Abstract:
OBJECTIVES:Angiotensin-converting enzyme (ACE) is a key enzyme in the production of angiotensin II and thus may participate in the modulation of cardiac growth. The cloning of the ACE gene has made it possible to identify a deletion (D)-insertion (I) polymorphism that appears to affect the level of serum ACE activity. The aim of the study is to analyse the ACE gene I/D polymorphisms in healthy young subjects and to evaluate its relationship to left ventricular mass and functions. METHODS:38 women and 40 men (mean age 21.1 +/- 1.7 and 21.4 +/- 1.7 years) were studied. They underwent complete echocardiographic assessment and analysis of ACE insertion (I) and deletion (D) allele frequencies in peripheral blood by polymerase chain reaction. Thickness of interventricular septum (IVS) and posterior wall (LVPW) and left ventricular mass (LVM) and LVM index (LVMI) were measured by M-mode. Left ventricular ejection fraction (LVEF) was calculated by Simpson's method. RESULTS:There was no statistically significant difference among the DD, DI and II genotypes, concerning age, body mass index, heart rate, systolic and diastolic blood pressures.The thickness of IVS (9.5 mm), LVPW (9.0 mm), LVM (204.5 g) and LVMI (105.5 g/m2) in DD genotypes were higher than both DI (8.3 mm; 8.1 mm; 168.1 g; 90.9 g/m2) and II genotypes (8.2 mm; 7.0 mm; 141.7 g; 77.8 g/m2) in men, but not in women. LVEF among the 3 genotypes were not statistically different. CONCLUSION:Our findings suggest that left ventricular hypertrophy is partially determined by genetic disposition especially in men but not in women.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Dursunoglu D,Evrengül H,Tanriverdi H,Turgut G,Genç O,Kaftan HA,Kilic Mdoi
10.2143/AC.60.2.2005025subject
Has Abstractpub_date
2005-04-01 00:00:00pages
153-8issue
2eissn
0001-5385issn
1784-973Xjournal_volume
60pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study was to examine the practice of cardiac bradycardia pacing in an electrophysiology laboratory and to evaluate the safety and efficacy of pacemaker implantation by cardiologists in this setting. METHODS AND RESULTS:We evaluated a consecutive series of the first 500 permanent pacemaker...
journal_title:Acta cardiologica
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
abstract:INTRODUCTION:There has been a long-standing controversy regarding the mechanism(s) to explain the irregular ventricular response during atrial tachycardia (AT) or atrial fibrillation (AF) and where the site of block, if any, resides in the atrioventricular (AV) junction. METHODS:We studied 12 Langendorff preparations ...
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doi:10.1080/ac.67.2.2154213
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Cardiac resynchronization therapy (CRT), combined with optimal medical therapy (OMT), is an established treatment for patients with advanced chronic heart failure (ACHF). In ACHF, carvedilol at the dose used in clinical trials, reduces morbidity and mortality. However, patients often do not tolerate the drug ...
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pub_type: 临床试验,杂志文章
doi:10.1080/ac.66.5.2131081
更新日期:2011-10-01 00:00:00
abstract::Creatine kinase (CK) and its isoenzyme CK-MB are important tools for the diagnosis of acute myocardial infarction. The content of CK-MB relative to total CK in myocardial cells is variable; it is low in normal myocardium and increased several-fold in hypoxic myocardium. We tested the hypothesis that CK-MB mass (CK-MBm...
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更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Smoking mentholated cigarettes inhibits the metabolism of nicotine and increases systemic exposure to cigarette smoke toxins. However, the possible effects of smoking mentholated cigarettes on coronary microvascular functions are unknown. We sought to investigate whether smoking mentholated cigarettes impairs...
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pub_type: 杂志文章
doi:10.2143/AC.63.2.2029518
更新日期:2008-04-01 00:00:00
abstract::The pharmacokinetic parameters for a two compartment open model were defined for six patients receiving a wide range of Digoxin doses. It was demonstrated that the two compartment model is a valid one to use for Digoxin pharmacokinetics. This model is an useful concept because it can explain the necessity to vary Digo...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::A young woman with systemic lupus erythematosus (SLE) developed progressive heart failure several years after mitral valve replacement with a Björk-Shiley prosthesis for treating mitral stenosis due to Libman-Sacks endocarditis. She was admitted to the hospital with pulmonary oedema. Transoesophageal echocardiography ...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:10.2143/AC.55.1.2005719
更新日期:2000-02-01 00:00:00
abstract::A 67-year-old Caucasian woman presented with chest pain suggestive of acute pericarditis. On initial evaluation the apical ballooning variant of stress-related cardiomyopathy (CMP) was present. The stress CMP and acute pericarditis resolved within a week. The patient returned in four weeks with early cardiac tamponade...
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doi:10.2143/AC.65.3.2050358
更新日期:2010-06-01 00:00:00
abstract::Meningitis due to Neisseria meningitidis occurred in a young man. On admission, he was in septic shock and the electrocardiogram revealed convex upwards ST-segment elevation in inferior and lateral leads. Rapid and complete normalisation of the ECG was observed and the patient had a favourable evolution with intensive...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.56.5.2005695
更新日期:2001-10-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-01-01 00:00:00
abstract::The aim of our study is to evaluate the prognostic value of heart rate turbulence and heart rate variability in children with dilated cardiomyopathy (DCM). Twenty-five children with DCM and 24 age- and sex-matched healthy children who were admitted between January 2002 and September 2004, enrolled in this prospective ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.62.1.2019368
更新日期:2007-02-01 00:00:00
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更新日期:2011-08-01 00:00:00
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doi:10.2143/AC.63.1.2025331
更新日期:2008-02-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章
doi:10.2143/AC.59.1.2005154
更新日期:2004-02-01 00:00:00
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journal_title:Acta cardiologica
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doi:
更新日期:1987-01-01 00:00:00
abstract::Atherosclerotic involvement of extracoronary arteries in patients undergoing myocardial revascularization can cause severe postoperative complications and increase postoperative mortality. Between January and November 1998, routine preoperative echo-Doppler study of carotid vessels, abdominal aorta and iliac-femoral a...
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pub_type: 杂志文章
doi:10.2143/AC.56.2.2005623
更新日期:2001-04-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::We report the case of a 73-year-old man admitted to our hospital for acute hepatic failure. Antemortem diagnosis of systemic AA amyloidosis was made because of typical electrocardiographic and echocardiographic findings, in the absence of the classic clinical picture of kidney involvement. ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.4.2053906
更新日期:2010-08-01 00:00:00
abstract::The clinical, fono-mechano-echocardiographic, hemodynamic and angiographic findings before and after surgery of a patient who developed bilateral extensive endomyocardial fibrosis probably secondary to filariasis, are described. The patient was surgically treated by endocardial decortication and insertion of a mitral ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.68.2.2967285
更新日期:2013-04-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.1.2045899
更新日期:2010-02-01 00:00:00
abstract::Conventional repair of pararenal aortic aneurysms has been a technically challenging operation, with a significant morbidity rate of 28-35%. Endovascular stent grafting requires satisfactory landing zones for stent graft anchoring. Therefore, pararenal abdominal aortic aneurysms are usually contraindicated for this pr...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.4.3036661
更新日期:2014-08-01 00:00:00
abstract::Nineteen asymptomatic patients affected by isolated chronic aortic regurgitation received 20 mg of nifedipine sublingually: the acute hemodynamic effects of nifedipine were evaluated by combined cross-sectional and Doppler echocardiography. To assess variations in the regurgitant flow volume, the flow volume across th...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The presence of adhesions after heart operations increases the risk of life-threatening damage to the heart and extracardiac grafts. Infections, tissue injury and inflammations are suspected aetiologic agents. The main purpose of our study is to evaluate the effect of an antiinflammatory agent piroxicam on t...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.62.6.2024014
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to test the hypothesis that smoking induces peripheral endothelial dysfunction and altered function in central conduit arteries. METHODS:A total of 22 healthy volunteers (10 women and 12 men; mean age 25.3 +/- 5.8 years) were included. At baseline, brachial artery flowmediate...
journal_title:Acta cardiologica
pub_type: 杂志文章,随机对照试验
doi:10.1080/ac.68.3.2983419
更新日期:2013-06-01 00:00:00
abstract:UNLABELLED:In order to detect myocardial viability in coronary artery disease patients (CAD) with a previous myocardial infarction and dysfunction of the left ventricle (LV), the reliability of the left atrioventricular plane displacement (LAVPD) during low dose dobutamine stress echocardiography (DSE), was validated. ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::In order to define the role of the ubiquitin-proteasome system in atherosclerotic plaque rupture in patients with type 2 diabetes mellitus (T2DM), we evaluated the amount of this system, of the main inflammatory cells, of the collagen content and some indexes indicative of oxidative stress in the carotid plaques of bo...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.6.2017962
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章
doi:10.2143/AC.57.5.2005449
更新日期:2002-10-01 00:00:00