The balance of omega-3 polyunsaturated fatty acids for -reducing residual risks in patients with coronary artery disease.

Abstract:

:Residual risk, which cannot be prevented by statins alone, must be controlled for inhibiting the onset of coronary events. Omega-3 polyunsaturated fatty acids (PUFAs) play an important role in controlling residual risk. The Japan eicosapentaenoic acid (EPA) Lipid Intervention Study demonstrated the inhibitory effect of high-purity EPA preparations on the residual risk of cardiovascular events. Omega-3 PUFAs inhibit coronary artery disease (CAD) through various actions, including triglyceride-lowering action. Besides lipid metabolism, platelet aggregation inhibition, anti-inflammatory effects, improved vascular endothelium function, and anti-hypertensive action contribute to arteriosclerosis inhibition. Conversely, several recent studies did not demonstrate the efficacy of omega-3 PUFAs for CAD prevention. PUFAs levels may need to exceed a threshold for anti-arteriosclerotic action. The efficacy of EPA might depend on the baseline value of the EPA/arachidonic acid (AA) ratio prior to EPA administration. This baseline EPA/AA ratio value varies according to country and region as well as changes of dietary habits. More global research in this field is needed to identify an optimal omega-3 PUFAs administration strategy.

journal_name

Acta Cardiol

journal_title

Acta cardiologica

authors

Nishizaki Y,Shimada K,Daida H

doi

10.1080/00015385.2017.1305174

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

240-248

issue

3

eissn

0001-5385

issn

1784-973X

journal_volume

72

pub_type

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