Vascular smooth muscle cell remodelling in elastase-induced aortic aneurysm.

Abstract:

UNLABELLED:OBJECTIVE; ; The objective of this study was to identify developmental changes in vascular smooth muscle cells (VSMC) during aneurysm formation using an elastase-induced rabbit carotid artery aneurysm model. METHODS:- Aneurysms were induced in carotid arteries of rabbits by exposure to elastase. Tissues from developing aneurysms were isolated at various time points for histological, immunohistochemical and RT-PCR analysis. RESULTS:During aneurysm growth, the vascular media became thinner and elastic fibres became fragmented.The expression of smooth muscle marker SM22alpha and cytoskeleton proteins (SM alpha-actin, beta-tubulin and desmin) expression was decreased while platelet-derived growth factor (PDGF) was increased, which correlated with a remodelling ofVSMC from contractile to synthetic functions. CONCLUSION:During the development of aneurysm, despite the induction of apoptosis, VSMC undergoes a remodelling from a contractile phenotype to a synthetic phenotype as a potential repair mechanism. Further studies may reveal the causative effects between these events.

journal_name

Acta Cardiol

journal_title

Acta cardiologica

authors

Jiao L,Xu Z,Xu F,Zhang S,Wu K

doi

10.1080/ac.65.5.2056235

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

499-506

issue

5

eissn

0001-5385

issn

1784-973X

journal_volume

65

pub_type

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