaterial scaffolds. Both adenoviral vectors and gelatin sponges were biotinylated and avidin was applied to link them in a virus-biotin-avidin...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.1774

    authors: Hu WW,Wang Z,Krebsbach PH

    更新日期:2016-02-01 00:00:00

  • Bone regeneration by means of a three-dimensional printed scaffold in a rat cranial defect.

    abstract::Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were ...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2532

    authors: Kwon DY,Park JH,Jang SH,Park JY,Jang JW,Min BH,Kim WD,Lee HB,Lee J,Kim MS

    更新日期:2018-02-01 00:00:00

  • Cellular versus acellular matrix devices in the treatment of diabetic foot ulcers: Interim results of a comparative efficacy randomized controlled trial.

    abstract::Healing of diabetic foot ulcers is a major challenge. Despite adhering to optimal standard of care (SOC), less than 30% of wounds heal after 20 weeks. Advanced cellular tissue-based products have shown better healing over SOC, albeit with great cost and modest improvement. We hypothesized no difference in healing effe...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/term.2884

    authors: Tchanque-Fossuo CN,Dahle SE,Lev-Tov H,West KIM,Li CS,Rocke DM,Isseroff RR

    更新日期:2019-08-01 00:00:00

  • Local delivery of allogeneic bone marrow and adipose tissue-derived mesenchymal stromal cells for cutaneous wound healing in a porcine model.

    abstract::Wound healing remains a major challenge in modern medicine. Bone marrow- (BM) and adipose tissue- (AT) derived mesenchymal stromal/stem cells (MSCs) are of great interest for tissue reconstruction due to their unique immunological properties and regenerative potential. The purpose of this study was to characterize BM ...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.1700

    authors: Hanson SE,Kleinbeck KR,Cantu D,Kim J,Bentz ML,Faucher LD,Kao WJ,Hematti P

    更新日期:2016-02-01 00:00:00

  • Improving pulp revascularization outcomes with buccal fat autotransplantation.

    abstract::Several techniques have been introduced to improve the pulp revascularization outcomes. The use of the tissue graft can create more practical tissue regeneration, provide vascular supply, and enhance tissue healing. The aim of the present study was to investigate the histologic and molecular outcomes of pulp revascula...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.3094

    authors: Khazaei S,Khademi A,Torabinejad M,Nasr Esfahani MH,Khazaei M,Razavi SM

    更新日期:2020-09-01 00:00:00

  • Platelet lysate activates quiescent cell proliferation and reprogramming in human articular cartilage: Involvement of hypoxia inducible factor 1.

    abstract::The idea of rescuing the body self-repair capability lost during evolution is progressively gaining ground in regenerative medicine. In particular, growth factors and bioactive molecules derived from activated platelets emerged as promising therapeutic agents acting as trigger for repair of tissue lesions and restorat...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2595

    authors: Nguyen VT,Cancedda R,Descalzi F

    更新日期:2018-03-01 00:00:00

  • Oxygen diffusion through collagen scaffolds at defined densities: implications for cell survival in tissue models.

    abstract::For the success of any biomaterial for tissue engineering, its mechanical properties and ability to support nutrient diffusion will be critical. Collagen scaffolds are ideal candidates, due to their ability to immerse cells in a biomimetic nanofibrous matrix. We have established O(2) diffusion coefficients through nat...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.402

    authors: Cheema U,Rong Z,Kirresh O,Macrobert AJ,Vadgama P,Brown RA

    更新日期:2012-01-01 00:00:00

  • Kartogenin with PRP promotes the formation of fibrocartilage zone in the tendon-bone interface.

    abstract::Treatment of tendon-bone junction injuries is a challenge because tendon-bone interface often heals poorly and the fibrocartilage zone, which reduces stress concentration, at the interface is not formed. In this study, we used a compound called kartogenin (KGN) with platelet-rich plasma (PRP) to induce the formation o...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2258

    authors: Zhou Y,Zhang J,Yang J,Narava M,Zhao G,Yuan T,Wu H,Zheng N,Hogan MV,Wang JH

    更新日期:2017-12-01 00:00:00

  • Optimization of culture conditions for osteogenically-induced mesenchymal stem cells in β-tricalcium phosphate ceramics with large interconnected channels.

    abstract::The aim of this study was to optimize culture conditions for human mesenchymal stem cells (hMSCs) in β-tricalcium phosphate ceramics with large interconnected channels. Fully interconnected macrochannels comprising pore diameters of 750 µm and 1400 µm were inserted into microporous β-tricalcium phosphate (β-TCP) scaff...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.331

    authors: Bernhardt A,Lode A,Peters F,Gelinsky M

    更新日期:2011-06-01 00:00:00

  • Clinical-scale expansion of adipose-derived stromal cells starting from stromal vascular fraction in a single-use bioreactor: proof of concept for autologous applications.

    abstract::Adipose-derived stromal cells (ASCs) are adult multipotent cells increasingly used for cell therapy due to their differentiation potential, their paracrine effect and their convenience. ASCs are currently selected from stromal vascular fractions (SVFs) of adipose tissue and expanded in 2D flasks following good manufac...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2377

    authors: Gadelorge M,Bourdens M,Espagnolle N,Bardiaux C,Murrell J,Savary L,Ribaud S,Chaput B,Sensebé L

    更新日期:2018-01-01 00:00:00

  • Asymmetrical seeding of MSCs into fibrin-poly(ester-urethane) scaffolds and its effect on mechanically induced chondrogenesis.

    abstract::Mesenchymal stem cells (MSCs) are currently being investigated as candidate cells for regenerative medicine approaches for the repair of damaged articular cartilage. For these cells to be used clinically, it is important to understand how they will react to the complex loading environment of a joint in vivo. In additi...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2194

    authors: Gardner OFW,Musumeci G,Neumann AJ,Eglin D,Archer CW,Alini M,Stoddart MJ

    更新日期:2017-10-01 00:00:00

  • Platelet-rich plasma activates tendon-derived stem cells to promote regeneration of Achilles tendon rupture in rats.

    abstract::This study investigates whether platelet-rich plasma (PRP) is an activator of tendon-derived stem cells (TDSCs) to promote regeneration of Achilles tendon post-rupture in rats. In the in vitro study, PRGF (activated PRP) significantly enhanced cell DNA synthesis, improved viability and promoted proliferation, while fa...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2020

    authors: Xu K,Al-Ani MK,Sun Y,Xu W,Pan L,Song Y,Xu Z,Pan X,Yang L

    更新日期:2017-04-01 00:00:00

  • Posterior talar process as a suitable cell source for treatment of cartilage and osteochondral defects of the talus.

    abstract::Osteochondral defects of the ankle are common lesions affecting the talar cartilage and subchondral bone. Current treatments include cell-based therapies but are frequently associated with donor-site morbidity. Our objective is to characterize the posterior process of the talus (SP) and the os trigonum (OT) tissues an...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2092

    authors: Correia SI,Silva-Correia J,Pereira H,Canadas RF,da Silva Morais A,Frias AM,Sousa RA,van Dijk CN,Espregueira-Mendes J,Reis RL,Oliveira JM

    更新日期:2017-07-01 00:00:00

  • Fetal subcutaneous cells have potential for autologous tissue engineering.

    abstract::Major congenital malformations affect up to 3% of newborns. Infants with prenatally diagnosed soft tissue defects should benefit from having autologous tissue readily available for surgical implantation in the perinatal period. In this study, we investigate fetal subcutaneous cells as cellular source for tissue engine...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2639

    authors: Ekblad Å,Westgren M,Fossum M,Götherström C

    更新日期:2018-05-01 00:00:00

  • Cultivation of human bone marrow stromal cells on three-dimensional scaffolds of mineralized collagen: influence of seeding density on colonization, proliferation and osteogenic differentiation.

    abstract::In this study human bone marrow stromal cells (hBMSCs) were cultured on three-dimensional porous scaffolds of biomimetically mineralized collagen type I developed for bone engineering. Three different cell numbers were used for seeding of the nanocomposites, and the impact of the seeding density on proliferation and o...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.110

    authors: Lode A,Bernhardt A,Gelinsky M

    更新日期:2008-10-01 00:00:00

  • Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner.

    abstract::The effects of mesenchymal stem cells (MSCs) on the phenotype and function of natural killer T (NKT) cells is not understood. We used concanavalin A (Con A) and α-galactosylceramide (α-GalCer)-induced liver injury to evaluate the effects of MSCs on NKT-dependent hepatotoxicity. Mouse MSCs (mMSCs) significantly reduced...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.2452

    authors: Gazdic M,Simovic Markovic B,Vucicevic L,Nikolic T,Djonov V,Arsenijevic N,Trajkovic V,Lukic ML,Volarevic V

    更新日期:2018-02-01 00:00:00

  • Biofabrication of a PLGA-TCP-based porous bioactive bone substitute with sustained release of icaritin.

    abstract::A phytomolecule, icaritin, has been identified and shown to be osteopromotive for the prevention of osteoporosis and osteonecrosis. This study aimed to produce a bioactive poly (l-lactide-co-glycolide)-tricalcium phosphate (PLGA-TCP)-based porous scaffold incorporating the osteopromotive phytomolecule icaritin, using ...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.1679

    authors: Xie XH,Wang XL,Zhang G,He YX,Leng Y,Tang TT,Pan X,Qin L

    更新日期:2015-08-01 00:00:00

  • Boron nitride nanotube-functionalised myoblast/microfibre constructs: a nanotech-assisted tissue-engineered platform for muscle stimulation.

    abstract::In this communication, we introduce boron nitride nanotube (BNNT)-functionalised muscle cell/microfibre mesh constructs, obtained via tissue engineering, as a three-dimensional (3D) platform to study a wireless stimulation system for electrically responsive cells and tissues. Our stimulation strategy exploits the piez...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.1878

    authors: Danti S,Ciofani G,Pertici G,Moscato S,D'Alessandro D,Ciabatti E,Chiellini F,D'Acunto M,Mattoli V,Berrettini S

    更新日期:2015-07-01 00:00:00

  • Three-dimensional 10% cyclic strain reduces bovine aortic endothelial cell angiogenic sprout length and augments tubulogenesis in tubular fibrin hydrogels.

    abstract::The development of a functional microvasculature is critical to the long-term survival of implanted tissue-engineered constructs. Dynamic culture conditions have been shown to significantly modulate phenotypic characteristics and stimulate proliferation of cells within hydrogel-based tissue engineered blood vessels. A...

    journal_title:Journal of tissue engineering and regenerative medicine

    pub_type: 杂志文章

    doi:10.1002/term.323

    authors: Gassman AA,Kuprys T,Ucuzian AA,Brey E,Matsumura A,Pang Y,Larson J,Greisler HP

    更新日期:2011-05-01 00:00:00