Abstract:
OBJECTIVES:The objective of this study is to evaluate the prevalence of HR2 polymorphism among patients with pulmonary embolism (PE) and healthy subjects. BACKGROUND:Polymorphism in the factor V gene named HR2 has been described as a possible risk factor for venous thromboembolism (VTE) development. Contradictive results on this association have been reported. METHODS:Eighty-five patients admitted for PE and 72 healthy subjects were included in the study. Thrombophilia screening using genetic tests for factor V Leiden (G1691A/Leiden and HR2 haplotype) and other genetic mutations were investigated. RESULTS:Of 85 patients with PE, 20 (23.53%) carried the HR2 haplotype. Further, a majority of the patients with HR2 haplotype had recurrent venous thrombosis or PE (15 out of 20 patients). The HR2 haplotype was detected in 6 (8.3%) out of 72 healthy subjects. Patients had significantly higher HR2 haplotype frequency than healthy controls (P = 0.001). HR2 carriers had a three-fold increase in risk of developing PE (OR = 3.38, 95% CI = 1.27-8.96, P = 0.011). After adjustment for other tested defects for thrombophilia, HR2 haplotype was associated with increased risk of thromboembolic events (OR = 3.05, 95% CI = 1.11-8.35, P = 0.03). However, after adjustment for sex and age, HR2 polymorphism was no longer associated with the risk of thromboembolic event (OR = 1.22, 95% CI = 0.34-4.38, P = 0.76). CONCLUSIONS:Our study does not support the notion that factor V HR2 haplotype might be a risk factor for thrombosis despite its high prevalence among patients with PE.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Aleksova A,Di Nucci M,Gobbo M,Bevilacqua E,Pradella P,Salam K,Barbati G,De Luca A,Mascaretti L,Sinagra Gdoi
10.2143/AC.70.6.3120184subject
Has Abstractpub_date
2015-12-01 00:00:00pages
707-11issue
6eissn
0001-5385issn
1784-973Xjournal_volume
70pub_type
杂志文章abstract::Sixteen patients were examined hemodynamically with echocardiography, calibrated apexcardiography, and systolic time intervals before treatment, after 1 week treatment with amiodarone 600 mg daily and after 2-4 months treatment with 300 mg daily. During the treatment thyroid function was controlled. The echocardiogram...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Primary cardiac tumours are uncommon, with an estimated incidence between 0.0017% and 0.19%. Cardiac myxoma is a rare cause of cerebrovascular disease, especially in children. This case report emphasizes the importance of cardiac evaluation, especially echocardiographic examination in cases with stroke and peripheral ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.1.2045899
更新日期:2010-02-01 00:00:00
abstract::Background: Quality indicators (QIs) are used to measure and evaluate quality of care. However, QIs to evaluate care for HF patients in general practice in Belgium are lacking. Therefore, this study aimed to determine which QIs, rooted in the electronic health record (EHR), are useful to monitor quality of care for pa...
journal_title:Acta cardiologica
pub_type: 共识发展会议,杂志文章,评审
doi:10.1080/00015385.2018.1492659
更新日期:2019-08-01 00:00:00
abstract::Background: This study aimed to examine the value of prognostic nutritional index (PNI) as a predictor of outcomes in patients with heart failure and preserved ejection fraction (HFpEF).Methods: We prospectively followed consecutive adult patients admitted to the cardiology outpatient units with HFPEF. Echocardiograph...
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pub_type: 杂志文章
doi:10.1080/00015385.2019.1661139
更新日期:2020-09-01 00:00:00
abstract:AIM:To determine whether statin therapy initiated early in acute myocardial infarction together with thrombolytic therapy in patients with acute myocardial infarction results in clinical benefit through early plaque stabilization. METHODS AND RESULTS:The study population consisted of 77 patients who underwent coronary...
journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2143/AC.57.4.2005430
更新日期:2002-08-01 00:00:00
abstract::Introduction Strength exercises influence the cardiovascular system by promoting autonomic adjustments induced by the increased metabolic demand and consequent increase in local blood flow. However, it is unclear whether there are differences between upper and lower limbs. We aimedto evaluate recovery of cardiac auton...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2017.1335454
更新日期:2017-08-01 00:00:00
abstract:UNLABELLED:The aim of study was to determine the significance of the best echocardiographic parameters for assessing the severity of mitral regurgitation (MR). METHODS:The study population consisted of 107 patients, mean age 52 +/- 7 y with chronic isolated non-ischaemic MR. Quantification of the MR was performed usin...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.64.2.2036136
更新日期:2009-04-01 00:00:00
abstract::Indices of the first derivative and of the normalized first derivative of the left apexcardiogram were used to evaluate the contractile state of the left ventricle of cyclists in the competitive season compared to their resting season and of cardiac patients before and after a physical training program. In both groups...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.6.1000012
更新日期:2014-12-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.57.6.2005466
更新日期:2002-12-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2018.1493248
更新日期:2019-08-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::In order to prepare Belgian participation in the International Study "Monitoring of trends and determinants in cardiovascular disease (MONICA)", a pilot project for registration of acute myocardial infarctions was organized in the Flemish city of Ghent and the Walloon city of Charleroi. Thanks to the collaboration of ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.3.1020306
更新日期:2008-06-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 历史文章,杂志文章
doi:
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/ac.66.5.2131091
更新日期:2011-10-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:
更新日期:1986-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-01-01 00:00:00
abstract::A 67-year-old Caucasian woman presented with chest pain suggestive of acute pericarditis. On initial evaluation the apical ballooning variant of stress-related cardiomyopathy (CMP) was present. The stress CMP and acute pericarditis resolved within a week. The patient returned in four weeks with early cardiac tamponade...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.3.2050358
更新日期:2010-06-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.3.2014841
更新日期:2006-06-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2019.1639269
更新日期:2019-07-17 00:00:00
abstract::Background and aim The purpose of this study was to assess incidence, predictors and outcome of radial artery occlusion (RAO) after transradial catheterization (TRC) based on clinical and Doppler ultrasound study. Methods A total of 1,945 consecutive patients undergoing transradial catheterization for diagnostic evalu...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2017.1305158
更新日期:2017-06-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.66.2.2071253
更新日期:2011-04-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2017.1291181
更新日期:2017-04-01 00:00:00
abstract::Electroconvulsive therapy (ECT) is used frequently in psychiatric practice and various electrocardiographic (ECG) changes have been described during ECT. QT dispersion (defined as maximal QT interval minus minimal QT interval) as assessed on the surface electrocardiogram has been demonstrated to reflect regional inhom...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The increasing number of amateur sportsmen enhances the need for a correct evaluation of subjects suspected of overt and mild cardiac disease. Out of 4000 athletes, 72 subjects were clinically preselected by the sport doctor during an annual routine examination. They were studied with mono and 2D echo, pulsed color (P...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00