Abstract:
:The effectiveness and safety of intravenous lorcainide was evaluated in 14 patients with normal (QRS less than 110 ms) and in 9 patients with prolonged QRS duration (QRS greater than or equal to 110 ms) showing chronic high frequency premature ventricular complexes (mean value of PVCs 17 min-1). Lorcainide was infused intravenously by intermittent bolus at 10 mg every minute to a total dose of 160 mg with exception of 5 patients with a prolonged QRS duration who only received 100 mg. The overall reduction of PVCs 1 hour after administration of the drug was 86% (p less than 0.05) in the patients with normal QRS duration and 98.5% (p less than 0.05) in the patients with a prolonged QRS duration. The mean plasma drug level achieved 1 h after treatment was 280 +/- 60 ng/ml in the patients with QRS less than 110 ms and 170 +/- 40 ng/ml in the patients with a QRS greater than or equal to 110 ms. Heart rate and blood pressure did not change but a significant increase (p less than 0.05) in QRS duration (+37%) was observed 30 min after the infusion of 160 mg lorcainide in the patient group with normal QRS duration. Lorcainide was well tolerated. Mild adverse effects were observed in five patients including: warmth sensation, vomiting, paresthesias, transient hypotension and the development of a junctional escape rhythm. Therefore lorcainide appears to be a safe and effective drug, that can even be administered to patients with a prolonged QRS duration.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Stroobandt R,Kesteloot Hsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
637-48issue
6eissn
0001-5385issn
1784-973Xjournal_volume
40pub_type
杂志文章abstract::We present a 64-year-old woman who was brought to the emergency department after suffering a motor vehicle accident, involving multiple soft tissue and bone trauma. Even though she was free from cardiovascular symptoms for the last three years, her past medical history of aorto-coronary bypass surgery prompted preoper...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.58.2.2005271
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:Results of many studies show that apolipoprotein B (apo B) is a better marker of risk of vascular disease than other lipid markers including LDL and HDL-cholesterol and triglycerides. We investigated the association between two infectious agents: C. pneumoniae and H. pylori, known to have an atherogenic effec...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.6.2004930
更新日期:2005-12-01 00:00:00
abstract::Left ventricular (LV) asynchrony has been demonstrated to result in diastolic dysfunction. To test the hypothesis that altered LV synchrony interferes with LV diastolic function in essential hypertensive patients (HT), we performed radionuclide ventriculography and echocardiography in 38 HT and 11 normotensive subject...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to test the hypothesis that smoking induces peripheral endothelial dysfunction and altered function in central conduit arteries. METHODS:A total of 22 healthy volunteers (10 women and 12 men; mean age 25.3 +/- 5.8 years) were included. At baseline, brachial artery flowmediate...
journal_title:Acta cardiologica
pub_type: 杂志文章,随机对照试验
doi:10.1080/ac.68.3.2983419
更新日期:2013-06-01 00:00:00
abstract::A patient with unstable angina and known heart failure, and marked U wave alternans on the electrocardiogram is reported. Alternans of the U wave with no change in the QRS complex is extremely rare. The relevant literature is reviewed. ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:Acute cardiac allograft rejection continues to be the cause of graft loss and contributes to the morbidity and mortality after cardiac transplantation. Repetitive endomyocardial biopsies are necessary to monitor the effects of immunosuppressants after cardiac transplantation. In this study, we investigate whe...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.66.6.2136963
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The metabolic syndrome is associated with increased risk of cardiovascular disease. It is important to examine the relation of the metabolic syndrome with the early stages of atherosclerosis. We sought to determine the impact of the metabolic syndrome, defined with International Diabetes Federation criteria, ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.3.2050348
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Cigarette smoking increases the synthesis of angiotensin-1 converting enzyme (ACE) and induces oxidative modifications of the apolipoprotein E (apo E).Thus we explored the gene-environment interactions between APOE gene epsilon and ACE gene insertion/deletion polymorphisms and cigarette smoking in coronary ar...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.6.2033392
更新日期:2008-12-01 00:00:00
abstract::Congenital left ventricular diverticulum is rare and usually isolated or associated with midline thoracoabdominal defects and other congenital cardiac malformations. We describe a case with a previously undescribed malformation syndrome including bilateral obstruction of the ureteropelvic junction, agenesis of corpus ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.58.3.2005280
更新日期:2003-06-01 00:00:00
abstract::The clinical, hemodynamic findings and surgical results of forty patients with rheumatic tricuspid stenosis are presented. It is concluded that tricuspid stenosis is a frequent lesion. Its signs should be sought carefully and documented by simultaneous measurements of the right ventricular diastolic and right atrial p...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Background: Patients with chest pain are risk-stratified using serial high-sensitivity troponin (T) assays (hsTnT). Those with change in (Δ)hsTnT <20% are often categorised as low-risk and are less likely to be managed as acute coronary syndromes (ACS). We sought to characterise such a population of 'low-risk' chest p...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2018.1561598
更新日期:2020-04-01 00:00:00
abstract::Between March 1982 and March 1991, 225 heart transplantations (HTx) have been performed in 220 patients suffering end stage cardiac disease. Thirteen percent were females and 87% were males. Age range was from 5 to 68 years. The underlying cardiac disease was ischemic cardiopathy in 51.5%, congestive dilated cardiomyo...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Background: AF, anticoagulation, NOACs, changing patterns of prescription. Methods: We describe baseline data and treatment patterns of patients recruited in Belgium in the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF). Recruitment began when novel oral anticoagulants (NOACs) were introd...
journal_title:Acta cardiologica
pub_type: 杂志文章,多中心研究
doi:10.1080/00015385.2018.1494089
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:This study sought to evaluate the potential prognostic usefulness of QT dispersion (QTd) in patients with unstable angina. METHODS AND RESULTS:QTd was calculated and plasma troponin T (TnT) level was measured and rest perfusion imaging with Tc-99m sestamibi was performed in 62 patients admitted with chest pa...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.59.3.2005183
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Although non-adherence to medications is associated with increased cardiovascular risks, very little information is focused on the relationship between knowledge and medication adherence among patients with coronary heart disease (CHD). AIM:The purposes were to assess the relationship between medication adh...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.70.2.3073511
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the practice of cardiac bradycardia pacing in an electrophysiology laboratory and to evaluate the safety and efficacy of pacemaker implantation by cardiologists in this setting. METHODS AND RESULTS:We evaluated a consecutive series of the first 500 permanent pacemaker...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::The Cardiology Foundation supported by the perspicacious Princess Lilian was created in 1958. As an introduction to this symposium, the challenges that the cardiologist and surgeon encountered in 1958, are recalled as well as the essential problems requiring solutions in that era of evolving cardiac surgery. ...
journal_title:Acta cardiologica
pub_type: 历史文章,杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Residual risk, which cannot be prevented by statins alone, must be controlled for inhibiting the onset of coronary events. Omega-3 polyunsaturated fatty acids (PUFAs) play an important role in controlling residual risk. The Japan eicosapentaenoic acid (EPA) Lipid Intervention Study demonstrated the inhibitory effect o...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.1080/00015385.2017.1305174
更新日期:2017-06-01 00:00:00
abstract::The association between early atherosclerosis (IMT) and Atherogenic index of plasma (AIP), a marker of atherogenicity (log triglycerides/HDL Cholesterol) was evaluated in a population-based cohort study in women, aged 30-69, living in the metropolitan area of Naples, Southern Italy (Progetto ATENA). Serum cholesterol,...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1858537
更新日期:2020-12-11 00:00:00
abstract::Clinical experience with repeated tilt testing and standing training has shown that this procedure can be used as a new therapy for the restoration of abnormal autonomic orthostatic reflexes. The introduction of tilt training therapy for neurally mediated syncope is a new and effective treatment. This new therapy has ...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.2143/AC.61.2.2014332
更新日期:2006-04-01 00:00:00
abstract::Annular calcifications carry some technical difficulties for success in conventional valve surgery. In this paper we present an easy alternative mitral valve replacement method applied for a patient with a heavily calcified mitral annulus. Excision of both leaflets and partial resection of the annular calcification wi...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.62.2.2020242
更新日期:2007-04-01 00:00:00
abstract::The clinical, fono-mechano-echocardiographic, hemodynamic and angiographic findings before and after surgery of a patient who developed bilateral extensive endomyocardial fibrosis probably secondary to filariasis, are described. The patient was surgically treated by endocardial decortication and insertion of a mitral ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Decreased effects of smoking on serum high-density lipoprotein cholesterol (HDL-c) were demonstrated in subjects smoking more than 20 cigarettes a day. We aimed to evaluate the effects of non-heavy smoking (< or =20 cigarettes a day) on HDL-c in young, healthy men who are similar in terms of age, physical act...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.4.2017301
更新日期:2006-08-01 00:00:00
abstract::Aim of this study was to elucidate the diagnostic significance of left axis deviation (LAD) in patients (pts) with chronic (> 6 months) left bundle branch block (LBBB). We retrospectively studied 2094 consecutive pts who underwent cardiac catheterization. All pts had left heart catheterization and coronary angiography...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:A prospective randomized multicentre pilot trial, comparing stenting with balloon angioplasty as a treatment for coronary lesions, located in a bifurcation was performed. METHODS AND RESULTS:After balloon dilatation, with a < 30% residual stenosis in the main vessel and < 50% residual stenosis in the side br...
journal_title:Acta cardiologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2143/AC.60.4.2004986
更新日期:2005-08-01 00:00:00
abstract::We investigated the effect of an orally administered, long-acting, beta-adrenergic blocking agent, penbutolol, on the circadian rhythm of blood pressure (BP) and heart rate (HR), and plasma renin activity (PRA), aldosterone (PA) and cortisol (PC) levels in hospital patients with essential hypertension validated by a c...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:Subclinical hypothyroidism (SH) is characterized by normal serum free T4 (fT4), free T3 (fT3) levels and increased serum thyroid stimulating hormone (TSH) levels.The aim of this study was to assess the validity of tissue Doppler imaging (TDI) in evaluating cardiac effects of SH and to demonstrate the improvi...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.66.1.2064966
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:Coronary revascularization methods are among the most common major medical procedures performed in industrialized countries. The short- and long-term comparative effectiveness of different techniques remains undetermined. METHODS AND RESULTS:The study population included all adult patients (94,864 subjects) ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.65.6.2059861
更新日期:2010-12-01 00:00:00
abstract::Electroconvulsive therapy (ECT) is used frequently in psychiatric practice and various electrocardiographic (ECG) changes have been described during ECT. QT dispersion (defined as maximal QT interval minus minimal QT interval) as assessed on the surface electrocardiogram has been demonstrated to reflect regional inhom...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Epidemiological information on the prevalence, incidence and natural history of intermittent claudication and peripheral vascular disease is limited, partially by the limitation of techniques of their study. The available data from the literature are review and supplemented by results from an on-going survey the ankle...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00