Abstract:
OBJECTIVE:Cigarette smoking increases the synthesis of angiotensin-1 converting enzyme (ACE) and induces oxidative modifications of the apolipoprotein E (apo E).Thus we explored the gene-environment interactions between APOE gene epsilon and ACE gene insertion/deletion polymorphisms and cigarette smoking in coronary artery disease (CAD) patients. METHODS:We analysed 360 subjects: 171 CAD patients and 189 blood donors without a history of cardiovascular diseases. ACE and APOE polymorphisms were genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods, respectively. To determine gene-environment interactions, epidemiological methodology was used. RESULTS:The ACE DD genotype was a rather weak risk factor of CAD in the analysed population (OR = 1.87, P = 0.01).The differences in allele and genotype distribution of the APOE polymorphism were not statistically significant.The carriers of the combined genotype ACE(DD) + APOE(epsilon4epsilon4,epsilon3epsilon4,epsilon2epsilon4) were more frequent in patients, however, the differences were on the bound of statistical significance (P = 0.08). Logistic regression analysis showed that the ACE(DD) + apo E(epsilon4epsilon4,epsilon3epsilon4,epsilon2epsilon4) cigarette smokers were much more frequent in the CAD group (OR = 11.68, 95%CI; 1.52-246.43, P = 0.009).We confirmed these results using the 4 x 2 table approach and we found a synergistic effect of the ACE(DD) + APOE(epsilon4epsilon4,epsilon3epsilon4,epsilon2epsilon4) combined genotype and cigarette smoking (SI = 10.52, SIM = 6.09). CONCLUSIONS:We demonstrated the existence of the synergistic effect between cigarette smoking and the contemporaneous carrier-state of APOE epsilon4 and ACE D alleles which increased the risk of CAD to a large extent.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Zak I,Niemiec P,Balcerzyk A,Krauze Jdoi
10.2143/AC.63.6.2033392subject
Has Abstractpub_date
2008-12-01 00:00:00pages
741-7issue
6eissn
0001-5385issn
1784-973Xjournal_volume
63pub_type
杂志文章abstract::Atrial bigeminy is a supraventricular arrhythmia rarely associated with severe symptoms. We report the case of a 22-year-old woman with no prior cardiac disease presenting with exercise intolerance since several months. No apparent heart disease other than a spontaneous conducted atrial bigeminy with a short coupling ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.66.4.2126602
更新日期:2011-08-01 00:00:00
abstract::A total of 10 cases of non-bacterial thrombotic endocarditis (NBTE) were found among 1640 adult patients, autopsied in a 24-year period. Eight out of 10 patients had an underlying malignant tumor, NBTE was more common in cancer patients than in patients without malignancy (1.25% vs 0.2%, P less than 0.05). Patients wi...
journal_title:Acta cardiologica
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abstract::Nineteen asymptomatic patients affected by isolated chronic aortic regurgitation received 20 mg of nifedipine sublingually: the acute hemodynamic effects of nifedipine were evaluated by combined cross-sectional and Doppler echocardiography. To assess variations in the regurgitant flow volume, the flow volume across th...
journal_title:Acta cardiologica
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doi:
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abstract::We describe two cases of Duchenne's cardiomyopathy with severe cardiac dysfunction, sporadic episodes of myoglobinuria induced by effort and increased levels of serum creatine kinase. Very mild signs of skeletal myopathy were clinically evident. Left ventriculography showed diffuse severe hypokinesia. Skeletal muscle ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.4.2017311
更新日期:2006-08-01 00:00:00
abstract::Introduction Strength exercises influence the cardiovascular system by promoting autonomic adjustments induced by the increased metabolic demand and consequent increase in local blood flow. However, it is unclear whether there are differences between upper and lower limbs. We aimedto evaluate recovery of cardiac auton...
journal_title:Acta cardiologica
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doi:10.1080/00015385.2017.1335454
更新日期:2017-08-01 00:00:00
abstract::Isolated ventricular noncompaction of myocardium is a rare congenital disease due to an arrest of myocardial morphogenesis during foetal development. It is characterized by a thin compacted epicardial and an extremely thickened endocardial layer with prominent trabeculations and deep intertrabecular recesses. The pers...
journal_title:Acta cardiologica
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doi:10.2143/AC.59.2.2005174
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abstract:BACKGROUND:High platelet reactivity (HPR) to clopidogrel is associated with an increased risk of ischaemic complications during and after coronary interventions and concerns up to 50% of patients undergoing PCI. AIM OF THE STUDY:The aim of the study was to identify patients with HPR to clopidogrel using bedside clinic...
journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2015-10-01 00:00:00
abstract::We present a case of a 87-year-old patient presenting with signs suggestive of new-onset heart failure which lead to the diagnosis of a large right ventricular mass occupying the entire cavity and extending to the right ventricular outflow tract. ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.70.1.3064600
更新日期:2015-02-01 00:00:00
abstract::Primary ventricular fibrillation especially occurs during the first hours after acute myocardial infarction and is often not preceded by premonitory ventricular premature beats. In hospital primary ventricular fibrillation can be prevented by an intravenous lidocaine regimen in a rather high dosage. By contrast the ef...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::This is a report on a prospective case-control study, in which a group of patients with an electrocardiographic diagnosis of QTc-prolongation (cases) was compared with a group of patients with a normal QTc (controls) for the presence of potential causative factors. Twelve cases and twelve carefully-matched controls we...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the practice of cardiac bradycardia pacing in an electrophysiology laboratory and to evaluate the safety and efficacy of pacemaker implantation by cardiologists in this setting. METHODS AND RESULTS:We evaluated a consecutive series of the first 500 permanent pacemaker...
journal_title:Acta cardiologica
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
abstract::A clinical, electrocardiographic and coronarographic study of ten cases shows that surelevation of ST-segment during exercise (without any signs of infarction) correspond to very different clinical situations of anatomical state of coronary vessels, occurrence of coronary spasm and evolution of the ischemic disease. "...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Familial hypercholesterolaemia (FH) is underdiagnosed in most countries. We report our first experience from a national pilot project of cascade screening in relatives of FH patients. METHODOLOGY:Participating specialists recruited consecutive index patients (IP) with Dutch Lipid Clinic Network (DLCN) score...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1820683
更新日期:2020-09-23 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.2.2029518
更新日期:2008-04-01 00:00:00
abstract::A young woman with systemic lupus erythematosus (SLE) developed progressive heart failure several years after mitral valve replacement with a Björk-Shiley prosthesis for treating mitral stenosis due to Libman-Sacks endocarditis. She was admitted to the hospital with pulmonary oedema. Transoesophageal echocardiography ...
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pub_type: 杂志文章,评审
doi:10.2143/AC.55.1.2005719
更新日期:2000-02-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2017.1406884
更新日期:2018-08-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::Mitral annular calcification is a degenerative process. It is mostly asymptomatic. As the calcification becomes more extensive it might be mistaken for an intracardiac tumour. Mitral annular calcification predicts cardiovascular events, cardiovascular death and overall death. It is predictive of a doubling of the stro...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.3.3027838
更新日期:2014-06-01 00:00:00
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doi:10.2143/AC.56.2.2005623
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更新日期:2010-12-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2017.1291181
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doi:
更新日期:1996-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::The left ventricular haemodynamic alterations during right atrial pacing were studied in 12 cases. Cardiac index varied little: during maximal rate however, its mean value was slightly lower than the resting one. Stroke index decreased inversely to the heart rate. The course of these indices did not separate the norma...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::We present a 64-year-old woman who was brought to the emergency department after suffering a motor vehicle accident, involving multiple soft tissue and bone trauma. Even though she was free from cardiovascular symptoms for the last three years, her past medical history of aorto-coronary bypass surgery prompted preoper...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.58.2.2005271
更新日期:2003-04-01 00:00:00
abstract::Background: Cardiovascular rehabilitation and retraining seek to increase cardiorespiratory fitness and to manage certain risk factors such as smoking, hypercholesterolaemia and sedentary lifestyle. Such lifestyle changes can be influenced by a combination of health determinants. Aim: The purpose of this study is to a...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2019.1639269
更新日期:2019-07-17 00:00:00
abstract::We investigated the effect of an orally administered, long-acting, beta-adrenergic blocking agent, penbutolol, on the circadian rhythm of blood pressure (BP) and heart rate (HR), and plasma renin activity (PRA), aldosterone (PA) and cortisol (PC) levels in hospital patients with essential hypertension validated by a c...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:The main function of hepatic lipase (HL) with respect to high-density lipoprotein (HDL) is hydrolysis of phospholipids and triglycerides. The -514C-->T polymorphism in the promoter region of the hepatic lipase gene affects HL activity. We aimed to investigate the association between the frequency of the -514C...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.2.2029528
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00