Abstract:
OBJECTIVE:The effect of inhibiting mitochondrial permeability transition (MPT) on cardioprotection induced by ischaemic postconditioning remains debatable. The aim of the present study was to investigate whether ischaemic postconditioning attenuates cardiomyocyte ultrastructure injury and apoptosis by blocking MPT. METHODS AND RESULTS:Sprague-Dawley rats were randomly allocated to eight groups (n = 12) including sham without ischaemia (I), control given 30 min 1 and 5 min or 120 min reperfusion (R), postconditioning (Post) treated the same as control and 3 cycles of 10 s R and 10 s I before R, preconditioning (Pre) treated the same as control and 3 cycles of 5 min 1 and 5 min R before 30 min 1, and other groups treated the same as control or Post and given cyclosporin A (CsA) or atractyloside (Atr). Infarct size was evaluated by TTC, ultrastructure by electron microscope, MPT by spectrophotometry, and apoptosis by TUNEL. Compared with the control treatment, the Post, CsA and Pre treatments had smaller infarct size, less reduction in optical density at 540 nm (OD540) for MPT (20.2% +/- 2.3% versus 12.1% +/- 1.8%, 11.2% +/- 3.3% and 12.1% +/- 5.6%, P < 0.01, respectively), lower mitochondrial score (2.09 +/- 0.27 versus 1.27 +/- 0.27, 0.97 +/- 0.26 and 1.28 +/- 0.32, P < 0.01, respectively) and percentage of apoptosis (34.9% +/- 2.6% versus 17.5% +/- 1.7%, 17.6% +/- 2.1% and 17.2% +/- 2.1%, P < 0.01, respectively). Post-induced cardioprotection was abrogated by Atr and failed to be enhanced by CsA. CONCLUSIONS:Blockage of MPT may be involved in attenuation of ultrastructure injury and apoptosis by ischaemic postconditioning.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Fang J,Wu L,Chen Ldoi
10.2143/AC.63.3.1020316subject
Has Abstractpub_date
2008-06-01 00:00:00pages
377-87issue
3eissn
0001-5385issn
1784-973Xjournal_volume
63pub_type
杂志文章abstract::Conventional repair of pararenal aortic aneurysms has been a technically challenging operation, with a significant morbidity rate of 28-35%. Endovascular stent grafting requires satisfactory landing zones for stent graft anchoring. Therefore, pararenal abdominal aortic aneurysms are usually contraindicated for this pr...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.4.3036661
更新日期:2014-08-01 00:00:00
abstract::We report the case of a 73-year-old man admitted to our hospital for acute hepatic failure. Antemortem diagnosis of systemic AA amyloidosis was made because of typical electrocardiographic and echocardiographic findings, in the absence of the classic clinical picture of kidney involvement. ...
journal_title:Acta cardiologica
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更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:The beneficial effect of pentoxifylline (PTX) on ischaemic-reperfusion injury was assessed in a rat model of transient global cerebral ischaemia. DESIGN:Randomized, controlled, prospective study. SETTING:University research laboratory. SUBJECTS:Thirty-six male Wistar albino rats. INTERVENTIONS:Ischaemia w...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
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abstract::A definitive diagnosis in patients with syncope is often problematic if the cause is not evident after initial clinical assessment. The cause of syncope may be not established due to the infrequent, episodic occurrence. A symptom-rhythm correlation is frequently an unattainable gold standard in many patients. The impl...
journal_title:Acta cardiologica
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pub_type: 杂志文章
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journal_title:Acta cardiologica
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更新日期:1993-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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更新日期:2012-08-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.56.4.2005651
更新日期:2001-08-01 00:00:00
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journal_title:Acta cardiologica
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更新日期:2003-10-01 00:00:00
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更新日期:2009-12-01 00:00:00
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journal_title:Acta cardiologica
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.6.2017962
更新日期:2006-12-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.58.3.2005280
更新日期:2003-06-01 00:00:00
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journal_title:Acta cardiologica
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更新日期:1991-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 共识发展会议,杂志文章,评审
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更新日期:2019-08-01 00:00:00
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更新日期:2006-08-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Acta cardiologica
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doi:
更新日期:1976-01-01 00:00:00
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doi:10.2143/AC.61.1.2005137
更新日期:2006-02-01 00:00:00
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更新日期:2012-06-01 00:00:00
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更新日期:2004-08-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.6.1000012
更新日期:2014-12-01 00:00:00