Analytical description of dose profile behaviour in Gamma Knife radiosurgery.

Abstract:

:Stereotactic Gamma Knife radiosurgery utilizes ionizing beams from (60)Co sources and relies on a combination of collimator sizes, weighting, etc to generate a high-dose region that is conformal with a designated target volume. Dose computation is typically performed by computer, but in this paper, single collimator dose profile behaviour is modelled analytically and then extended to accommodate multiple collimators of different weights with co-located isocentres. The dose profile from a single helmet is derived from a top-hat beam profile approximation and an idealized symmetric distribution of sources is used to represent the 201 sources within a collimating helmet. The results from the analysis are validated by an independent numerical model and also compared with those obtained by other groups using numerical and experimental methods. With respect to multiple collimators, the relationship between the size (full width half maximum) of the irradiated volume and relative collimator weighting is also examined using the simple analytical model. The simplicity of the mathematics clarifies the relationship between beam profile, dose profile and multiple collimator behaviour, and provides data that compare favourably with published literature.

journal_name

Phys Med Biol

authors

Fenner J,Gwilliam M,Mehrem R,Bird A,Walton L

doi

10.1088/0031-9155/53/8/003

subject

Has Abstract

pub_date

2008-04-21 00:00:00

pages

2035-49

issue

8

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(08)64292-X

journal_volume

53

pub_type

杂志文章
  • Improved accuracy of markerless motion tracking on bone suppression images: preliminary study for image-guided radiation therapy (IGRT).

    abstract::The bone suppression technique based on advanced image processing can suppress the conspicuity of bones on chest radiographs, creating soft tissue images obtained by the dual-energy subtraction technique. This study was performed to evaluate the usefulness of bone suppression image processing in image-guided radiation...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/10/n209

    authors: Tanaka R,Sanada S,Sakuta K,Kawashima H

    更新日期:2015-05-21 00:00:00

  • Strategies to improve 3D whole-body PET image reconstruction.

    abstract::An algorithm is described for three-dimensional whole-body (3DWB) image reconstruction in positron emission tomography. For whole-body applications, improvements to the popular fixed-axial-acceptance-angle technique are achieved by combining axially adjacent projection data available with a long-axis data set. Time-co...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/8/013

    authors: Cutler PD,Xu M

    更新日期:1996-08-01 00:00:00

  • Investigation of a scanned cylindrical ultrasound system for breast hyperthermia.

    abstract::This paper investigates the feasibility of a scanned cylindrical ultrasound system for producing uniform heating from the central to the superficial portions of the breast or localized heating within the breast at a specific location. The proposed system consists of plane ultrasound transducer(s) mounted on a scanned ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/3/005

    authors: Ju KC,Tseng LT,Chen YY,Lin WL

    更新日期:2006-02-07 00:00:00

  • A three-dimensional model-based partial volume correction strategy for gated cardiac mouse PET imaging.

    abstract::Quantification in cardiac mouse positron emission tomography (PET) imaging is limited by the imaging spatial resolution. Spillover of left ventricle (LV) myocardial activity into adjacent organs results in partial volume (PV) losses leading to underestimation of myocardial activity. A PV correction method was develope...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/13/4309

    authors: Dumouchel T,Thorn S,Kordos M,DaSilva J,Beanlands RS,deKemp RA

    更新日期:2012-07-07 00:00:00

  • Automatic bi-objective parameter tuning for inverse planning of high-dose-rate prostate brachytherapy.

    abstract::We present an automatic bi-objective parameter-tuning approach for inverse planning methods for high-dose-rate prostate brachytherapy, which aims to overcome the difficult and time-consuming manual parameter tuning that is currently required to obtain patient-specific high-quality treatment plans. We modelled treatmen...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab7362

    authors: Maree SC,Bosman PAN,van Wieringen N,Niatsetski Y,Pieters BR,Bel A,Alderliesten T

    更新日期:2020-04-02 00:00:00

  • The relative effects of arterial curvature and lumen diameter on wall shear stress distributions in human right coronary arteries.

    abstract::This study looks at blood flow in four different human right coronary arteries (RCAs), which have been reconstructed from bi-plane angiograms. A generalized power-law model of blood viscosity is used to study the blood flow at a particular point in the cardiac cycle. Large differences are found in the wall shear stres...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/9/013

    authors: Johnston BM,Johnston PR

    更新日期:2007-05-07 00:00:00

  • A complete distortion correction for MR images: II. Rectification of static-field inhomogeneities by similarity-based profile mapping.

    abstract::Radiotherapy treatment planning relies on the use of geometrically correct images. This paper presents a fully automatic tool for correcting MR images for the effects of B(0) inhomogeneities. The post-processing method is based on the gradient-reversal technique of Chang and Fitzpatrick (1992 IEEE Trans. Med. Imaging ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/11/014

    authors: Reinsberg SA,Doran SJ,Charles-Edwards EM,Leach MO

    更新日期:2005-06-07 00:00:00

  • Improved dose-calculation accuracy in proton treatment planning using a simplified Monte Carlo method verified with three-dimensional measurements in an anthropomorphic phantom.

    abstract::Treatment planning for proton tumor therapy requires a fast and accurate dose-calculation method. We have implemented a simplified Monte Carlo (SMC) method in the treatment planning system of the National Cancer Center Hospital East for the double-scattering beam delivery scheme. The SMC method takes into account the ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/12/018

    authors: Hotta K,Kohno R,Takada Y,Hara Y,Tansho R,Himukai T,Kameoka S,Matsuura T,Nishio T,Ogino T

    更新日期:2010-06-21 00:00:00

  • Another decade of photoacoustic imaging.

    abstract::Photoacoustic imaging - a hybrid biomedical imaging modality finding its way to clinical practices. Although the photoacoustic phenomenon was known more than a century back, only in the last two decades it has been widely researched and used for biomedical imaging applications. In this review we focus on the developme...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abd669

    authors: Das D,Sharma A,Rajendran P,Pramanik M

    更新日期:2020-12-23 00:00:00

  • Skin dose in chest wall radiotherapy with bolus: a Monte Carlo study.

    abstract::Monte Carlo simulations are used to investigate skin dose resulting from chest wall radiotherapy with bolus. A simple model of a female thorax is developed, which includes a 2 mm-thick skin layer. Two representative 6 MV source models are considered: a tangents source model consisting of a parallel opposed pair of med...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab95dc

    authors: Oliver PAK,Monajemi TT

    更新日期:2020-08-11 00:00:00

  • Automatic system for measuring dose-area product (DAP) in ROI fluoroscopy.

    abstract::A computerized system for monitoring dose-area product (DAP) has been developed for region of interest (ROI) fluoroscopy in which patient exposure is reduced using an x-ray attenuating filter with an aperture. The system includes an IBM compatible computer which is connected through an IEEE-488 interface to an electro...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/42/4/001

    authors: Kezerashvili M,Bednarek DR,Rudin S

    更新日期:1997-04-01 00:00:00

  • Measuring the imaged-object distance with a stationary high-spatial-resolution scintillation camera.

    abstract::A method to measure the detector-to-object distance from the images obtained with stationary high-spatial-resolution gamma-ray cameras for in vivo studies has been developed. It exploits the shift of the imaged object in the image plane, obtained at a certain tilt of the parallel-hole collimator. A linear dependence o...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/9/N04

    authors: Uzunov N,Bello M,Boccaccio P,Moschini G,Bollini D,de Notaristefani F

    更新日期:2006-05-07 00:00:00

  • Electric fields induced in humans and rodents by 60 Hz magnetic fields.

    abstract::Numerical computations are used to evaluate electric field dosimetry for high-resolution anatomically based inhomogeneous models of a human male child, and male and female rats and mice, under exposure to 60 Hz uniform magnetic field sources of three perpendicular orientations. The goal is to compare the child data to...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/14/313

    authors: Dawson TW,Caputa K,Stuchly MA

    更新日期:2002-07-21 00:00:00

  • Dosimetric and workflow evaluation of first commercial synthetic CT software for clinical use in pelvis.

    abstract::To evaluate a commercial synthetic CT (syn-CT) software for use in prostate radiotherapy. Twenty-five prostate patients underwent CT and MR simulation scans in treatment position on a 3T MR scanner. A commercially available MR protocol was used that included a T2w turbo spin-echo sequence for soft-tissue contrast and ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa5452

    authors: Tyagi N,Fontenla S,Zhang J,Cloutier M,Kadbi M,Mechalakos J,Zelefsky M,Deasy J,Hunt M

    更新日期:2017-04-21 00:00:00

  • Dose distribution measurements by MRI of a phantom containing lung tissue equivalent compartments made of ferrous sulphate gel.

    abstract::Gel dosimetry based on magnetic resonance imaging (MRI) has previously been shown to provide verification of calculated dose distributions in soft tissue equivalent homogeneous phantoms. This study demonstrates how measurements of dose distribution can also be achieved in a phantom containing porous, lung-equivalent, ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/10/303

    authors: Olberg S,Skretting A,Bruland O,Olsen DR

    更新日期:2000-10-01 00:00:00

  • Correlation between dosimetric effect and intrafraction motion during prostate treatments delivered with helical tomotherapy.

    abstract::The dosimetric impact of intrafraction prostate motion was investigated for helical tomotherapy treatments. Measured motion tracks were used to calculate the dosimetric impact on delivered target dose distributions. A dynamic dose calculation engine was developed to facilitate this evaluation. It was found that the D9...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/24/005

    authors: Langen KM,Lu W,Ngwa W,Willoughby TR,Chauhan B,Meeks SL,Kupelian PA,Olivera G

    更新日期:2008-12-21 00:00:00

  • Breast composition measurements using retrospective standard mammogram form (SMF).

    abstract::The standard mammogram form (SMF) representation of an x-ray mammogram is a standardized, quantitative representation of the breast from which the volume of non-fat tissue and breast density can be easily estimated, both of which are of significant interest in determining breast cancer risk. Previous theoretical analy...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/11/001

    authors: Highnam R,Pan X,Warren R,Jeffreys M,Davey Smith G,Brady M

    更新日期:2006-06-07 00:00:00

  • Penetration of electromagnetic fields of an open-ended coaxial probe between 1 MHz and 1 GHz in dielectric skin measurements.

    abstract::An open-ended coaxial probe is often used for investigating the dielectric properties of biological tissues. The present study indicates that in addition to the probe size, the penetration of the electromagnetic (EM) fields of an open-ended coaxial probe in contact with the skin is dependent on the applied frequency b...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/7/404

    authors: Alanen E,Lahtinen T,Nuutinen J

    更新日期:1999-07-01 00:00:00

  • A Monte Carlo-based method to estimate radiation dose from spiral CT: from phantom testing to patient-specific models.

    abstract::The purpose of this work is to develop and test a method to estimate the relative and absolute absorbed radiation dose from axial and spiral CT scans using a Monte Carlo approach. Initial testing was done in phantoms and preliminary results were obtained from a standard mathematical anthropomorphic model (MIRD V) and ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/16/306

    authors: Jarry G,DeMarco JJ,Beifuss U,Cagnon CH,McNitt-Gray MF

    更新日期:2003-08-21 00:00:00

  • Computed LET distributions in the build-up region of tissue for 14 MeV neutrons.

    abstract::Experimental radiobiological investigations of fast neutron beams involve irradiation of thin cell layers. The irradiation of cells is done either in free air or with a material such as graphite, TE plastic or bone-equivalent plastic covering the cells. This paper discusses the computed dose distributions in LET at sh...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/24/5/007

    authors: Bhatia DP,Nagarajan PS

    更新日期:1979-09-01 00:00:00

  • Automatic bladder segmentation on CBCT for multiple plan ART of bladder cancer using a patient-specific bladder model.

    abstract::In multiple plan adaptive radiotherapy (ART) strategies of bladder cancer, a library of plans corresponding to different bladder volumes is created based on images acquired in early treatment sessions. Subsequently, the plan for the smallest PTV safely covering the bladder on cone-beam CT (CBCT) is selected as the pla...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/12/3945

    authors: Chai X,van Herk M,Betgen A,Hulshof M,Bel A

    更新日期:2012-06-21 00:00:00

  • Noninvasive reconstruction of cardiac transmembrane potentials using a kernelized extreme learning method.

    abstract::Non-invasively reconstructing the cardiac transmembrane potentials (TMPs) from body surface potentials can act as a regression problem. The support vector regression (SVR) method is often used to solve the regression problem, however the computational complexity of the SVR training algorithm is usually intensive. In t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/8/3237

    authors: Jiang M,Zhang H,Zhu L,Cao L,Wang Y,Xia L,Gong Y

    更新日期:2015-04-21 00:00:00

  • Planning 4D intensity-modulated arc therapy for tumor tracking with a multileaf collimator.

    abstract::This study introduces a practical four-dimensional (4D) planning scheme of IMAT using 4D computed tomography (4D CT) for planning tumor tracking with dynamic multileaf beam collimation. We assume that patients can breathe regularly, i.e. the same way as during 4D CT with an unchanged period and amplitude, and that the...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa56b7

    authors: Niu Y,Betzel GT,Yang X,Gui M,Parke WC,Yi B,Yu CX

    更新日期:2017-02-21 00:00:00

  • A modified lead attenuation method to determine the fast neutron sensitivity kU of a photon dosemeter.

    abstract::Various lead attenuation techniques to determine the fast neutron sensitivity kU of a photon dosemeter are reviewed and a modified method is proposed to determine the kU value of a commercially available Geiger--Müller detector. The dependence on the 'effective' photon energy of the gamma-component of the mixed n--gam...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/24/4/005

    authors: Hough JH

    更新日期:1979-07-01 00:00:00

  • Direct 4D reconstruction of parametric images incorporating anato-functional joint entropy.

    abstract::We developed an anatomy-guided 4D closed-form algorithm to directly reconstruct parametric images from projection data for (nearly) irreversible tracers. Conventional methods consist of individually reconstructing 2D/3D PET data, followed by graphical analysis on the sequence of reconstructed image frames. The propose...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/15/005

    authors: Tang J,Kuwabara H,Wong DF,Rahmim A

    更新日期:2010-08-07 00:00:00

  • A theoretical study of quantitative flow measurements with constant infusion of short-lived isotopes.

    abstract::Recent developments in the technique of constant infusion and in emission computed tomography have provided a new method for quantitative regional flow measurements. This paper re-examines critically the theoretical relationship between flow and radioactivity during constant infusion of short-lived isotopes. Sensitivi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/24/6/005

    authors: Huang SC,Phelps ME,Hoffman EJ,Kuhl DE

    更新日期:1979-11-01 00:00:00

  • Optimizing functional parameter accuracy for breath-hold DCE-MRI of liver tumours.

    abstract::Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is a valuable tool for assessing treatment response to novel cancer therapeutics. With appropriate data acquisition, quantitative functional parameter estimates can be obtained by fitting a model to the data. This research focuses on applying a dual-input ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/7/023

    authors: Orton MR,Miyazaki K,Koh DM,Collins DJ,Hawkes DJ,Atkinson D,Leach MO

    更新日期:2009-04-07 00:00:00

  • The exponential edge-gradient effect in x-ray computed tomography.

    abstract::The exponential edge-gradient effect must arise in any x-ray transmission CT scanner whenever long sharp edges of high contrast are encountered. The effect is non-linear and is due to the interaction of the exponential law of x-ray attenuation and the finite width of the scanning beam in the x-y plane. The error induc...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/26/3/010

    authors: Joseph PM,Spital RD

    更新日期:1981-05-01 00:00:00

  • A neural network regression model for relative dose computation.

    abstract::This paper describes a neural network (NN) regression model for relative dose computation. The input signal of the NN model includes depths and field sizes and the output is the relative dose, for example, percentage depth dose (%DD) or tissue-air ratio (TAR) in this paper. After a functional link has been created, th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/4/307

    authors: Wu X,Zhu Y

    更新日期:2000-04-01 00:00:00

  • ALGEBRA: ALgorithm for the heterogeneous dosimetry based on GEANT4 for BRAchytherapy.

    abstract::Task group 43 (TG43)-based dosimetry algorithms are efficient for brachytherapy dose calculation in water. However, human tissues have chemical compositions and densities different than water. Moreover, the mutual shielding effect of seeds on each other (interseed attenuation) is neglected in the TG43-based dosimetry ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/11/3273

    authors: Afsharpour H,Landry G,D'Amours M,Enger S,Reniers B,Poon E,Carrier JF,Verhaegen F,Beaulieu L

    更新日期:2012-06-07 00:00:00