Abstract:
AIM:To determine whether statin therapy initiated early in acute myocardial infarction together with thrombolytic therapy in patients with acute myocardial infarction results in clinical benefit through early plaque stabilization. METHODS AND RESULTS:The study population consisted of 77 patients who underwent coronary balloon angioplasty of the infarct-related artery during the first month of acute myocardial infarction. These patients belonged to the cohort of the Pravastatin Turkish Trial (PTT). Forty of them were assigned randomly to have immediate pravastatin (40 mg/day) therapy adjunctive to thrombolytic therapy regardless of serum lipid levels and received statin treatment throughout the study. Lipid levels were determined immediately after admission and before angioplasty and at the end of 6 months. Patients were re-evaluated clinically and angiographically for cardiovascular adverse events and restenosis after a 6-month follow-up period. The baseline angiographic and clinical characteristics of the two groups were similar. The incidence of angina was significantly lower in the pravastatin group (30.0%, 12 patients) compared to the control group (59.5%, 22 patients) (p = 0.018). The cumulative major adverse cardiac events in the pravastatin group were significantly lower when compared to the control group (32.5% vs. 75.6%, p = 0.0001). CONCLUSIONS:Early initiation of pravastatin therapy immediately after an acute myocardial infarction significantly decreased the frequency of major cardiac adverse events. Such early potential clinical benefits further strengthen the rationale for starting statin treatment as soon as possible after acute coronary events particularly in patients in whom invasive intervention is planned.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Kayikçioğlu M,Can L,Kültürsay H,Payzin S,Turkoğlu Cdoi
10.2143/AC.57.4.2005430subject
Has Abstractpub_date
2002-08-01 00:00:00pages
295-302issue
4eissn
0001-5385issn
1784-973Xjournal_volume
57pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVES:Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. In this study, we aimed to evaluate the utility of serum LOX-1 levels in the diagnosis and assessment of left ventricular systolic HF and LOX-1’s relationship with serum...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.71.2.3141848
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The effects of cigarette smoking on the circadian rhythm of heart rate variability (HRV) are not known. METHODS:We studied the effects of cigarette smoking on the circadian rhythm of HRV in 24 smoking and 21 non-smoking healthy subjects. Twenty-four hour ambulatory electrocardiograms were recorded and time ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.55.5.2005757
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:High platelet reactivity (HPR) to clopidogrel is associated with an increased risk of ischaemic complications during and after coronary interventions and concerns up to 50% of patients undergoing PCI. AIM OF THE STUDY:The aim of the study was to identify patients with HPR to clopidogrel using bedside clinic...
journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2143/AC.70.5.3110511
更新日期:2015-10-01 00:00:00
abstract::Background: Since many years catheter ablation is widely used for the treatment of atrial fibrillation (AF), however, long-term follow-up data of ablation techniques are rare. This study presents a 10-year follow-up period in patients treated for paroxysmal AF (PAF) with point-by-point pulmonary vein isolation (PVI) u...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1756087
更新日期:2020-05-01 00:00:00
abstract::Between April 1988 and October 1989, 22 adult patients with isolated or predominant severe mitral stenosis underwent Percutaneous Transvenous Mitral Valvuloplasty (PTMV). In 20 patients, a transseptal double balloon technique was used; in the last 2 patients, dilatation was performed using the Inoué balloon. Immediate...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Between March 1982 and March 1991, 225 heart transplantations (HTx) have been performed in 220 patients suffering end stage cardiac disease. Thirteen percent were females and 87% were males. Age range was from 5 to 68 years. The underlying cardiac disease was ischemic cardiopathy in 51.5%, congestive dilated cardiomyo...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Cigarette smoking increases the synthesis of angiotensin-1 converting enzyme (ACE) and induces oxidative modifications of the apolipoprotein E (apo E).Thus we explored the gene-environment interactions between APOE gene epsilon and ACE gene insertion/deletion polymorphisms and cigarette smoking in coronary ar...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.6.2033392
更新日期:2008-12-01 00:00:00
abstract::Left ventricular (LV) asynchrony has been demonstrated to result in diastolic dysfunction. To test the hypothesis that altered LV synchrony interferes with LV diastolic function in essential hypertensive patients (HT), we performed radionuclide ventriculography and echocardiography in 38 HT and 11 normotensive subject...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:This study aimed at determining the effect of percutaneous ASD closure on the AV conduction. Percutaneous closure of ostium secundum atrial septal defects (ASDs) has been widely accepted and has become the standard treatment of this malformation. However, some complications have been reported. Because of the ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.66.3.2114130
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:The primary aim of the study was to investigate whether there is a difference in plasma B-type natriuretic peptide (BNP) levels among the left ventricular systolic dysfunction caused by different types of heart disease. METHODS AND RESULTS:Plasma BNP was measured in patients with left ventricular systolic d...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.3.2005008
更新日期:2005-06-01 00:00:00
abstract::Primary ventricular fibrillation especially occurs during the first hours after acute myocardial infarction and is often not preceded by premonitory ventricular premature beats. In hospital primary ventricular fibrillation can be prevented by an intravenous lidocaine regimen in a rather high dosage. By contrast the ef...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:The scope of this study is to detect whether or not the entropy (E) circadian rhythm (CR) is maintained preserved in sinusal R-R intervals (SRRI), its loss being the expression of a transition to an indeterministic chaos in heart rate variability (HRV). METHODS:The E of SRRI was estimated in 14 type I diabet...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/ac.62.3.2020814
更新日期:2007-06-01 00:00:00
abstract::Background: Patients with chest pain are risk-stratified using serial high-sensitivity troponin (T) assays (hsTnT). Those with change in (Δ)hsTnT <20% are often categorised as low-risk and are less likely to be managed as acute coronary syndromes (ACS). We sought to characterise such a population of 'low-risk' chest p...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2018.1561598
更新日期:2020-04-01 00:00:00
abstract::European Society of Cardiology (ESC) National Society Cardiovascular Journals (NSCJs) are high-quality biomedical journals focused on cardiovascular diseases. The Editors' Network of the ESC devises editorial initiatives aimed at improving the scientific quality and diffusion of NSCJ. In this article we will discuss o...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.1080/ac.68.5.2994483
更新日期:2013-10-01 00:00:00
abstract::Pulmonary dissemination of a cardiac cyst is a rare condition. In the present study, we report a case of a 20-year-old patient with cardiac hydatosis located in the interventricular septum, which was previously diagnosed and treated as pulmonary hydatid disease. Diagnosis was made by spiral computed tomography and tre...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.58.5.2005309
更新日期:2003-10-01 00:00:00
abstract::The association between early atherosclerosis (IMT) and Atherogenic index of plasma (AIP), a marker of atherogenicity (log triglycerides/HDL Cholesterol) was evaluated in a population-based cohort study in women, aged 30-69, living in the metropolitan area of Naples, Southern Italy (Progetto ATENA). Serum cholesterol,...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1858537
更新日期:2020-12-11 00:00:00
abstract:UNLABELLED:OBJECTIVE; ; The objective of this study was to identify developmental changes in vascular smooth muscle cells (VSMC) during aneurysm formation using an elastase-induced rabbit carotid artery aneurysm model. METHODS:- Aneurysms were induced in carotid arteries of rabbits by exposure to elastase. Tissues fro...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.65.5.2056235
更新日期:2010-10-01 00:00:00
abstract:AIM:We aimed to compare the incidence of contrast-induced nephropathy (CIN) between atorvastatin versus rosuvastatin in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary coronary angioplasty. METHODS:One hundred ninety-two consecutive patients, who underwent primary percutaneous inter...
journal_title:Acta cardiologica
pub_type: 杂志文章,随机对照试验
doi:10.1080/ac.68.5.2994472
更新日期:2013-10-01 00:00:00
abstract::The optimal management of high-risk patients requiring urgent or emergency noncardiac surgery when the options for further testing and evaluation are limited, is unclear. The focus of most of the literature, including the American College of Cardiology/American Heart Association guidelines, has been on patients underg...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.5.2004980
更新日期:2005-10-01 00:00:00
abstract::Residual risk, which cannot be prevented by statins alone, must be controlled for inhibiting the onset of coronary events. Omega-3 polyunsaturated fatty acids (PUFAs) play an important role in controlling residual risk. The Japan eicosapentaenoic acid (EPA) Lipid Intervention Study demonstrated the inhibitory effect o...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.1080/00015385.2017.1305174
更新日期:2017-06-01 00:00:00
abstract::This study was conducted to determine the zinc status and assess relationship between serum zinc and in vivo cell mediated immunity (CMI) in patients with rheumatic heart disease (RHD). The study comprised 22 patients with active rheumatic heart disease (ARHD), 15 patients with chronic rheumatic heart disease without ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Thromboembolic events are major causes of morbidity and mortality in patients with native heart valve disease and artificial heart valves. Oral anticoagulation can reduce these complications. The indication for and intensity of oral anticoagulation depends on both, the risk for thromboembolic events and the risk of he...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::Creatine kinase (CK) and its isoenzyme CK-MB are important tools for the diagnosis of acute myocardial infarction. The content of CK-MB relative to total CK in myocardial cells is variable; it is low in normal myocardium and increased several-fold in hypoxic myocardium. We tested the hypothesis that CK-MB mass (CK-MBm...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Background: This study aimed to examine the value of prognostic nutritional index (PNI) as a predictor of outcomes in patients with heart failure and preserved ejection fraction (HFpEF).Methods: We prospectively followed consecutive adult patients admitted to the cardiology outpatient units with HFPEF. Echocardiograph...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2019.1661139
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:The aim of this randomized trial was to evaluate whether omission of heparin infusion after successful coronary interventions increased the incidence of ischaemic complications. Continuous heparin infusion after percutaneous coronary interventions could increase the occurrence of bleeding; however, the probab...
journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2143/AC.64.1.2034364
更新日期:2009-02-01 00:00:00
abstract:AIMS:We retrospectively followed 250 patients who started dialysis between 2005 and 2009 to clarify the prevalence, the prognosis and the prescribed heart failure treatment of systolic heart failure patients on dialysis. METHODS AND RESULTS:This cohort was divided according to left ventricular ejection fraction (LVEF)...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.68.1.2959632
更新日期:2013-02-01 00:00:00
abstract::Atrial bigeminy is a supraventricular arrhythmia rarely associated with severe symptoms. We report the case of a 22-year-old woman with no prior cardiac disease presenting with exercise intolerance since several months. No apparent heart disease other than a spontaneous conducted atrial bigeminy with a short coupling ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.66.4.2126602
更新日期:2011-08-01 00:00:00
abstract::Background: AF, anticoagulation, NOACs, changing patterns of prescription. Methods: We describe baseline data and treatment patterns of patients recruited in Belgium in the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF). Recruitment began when novel oral anticoagulants (NOACs) were introd...
journal_title:Acta cardiologica
pub_type: 杂志文章,多中心研究
doi:10.1080/00015385.2018.1494089
更新日期:2019-08-01 00:00:00
abstract::Ventricular noncompaction is a rare cardiomyopathy characterized by numerous, prominent ventricular trabeculations and deep intertrabecular recesses and is caused by a disorder of endomyocardial morphogenesis. It can occur in patients with other congenital anomalies, such as various ventricular obstructive lesions, or...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.57.3.2005392
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:The European Society of Cardiology designated 2008 as the year of imaging. However, despite the intense focus on the many types of imaging and the relative benefits of each one, the optimal modalityfor the diagnosis of coronary artery disease remains controversial. Among the currently available techniques, co...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.66.2.2071253
更新日期:2011-04-01 00:00:00