Abstract:
OBJECTIVE:The present study was designed to examine the changes of MMP-2/TIMP-2 in the hearts of streptozotocin-induced diabetic rats and gain insight into their roles in extracellular matrix (ECM) remodelling on an experimental animal model of diabetic cardiomyopathy. METHODS AND RESULTS:Sixteen male Wistar rats were randomly divided into two groups: normal control and diabetic rats. Diabetes mellitus was induced in rats by streptozotocin injection. All rats were fed with standard chow and water ad libitum for 4 weeks. At 4 weeks diabetic rats were associated with a lower body weight (BW) and heart weight (HW) but a higher HW/BW. In the diabetic group, serum MMP-2 level had a tendency to increase but not significantly, while serum TIMP-2 significantly increased. Both the activity and expression of MMP-2 weakened in the hearts of diabetic rats. TIMP-2 gene expression in myocardium enhanced significantly. TIMP-2 protein level in diabetic heart was strengthened slightly but not significantly. VG staining showed a marked deposition of collagen in the diabetic group. Multivariate analysis revealed that total collagen content correlated negatively with the activity and gene expression of MMP-2 in the myocardium, and correlated positively with TIMP-1 mRNA expression. CONCLUSIONS:The decrease in MMP-2 activity and expression and increase in TIMP-2 gene expression in the myocardium of diabetic rats may lead to impairment of collagen degradation and contribute to the matrix deposition in diabetic myocardiopathy. The correlation between the serum level and cardiac expression of TIMP-2 in diabetic rats suggested that serum TIMP-2 level may be a viable marker for early diagnosis of diabetic myocardiopathy.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Li Q,Sun SZ,Wang Y,Tian YJ,Liu MHdoi
10.2143/AC.62.5.2023412subject
Has Abstractpub_date
2007-10-01 00:00:00pages
485-91issue
5eissn
0001-5385issn
1784-973Xjournal_volume
62pub_type
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journal_title:Acta cardiologica
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:Acta cardiologica
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abstract::Sixteen patients were examined hemodynamically with echocardiography, calibrated apexcardiography, and systolic time intervals before treatment, after 1 week treatment with amiodarone 600 mg daily and after 2-4 months treatment with 300 mg daily. During the treatment thyroid function was controlled. The echocardiogram...
journal_title:Acta cardiologica
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更新日期:1984-01-01 00:00:00
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journal_title:Acta cardiologica
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doi:10.1080/00015385.2017.1406884
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.64.2.2036136
更新日期:2009-04-01 00:00:00
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journal_title:Acta cardiologica
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doi:
更新日期:1999-06-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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更新日期:2006-06-01 00:00:00
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更新日期:2013-04-01 00:00:00
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doi:10.2143/AC.71.1.3132094
更新日期:2016-02-01 00:00:00
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journal_title:Acta cardiologica
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doi:
更新日期:1998-01-01 00:00:00
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更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
doi:10.2143/AC.64.5.2042704
更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章
doi:10.2143/AC.64.3.2038035
更新日期:2009-06-01 00:00:00
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doi:
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pub_type: 杂志文章
doi:10.2143/AC.59.6.2005249
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journal_title:Acta cardiologica
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doi:
更新日期:1999-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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更新日期:2005-08-01 00:00:00
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journal_title:Acta cardiologica
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doi:10.1080/00015385.2017.1324658
更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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pub_type: 历史文章,杂志文章
doi:
更新日期:2004-01-01 00:00:00
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