Age-related changes in myocardial nerve and collagen networks of the auricle of the right atrium.

Abstract:

OBJECTIVE:The objective of this study was to analyse age-related changes in human myocardial nerve plexuses and collagen networks of the auricle of the right atrium in subjects in whom no cardiac diseases or pathology had been diagnosed. METHODS AND RESULTS:Morphometric analysis of acetylcholinesterase (AChE)-stained nerve plexuses and picrosirius-stained cardiac collagen networks from 17 persons of both genders aged 20-94 years was performed using video microscopy and a digital video camera. It was found that with age linear regression of nerve plexuses occurred.Atrial collagen content increases lifelong. CONCLUSION:Aging of human atrial myocardium is accompanied by a decrease of nerve plexuses and an increase in fibrosis.

journal_name

Acta Cardiol

journal_title

Acta cardiologica

authors

Burkauskiene A,Mackiewicz Z,Virtanen I,Konttinen YT

doi

10.2143/AC.61.5.2017765

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

513-8

issue

5

eissn

0001-5385

issn

1784-973X

journal_volume

61

pub_type

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