Abstract:
OBJECTIVE:Coronary revascularization methods are among the most common major medical procedures performed in industrialized countries. The short- and long-term comparative effectiveness of different techniques remains undetermined. METHODS AND RESULTS:The study population included all adult patients (94,864 subjects) admitted for acute myocardial infarction (AMI) in 2004 in Italy, as recorded in the National Hospital Discharge Records. Invasive reperfusion therapy (coronary artery bypass graft, percutaneous coronary intervention), and standard medical treatments were compared. End points were short-term (30-day) in-hospital mortality and any combination of new revascularizations, re-AMI, stroke, or death (MACCE) occurring within 6 and 12 months from initial treatment. Risk factors and comorbidities were used to define patients' health status. The Cox model was applied to evaluate risk-adjusted hazard ratios (HR) for different approaches. Medical treatment was used as the reference category. Propensity score matching was performed to evaluate selection bias in the allocation to CABG or percutaneous coronary intervention (PCI). Both short-term mortality and 6- and 12-month MACCE risk for invasive reperfusion therapy was significantly lower than the reference (HR: 0.50, P < 0.001; 0.54, P < 0.001; 0.64, P < 0.001, respectively). In the matched population, while short-term mortality was significantly lower for PCI (HR 0.36, P < 0.001), long-term MACCE risk was lower for CABG (6-month HR 2.93, P < 0.001; 12-month HR 3.01, P < 0.001). CONCLUSIONS:In spite of adjustments for patients' health status, medical treatment resulted in a higher mortality and increased MACCE risk. While PCI gave the best short-term results, after 1 year the risk of re-interventions or further events was significantly lower for patients undergoing CABG.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
D'Errigo P,Seccareccia F,Barone AP,Fusco D,Rosato S,Maraschini A,Colais P,Casali Gdoi
10.1080/ac.65.6.2059861subject
Has Abstractpub_date
2010-12-01 00:00:00pages
645-52issue
6eissn
0001-5385issn
1784-973Xjournal_volume
65pub_type
杂志文章abstract::Stereological methods under light and electron microscopy have been used to study the ventricular myocardium of rats exhausted by swimming exercise. The proportion of myocardial cell/interstitium diminishes with the exercise. This result is interpreted as a consequence of an intercellular edema which becomes more pron...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:Subclinical hypothyroidism (SH) is characterized by normal serum free T4 (fT4), free T3 (fT3) levels and increased serum thyroid stimulating hormone (TSH) levels.The aim of this study was to assess the validity of tissue Doppler imaging (TDI) in evaluating cardiac effects of SH and to demonstrate the improvi...
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doi:10.1080/ac.66.1.2064966
更新日期:2011-02-01 00:00:00
abstract::Clinical experience with repeated tilt testing and standing training has shown that this procedure can be used as a new therapy for the restoration of abnormal autonomic orthostatic reflexes. The introduction of tilt training therapy for neurally mediated syncope is a new and effective treatment. This new therapy has ...
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pub_type: 杂志文章,评审
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abstract::Color-coded liquid plastic was injected intraparenchymally (not into the blood vessels) into more than 300 hearts of homeotherms--including dog, cat, sheep, beef, horse, mammalian dolphins, chickens, turkeys, etc. The organization of the hearts of all these species appears to be similar. After injection of a heart seg...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:The coronary slow flow phenomenon is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease, and is an important clinical entity because it may be the cause of angina at rest or during exercise, acute myocardial infarction, and h...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.5.2033224
更新日期:2008-10-01 00:00:00
abstract::A 67-year-old Caucasian woman presented with chest pain suggestive of acute pericarditis. On initial evaluation the apical ballooning variant of stress-related cardiomyopathy (CMP) was present. The stress CMP and acute pericarditis resolved within a week. The patient returned in four weeks with early cardiac tamponade...
journal_title:Acta cardiologica
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doi:10.2143/AC.65.3.2050358
更新日期:2010-06-01 00:00:00
abstract::"No-reflow" is an important complication of percutaneous coronary intervention (PCI) in the setting of acute myocardial infarction and is associated with worse outcomes. Visible thrombus on the angiogram is a significant risk factor for "no-reflow". A variety of strategies have been employed to prevent this phenomenon...
journal_title:Acta cardiologica
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doi:10.2143/AC.60.6.2004941
更新日期:2005-12-01 00:00:00
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journal_title:Acta cardiologica
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doi:
更新日期:1983-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.3.2005008
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更新日期:2009-06-01 00:00:00
abstract::European Society of Cardiology (ESC) National Society Cardiovascular Journals (NSCJs) are high-quality biomedical journals focused on cardiovascular diseases. The Editors' Network of the ESC devises editorial initiatives aimed at improving the scientific quality and diffusion of NSCJ. In this article we will discuss o...
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journal_title:Acta cardiologica
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doi:
更新日期:1995-01-01 00:00:00
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doi:10.1080/ac.67.2.2154213
更新日期:2012-04-01 00:00:00
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更新日期:2012-12-01 00:00:00
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journal_title:Acta cardiologica
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journal_title:Acta cardiologica
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doi:
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journal_title:Acta cardiologica
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Between March 1982 and March 1991, 225 heart transplantations (HTx) have been performed in 220 patients suffering end stage cardiac disease. Thirteen percent were females and 87% were males. Age range was from 5 to 68 years. The underlying cardiac disease was ischemic cardiopathy in 51.5%, congestive dilated cardiomyo...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.70.4.3096895
更新日期:2015-08-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00