Abstract：
:Background: Atrial fibrillation (AF) is related to an increased stroke risk. At present, differentiation between patients with paroxysmal AF (pAF) and without is only possible during AF episodes and not during sinus rhythm. If AF could be diagnosed more quickly and reliably, anticoagulation therapy may be administered and prevent from cardioembolic strokes. The DETECT AF trial evaluated the hypothesis that propagation of electric activities in patients with pAF differs from propagation in healthy atria and that this can be detected with a three-dimensional electrocardiogram in patients during sinus rhythm. Methods: We conducted a case-control study including patients with a history of pAF and a control group with no history of AF. Vectorcardiographic beat-to-beat variability of atrial activation in sinus rhythm was tested and compared between the two groups. Results: One hundred and eight patients with a history of pAF in sinus rhythm and 121 controls in sinus rhythm were included. With a combination of specific vectorcardiographic beat-to-beat variability parameters discrimination between the two groups was possible with a specificity of 82% and a sensitivity of 71% (p≤.01). Using heart rate independent parameters, both specificity and sensitivity were reduced to 70%. Conclusions: Analysis of atrial vectorcardiographic beat-to-beat variability indicates that atrial conduction variability in patients with pAF differs from patients without AF and may be used as an indicator to estimate the risk for pAF in patients during sinus rhythm. Further studies to investigate the potential of this parameter are needed. Clinical trial registration number: NCT02270112.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Brasier N,Engelter S,Kolbitsch T,Tabord A,Knobeloch J,Kühne M,Conen D,Traenka C,Kreutzberger T,Völlmin G,Eckstein Jdoi
10.1080/00015385.2018.1493248subject
Has Abstractpub_date
2019-08-01 00:00:00pages
301-307issue
4eissn
0001-5385issn
1784-973Xjournal_volume
74pub_type
杂志文章abstract：:Background: Defibrillation threshold testing (DT) following implantable cardioverter defibrillator (ICD) implantation has not shown to improve mortality. However, the impact of DT on burden of heart failure (HF) hospitalisations has not been well defined.Methods: We studied retrospectively consecutive patients who und...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/00015385.2019.1630586
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:With the aim of recommending proper anticoagulation for patients with atrial fibrillation (AF) and diabetes mellitus, we performed the network meta-analysis comparing the non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin in terms of efficacy (stroke or systemic embolism) and safety (major bleedi...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/00015385.2020.1869671
更新日期：2021-01-12 00:00:00
abstract：UNLABELLED:The aim of study was to determine the significance of the best echocardiographic parameters for assessing the severity of mitral regurgitation (MR). METHODS:The study population consisted of 107 patients, mean age 52 +/- 7 y with chronic isolated non-ischaemic MR. Quantification of the MR was performed usin...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.64.2.2036136
更新日期：2009-04-01 00:00:00
abstract：:This is a review of the effects of E on the symptoms of CHF which affect patients' (pts) quality of life and the signs associated with pts' prognosis. The review is based on clinical studies which were included in the New Drug Application for Vasotec (enalapril maleate, MSD) in the United States. There were 3 open-lab...
journal_title：Acta cardiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-01-01 00:00:00
abstract：:Aims: Response to cardiac resynchronisation therapy (CRT) in patients with heart failure depends on the degree of correction of electromechanical dyssynchrony between the left and right ventricles (LV, RV). It is not known whether chronic programming of interventricular (VV) intervals based on characterisation of myoc...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/00015385.2019.1690261
更新日期：2019-11-14 00:00:00
abstract：:Diffuse intra-alveolar haemorrhage is a rare complication of thrombolytic therapy (TT). We report a patient who developed haemoptysis due to pulmonary haemorrhage. This diagnosis should be considered in any patients with respiratory distress, diffuse pulmonary infiltrates, and haemoptysis and otherwise unexplained dec...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.59.3.2005194
更新日期：2004-06-01 00:00:00
abstract：:Most decision-support systems in medicine have been developed in hospital environments, but only few are designed for being used by general practitioners. The present work aims to design an expert system for practitioners in chronic heart failure (CHF) treatment. It provides assistance in defining the therapy relying ...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：INTRODUCTION:3D echocardiography offers options of left ventricular systolic function analysis. The aims of this study are: to assess the usefulness of 3D echocardiography, to test 3D regional measurements (with area strain) among a spectrum of patients and then to check prospectively the value of 3D echocardiography v...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/ac.70.1.3064590
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:Smoking mentholated cigarettes inhibits the metabolism of nicotine and increases systemic exposure to cigarette smoke toxins. However, the possible effects of smoking mentholated cigarettes on coronary microvascular functions are unknown. We sought to investigate whether smoking mentholated cigarettes impairs...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.63.2.2029518
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Available clinical and angiographic scoring systems fail to predict clinical outcomes in real-world patients undergoing revascularization of the unprotected left main coronary artery (ULMCA). METHODS:We prospectively assessed major adverse cardiac and cerebrovascular events (MACCE) in a real-world populatio...
journal_title：Acta cardiologica
pub_type： 杂志文章,多中心研究
doi：10.1080/ac.67.5.2174124
更新日期：2012-10-01 00:00:00
abstract：:Between April 1988 and October 1989, 22 adult patients with isolated or predominant severe mitral stenosis underwent Percutaneous Transvenous Mitral Valvuloplasty (PTMV). In 20 patients, a transseptal double balloon technique was used; in the last 2 patients, dilatation was performed using the Inoué balloon. Immediate...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Mitral annular calcification is a degenerative process. It is mostly asymptomatic. As the calcification becomes more extensive it might be mistaken for an intracardiac tumour. Mitral annular calcification predicts cardiovascular events, cardiovascular death and overall death. It is predictive of a doubling of the stro...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/ac.69.3.3027838
更新日期：2014-06-01 00:00:00
abstract：:The present study is a revision of the patterns of the jugular and hepatic tracings, two non-invasive tracings of the venous system. The study was performed in 40 subjects; 30 of them were normal while 10 had minor conditions affecting the left heart. The time of onset and peak of the various waves was statistically e...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:We present a 64-year-old woman who was brought to the emergency department after suffering a motor vehicle accident, involving multiple soft tissue and bone trauma. Even though she was free from cardiovascular symptoms for the last three years, her past medical history of aorto-coronary bypass surgery prompted preoper...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.58.2.2005271
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVES:Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. In this study, we aimed to evaluate the utility of serum LOX-1 levels in the diagnosis and assessment of left ventricular systolic HF and LOX-1’s relationship with serum...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.71.2.3141848
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:Cytomegalovirus (CMV), Helicobacter pylori (H. pylori) and Chlamydia pneumoniae (C. pneumoniae) have been associated with human atherosclerosis. The reported rates of detection within atherosclerotic lesions by PCR vary widely for all of these pathogens. We investigated their presence in carotid atherosclerot...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.59.6.2005249
更新日期：2004-12-01 00:00:00
abstract：:Primary ventricular fibrillation especially occurs during the first hours after acute myocardial infarction and is often not preceded by premonitory ventricular premature beats. In hospital primary ventricular fibrillation can be prevented by an intravenous lidocaine regimen in a rather high dosage. By contrast the ef...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:After D.C. countershock to terminate cardiac arrhythmias, in 3 out of 8 patients studied, an increase in both plasma myoglobin (Mb) and CK-MB (assessed by radioimmunoassay) was found. In 2 patients there was an increase of only plasma Mb and in 1 an increase of only CK-MB. In 2 cases no increase of either parameters w...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:This study investigates the relationship between post-heparin plasma lipoprotein lipase (LPL) activity, chronic inflammation and premature stable coronary artery disease (CAD) in male patients. METHODS AND RESULTS:132 male patients (< 55 years) with documented stable CAD (cases) and 130 male subjects without...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.64.3.2038025
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVES:Angiotensin-converting enzyme (ACE) is a key enzyme in the production of angiotensin II and thus may participate in the modulation of cardiac growth. The cloning of the ACE gene has made it possible to identify a deletion (D)-insertion (I) polymorphism that appears to affect the level of serum ACE activity. ...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.60.2.2005025
更新日期：2005-04-01 00:00:00
abstract：:The present study was designated to assess long term functional capacity, blood pressure and renal function at 12 and 60 months after heart transplantation. The data of sixty heart transplant recipients were retrospectively reviewed. At rest, radionuclide ejection fraction and cardiac index measured by thermodilution ...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The case reported in this paper, besides illustrating several aspects of the eosinophilic myocarditis, documents a yet undescribed feature of the cardiac involvement in idiopathic hypereosinophilic syndrome characterized by marked basement membrane thickening of small intramyocardial vessels. We are unaware of previou...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVE:We investigated the survival of patients who had undergone elective reconstruction of the ascending aorta for degenerative aneurysms. The long-term survival was compared to an age- and sex-matched case-control population. An analysis of risk factors, influencing survival was made. METHODS AND RESULTS:From Ma...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/ac.68.4.2988887
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:The present study was designed to examine the changes of MMP-2/TIMP-2 in the hearts of streptozotocin-induced diabetic rats and gain insight into their roles in extracellular matrix (ECM) remodelling on an experimental animal model of diabetic cardiomyopathy. METHODS AND RESULTS:Sixteen male Wistar rats were...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.62.5.2023412
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Despite the availability of guidelines for preoperative cardiology consultations, their efficacy in real clinical practice remains unknown. Furthermore, there are concerns that overused cardiology consultations can lead to unnecessary investigations, prolonged hospital stays, and even cancellation of necessa...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/ac.66.4.2126592
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:We aimed to investigate the role of QRS duration on the surface electrocardiogram (ECG) in predicting response to levosimendan therapy in patients with acute systolic heart failure. METHODS:Patients with an ejection fraction (EF) lower than 35% who required intravenous inotropic support despite optimal heart f...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.1080/ac.67.3.2160721
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:This study sought to evaluate the potential prognostic usefulness of QT dispersion (QTd) in patients with unstable angina. METHODS AND RESULTS:QTd was calculated and plasma troponin T (TnT) level was measured and rest perfusion imaging with Tc-99m sestamibi was performed in 62 patients admitted with chest pa...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.59.3.2005183
更新日期：2004-06-01 00:00:00
abstract：INTRODUCTION:The added value of routine echocardiography, in respect to clinical examination and ECG, has received little attention. We sought to evaluate the contribution of two-dimensional echocardiography, in respect to clinical examination and ECG, in detecting left ventricular (LV) dilatation and systolic dysfunct...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：10.2143/AC.63.4.2033051
更新日期：2008-08-01 00:00:00
abstract：:The purpose of the present study was to determine whether the cardiorespiratory variables measured during an exercise test with a continuously increasing workload (ramp) protocol are reproducible and to compare them to the values obtained with a step-wise incremental (James) protocol. Twenty normal adolescents and you...
journal_title：Acta cardiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-01-01 00:00:00
abstract：:We describe the case of a 44-year-old man, with a history of recurrent syncopal episodes and effort angina, the latter attributed to cardiac syndrome-X, who was admitted to our department because of a syncopal episode. During his hospitalization laboratory investigations including haematologic and blood chemical findi...
journal_title：Acta cardiologica
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
