Effect of dobutamine stress echocardiography on serum heart fatty acid binding protein levels.

Abstract:

:Objective Heart fatty acid binding protein (HFABP) is a low-molecular-weight free protein that is abundant in the intracytoplasmic space of myocytes. Due to its unique features, serum HFABP levels may increase in myocardial ischaemia. The aim of this study was to evaluate the effect of myocardial ischaemia induced by dobutamine stress echocardiography (DSE) on serum HFABP levels. Methods and results A total of 30 consecutive patients with suspected myocardial ischaemia underwent DSE examination. HFABP levels were measured immediately before and 1 hour after DSE. HFABP rose significantly in individuals in the DSE positive group (1.66 ± 1.18 ng/ml vs 2.65 ± 1.34 ng/ml, P = 0.004), but remained unchanged in the DSE negative group (1.61 ± 0.77 ng/ml vs 1.85 ± 0.76 ng/ml, P = 0.066). Conclusion Serum HFABP levels increased significantly at 1 hour in the presence of ischaemia induced by DSE in patients with stable clinical coronary syndromes. No such increase was evident in the absence of ischaemia.

journal_name

Acta Cardiol

journal_title

Acta cardiologica

authors

Akinci S,Balcioğlu AS,Taçoy G,Tavil Y,Gülbahar Ö,Özdemir M

doi

10.1080/00015385.2017.1291181

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

161-166

issue

2

eissn

0001-5385

issn

1784-973X

journal_volume

72

pub_type

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