Composite clinoptilolite/PCL-PEG-PCL scaffolds for bone regeneration: In vitro and in vivo evaluation.

abstract：:In this study, a simple three-dimensional (3D) suspension culture method for the expansion and cardiac differentiation of human induced pluripotent stem cells (hiPSCs) is reported. The culture methods were easily adapted from two-dimensional (2D) to 3D culture without any additional manipulations. When hiPSCs were dir...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Haraguchi Y,Matsuura K,Shimizu T,Yamato M,Okano T

更新日期：2015-12-01 00:00:00

abstract：:The aim of this work was to study the in vitro biocompatibility of glass-ceramic scaffolds based on 45S5 Bioglass, using a human osteosarcoma cell line (HOS-TE85). The highly porous scaffolds were produced by the foam replication technique. Two different types of scaffolds with different porosities were analysed. They...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bretcanu O,Misra S,Roy I,Renghini C,Fiori F,Boccaccini AR,Salih V

更新日期：2009-02-01 00:00:00

abstract：:The mechanism for stem cell-mediated improvement following acute myocardial infarction has been actively debated. We support hypotheses that the stem cell effect is primarily paracrine factor-linked. We used a heparin-presenting injectable nanofibre network to bind and deliver paracrine factors derived from hypoxic co...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Webber MJ,Han X,Murthy SN,Rajangam K,Stupp SI,Lomasney JW

更新日期：2010-12-01 00:00:00

abstract：:Surface-modified titanium (Ti) samples with hydroxyapatite (HAp) and heparin (Hep)-bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared, and their efficacies on the enhancements of bone formation and osseointegration in vitro and in vivo were examined as compared to Ti/HAp and Ti/Hep/BMP-2. Th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Yang DH,Lee DW,Kwon YD,Kim HJ,Chun HJ,Jang JW,Khang G

更新日期：2015-09-01 00:00:00

abstract：:Aerosol-based cell therapy has emerged as a novel and promising therapeutic strategy for treating lung diseases. The goal of this study was to determine the safety and efficacy of aerosol-based airway epithelial cell (AEC) delivery in the setting of acute lung injury induced by tracheal brushing in rabbit. Twenty-four...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kardia E,Ch'ng ES,Yahaya BH

更新日期：2018-02-01 00:00:00

abstract：:Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely efficient for economic viability given a relatively low value product and high (2 × 1012 ) cell dose. Therefore, the aim of these studies was to define the produc...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bayley R,Ahmed F,Glen K,McCall M,Stacey A,Thomas R

更新日期：2018-01-01 00:00:00

abstract：:Previous researches have emphasized on suitability of decellularized tissues for regenerative applications. The decellularization of cartilage tissue has always been a challenge as the final product must be balanced in both immunogenic residue and mechanical properties. This study was designed to compare and optimize ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ghassemi T,Saghatoleslami N,Mahdavi-Shahri N,Matin MM,Gheshlaghi R,Moradi A

更新日期：2019-10-01 00:00:00

abstract：:Damage of non-vascularised tissues such as cartilage and cornea can result in healing processes accompanied by a non-physiological angiogenesis. Peptidic aptamers have recently been reported to block the vascular endothelial growth factor (VEGF). However, the therapeutic applications of these aptamers are limited due ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Perugini V,Guildford AL,Silva-Correia J,Oliveira JM,Meikle ST,Reis RL,Santin M

更新日期：2018-02-01 00:00:00

abstract：:In clinical cases, many orthopaedists have been troubled with bone fragility, such as fractures after devitalization therapy for bone tumour, pathological fractures and metastatic tumours. The aim of this study was to determine whether loss of osteogenic capacity of devitalized autologous bones can be rescued using cu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tohma Y,Ohgushi H,Morishita T,Dohi Y,Tadokoro M,Tanaka Y,Takakura Y

更新日期：2008-01-01 00:00:00

abstract：:This work reports the effects of phosphoserine addition on the biodegradability of calcium phosphate cements. The characteristics of a phosphoserine-modified calcium phosphate cement without collagen in a large animal model are presented here for the first time. Critical size bone defects in the proximal tibia of 10 s...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Offer L,Veigel B,Pavlidis T,Heiss C,Gelinsky M,Reinstorf A,Wenisch S,Lips KS,Schnettler R

更新日期：2011-01-01 00:00:00

abstract：:Massive bone defects are a challenge in orthopaedic research. Defective regeneration leads to bone atrophy, non-union of bone, and physical morbidity. Large animals are important models, however, production costs are high, nursing is complex, and evaluation methods are limited. A suitable laboratory animal model is re...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Jiang H,Cheng P,Li D,Li J,Wang J,Gao Y,Zhang S,Cao T,Wang C,Yang L,Pei G

更新日期：2018-04-01 00:00:00

abstract：:Nonunion treatment has a high rate of success, although recalcitrant nonunion may determine the need for amputation. Therefore, new treatment options are continuously investigated in order to further reduce the risk of nonunion recurrence. This study aimed to (a) develop a new large animal model for bone atrophic nonu...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Dozza B,Salamanna F,Baleani M,Giavaresi G,Parrilli A,Zani L,Lucarelli E,Martini L,Fini M,Donati DM

更新日期：2018-09-01 00:00:00

abstract：:Biomaterials capable of controlling the release of multiple growth factors (GFs) could potentially promote the integration of co-transplanted neural progenitor cells (NPCs) and stimulate the plasticity and regenerability of the lesioned spinal cord. As a first step towards the employment of such a vehicle for cell the...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Cizkova D,Slovinska L,Grulova I,Salzet M,Cikos S,Kryukov O,Cohen S

更新日期：2015-08-01 00:00:00

abstract：:Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions. However, a dearth of available donor organs for transplantation leads to the death of numerous patients waiting for a suitable organ donor. The potential of decellularized scaffolds, derived from native tissues or organs in th...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rana D,Zreiqat H,Benkirane-Jessel N,Ramakrishna S,Ramalingam M

更新日期：2017-04-01 00:00:00

abstract：:In order to examine the differentiation potential of the tenocytes expanded in our defined culture medium (reported previously) and the effect of sequential combination of the two culture conditions on human tenocytes, a two-dimensional and three-dimensional experimental approach was used. Human tenocytes were sequent...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Qiu Y,Wang X,Zhang Y,Carr AJ,Zhu L,Xia Z,Sabokbar A

更新日期：2016-03-01 00:00:00

abstract：:Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Kwon DY,Park JH,Jang SH,Park JY,Jang JW,Min BH,Kim WD,Lee HB,Lee J,Kim MS

更新日期：2018-02-01 00:00:00

abstract：:The objective of this preliminary study was to evaluate the applying of chitosan (CS)-based microparticles (MPs) in bone regeneration in vivo. The CS MPs were fabricated using our scale-up method, as previously described. Mesenchymal stem cells (MSC) were harvested from the femora and tibiae of Dark Agouti (DA) rats a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Bhat A,Dreifke MB,Kandimalla Y,Gomez C,Ebraheim NA,Jayasuriya AC

更新日期：2010-10-01 00:00:00

abstract：:Biomaterials and, especially, scaffolds may function as temporary extracellular matrix (ECM), mimicking in vivo environmental structures and facilitating cell growth and tissue regeneration. ECM is composed mostly of glycosaminoglycans (GAGs) and proteins, the ratio of GAGs, hyaluronic acid (HA):sulphated GAGs (sGAGs)...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Herrero-Mendez A,Palomares T,Castro B,Herrero J,Alonso-Varona A

更新日期：2016-12-01 00:00:00

abstract：:Limitations of current treatments for intervertebral disc (IVD) degeneration have promoted interest in the development of tissue-engineering approaches. Injectable hydrogels loaded with cells can be used as a substitute material for the inner IVD part, the nucleus pulposus (NP), and provide an opportunity for minimall...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Tsaryk R,Silva-Correia J,Oliveira JM,Unger RE,Landes C,Brochhausen C,Ghanaati S,Reis RL,Kirkpatrick CJ

更新日期：2017-03-01 00:00:00

abstract：:A phytomolecule, icaritin, has been identified and shown to be osteopromotive for the prevention of osteoporosis and osteonecrosis. This study aimed to produce a bioactive poly (l-lactide-co-glycolide)-tricalcium phosphate (PLGA-TCP)-based porous scaffold incorporating the osteopromotive phytomolecule icaritin, using ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Xie XH,Wang XL,Zhang G,He YX,Leng Y,Tang TT,Pan X,Qin L

更新日期：2015-08-01 00:00:00

abstract：:Nerve guides are currently being fabricated by blending a variety of biomaterials with different proteins. Adding proteins, which can support nerve repair and regeneration, optimizes the biological properties of a nerve guide. In our study we have blended glial cell line-derived nerve growth factor (GDNF) and laminin ...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Patel M,Mao L,Wu B,Vandevord PJ

更新日期：2007-09-01 00:00:00

abstract：:Clinical translation of engineered tissues into regenerative medicine applications, and the effort to reduce the use of animals for the screening of drugs and other compounds, result in an increasing demand for human tissues engineered in vitro for implantation, in vitro screening systems and basic research. Further d...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Rouwkema J,Gibbs S,Lutolf MP,Martin I,Vunjak-Novakovic G,Malda J

更新日期：2011-08-01 00:00:00

abstract：:The development of a functional microvasculature is critical to the long-term survival of implanted tissue-engineered constructs. Dynamic culture conditions have been shown to significantly modulate phenotypic characteristics and stimulate proliferation of cells within hydrogel-based tissue engineered blood vessels. A...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Gassman AA,Kuprys T,Ucuzian AA,Brey E,Matsumura A,Pang Y,Larson J,Greisler HP

更新日期：2011-05-01 00:00:00

abstract：:There is a need for new materials and architectures for tissue engineering and regenerative medicine. Based upon our recent results developing novel scaffold architecture, we hypothesized that this new architecture would foster vascularization, a particular need for tissue engineering. We report on the potential of su...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Keskar V,Gandhi M,Gemeinhart EJ,Gemeinhart RA

更新日期：2009-08-01 00:00:00

abstract：:Cardiac stem cells (CSCs) represent a logical cell type to exploit as a regenerative treatment option for tissue damage accrued as a result of a myocardial infarction. However, the isolation and expansion of CSCs prior to cell transplantation is time consuming, costly and invasive, and the reliability of cell expansio...

journal_title：Journal of tissue engineering and regenerative medicine

authors： O'Neill HS,O'Sullivan J,Porteous N,Ruiz-Hernandez E,Kelly HM,O'Brien FJ,Duffy GP

更新日期：2018-01-01 00:00:00

abstract：:Chronic proteolytic disruption of elastic fibres within the abdominal aortic wall results in wall vessel expansion to form rupture-prone abdominal aortic aneurysms (AAA). Arresting AAA growth is not possible as adult vascular smooth muscle cells (SMCs) poorly auto-regenerate and repair elastic fibres. Thus, there is a...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Swaminathan G,Stoilov I,Broekelmann T,Mecham R,Ramamurthi A

更新日期：2018-01-01 00:00:00

abstract：:Lubricin, homologous to superficial zone protein (SZP), functions as a boundary lubricant in articular cartilage and plays an essential role in the maintenance of joint function and homeostasis. Wnt signalling plays a key role in joint development, including synovial joint formation, and several Wnt proteins are expre...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Inui A,Iwakura T,Hari Reddi A

更新日期：2016-02-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) transplantation enhances functional recovery after cerebral infarct, but the optimal delivery route is undetermined. This study was aimed to assess whether a novel cell-sheet technology non-invasively serves therapeutic benefits to ischemic stroke. First, the monolayered cell sheet was...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ito M,Shichinohe H,Houkin K,Kuroda S

更新日期：2017-02-01 00:00:00

abstract：:Major congenital malformations affect up to 3% of newborns. Infants with prenatally diagnosed soft tissue defects should benefit from having autologous tissue readily available for surgical implantation in the perinatal period. In this study, we investigate fetal subcutaneous cells as cellular source for tissue engine...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Ekblad Å,Westgren M,Fossum M,Götherström C

更新日期：2018-05-01 00:00:00

abstract：:Tissue engineered tracheae have been successfully implanted to treat a small number of patients on compassionate grounds. The treatment has not become mainstream due to the time taken to produce the scaffold and the resultant financial costs. We have developed a method for decellularization (DC) based on vacuum techno...

journal_title：Journal of tissue engineering and regenerative medicine

authors： Lange P,Greco K,Partington L,Carvalho C,Oliani S,Birchall MA,Sibbons PD,Lowdell MW,Ansari T

更新日期：2017-03-01 00:00:00