Abstract：
:The mannosylated lipoarabinomanan (ManLAM) from mycobacterial species possesses strong anti-apoptotic action. Here we examined the ability of ManLAM isolated from Mycobacterium tuberculosis H37Rv to alter expression profiles of apoptosis-related genes in mouse macrophages infected with Mycobacterium bovis BCG Danish strain. ManLAM suppressed BCG-induced apoptosis and activities of caspase-1, -3, -8 and 9. Mouse Apoptosis Gene Array showed that ManLAM significantly down-regulated pro-apoptotic and proinflammatory genes: caspase-1, -3, -7, -8 and -9, TNF-alpha/TNFSF2, Fas/TNFRSF6, Bax-alpha, as well as IL-12 p35 and iNOS simultaneously up-regulating anti-apoptotic genes such as Bcl-2 and Mcl-1. The effect of ManLAM was contrary to BCG-induced up-regulation of proapoptotic and pro-inflammatory genes and consistent with the functional data.
journal_name
Pol J Microbioljournal_title
Polish journal of microbiologyauthors
Krzyzowska M,Malewski T,Hamasur B,Augustynowicz-Kopeć E,Schollenberger A,Pawłowski A,Niemiałtowski Msubject
Has Abstractpub_date
2008-01-01 00:00:00pages
125-33issue
2eissn
1733-1331issn
2544-4646journal_volume
57pub_type
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