Platelet-rich plasma activates tendon-derived stem cells to promote regeneration of Achilles tendon rupture in rats.

abstract：BACKGROUND:According to experimental studies, mesh implants may reduce in size up to 50.8% during their integration into soft tissues. This results in impaired mobility of the anterior abdominal wall and hernia recurrences, as well as affects patients' quality of life. Due to unsatisfactory radiographic contrast of pol...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Shemyatovsky KA,Azimov RH,Alekhin AI,Kazantsev AA,Alekhin AA

更新日期：2020-05-01 00:00:00

abstract：:The combination of scaffolds and mesenchymal stromal cells (MSCs) is a promising approach in bone tissue engineering (BTE). Knowledge on the survival, outgrowth and bone-forming capacity of MSCs in vivo is limited. Bioluminescence imaging (BLI), histomorphometry and immunohistochemistry were combined to study the fate...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Prins HJ,Fernandes H,Rozemuller H,van Blitterswijk C,de Boer J,Martens AC

更新日期：2016-03-01 00:00:00

abstract：:Wound healing remains a major challenge in modern medicine. Bone marrow- (BM) and adipose tissue- (AT) derived mesenchymal stromal/stem cells (MSCs) are of great interest for tissue reconstruction due to their unique immunological properties and regenerative potential. The purpose of this study was to characterize BM ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Hanson SE,Kleinbeck KR,Cantu D,Kim J,Bentz ML,Faucher LD,Kao WJ,Hematti P

更新日期：2016-02-01 00:00:00

abstract：:Nerve guides are currently being fabricated by blending a variety of biomaterials with different proteins. Adding proteins, which can support nerve repair and regeneration, optimizes the biological properties of a nerve guide. In our study we have blended glial cell line-derived nerve growth factor (GDNF) and laminin ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Patel M,Mao L,Wu B,Vandevord PJ

更新日期：2007-09-01 00:00:00

abstract：:Lubricin, homologous to superficial zone protein (SZP), functions as a boundary lubricant in articular cartilage and plays an essential role in the maintenance of joint function and homeostasis. Wnt signalling plays a key role in joint development, including synovial joint formation, and several Wnt proteins are expre...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Inui A,Iwakura T,Hari Reddi A

更新日期：2016-02-01 00:00:00

abstract：:A highly efficient cardiac differentiation from human pluripotent stem cells (hPSCs) is achievable using existing methods, especially with the standard B27 induction system. However, bovine serum albumin (BSA), one of the essential ingredients in B27, may pose significant complications for clinical studies owing to it...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tan Y,Han P,Gu Q,Chen G,Wang L,Ma R,Wu J,Feng C,Zhang Y,Wang L,Hu B,Li W,Hao J,Zhou Q

更新日期：2018-01-01 00:00:00

abstract：:Electrospinning has recently gained widespread attention as a process capable of producing nanoscale fibres that mimic native extracellular matrix. In this study, we compared the osteogenic differentiation behaviour of human adipose stem cells (ASCs) on a 3D nanofibre matrix of type I rat tail collagen (RTC) and a 2D ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Sefcik LS,Neal RA,Kaszuba SN,Parker AM,Katz AJ,Ogle RC,Botchwey EA

更新日期：2008-06-01 00:00:00

abstract：:Previous researches have emphasized on suitability of decellularized tissues for regenerative applications. The decellularization of cartilage tissue has always been a challenge as the final product must be balanced in both immunogenic residue and mechanical properties. This study was designed to compare and optimize ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ghassemi T,Saghatoleslami N,Mahdavi-Shahri N,Matin MM,Gheshlaghi R,Moradi A

更新日期：2019-10-01 00:00:00

abstract：:Rapid vascular remodelling of damaged dermal tissue is required to heal burn wounds. Thymosin β4 (Tβ4) is a growth factor that has been shown to promote angiogenesis and dermal wound repair. However, the underlying mechanisms based on Tβ4 function have not yet been fully investigated. In the present study, we investig...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kim S,Kwon J

更新日期：2017-04-01 00:00:00

abstract：:Aerosol-based cell therapy has emerged as a novel and promising therapeutic strategy for treating lung diseases. The goal of this study was to determine the safety and efficacy of aerosol-based airway epithelial cell (AEC) delivery in the setting of acute lung injury induced by tracheal brushing in rabbit. Twenty-four...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kardia E,Ch'ng ES,Yahaya BH

更新日期：2018-02-01 00:00:00

abstract：:Bone-patellar tendon-bone (BPTB) autografts are the gold standard for anterior cruciate ligament (ACL) reconstruction because the bony ends allow for superior healing and anchoring through bone-to-bone regeneration. However, the disadvantages of BPTB grafts include donor site morbidity and patellar rupture. In order t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chung EJ,Sugimoto MJ,Koh JL,Ameer GA

更新日期：2017-03-01 00:00:00

abstract：:Many types of cells respond to applied direct current electric fields (dcEFs) by directional cell migration, a phenomenon called galvanotaxis or electrotaxis. In this study, electrotaxis was used to control cell migration. We designed a new electrotaxis incubator and chamber system to facilitate long-term (> 12 h) obs...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kim MS,Lee MH,Kwon BJ,Seo HJ,Koo MA,You KE,Kim D,Park JC

更新日期：2017-03-01 00:00:00

abstract：:Nonunion treatment has a high rate of success, although recalcitrant nonunion may determine the need for amputation. Therefore, new treatment options are continuously investigated in order to further reduce the risk of nonunion recurrence. This study aimed to (a) develop a new large animal model for bone atrophic nonu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dozza B,Salamanna F,Baleani M,Giavaresi G,Parrilli A,Zani L,Lucarelli E,Martini L,Fini M,Donati DM

更新日期：2018-09-01 00:00:00

abstract：:There has been increased interest in co-cultures of stem cells and chondrocytes for cartilage tissue engineering as there are the limitations associated with using either cell type alone. Drawbacks associated with the use of chondrocytes include the limited numbers of cells available for isolation from damaged or dise...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Critchley SE,Eswaramoorthy R,Kelly DJ

更新日期：2018-04-01 00:00:00

abstract：:Many studies have highlighted the role of silicon in human bone formation and maintenance. Silicon, in fact, is considered to nucleate the precipitation of hydroxyapatite and to reduce the bone resorption. For this reason, we have combined silk fibroin (SF) with silicon-releasing diatom particles (DPs), as potential m...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Le TDH,Liaudanskaya V,Bonani W,Migliaresi C,Motta A

更新日期：2018-01-01 00:00:00

abstract：:The osteo-regenerative properties of allograft have recently been enhanced by addition of autogenous human bone marrow stromal cells (HBMSCs). Limitations in the use of allograft have prompted the investigation of tantalum trabecular metal (TTM) as a potential alternative. TTM is already in widespread orthopaedic use,...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Smith JO,Sengers BG,Aarvold A,Tayton ER,Dunlop DG,Oreffo RO

更新日期：2014-04-01 00:00:00

abstract：:Clinical translation of engineered tissues into regenerative medicine applications, and the effort to reduce the use of animals for the screening of drugs and other compounds, result in an increasing demand for human tissues engineered in vitro for implantation, in vitro screening systems and basic research. Further d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rouwkema J,Gibbs S,Lutolf MP,Martin I,Vunjak-Novakovic G,Malda J

更新日期：2011-08-01 00:00:00

abstract：:Cranioplasty is necessary for patients that have undergone craniectomy following trauma, stroke or other causes of elevated intracranial pressure. This study assessed the effectiveness of treating cranial defects with allogeneic mesenchymal stromal cells (MSC) on a ceramic carrier and polymer scaffold, to produce viab...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Morrison DA,Kop AM,Nilasaroya A,Sturm M,Shaw K,Honeybul S

更新日期：2018-02-01 00:00:00

abstract：:The aim of this work was to study the in vitro biocompatibility of glass-ceramic scaffolds based on 45S5 Bioglass, using a human osteosarcoma cell line (HOS-TE85). The highly porous scaffolds were produced by the foam replication technique. Two different types of scaffolds with different porosities were analysed. They...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bretcanu O,Misra S,Roy I,Renghini C,Fiori F,Boccaccini AR,Salih V

更新日期：2009-02-01 00:00:00

abstract：:The purpose of this study was to develop freeze-dried chitosan formulations that can be solubilized in platelet-rich plasma (PRP) to form injectable implants for tissue repair. A systematic approach to adjust formulation parameters, including chitosan number average molar mass (Mn ), chitosan concentration and lyoprot...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Chevrier A,Darras V,Picard G,Nelea M,Veilleux D,Lavertu M,Hoemann CD,Buschman MD

更新日期：2018-01-01 00:00:00

abstract：:Biomaterials and, especially, scaffolds may function as temporary extracellular matrix (ECM), mimicking in vivo environmental structures and facilitating cell growth and tissue regeneration. ECM is composed mostly of glycosaminoglycans (GAGs) and proteins, the ratio of GAGs, hyaluronic acid (HA):sulphated GAGs (sGAGs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Herrero-Mendez A,Palomares T,Castro B,Herrero J,Alonso-Varona A

更新日期：2016-12-01 00:00:00

abstract：:Anti-inflammatory gene therapy can inhibit inflammation driven by TNFalpha in experimental models of rheumatoid arthritis. However, assessment of the therapeutic effect on cartilage and bone quality is either missing or unsatisfactory. A multimodal imaging approach, using confocal laser scanning microscopy (CLSM) and ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Stok KS,Noël D,Apparailly F,Gould D,Chernajovsky Y,Jorgensen C,Müller R

更新日期：2010-07-01 00:00:00

abstract：:The idea of rescuing the body self-repair capability lost during evolution is progressively gaining ground in regenerative medicine. In particular, growth factors and bioactive molecules derived from activated platelets emerged as promising therapeutic agents acting as trigger for repair of tissue lesions and restorat...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Nguyen VT,Cancedda R,Descalzi F

更新日期：2018-03-01 00:00:00

abstract：:Current approaches for precision deposition of cells are not optimized for moist environments or for substrates with complex surface topographic features, for example, the surface of dermal matrices and other biomaterials. To overcome these challenges, an approach is presented that utilizes cell confinement in phase-s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Agarwal R,Liu G,Tam NW,Gratzer PF,Frampton JP

更新日期：2019-06-01 00:00:00

abstract：:The goal of this study was to evaluate human epiphyseal chondroprogenitor cells (ECPs) as a potential new cell source for cartilage regeneration. ECPs were compared to human bone marrow stromal cells (MSCs) and human adult articular chondrocytes (ACs) for their chondrogenic potential and phenotypic stability in vitro ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Studer D,Cavalli E,Formica FA,Kuhn GA,Salzmann G,Mumme M,Steinwachs MR,Laurent-Applegate LA,Maniura-Weber K,Zenobi-Wong M

更新日期：2017-11-01 00:00:00

abstract：:Damage of non-vascularised tissues such as cartilage and cornea can result in healing processes accompanied by a non-physiological angiogenesis. Peptidic aptamers have recently been reported to block the vascular endothelial growth factor (VEGF). However, the therapeutic applications of these aptamers are limited due ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Perugini V,Guildford AL,Silva-Correia J,Oliveira JM,Meikle ST,Reis RL,Santin M

更新日期：2018-02-01 00:00:00

abstract：:Tissue engineered tracheae have been successfully implanted to treat a small number of patients on compassionate grounds. The treatment has not become mainstream due to the time taken to produce the scaffold and the resultant financial costs. We have developed a method for decellularization (DC) based on vacuum techno...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lange P,Greco K,Partington L,Carvalho C,Oliani S,Birchall MA,Sibbons PD,Lowdell MW,Ansari T

更新日期：2017-03-01 00:00:00

abstract：:Nucleus pulposus (NP) regeneration by the application of injectable cell-embedded hydrogels is an appealing approach for tissue engineering. We investigated a thermo-reversible hydrogel (TR-HG), based on a modified polysaccharide with a thermo-reversible polyamide [poly(N-isopropylacrylamide), pNIPAM], which is made t...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Malonzo C,Chan SC,Kabiri A,Eglin D,Grad S,Bonél HM,Benneker LM,Gantenbein-Ritter B

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study was to optimize culture conditions for human mesenchymal stem cells (hMSCs) in β-tricalcium phosphate ceramics with large interconnected channels. Fully interconnected macrochannels comprising pore diameters of 750 µm and 1400 µm were inserted into microporous β-tricalcium phosphate (β-TCP) scaff...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bernhardt A,Lode A,Peters F,Gelinsky M

更新日期：2011-06-01 00:00:00

abstract：:Limitations of current treatments for intervertebral disc (IVD) degeneration have promoted interest in the development of tissue-engineering approaches. Injectable hydrogels loaded with cells can be used as a substitute material for the inner IVD part, the nucleus pulposus (NP), and provide an opportunity for minimall...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tsaryk R,Silva-Correia J,Oliveira JM,Unger RE,Landes C,Brochhausen C,Ghanaati S,Reis RL,Kirkpatrick CJ

更新日期：2017-03-01 00:00:00