Abstract:
:The pharmacokinetic parameters for a two compartment open model were defined for six patients receiving a wide range of Digoxin doses. It was demonstrated that the two compartment model is a valid one to use for Digoxin pharmacokinetics. This model is an useful concept because it can explain the necessity to vary Digoxin dosage in patients with different body weights, the time course of the effect of Digoxin and certain causes of increased tolerance to Digoxin. There were no alterations in the parameters of this model or of the percent of an injected Digoxin dose excreted in the urine and stool in our patients in atrial fibrillation who appeared to require larger doses to control their ventricular rates. This also suggests that the kinetics of excretion of Digoxin are not influenced by altering the Digoxin dose.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Rabkin SW,Grupp Gsubject
Has Abstractpub_date
1975-01-01 00:00:00pages
343-51issue
5eissn
0001-5385issn
1784-973Xjournal_volume
30pub_type
杂志文章abstract:AIM:To determine whether statin therapy initiated early in acute myocardial infarction together with thrombolytic therapy in patients with acute myocardial infarction results in clinical benefit through early plaque stabilization. METHODS AND RESULTS:The study population consisted of 77 patients who underwent coronary...
journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2143/AC.57.4.2005430
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the practice of cardiac bradycardia pacing in an electrophysiology laboratory and to evaluate the safety and efficacy of pacemaker implantation by cardiologists in this setting. METHODS AND RESULTS:We evaluated a consecutive series of the first 500 permanent pacemaker...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Color-coded liquid plastic was injected intraparenchymally (not into the blood vessels) into more than 300 hearts of homeotherms--including dog, cat, sheep, beef, horse, mammalian dolphins, chickens, turkeys, etc. The organization of the hearts of all these species appears to be similar. After injection of a heart seg...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Background: All previous meta-analyses including clinical outcomes after remote ischaemic conditioning (RIC) in patients with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) demonstrated that RIC significantly reduced all-cause mortality and major adverse cardiovascular...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1766259
更新日期:2020-07-03 00:00:00
abstract::Aim of this study was to elucidate the diagnostic significance of left axis deviation (LAD) in patients (pts) with chronic (> 6 months) left bundle branch block (LBBB). We retrospectively studied 2094 consecutive pts who underwent cardiac catheterization. All pts had left heart catheterization and coronary angiography...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:dobutamine stress echocardiography (DSE) in patients with ischaemic cardiomyopathy. We explored the accuracy of resting echocardiographic and tissue Doppler parameters to predict a positive response by low-dose METHODS AND RESULTS:We enrolled 100 consecutive patients with prior myocardial infarction, and a l...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.67.6.2184672
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Coronary stenoses of intermediate severity create difficulties in decision making when revascularization is concerned. Myocardial fractional flow reserve (mFFR), an accurate tool to identify physiological significance of individual coronary stenoses, may help solve this problem. METHODS AND RESULTS:Fifty-eig...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.57.5.2005449
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. In this study, we aimed to evaluate the utility of serum LOX-1 levels in the diagnosis and assessment of left ventricular systolic HF and LOX-1’s relationship with serum...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.71.2.3141848
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:There has been a long-standing controversy regarding the mechanism(s) to explain the irregular ventricular response during atrial tachycardia (AT) or atrial fibrillation (AF) and where the site of block, if any, resides in the atrioventricular (AV) junction. METHODS:We studied 12 Langendorff preparations ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.67.2.2154213
更新日期:2012-04-01 00:00:00
abstract::Conventional repair of pararenal aortic aneurysms has been a technically challenging operation, with a significant morbidity rate of 28-35%. Endovascular stent grafting requires satisfactory landing zones for stent graft anchoring. Therefore, pararenal abdominal aortic aneurysms are usually contraindicated for this pr...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.4.3036661
更新日期:2014-08-01 00:00:00
abstract::We investigated the clinical significance of recovery systolic blood pressure (SBP) ratio, obtained dividing the recovery SBP at 1st (R1/A) or 3rd min (R3/A) by the peak exercise SBP (before stopping), during upright bicycle exercise in 530 subjects (ranging from 17 to 73 years). Our results may be summarized as follo...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The modifications that atrial flutter determines on the phonocardiogram, apexcardiogram, carotid pulse tracing, jugular venous pulse tracing, and indirect (esophageal) left atrial pulse tracing were studied. On the basis of the data here presented and that of the literature, a polygraphic profile of atrial flutter has...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Sixteen patients were examined hemodynamically with echocardiography, calibrated apexcardiography, and systolic time intervals before treatment, after 1 week treatment with amiodarone 600 mg daily and after 2-4 months treatment with 300 mg daily. During the treatment thyroid function was controlled. The echocardiogram...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:This study was performed to assess whether post-stress and rest functional parameters, as measured by gated-SPECT, provide additional predictive value for long-term prognosis, over clinical and perfusion data in patients (pts.) with low left ventricular ejection fraction (LVEF). METHODS:647 consecutive pts. ...
journal_title:Acta cardiologica
pub_type: 临床试验,杂志文章
doi:10.2143/AC.59.1.2005154
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to test the hypothesis that smoking induces peripheral endothelial dysfunction and altered function in central conduit arteries. METHODS:A total of 22 healthy volunteers (10 women and 12 men; mean age 25.3 +/- 5.8 years) were included. At baseline, brachial artery flowmediate...
journal_title:Acta cardiologica
pub_type: 杂志文章,随机对照试验
doi:10.1080/ac.68.3.2983419
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:The role of adenosine as a cardioprotective agent is well known and recent experimental studies suggest that impairment of adenosine-related signal transduction contributes to the pathophysiology of chronic heart failure. The recent observation of an association between ADA, genetic polymorphism and coronary...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.1.3011343
更新日期:2014-02-01 00:00:00
abstract::"No-reflow" is an important complication of percutaneous coronary intervention (PCI) in the setting of acute myocardial infarction and is associated with worse outcomes. Visible thrombus on the angiogram is a significant risk factor for "no-reflow". A variety of strategies have been employed to prevent this phenomenon...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.6.2004941
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:The metabolic syndrome is associated with increased risk of cardiovascular disease. It is important to examine the relation of the metabolic syndrome with the early stages of atherosclerosis. We sought to determine the impact of the metabolic syndrome, defined with International Diabetes Federation criteria, ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.3.2050348
更新日期:2010-06-01 00:00:00
abstract::Introduction Strength exercises influence the cardiovascular system by promoting autonomic adjustments induced by the increased metabolic demand and consequent increase in local blood flow. However, it is unclear whether there are differences between upper and lower limbs. We aimedto evaluate recovery of cardiac auton...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2017.1335454
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:This study sought to examine the use of treatments at discharge in patients hospitalized for myocardial infarction in a French region. METHODS AND RESULTS:Data from 2,102 patients discharged after myocardial infarction were prospectively collected at 48 university, community, and private hospitals in three d...
journal_title:Acta cardiologica
pub_type: 杂志文章,多中心研究
doi:10.2143/AC.56.1.2005589
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:The coronary slow flow phenomenon is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease, and is an important clinical entity because it may be the cause of angina at rest or during exercise, acute myocardial infarction, and h...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.5.2033224
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:Smoking mentholated cigarettes inhibits the metabolism of nicotine and increases systemic exposure to cigarette smoke toxins. However, the possible effects of smoking mentholated cigarettes on coronary microvascular functions are unknown. We sought to investigate whether smoking mentholated cigarettes impairs...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.2.2029518
更新日期:2008-04-01 00:00:00
abstract::Electroconvulsive therapy (ECT) is used frequently in psychiatric practice and various electrocardiographic (ECG) changes have been described during ECT. QT dispersion (defined as maximal QT interval minus minimal QT interval) as assessed on the surface electrocardiogram has been demonstrated to reflect regional inhom...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Vasoconstrictory responses to noradrenaline (NA) or high potassium chloride (130 mM) usually show a biphasic behaviour: an initial peak is followed by a lower steady state level. The influence of three beta-sympatholytic agents (propranolol, pindolol, practolol) and a "Ca-antagonist" (verapamil) on this particular beh...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::A clinical, electrocardiographic and coronarographic study of ten cases shows that surelevation of ST-segment during exercise (without any signs of infarction) correspond to very different clinical situations of anatomical state of coronary vessels, occurrence of coronary spasm and evolution of the ischemic disease. "...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::A follow-up study was carried out in 98 patients with congestive cardiomyopathy using clinical data and M-mode echocardiography. 59 patients survived (mean follow-up period 18 months), 39 patients died (mean survival period 12.6 months). Median survival time was 3 years. Prognosis was unfavorably affected by ECG signs...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::In order to prepare Belgian participation in the International Study "Monitoring of trends and determinants in cardiovascular disease (MONICA)", a pilot project for registration of acute myocardial infarctions was organized in the Flemish city of Ghent and the Walloon city of Charleroi. Thanks to the collaboration of ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The left ventricular haemodynamic alterations during right atrial pacing were studied in 12 cases. Cardiac index varied little: during maximal rate however, its mean value was slightly lower than the resting one. Stroke index decreased inversely to the heart rate. The course of these indices did not separate the norma...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:There are few studies detailing the prevalence of prehypertension and hypertension in India. METHODS:Men and women, over 25 years of age were included. After completion of a dietitian-administered questionnaire followed evaluation by a physician, physical examination and blood pressure measurement. Cross-se...
journal_title:Acta cardiologica
pub_type: 杂志文章,多中心研究
doi:10.1080/ac.66.1.2064964
更新日期:2011-02-01 00:00:00
abstract::An anomalous origin of the right coronary artery from the left sinus of Valsalva with an interarterial course is a rather rare congenital anomaly. Treatment strategies are determined by the risk of sudden cardiac death and the presence of cardiac ischaemia. We present two cases of middle-aged patients who were diagnos...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.2.3017300
更新日期:2014-04-01 00:00:00