Abstract:
:We investigated the effect of an orally administered, long-acting, beta-adrenergic blocking agent, penbutolol, on the circadian rhythm of blood pressure (BP) and heart rate (HR), and plasma renin activity (PRA), aldosterone (PA) and cortisol (PC) levels in hospital patients with essential hypertension validated by a chronobiological inferential statistic method. After a wash-out period of three weeks, a group of 8 hypertensive patients (5 women and 3 men, 27 to 41 years old) underwent automatic BP and HR monitoring, and blood sampling for 24 hours in a hospital room before and after 4 weeks of treatment with penbutolol (40-mg tablet once a day at 9 a.m.). In basal conditions, a statistically significant mean circadian rhythm was demonstrated for HR, diastolic BP, PRA, PA, and PC. Systolic and diastolic BP were lowered by penbutolol, with only a minor decrease of HR. The treatment eliminated also the mean circadian rhythm of BP and HR. Penbutolol induced both a remarkable reduction of PRA with disappearance of the related circadian rhythm and a significant decrease in PA levels with maintenance of their circadian rhythmicity. The circadian secretory patterns of PC were similar before and after therapy. In conclusion, long-term treatment with penbutolol appears not only to set BP, PRA and PA values to lower levels, but also to decrease the within-day variation of BP, HR, and PRA. In addition, penbutolol does not influence the 24 h-secretion of PC.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
degli Uberti EC,Portaluppi F,Margutti A,Trasforini G,Bianconi M,Teodori V,Rossi R,Pansini Rsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
5-20issue
1eissn
0001-5385issn
1784-973Xjournal_volume
43pub_type
杂志文章abstract::Background: All previous meta-analyses including clinical outcomes after remote ischaemic conditioning (RIC) in patients with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) demonstrated that RIC significantly reduced all-cause mortality and major adverse cardiovascular...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1766259
更新日期:2020-07-03 00:00:00
abstract::The optimal management of high-risk patients requiring urgent or emergency noncardiac surgery when the options for further testing and evaluation are limited, is unclear. The focus of most of the literature, including the American College of Cardiology/American Heart Association guidelines, has been on patients underg...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.5.2004980
更新日期:2005-10-01 00:00:00
abstract::After D.C. countershock to terminate cardiac arrhythmias, in 3 out of 8 patients studied, an increase in both plasma myoglobin (Mb) and CK-MB (assessed by radioimmunoassay) was found. In 2 patients there was an increase of only plasma Mb and in 1 an increase of only CK-MB. In 2 cases no increase of either parameters w...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The interest in transcatheter ventricular septal defect (VSD) closure is continuously growing. Therefore, we report our experience in perimembranous (Pm) and postinfarction (Pi) VSD closure. METHODS:All patients, older than 16 years, were selected from a data base, in which Pm and Pi VSDs were registered. T...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.62.4.2022283
更新日期:2007-08-01 00:00:00
abstract::A young woman with systemic lupus erythematosus (SLE) developed progressive heart failure several years after mitral valve replacement with a Björk-Shiley prosthesis for treating mitral stenosis due to Libman-Sacks endocarditis. She was admitted to the hospital with pulmonary oedema. Transoesophageal echocardiography ...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.2143/AC.55.1.2005719
更新日期:2000-02-01 00:00:00
abstract::A follow-up study was carried out in 98 patients with congestive cardiomyopathy using clinical data and M-mode echocardiography. 59 patients survived (mean follow-up period 18 months), 39 patients died (mean survival period 12.6 months). Median survival time was 3 years. Prognosis was unfavorably affected by ECG signs...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Available clinical and angiographic scoring systems fail to predict clinical outcomes in real-world patients undergoing revascularization of the unprotected left main coronary artery (ULMCA). METHODS:We prospectively assessed major adverse cardiac and cerebrovascular events (MACCE) in a real-world populatio...
journal_title:Acta cardiologica
pub_type: 杂志文章,多中心研究
doi:10.1080/ac.67.5.2174124
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Smoking mentholated cigarettes inhibits the metabolism of nicotine and increases systemic exposure to cigarette smoke toxins. However, the possible effects of smoking mentholated cigarettes on coronary microvascular functions are unknown. We sought to investigate whether smoking mentholated cigarettes impairs...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.2.2029518
更新日期:2008-04-01 00:00:00
abstract::A 22-year-old male who had Mustard repair for complete transposition presented with progressive exercise intolerance, documented by a gradual decrease in exercise capacity on cycle ergometer. Cardiac catheterization and angiography demonstrated subvalvular pulmonary stenosis. After surgical relief of the obstruction, ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:UNLABELLED:In order to detect myocardial viability in coronary artery disease patients (CAD) with a previous myocardial infarction and dysfunction of the left ventricle (LV), the reliability of the left atrioventricular plane displacement (LAVPD) during low dose dobutamine stress echocardiography (DSE), was validated. ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Residual risk, which cannot be prevented by statins alone, must be controlled for inhibiting the onset of coronary events. Omega-3 polyunsaturated fatty acids (PUFAs) play an important role in controlling residual risk. The Japan eicosapentaenoic acid (EPA) Lipid Intervention Study demonstrated the inhibitory effect o...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.1080/00015385.2017.1305174
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:The levels of adiponectin, an anti-atherogenic protein, are decreased in patients with coronary artery disease. Syndrome X is associated with endothelial dysfunction, which is a key feature in the evolution of atherosclerosis. We sought to determine whether serum adiponectin levels are decreased in patients w...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.2.2047056
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The presence of adhesions after heart operations increases the risk of life-threatening damage to the heart and extracardiac grafts. Infections, tissue injury and inflammations are suspected aetiologic agents. The main purpose of our study is to evaluate the effect of an antiinflammatory agent piroxicam on t...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.62.6.2024014
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Familial hypercholesterolaemia (FH) is underdiagnosed in most countries. We report our first experience from a national pilot project of cascade screening in relatives of FH patients. METHODOLOGY:Participating specialists recruited consecutive index patients (IP) with Dutch Lipid Clinic Network (DLCN) score...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1820683
更新日期:2020-09-23 00:00:00
abstract::Primary ventricular fibrillation especially occurs during the first hours after acute myocardial infarction and is often not preceded by premonitory ventricular premature beats. In hospital primary ventricular fibrillation can be prevented by an intravenous lidocaine regimen in a rather high dosage. By contrast the ef...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::In order to define the role of the ubiquitin-proteasome system in atherosclerotic plaque rupture in patients with type 2 diabetes mellitus (T2DM), we evaluated the amount of this system, of the main inflammatory cells, of the collagen content and some indexes indicative of oxidative stress in the carotid plaques of bo...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.6.2017962
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:Elevated mean platelet volume predicts restenosis after percutaneous transluminal coronary angioplasty but its effect on the development of in-stent restenosis is not known. We assessed the effect of mean platelet volume measured before coronary stent implantation for stable angina pectoris on subsequent deve...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.59.4.2005204
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:The mechanisms of the different haemodynamic and clinical responses to dobutamine infusion in mitral stenosis (MS) are not clearly established. The aim of this study was to evaluate the relation between left atrial (LA) function and haemodynamic response in patients with MS during dobutamine infusion. METHOD...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.58.6.2005319
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:The metabolic syndrome is associated with increased risk of cardiovascular disease. It is important to examine the relation of the metabolic syndrome with the early stages of atherosclerosis. We sought to determine the impact of the metabolic syndrome, defined with International Diabetes Federation criteria, ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.3.2050348
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Few studies described the home blood pressure (HBP) in young children. Using intrafamilial correlations of blood pressure as research focus, we assessed the feasibility of HBP monitoring in this age group. METHODS:We enrolled 382 mothers (mean age 38.8 years) and singletons (7.0 years) in theTohoku Study of ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.67.4.2170687
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:The renin-angiotensin-aldosterone system (RAAS) plays an important role in blood pressure regulation, left ventricular and vascular structure. Some hypertensive patients develop left ventricular dilatation and heart failure symptoms while others are relatively less affected. The purpose of our study was to d...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.1.2005137
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to determine plasma fibronectin level and its relationships with plasma lipids, lipoproteins and C-reactive protein (CRP) levels in patients with dyslipidaemia during lipid-lowering therapy. METHODS:Plasma levels of fibronectin, CRP, fibrinogen, lipids and lipoproteins in 38 pat...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.57.6.2005466
更新日期:2002-12-01 00:00:00
abstract:AIM:To determine whether statin therapy initiated early in acute myocardial infarction together with thrombolytic therapy in patients with acute myocardial infarction results in clinical benefit through early plaque stabilization. METHODS AND RESULTS:The study population consisted of 77 patients who underwent coronary...
journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2143/AC.57.4.2005430
更新日期:2002-08-01 00:00:00
abstract::Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disease characterized pathologically by fibrofatty replacement of right ventricular myocardium. It is further characterized by an electrical instability that precipitates ventricular arrhythmias and sudden death. The prevalence is estimated at 0.4% de...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.59.4.2005214
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND AIM:Decreased left ventricular mass index in anorexia nervosa is amply reported. The aim of this study is to identify non-burdensome predictors of reduced left yentricular mass/height (cLVM) in a cohort of adolescent restrictive anorexic girls. METHODS:This is a retrospective study of all anorexic girls...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.70.4.3094647
更新日期:2015-08-01 00:00:00
abstract::Though cardiac involvement is a frequent finding in patients with Duchenne muscular dystrophy (DMD) at the wheel-chair-bound stage, left ventricular hypertrabeculation (LVHT) has not been reported. The patient is a 28-year-old male with the typical clinical features of end stage DMD. Since the age of 16 years he requi...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.4.2004996
更新日期:2005-08-01 00:00:00
abstract::We describe two cases of Duchenne's cardiomyopathy with severe cardiac dysfunction, sporadic episodes of myoglobinuria induced by effort and increased levels of serum creatine kinase. Very mild signs of skeletal myopathy were clinically evident. Left ventriculography showed diffuse severe hypokinesia. Skeletal muscle ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.4.2017311
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:Results of many studies show that apolipoprotein B (apo B) is a better marker of risk of vascular disease than other lipid markers including LDL and HDL-cholesterol and triglycerides. We investigated the association between two infectious agents: C. pneumoniae and H. pylori, known to have an atherogenic effec...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.6.2004930
更新日期:2005-12-01 00:00:00
abstract::We report the M-mode and two-dimensional echocardiographic findings in a patient with familial amyloidosis. The diagnosis was made by the clinical picture and histologic evidence of amyloid in peripheral nerve biopsy. Though the patient had no clinical sign of heart failure, extensive involvement of the heart was demo...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:The primary aim of the study was to investigate whether there is a difference in plasma B-type natriuretic peptide (BNP) levels among the left ventricular systolic dysfunction caused by different types of heart disease. METHODS AND RESULTS:Plasma BNP was measured in patients with left ventricular systolic d...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.3.2005008
更新日期:2005-06-01 00:00:00