Abstract:
OBJECTIVE:The main function of hepatic lipase (HL) with respect to high-density lipoprotein (HDL) is hydrolysis of phospholipids and triglycerides. The -514C-->T polymorphism in the promoter region of the hepatic lipase gene affects HL activity. We aimed to investigate the association between the frequency of the -514C-->T polymorphism of hepatic lipase (PHL) and CAD in the East Anatolian region of Turkey. METHODS AND RESULTS:We conducted a case-control study in 302 unrelated subjects who were referred for coronary angiography. One hundred fifty-one patients with angiographically documented CAD and one hundred fifty-one subjects without angiographically documented CAD were studied to examine the association of the frequency of the -514C-->T polymorphism with CAD. Genotyping was determined by polymerase chain reaction. The PCR products were analysed for the -514C-->T polymorphism by enzyme digestion. The frequency of the -514C-->T polymorphism was found in 20 of 151 (13.2%) patients with CAD and in 9 of 151 (6%) of the control subjects (P < 0.05). There was a significant difference in terms of smoking (P = 0.001), gender (P < 0.05), total cholesterol levels (P < 0.05) and low-density lipoprotein (LDL) levels (P < 0.01) but there was no association with diabetes mellitus, hypertension, family history of CAD and HDL levels in the PHL (+) and PHL (-) patients with CAD. CONCLUSIONS:The results of this study suggest that the -514C-->T polymorphism of the hepatic lipase gene could act as a risk factor in the development of CAD in the East Anatolian region of Turkey as well as male gender, diabetes mellitus, hypertension, and a positive family history of CAD.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Gündoğdu F,Gurlertop Y,Pirim I,Aksakal E,Dogan H,Islamoglu Y,Ozkan A,Senocak Hdoi
10.2143/AC.63.2.2029528subject
Has Abstractpub_date
2008-04-01 00:00:00pages
197-202issue
2eissn
0001-5385issn
1784-973Xjournal_volume
63pub_type
杂志文章abstract:OBJECTIVE:Decreased effects of smoking on serum high-density lipoprotein cholesterol (HDL-c) were demonstrated in subjects smoking more than 20 cigarettes a day. We aimed to evaluate the effects of non-heavy smoking (< or =20 cigarettes a day) on HDL-c in young, healthy men who are similar in terms of age, physical act...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.4.2017301
更新日期:2006-08-01 00:00:00
abstract::A patient with unstable angina and known heart failure, and marked U wave alternans on the electrocardiogram is reported. Alternans of the U wave with no change in the QRS complex is extremely rare. The relevant literature is reviewed. ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::A 57-year-old woman suffering from severe Prinzmetal's angina was treated with a 7-week course of enhanced external counterpulsation (EECP). After completing EECP the angina intensity was reduced from CCS class IV to class I, quality of life was increased and medication was significantly reduced. The number of hospita...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.2.2047066
更新日期:2010-04-01 00:00:00
abstract::Background: To explore the prognostic value of combination of coronary artery calcium scoring (CACS) and single-photon emission computed tomography (SPECT) on the long-term risk of major adverse cardiac events (MACEs) in Chinese patients at low risk of suspected coronary artery disease (CAD).Methods: The medical recor...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2018.1530081
更新日期:2019-12-01 00:00:00
abstract::Endothelial cells release both relaxing and contracting factors that modulate vascular smooth muscle tone and also participate in the pathophysiology of essential hypertension. Endothelium-dependent vasodilation is regulated primarily by nitric oxide but also by an unidentified endothelium-derived hyperpolarizing fact...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.2143/AC.55.4.2005744
更新日期:2000-08-01 00:00:00
abstract::Indices of the first derivative and of the normalized first derivative of the left apexcardiogram were used to evaluate the contractile state of the left ventricle of cyclists in the competitive season compared to their resting season and of cardiac patients before and after a physical training program. In both groups...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Objective In modern cardiology practice, implantation of cardiac electronic devices in patients taking anticoagulant or antiplatelet therapy is a common clinical scenario. Bleeding complications are of particular concern in this patient population and pocket haematoma is one of the most frequent complications. We soug...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2017.1281539
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The renin-angiotensin-aldosterone system (RAAS) plays an important role in blood pressure regulation, left ventricular and vascular structure. Some hypertensive patients develop left ventricular dilatation and heart failure symptoms while others are relatively less affected. The purpose of our study was to d...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.1.2005137
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:The effect of inhibiting mitochondrial permeability transition (MPT) on cardioprotection induced by ischaemic postconditioning remains debatable. The aim of the present study was to investigate whether ischaemic postconditioning attenuates cardiomyocyte ultrastructure injury and apoptosis by blocking MPT. ME...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.3.1020316
更新日期:2008-06-01 00:00:00
abstract::We describe two cases of Duchenne's cardiomyopathy with severe cardiac dysfunction, sporadic episodes of myoglobinuria induced by effort and increased levels of serum creatine kinase. Very mild signs of skeletal myopathy were clinically evident. Left ventriculography showed diffuse severe hypokinesia. Skeletal muscle ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.4.2017311
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to evaluate the prevalence of HR2 polymorphism among patients with pulmonary embolism (PE) and healthy subjects. BACKGROUND:Polymorphism in the factor V gene named HR2 has been described as a possible risk factor for venous thromboembolism (VTE) development. Contradictive resu...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.70.6.3120184
更新日期:2015-12-01 00:00:00
abstract:UNLABELLED:The aim of study was to determine the significance of the best echocardiographic parameters for assessing the severity of mitral regurgitation (MR). METHODS:The study population consisted of 107 patients, mean age 52 +/- 7 y with chronic isolated non-ischaemic MR. Quantification of the MR was performed usin...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.64.2.2036136
更新日期:2009-04-01 00:00:00
abstract:UNLABELLED:The purpose of the study is the predictive value of determination of Tr-T in diagnosis of unstable angina. METHODS:35 pts (24 male, 11 female, mean age 53.4 +/- 5 years) were studied. Group A: 20 pts (15 male, 5 female, mean age 50 +/- 6 years) with unstable angina. Group B: 15 pts (9 male, 6 female, mean a...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::During inflammation, several cell types synthesize and secrete phospholipase A2 that catalyses lipid oxidation in LDL. Myeloperoxidase, a haeme protein secreted by activated phagocytes, oxidizes L-tyrosine to a tyrosyl radical that is a physiological catalyst for the initiation of lipid oxidation in LDL. Lipid oxidati...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.2143/AC.59.5.2005219
更新日期:2004-10-01 00:00:00
abstract::Left ventricular (LV) asynchrony has been demonstrated to result in diastolic dysfunction. To test the hypothesis that altered LV synchrony interferes with LV diastolic function in essential hypertensive patients (HT), we performed radionuclide ventriculography and echocardiography in 38 HT and 11 normotensive subject...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Familial hypercholesterolaemia (FH) is underdiagnosed in most countries. We report our first experience from a national pilot project of cascade screening in relatives of FH patients. METHODOLOGY:Participating specialists recruited consecutive index patients (IP) with Dutch Lipid Clinic Network (DLCN) score...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1820683
更新日期:2020-09-23 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.65.6.2059861
更新日期:2010-12-01 00:00:00
abstract:UNLABELLED:We describe the clinical and echocardiographic features in 12 patients with hydatid cyst of the heart who were screened between 1985 and 2001. Presenting symptoms have a wide variability but the main symptom was precordial pain. The electrocardiogram was always abnormal and showed T wave inversion in 8 cases...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.1.2005047
更新日期:2005-02-01 00:00:00
abstract::Purulent pericarditis is rarely the primary site of bacterial infection. It is usually a complication of an infection originating elsewhere in the body, arising by contiguous spread or haematogenous dissemination.This paper, however, describes a previously healthy young man, who developed a purulent streptococcal peri...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.57.5.2005459
更新日期:2002-10-01 00:00:00
abstract::In eighteen consecutive patients (14 male, 4 females, in the age 37-52 years, mean = 43 years) with dilated cardiomyopathy in NYHA functional classification groups III-IV, the efficacy of ambulatory long-term (mean = 6 years) vasodilator therapy by means mechanocardiography (systolic and diastolic time intervals) and ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Transradial approach to coronary angiography is a progressive and increasingly more often used technique. Apart from its advantages, radial artery occlusion (RAO) represents the most serious drawback. Re-canalization of an iatrogenic RAO, although asymptomatic in the majority of cases, remains a discussed and challeng...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.67.3.2160731
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Left atrial scarring is recognised as a critical component in the maintenance of atrial fibrillation and is associated with the failure of interventional treatment. Diminished bipolar voltage (LV) has been proposed as a useful tool for left atrial scar quantification. We hypothesised that, due to its anatomi...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2017.1420438
更新日期:2017-12-22 00:00:00
abstract:OBJECTIVE:Cigarette smoking increases the synthesis of angiotensin-1 converting enzyme (ACE) and induces oxidative modifications of the apolipoprotein E (apo E).Thus we explored the gene-environment interactions between APOE gene epsilon and ACE gene insertion/deletion polymorphisms and cigarette smoking in coronary ar...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.6.2033392
更新日期:2008-12-01 00:00:00
abstract::The present study was designated to assess long term functional capacity, blood pressure and renal function at 12 and 60 months after heart transplantation. The data of sixty heart transplant recipients were retrospectively reviewed. At rest, radionuclide ejection fraction and cardiac index measured by thermodilution ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The modifications that atrial flutter determines on the phonocardiogram, apexcardiogram, carotid pulse tracing, jugular venous pulse tracing, and indirect (esophageal) left atrial pulse tracing were studied. On the basis of the data here presented and that of the literature, a polygraphic profile of atrial flutter has...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Congenital left ventricular diverticulum is rare and usually isolated or associated with midline thoracoabdominal defects and other congenital cardiac malformations. We describe a case with a previously undescribed malformation syndrome including bilateral obstruction of the ureteropelvic junction, agenesis of corpus ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.58.3.2005280
更新日期:2003-06-01 00:00:00
abstract:AIM:To determine whether statin therapy initiated early in acute myocardial infarction together with thrombolytic therapy in patients with acute myocardial infarction results in clinical benefit through early plaque stabilization. METHODS AND RESULTS:The study population consisted of 77 patients who underwent coronary...
journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2143/AC.57.4.2005430
更新日期:2002-08-01 00:00:00
abstract:AIM:The purpose of this study was to investigate the role of oxidant stress in the clinical process and pathogenesis of acute rheumatic fever (ARF). MATERIAL AND METHODS:The study included 33 children with ARF and 20 healthy control subjects. The diagnosis of ARF was established according to the Jones Criteria. Malond...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.1.2045889
更新日期:2010-02-01 00:00:00
abstract::Sixteen patients were examined hemodynamically with echocardiography, calibrated apexcardiography, and systolic time intervals before treatment, after 1 week treatment with amiodarone 600 mg daily and after 2-4 months treatment with 300 mg daily. During the treatment thyroid function was controlled. The echocardiogram...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Primary cardiac tumours are uncommon, with an estimated incidence between 0.0017% and 0.19%. Cardiac myxoma is a rare cause of cerebrovascular disease, especially in children. This case report emphasizes the importance of cardiac evaluation, especially echocardiographic examination in cases with stroke and peripheral ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.1.2045899
更新日期:2010-02-01 00:00:00