Abstract:
:This is a review of the effects of E on the symptoms of CHF which affect patients' (pts) quality of life and the signs associated with pts' prognosis. The review is based on clinical studies which were included in the New Drug Application for Vasotec (enalapril maleate, MSD) in the United States. There were 3 open-label (242 pts) and 4 double-blind, placebo (P)-controlled (661 pts) studies of at least 1 month and up to about 2 years duration. One of these, the CONSENSUS Trial evaluated mortality in 253 pts with class IV CHF. Dyspnea and fatigue are considered the most disabling symptoms causing pts' functional impairment and thus reducing the quality of life. Left ventricular gallop, pulmonary rales, cardiomegaly, and ejection fractions are known to adversely effect pts' prognosis. Evaluations of these signs, symptoms, and scores related to these symptoms were included in most, but not all, studies. The pts' NYHA cardiac status was evaluated in all studies. E alleviated the signs and symptoms of CHF and improved various scores in significant number of pts. Pts' quality of life improved as indicated by the number of pts "feeling better" after Rx with E (p less than 0.01 vs P) in a multinational study of 256 pts; reductions of cardiomegaly and increases in ejection fraction were significantly greater in E than in P treated pts; and in severe CHF (CONSENSUS Trial) the mortality was significantly reduced (p less than 0.003 vs P).
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Rucinska EJsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
231-46issue
2eissn
0001-5385issn
1784-973Xjournal_volume
46pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:The objective of this study was to analyse age-related changes in human myocardial nerve plexuses and collagen networks of the auricle of the right atrium in subjects in whom no cardiac diseases or pathology had been diagnosed. METHODS AND RESULTS:Morphometric analysis of acetylcholinesterase (AChE)-stained ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.5.2017765
更新日期:2006-10-01 00:00:00
abstract::Open surgery for aortic dissection with crevasse in the vicinity of critical branching (CVCB-AD) is frequently associated with several complications and a high mortality rate. We report the management of 53 patients with CVCB-AD who underwent a novel hybrid procedure including both open surgery and endovascular stenti...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.3.3027828
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:Biodegradable polymer drug-eluting stents may improve biocompatibility and reduce the risk of very late stent thrombosis (ST) but outcomes are nevertheless unknown in diabetic patients. The purpose of this study was to assess the long-term efficacy and safety of the biodegradable polymer biolimus A9-eluting s...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.5.3044879
更新日期:2014-10-01 00:00:00
abstract::A 67-year-old Caucasian woman presented with chest pain suggestive of acute pericarditis. On initial evaluation the apical ballooning variant of stress-related cardiomyopathy (CMP) was present. The stress CMP and acute pericarditis resolved within a week. The patient returned in four weeks with early cardiac tamponade...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.65.3.2050358
更新日期:2010-06-01 00:00:00
abstract::The authors investigated the changes in cardiovascular and splanchnic hemodynamic, diuresis and urinary and hepatic veins osmolarity induced by hypotonic water load in five normal subjects and in five patients with congestive heart failure (CHF). Pulmonary wedge pressure increased significantly only in CHF patients wh...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:In coronary artery disease, the implementation of a cardiac rehabilitation (CR) programme favourably affects cardiovascular prognosis. However, it remains uncertain whether patients benefit to a similar extent from CR after coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.64.5.2042694
更新日期:2009-10-01 00:00:00
abstract::An anomalous origin of the right coronary artery from the left sinus of Valsalva with an interarterial course is a rather rare congenital anomaly. Treatment strategies are determined by the risk of sudden cardiac death and the presence of cardiac ischaemia. We present two cases of middle-aged patients who were diagnos...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.2.3017300
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:There are few studies detailing the prevalence of prehypertension and hypertension in India. METHODS:Men and women, over 25 years of age were included. After completion of a dietitian-administered questionnaire followed evaluation by a physician, physical examination and blood pressure measurement. Cross-se...
journal_title:Acta cardiologica
pub_type: 杂志文章,多中心研究
doi:10.1080/ac.66.1.2064964
更新日期:2011-02-01 00:00:00
abstract::We present a case of a 87-year-old patient presenting with signs suggestive of new-onset heart failure which lead to the diagnosis of a large right ventricular mass occupying the entire cavity and extending to the right ventricular outflow tract. ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.70.1.3064600
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. In this study, we aimed to evaluate the utility of serum LOX-1 levels in the diagnosis and assessment of left ventricular systolic HF and LOX-1’s relationship with serum...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.71.2.3141848
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:B-type natriuretic peptide (BNP) has diagnostic and prognostic value in a wide variety of cardiac disorders including heart failure and acute coronary syndromes. We aimed to evaluate the prognostic value of baseline and post-procedural BNP levels in predicting major adverse cardiac events (MACE) in stable cor...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.63.1.2025331
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:The role of adenosine as a cardioprotective agent is well known and recent experimental studies suggest that impairment of adenosine-related signal transduction contributes to the pathophysiology of chronic heart failure. The recent observation of an association between ADA, genetic polymorphism and coronary...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.69.1.3011343
更新日期:2014-02-01 00:00:00
abstract::Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) provides a bridge to recovery in patients with acute respiratory failure due to the acute respiratory distress syndrome (ARDS). Survival in ARDS has improved over 15 years, and VV-ECMO may rescue even the most severe of these patients. Predictors of survival on...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2020.1841971
更新日期:2021-01-04 00:00:00
abstract::Enalapril is a new angiotensin converting enzyme inhibitor which, when absorbed by the digestive tract, is converted to enalaprilat. This metabolite is, in fact, the active form of enalapril. Its duration of action is sufficiently long so that enalapril can be administered in a single daily dose. Enalapril has been pr...
journal_title:Acta cardiologica
pub_type: 杂志文章,评审
doi:
更新日期:1986-01-01 00:00:00
abstract::Stereological methods under light and electron microscopy have been used to study the ventricular myocardium of rats exhausted by swimming exercise. The proportion of myocardial cell/interstitium diminishes with the exercise. This result is interpreted as a consequence of an intercellular edema which becomes more pron...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The interest in transcatheter ventricular septal defect (VSD) closure is continuously growing. Therefore, we report our experience in perimembranous (Pm) and postinfarction (Pi) VSD closure. METHODS:All patients, older than 16 years, were selected from a data base, in which Pm and Pi VSDs were registered. T...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.62.4.2022283
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:The aortic distensibility index, as a measure of vascular function, can serve as a marker of coronary artery disease severity. This study explores the feasibility of using the non-invasively measured index as an indicator of severity of coronary stenosis. METHODS:One hundred patients with normal left ventric...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.70.4.3096895
更新日期:2015-08-01 00:00:00
abstract::A follow-up study was carried out in 98 patients with congestive cardiomyopathy using clinical data and M-mode echocardiography. 59 patients survived (mean follow-up period 18 months), 39 patients died (mean survival period 12.6 months). Median survival time was 3 years. Prognosis was unfavorably affected by ECG signs...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::We report the case of a 51-year-old man of central African origin. Medical evaluation revealed severe heart failure. Echocardiography disclosed poor left ventricular function. The apex of the left ventricle showed complete obliteration and retraction. Magnetic resonance imaging revealed subendocardial hyperenhancement...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.66.3.2114140
更新日期:2011-06-01 00:00:00
abstract::Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disease characterized pathologically by fibrofatty replacement of right ventricular myocardium. It is further characterized by an electrical instability that precipitates ventricular arrhythmias and sudden death. The prevalence is estimated at 0.4% de...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.59.4.2005214
更新日期:2004-08-01 00:00:00
abstract::Sixteen patients were examined hemodynamically with echocardiography, calibrated apexcardiography, and systolic time intervals before treatment, after 1 week treatment with amiodarone 600 mg daily and after 2-4 months treatment with 300 mg daily. During the treatment thyroid function was controlled. The echocardiogram...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to evaluate the prevalence of HR2 polymorphism among patients with pulmonary embolism (PE) and healthy subjects. BACKGROUND:Polymorphism in the factor V gene named HR2 has been described as a possible risk factor for venous thromboembolism (VTE) development. Contradictive resu...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.70.6.3120184
更新日期:2015-12-01 00:00:00
abstract::We describe two cases of Duchenne's cardiomyopathy with severe cardiac dysfunction, sporadic episodes of myoglobinuria induced by effort and increased levels of serum creatine kinase. Very mild signs of skeletal myopathy were clinically evident. Left ventriculography showed diffuse severe hypokinesia. Skeletal muscle ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.61.4.2017311
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:We investigated the survival of patients who had undergone elective reconstruction of the ascending aorta for degenerative aneurysms. The long-term survival was compared to an age- and sex-matched case-control population. An analysis of risk factors, influencing survival was made. METHODS AND RESULTS:From Ma...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.68.4.2988887
更新日期:2013-08-01 00:00:00
abstract::Diffuse intra-alveolar haemorrhage is a rare complication of thrombolytic therapy (TT). We report a patient who developed haemoptysis due to pulmonary haemorrhage. This diagnosis should be considered in any patients with respiratory distress, diffuse pulmonary infiltrates, and haemoptysis and otherwise unexplained dec...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.59.3.2005194
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:The primary aim of the study was to investigate whether there is a difference in plasma B-type natriuretic peptide (BNP) levels among the left ventricular systolic dysfunction caused by different types of heart disease. METHODS AND RESULTS:Plasma BNP was measured in patients with left ventricular systolic d...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.3.2005008
更新日期:2005-06-01 00:00:00
abstract::In order to study the arterial blood supply of the sinus atrial node in the Dog, the authors have performed the post-mortem injection of the arterial branches going to this node. They observed 65 cases and they came to the following conclusions: in 31 cases (47.7%) the sinus atrial node is supplied by the artery of th...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:Cardiac rehabilitation programmes result in reduced morbidity and mortality and improvement of functional class. Behaviour of natriuretic peptides coupled to these programmes is not well established. Our study's objective is to evaluate the behaviour of natriuretic peptides in a sample of patients undergoing ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.66.5.2131091
更新日期:2011-10-01 00:00:00
abstract::Background: This study aimed to examine the value of prognostic nutritional index (PNI) as a predictor of outcomes in patients with heart failure and preserved ejection fraction (HFpEF).Methods: We prospectively followed consecutive adult patients admitted to the cardiology outpatient units with HFPEF. Echocardiograph...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/00015385.2019.1661139
更新日期:2020-09-01 00:00:00
abstract::The increasing number of amateur sportsmen enhances the need for a correct evaluation of subjects suspected of overt and mild cardiac disease. Out of 4000 athletes, 72 subjects were clinically preselected by the sport doctor during an annual routine examination. They were studied with mono and 2D echo, pulsed color (P...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00