Abstract：
:During inflammation, several cell types synthesize and secrete phospholipase A2 that catalyses lipid oxidation in LDL. Myeloperoxidase, a haeme protein secreted by activated phagocytes, oxidizes L-tyrosine to a tyrosyl radical that is a physiological catalyst for the initiation of lipid oxidation in LDL. Lipid oxidation results in the generation of aldehydes that substitute lysine residues in the apolipoprotein B-100 moiety. Lipid together with protein oxidation in LDL results in the generation of oxidized LDL. We, among others, have demonstrated an association between coronary heart disease (CHD) and increased plasma levels of oxidized LDL. Recently, we have demonstrated a higher prevalence of elevated oxidized LDL in persons with high-calculated CHD risk prior to events. The odds of having elevated oxidized LDL for persons with high-calculated CHD risk prior to events were even higher than for persons with diagnosed CHD. A likely explanation is that once CHD has been diagnosed the patients are more treated with a statin that appears to decrease oxidized LDL even beyond its cholesterol-lowering effect. We have identified several metabolic syndrome components (high triglycerides, low HDL-cholesterol, glucose intolerance and diabetes) that independently of LDL-cholesterol, predicted high levels of oxidized LDL. Finally, elevated oxidized LDL predicted myocardial infarction in the Health ABC cohort consisting of well-functioning elderly people, even after adjusting for age, gender, race, smoking, and the metabolic syndrome.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Holvoet Pdoi
10.2143/AC.59.5.2005219subject
Has Abstractpub_date
2004-10-01 00:00:00pages
479-84issue
5eissn
0001-5385issn
1784-973Xjournal_volume
59pub_type
杂志文章,评审abstract：:An early exercise stress test was carried out in 116 patients 8 to 14 days after a myocardial infarction. This test is in good agreement with the late maximal stress test performed 8 weeks after the infarction, both tests being positive together in 86.4% and negative in 84.6% of the cases. Residual coronary insufficie...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:Cytomegalovirus (CMV), Helicobacter pylori (H. pylori) and Chlamydia pneumoniae (C. pneumoniae) have been associated with human atherosclerosis. The reported rates of detection within atherosclerotic lesions by PCR vary widely for all of these pathogens. We investigated their presence in carotid atherosclerot...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.59.6.2005249
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Left atrial scarring is recognised as a critical component in the maintenance of atrial fibrillation and is associated with the failure of interventional treatment. Diminished bipolar voltage (LV) has been proposed as a useful tool for left atrial scar quantification. We hypothesised that, due to its anatomi...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/00015385.2017.1420438
更新日期：2017-12-22 00:00:00
abstract：OBJECTIVE:The Gubbio Study is an Italian population study measuring risk factors for and incidence of major cardiovascular diseases. This analysis investigates the association of serum uric acid with the incidence of coronary and cardiovascular events. METHODS:A population sample of 2469 men and women aged 35-74 years...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.56.4.2005651
更新日期：2001-08-01 00:00:00
abstract：:The clinical, fono-mechano-echocardiographic, hemodynamic and angiographic findings before and after surgery of a patient who developed bilateral extensive endomyocardial fibrosis probably secondary to filariasis, are described. The patient was surgically treated by endocardial decortication and insertion of a mitral ...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Purulent pericarditis is rarely the primary site of bacterial infection. It is usually a complication of an infection originating elsewhere in the body, arising by contiguous spread or haematogenous dissemination.This paper, however, describes a previously healthy young man, who developed a purulent streptococcal peri...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.57.5.2005459
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVES:Angiotensin-converting enzyme (ACE) is a key enzyme in the production of angiotensin II and thus may participate in the modulation of cardiac growth. The cloning of the ACE gene has made it possible to identify a deletion (D)-insertion (I) polymorphism that appears to affect the level of serum ACE activity. ...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.60.2.2005025
更新日期：2005-04-01 00:00:00
abstract：:Nineteen asymptomatic patients affected by isolated chronic aortic regurgitation received 20 mg of nifedipine sublingually: the acute hemodynamic effects of nifedipine were evaluated by combined cross-sectional and Doppler echocardiography. To assess variations in the regurgitant flow volume, the flow volume across th...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:The clinical, hemodynamic findings and surgical results of forty patients with rheumatic tricuspid stenosis are presented. It is concluded that tricuspid stenosis is a frequent lesion. Its signs should be sought carefully and documented by simultaneous measurements of the right ventricular diastolic and right atrial p...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:This is a review of the effects of E on the symptoms of CHF which affect patients' (pts) quality of life and the signs associated with pts' prognosis. The review is based on clinical studies which were included in the New Drug Application for Vasotec (enalapril maleate, MSD) in the United States. There were 3 open-lab...
journal_title：Acta cardiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-01-01 00:00:00
abstract：:Left ventricular-right atrial communication is a relatively rare surgically corrigible congenital heart defect. We report a case with review of the literature. ...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Electroconvulsive therapy (ECT) is used frequently in psychiatric practice and various electrocardiographic (ECG) changes have been described during ECT. QT dispersion (defined as maximal QT interval minus minimal QT interval) as assessed on the surface electrocardiogram has been demonstrated to reflect regional inhom...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Background: This study aimed to examine the value of prognostic nutritional index (PNI) as a predictor of outcomes in patients with heart failure and preserved ejection fraction (HFpEF).Methods: We prospectively followed consecutive adult patients admitted to the cardiology outpatient units with HFPEF. Echocardiograph...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/00015385.2019.1661139
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:The intima-media thickness (IMT) of the carotid artery is dependent on the risk factor load during life and correlates well with the degree of atherosclerosis, also in other vascular beds. METHODS:We reviewed our database of IMT measurements, from January 2002 to February 2007. We compared the mean IMT value...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.63.3.1020306
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:Mild reductions in iodine concentration could reduce acute side effects after intraarterial contrast media administration without affecting the quality of coronary artery images. This study was designed to show the equivalence in terms of image quality of two nonionic low-osmolar monomers, iobitridol 350 and ...
journal_title：Acta cardiologica
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2143/AC.65.4.2053896
更新日期：2010-08-01 00:00:00
abstract：:Sixteen patients were examined hemodynamically with echocardiography, calibrated apexcardiography, and systolic time intervals before treatment, after 1 week treatment with amiodarone 600 mg daily and after 2-4 months treatment with 300 mg daily. During the treatment thyroid function was controlled. The echocardiogram...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Meningitis due to Neisseria meningitidis occurred in a young man. On admission, he was in septic shock and the electrocardiogram revealed convex upwards ST-segment elevation in inferior and lateral leads. Rapid and complete normalisation of the ECG was observed and the patient had a favourable evolution with intensive...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.56.5.2005695
更新日期：2001-10-01 00:00:00
abstract：:Objective In modern cardiology practice, implantation of cardiac electronic devices in patients taking anticoagulant or antiplatelet therapy is a common clinical scenario. Bleeding complications are of particular concern in this patient population and pocket haematoma is one of the most frequent complications. We soug...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/00015385.2017.1281539
更新日期：2017-02-01 00:00:00
abstract：AIM:To determine whether statin therapy initiated early in acute myocardial infarction together with thrombolytic therapy in patients with acute myocardial infarction results in clinical benefit through early plaque stabilization. METHODS AND RESULTS:The study population consisted of 77 patients who underwent coronary...
journal_title：Acta cardiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2143/AC.57.4.2005430
更新日期：2002-08-01 00:00:00
abstract：INTRODUCTION:There has been a long-standing controversy regarding the mechanism(s) to explain the irregular ventricular response during atrial tachycardia (AT) or atrial fibrillation (AF) and where the site of block, if any, resides in the atrioventricular (AV) junction. METHODS:We studied 12 Langendorff preparations ...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/ac.67.2.2154213
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:The effect of inhibiting mitochondrial permeability transition (MPT) on cardioprotection induced by ischaemic postconditioning remains debatable. The aim of the present study was to investigate whether ischaemic postconditioning attenuates cardiomyocyte ultrastructure injury and apoptosis by blocking MPT. ME...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.63.3.1020316
更新日期：2008-06-01 00:00:00
abstract：:Aneurysm and dissections localized to the ascending aorta are usually encountered in patients with atherosclerosis and hypertension. Behçet's syndrome is a rare vasculitic syndrome occasionally responsible for inflammation in small to large vessels. Aneurysm formation and dissection in the ascending aorta due to Behce...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.61.3.2014841
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:Biodegradable polymer drug-eluting stents may improve biocompatibility and reduce the risk of very late stent thrombosis (ST) but outcomes are nevertheless unknown in diabetic patients. The purpose of this study was to assess the long-term efficacy and safety of the biodegradable polymer biolimus A9-eluting s...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/ac.69.5.3044879
更新日期：2014-10-01 00:00:00
abstract：:A clinical, electrocardiographic and coronarographic study of ten cases shows that surelevation of ST-segment during exercise (without any signs of infarction) correspond to very different clinical situations of anatomical state of coronary vessels, occurrence of coronary spasm and evolution of the ischemic disease. "...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:A 15-year-old boy who was admitted to the neurology department had multiple cerebral infarcts on cranial magnetic resonance imaging. A transthoracic echocardiogram revealed myocardial thickening and apical thrombus in the left ventricle suggesting Loeffler endocarditis. There was remarkable hypereosinophilia on the ha...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.65.5.2056245
更新日期：2010-10-01 00:00:00
abstract：INTRODUCTION:3D echocardiography offers options of left ventricular systolic function analysis. The aims of this study are: to assess the usefulness of 3D echocardiography, to test 3D regional measurements (with area strain) among a spectrum of patients and then to check prospectively the value of 3D echocardiography v...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/ac.70.1.3064590
更新日期：2015-02-01 00:00:00
abstract：:Diffuse intra-alveolar haemorrhage is a rare complication of thrombolytic therapy (TT). We report a patient who developed haemoptysis due to pulmonary haemorrhage. This diagnosis should be considered in any patients with respiratory distress, diffuse pulmonary infiltrates, and haemoptysis and otherwise unexplained dec...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.59.3.2005194
更新日期：2004-06-01 00:00:00
abstract：:Endothelial cells release both relaxing and contracting factors that modulate vascular smooth muscle tone and also participate in the pathophysiology of essential hypertension. Endothelium-dependent vasodilation is regulated primarily by nitric oxide but also by an unidentified endothelium-derived hyperpolarizing fact...
journal_title：Acta cardiologica
pub_type： 杂志文章,评审
doi：10.2143/AC.55.4.2005744
更新日期：2000-08-01 00:00:00
abstract：:Aim of this study was to elucidate the diagnostic significance of left axis deviation (LAD) in patients (pts) with chronic (> 6 months) left bundle branch block (LBBB). We retrospectively studied 2094 consecutive pts who underwent cardiac catheterization. All pts had left heart catheterization and coronary angiography...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Background: All previous meta-analyses including clinical outcomes after remote ischaemic conditioning (RIC) in patients with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) demonstrated that RIC significantly reduced all-cause mortality and major adverse cardiovascular...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/00015385.2020.1766259
更新日期：2020-07-03 00:00:00
